2010
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胡洪波 研究员，博士生导师    

四川大学生物治疗全国重点实验室

四川大学华西医院免疫与血液研究院 院长

国家杰出青年基金获得者


工作及教育经历：

2021/09 - 至今 四川大学华西医院免疫和血液研究院，主任

2015/09 - 至今 四川大学华西医院生物治疗国家重点实验室，研究员

2012/04 - 2015/08，美国得克萨斯大学MD安德森癌症中心 免疫学系，讲师

2009/12 - 2012/04，美国得克萨斯大学MD安德森癌症中心 免疫学系，博士后

2006/12-2009/11，美国贝勒医学院 免疫学系， 博士后

2002/09 - 2005/11 中国协和医科大学，免疫学，博士

1999/09 - 2002/07  厦门大学，微生物学，硕士


      主持的科研项目：

       1.国家自然基金委“杰出青年”项目，T细胞发育和功能研究（82025002），在研，负责人

       2.国家自然基金委重点项目，T细胞起源和功能异质性及其调控机制（32230036），在研，负责人

       3.国家自然基金委面上项目，TRIM29在mtDNA诱导IFN－I产生中的作用研究（81871232），结题，负责人

       4.国家重点研发计划 “干细胞”专项，免疫细胞谱系发育的精细解析（2019YFA0110201），在研，课题骨干

       5.国家自然基金委重大研究计划项目，TRIM52 lncRNA在T细胞中的功能及其机制研究（91740111），结题，负责人

       6.国家重点研发计划 “蛋白质生命机器”专项，CD4+ T细胞转录后调控（2016YFA0502203），结题，子课题负责人


主要从事分子和细胞免疫学研究，集中在T细胞发育、分化和功能中信号传导以及分子调节机制等方面。解析了人T细胞起源和胸腺发育的关键事件，以及蛋白质翻译后修饰（泛素化等）在免疫细胞发育和功能中、免疫反应过程中的重要作用。以通讯/共同通讯、第一/共同第一作者已经在国际一流期刊Nature，Immunity、Trends in Immunology, Cell Research, Journal of Experiential Medicine Med, PNAS等上发表论文共50余篇。作为项目负责人承担的国家级课题：国家自然基金委杰出青年科学家项目、重点项目、重大研究计划和面上项目。以及科技部国家重点研发计划 “蛋白质生命机器”专项和“干细胞研究和转化”专项。任Cellular &Molecular Immunity，Journal of Immunotherapy for Cancer编委。

 

研究方向：

（1）免疫细胞（T细胞）发育和功能调控机制

（2）免疫细胞起源、衰老和再生

（3）多组学、单细胞水平解析免疫反应

（4）肿瘤免疫和新型免疫治疗策略


  1. Zou X, Wang K, Deng Y, Guan P, Pu Q, Wang Y, Mou J, Du Y, Lou X, Wang S, Jiang N, Zhou S, Wang H, Du D, Liu X*, Hu H*, Zhang H*. Hypoxia-inducible factor 2α promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism. Immunity. 2024 Nov 21:S1074-7613(24)00496-5. 

  2. ZhengCan Peng, Huiyuan Zhang and Hongbo Hu. Not to be and how not to be: the questions of Treg Controlled by RIPK1. Cellular and Molecular Immunology 21, 205–206 (2024).

  3. Liangbin Lin, Hui Yu, Li Li, Wenyong Yang, Xueying Chen, Yanqiu Gong, Qingqiang Lei, Zhonghan Li, Zhaocai Zhou, Lunzhi Dai, Huiyuan Zhang*, Hongbo Hu*. TRIM55 promotes noncanonical NF-kB pathway and B-cell-mediated immune response by coordinating p100 ubiquitination and processing. Science Signaling 2023 Oct 10;16(806): eabn5410.

  4. Hongbo Hu*. The progress and challenges of hematological malignancies in the era of big data and new therapy (Editorial:). Cancer Letters, 2023 Oct 28:575:216399.

  5. Xiaoqi Han, Siyuan Jiang, Yinmin Gu, Lihua Ding, Enhao Zhao, Dongxing Cao, Xiaodong Wang, Ya Wen, Yongbo Pan, Xin Ya2, Liqiang Duan, Minxuan Sun, Tao Zhou, Yajuan Liu, Hongbo Hu*, Qinong Ye* and Shan Gao*. HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1. Cell Death and Disease. 2023, 14:327

  6. Han Luo, Xuyang Xia, Li-Bin Huang, Hyunsu An, Minyuan Cao, Gyeong Dae Kim, Hai-Ning Chen, Wei-Han Zhang, Yang Shu, Xiangyu Kong, Zhixiang Ren, Pei-Heng Li, Yang Liu, Huairong Tang, Ronghao Sun, Chao Li, Bing Bai, Weiguo Jia, Yi Liu, Wei Zhang, Li Yang, Yong Peng, Lunzhi Dai, Hongbo Hu, Yong Jiang, Yiguo Hu, Jingqiang Zhu, Hong Jiang, Zhihui Li, Carlos Caulin, Jihwan Park, Heng Xu. Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment. Nature Communications. 2022 Nov 4;13(1):6619.

  7. Jinyuan Luoqian, Wenyong Yang, Xulong Ding, Qing-zhang Tuo, Zheng Xiang, Zhaoyue Zheng, Yu-jie Guo, Li Li, Pengbo Guan, Scott Ayton, Biao Dong, Huiyuan Zhang, Hongbo Hu*, Peng Lei*. Ferroptosis promotes T cell activation-induced neurodegeneration in multiple sclerosis, Cellular & Molecular Immunology. 2022. Published online 08-June-2020.

  8. Chen Liu, Yandong Gong, Han Zhang, Hua Yang, Yang Zeng, Zhilei Bian, Qian Xin, Zhijie Bai, Man Zhang, Jian He, Jing Yan, Jie Zhou, Zongcheng Li, Yanli Ni, Aiqing Wen*, Yu Lan*, Hongbo Hu*, and Bing Liu*. Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells. Cell Research, 2021 Oct;31(10):1106-1122.

  9. Yujun Deng, Hong Chen, Yang Zeng, Keyue Wang Huiyuan Zhang*, Hongbo Hu*. Leaving no one behind: tracing every human thymocyte by single-cell RNA-sequencing. Semin Immunopathol. 2021 Feb;43(1):29-43.

  10. Chen Liu, Yu Lan, Bing Liu, Huiyuan Zhang* and Hongbo Hu*. T Cell Development: Old Tales Retold By Single-Cell RNA Sequencing. Trends Immunol.  2021 Feb;42(2):165-175. doi: 10.1016/j.it.2020.12.004.

  11. Zhiwen Gu, Xueying Chen, Wenyong Yang, Yu Qi, Hui Yu, Xiaomeng Wang, Yanqiu Gong, Qianqian Chen, Bo Zhong, Lunzhi Dai, Shiqian Qi, Zhiqiang Zhang*, Huiyuan Zhang*, Hongbo Hu*. The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-kB activation and innate immune response. Cell Mol Immunol. 2021 Aug;18(8):1981-1994

  12. Yang Zeng, Chen Liu, Yandong Gong, Zhijie Bai, Siyuan Hou, Jian He, Zhilei Bian, Zongcheng Li, Yanli Ni, Jing Yan, Tao Huang, Hui Shi, Chunyu Ma, Xueying Chen, Jinyong Wang, Lihong Bian, Yu Lan*, Bing Liu* and Hongbo Hu*. Single-cell RNA sequencing resolves spatiotemporal development of pre-thymic lymphoid progenitors and thymus organogenesis in human embryos. Immunity, 2019, 51(5):930-948

  13. Hui Yu, Liangbin Lin, Zhiqiang Zhang, Huiyuan Zhang* and Hongbo Hu*. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduction Targeted Therapy. 2020 Sep 21;5(1):209.

  14. Linjie Zhao, Hongbo Hu, Jan-Ake Gustafsson* and Shengtao Zhou*. Nuclear Receptors in Cancer Inflammation and Immunity. Trends in Immunology. 2020. 41(2):172-185

  15. Wenyong Yang, Zhiwen Gu, Huiyuan Zhang* and Hongbo Hu*. To TRIM the immunity: from innate to adaptive immunity. Frontiers in Immunology, 2020. 11:2157.

  16. Wenyong Yang, Xueying Chen and Hongbo Hu*. CD4+ T-cell differentiation in vitro. Methods in Molecular Biology. 2020; 2111:91-99.

  17. Liangbin Lin, Xiang Hu, Huiyuan Zhang* and Hongbo Hu*. Tertiary lymphoid organs in cancer immunology: mechanisms and the new strategy for immunotherapy. Frontiers in Immunology. 2019 (10):1398.

  18. Tao Huang, Zhengjun Gao, Yu Zhang, Keqi Fan, Fei Wang, Yiyuan Li, Jiangyan Zhong, Heng Y. Fan, Qian Cao, Jiyong Zhou, Yichuan Xiao, Hongbo Hu, Jin Jin*. CRL4DCAF2 negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis Journal of Experiential Medicine. 2018 Aug 6;215(8):1999-2017.

  19. Qijie Li, Liangbin Lin, Yanli Tong, Yantong Liu, Jun Mou, Xiaodong Wang, Xiuxuan Wang, Yanqiu Gong, Yi Zhao, Yi Liu, Bo Zhong, Lunzhi Dai, Yu-quan Wei, Huiyuan Zhang*, Hongbo Hu*. TRIM29 negatively controls anti-viral immune response through targeting STING for degradation. Cell Discovery. 2018 4:13,

  20. Hongbo Hu, George Brittain, Jae-Hoon Chang, Nahum Puebla-Osorio, Jin Jin, Anna Zal, Yichuan, Xiao, Xuhong Cheng, Mikyoung Chang, Yang-Xin Fu, Tomasz Zal, Chengming Zhu, and Shao-Cong Sun*. Otud7b controls noncanonical NF-kB activation via deubiquitination of TRAF3. Nature. 2013 Feb 21; 494(7437):371-4.

  21. Hongbo Hu, Hui Wang, Yichuan, Xiao, Jin, Jin, Jae-Hoon Chang, Qiang Zou, Xiaoping Xie, Xuhong Cheng, Shao-Cong Sun*. Otud7b facilitates T cell activation and inflammatory response by regulating Zap70 ubiquitination. Journal of Experiment Medicine. 2016. 213(3):399-414.

  22. Hongbo Hu, Shao-Cong Sun*. Ubiquitin Signaling in Immune Response. Cell Research. 2016, 26(4):457-83

  23. Yunqiang Bai, Yanli Tong, Yi Liu and Hongbo Hu*. Self-dsDNA in the pathogenesis of systemic lupus erythematosus. Clinical & Experimental Immunology. 2017, 191(1):1-10. 

  24. Jin Jin, Xiaoping Xie, Yichuan Xiao, Hongbo Hu, Qiang Zou, Xuhong Cheng, Shao-Cong Sun*. Epigenetic regulation of IL-12/IL-23 gene expression and autoimmune response by deubiquitinase Tradid. Nature Immunology, 2016. 17(3):259-68.

  25. Jae-Hoon Chang, Hongbo Hu, Jin Jin, Nahum Puebla-Osorio, Yichuan Xiao, Robert Brink, Stephen E Ullrich, and Shao-Cong Sun*. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. Journal of Experimental Medicine. 2014 211:137-151 As Co-first author.

  26. Jae-Hoon Chang, Hongbo Hu, Shao-Cong Sun*. Survival and maintenance of regulatory T-cell require the kinase TAK1. Cellular and Molecular Immunology. 2015 Sep;12(5):572-9. doi: 10.1038/cmi.2015.27.

  27. Jin Jin, Yichuan Xiao, Hongbo Hu, Qiang Zou, Yanchuan Li, Yanpan Gao, Wei Ge, Xuhong Cheng and Shao-Cong Sun*. Proinflammatory TLR signaling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nature Communications. 2015 Jan 7;6:5930. doi: 10.1038/ncomms6930

  28. Huiyuan Zhang, Hongbo Hu, Nathaniel Greeley, Jin Jin, Allison J. Matthews, Erika Ohashi, Mauricio S. Caetano, Haiyan S. Li, Xuefeng Wu, Pijus K. Mandal, John S. McMurray, Seyed Javad Moghaddam, Shao-Cong Sun, Stephanie S. Watowich*. Role for STAT3 in inflammation: regulation of the ubiquitin-conjugating (E2) enzyme UBC13. Nature Communications. 2014 Dec 15;5:5798. doi: 10.1038/ncomms6798

  29. Qiang Zou, Jin Jin, Hongbo Hu, Haiyan Li, Simona Romano, Yichuan Xiao, Mako NAkaya, Xiaofei Zhou, Xuhong Cheng, Peirong Yang, Guillernima Lozano, Chengming Zhu ,Stephanine S. Watowich, Stephen Ullrich, Shao-Cong Sun*. USP15 stabilizes MDM2 to mediate cancer cell survival and inhibit autitumor T-cell response. Nature Immunology, 2014, doi:10.1038/ni.2885

  30. Jin Jin, Hongbo Hu, Haiyuan Li, Jiayi Yu, Yichuan Xiao, Qiang Zou, Xuhong Cheng, Robyn Starr, Stephanie S. Watowich and Shao-Cong Sun*. Non-canonical NF-kB pathway controls the production of type I Interferons in antivirual innate immunity. Immunity, 03/2014; 40(3):342-54.

  31. Jae-Hoon Chang, Yichuan Xiao, Hongbo Hu, Jin Jin, Jiayi Yu, Howard M Johnson, Shizuo Akira, Xuhong Cheng, and Shao-Cong Sun*. UBC13 maintains the suppressive function of regulatory T cells and prevent their conversion into effector-like T cells. Nature Immunology. (2012) May;13(5):481-90.

  32. Hongbo Hu, Xuefeng Wu, Wei Jin, Mikyong Chang, Xuhong Cheng and Shao-Cong Sun*. Noncanonical NF-kB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development. Proceedings of National Academy of Sciences. 2011 Aug 2; 108(31):12827-32.

  33. 32. Zhun Wang, Tie Zhang, Hongbo Hu, Huiyuan Zhang, Zhi Yang, Lianxian Cui, Wei He*. Targeting solid tumors via T cell receptor complementarity-determining region 3δ in an engineered antibody. Cancer Letter. 2008 272:242-252.

  34. 33. Chunping Xu, Huiyuan Zhang, Hongbo Hu, Hongbie He, Zhun Wang, Yong Xu, Hui Chen, Wei Cao, Sumei Zhang, Lianxian Cui, Denian Ba, Wei He*. gd T cells recognize tumor cells via CDR3d region. Molecular Immunology, 2007; 44(4):302-10. Co-first author.

  35. Hongbo Hu, Li L, Richard Y, Kao, Binbin Kou, Zhanguo Wang, Huiyuan Zhang, Zhiyong Hao, Wayne H. Tsui, Anping Ni, Lianxian Cui, Baoxing Fan, Qian Li, Manji Sun, Wei He*, Gang Liu*. Screening and Identification of Linear B-cell Epitopes and Entry Blocking Peptide of Severe Acute Respiratory Syndrome (SARS) Associated Coronavirus Using Synthetic Overlapping Peptide Library. Journal of Combinatorial Chemistry, 2005; 12 ;7(5):648-656.

  36. Huiyuan Zhang, Hongbo Hu, Xinxin Jiang, Hongbin He, Lianxian Cui, Wei He*. Membrane HSP70: the molecule triggering gd T cells in the early stage of tumor-genesis. Immunological investigations. 2005; 34:453-468.



    联系方式：hongbohu@scu.edu.cn