四川大学生物治疗全国重点实验室

华西医院免疫与血液研究院

四川省高级人才计划获得者

工作及教育经历：

2000-2005年，中国协和医科大学，获得博士学位（免疫学）。

2007-2016年，美国MD安德森癌症中心免疫学系，博士后；2012年晋升为讲师。

2016-至今，四川大学华西医院/生物治疗全国重点实验室，担任研究室负责人。

主持的科研项目：

1.国家自然基金重大项目，人胸腺老化的规律和机制研究（82394411），在研，负责人

2.国家自然基金面上项目，造血干细胞衰老及免疫老化相关新型表观遗传标志H4K77ac的鉴定和机制研究（82170113），在研，负责人

3.国家重点研发专项干细胞专项，功能性免疫细胞再生技术（2019YFA010203），结题，子课题负责人

4.国家老年疾病临床医学研究中心，新型表观遗传标志调控造血干细胞衰老的机制研究（Z2021JC009），结题，负责人

5.国家自然基金面上项目，Ubc13调控造血干细胞炎性反应的细胞和分子机制研究（31870881）,结题，负责人

研究方向：

      造血免疫系统和器官发育和衰老调控：以单细胞多组学结合fate mapping等手段，揭示了造血和免疫系统和胸腺等重要器官在机体稳态发育 

      衰老和炎症等疾病过程中系统变化和关键调控机制相关研究成果多次被Nat Immunol重点推荐。

      蛋白质修饰与免疫调控：揭示了多个泛素化调控酶在天然和获得性免疫中的关键调控作用。

      肿瘤微环境免疫细胞的功能调控：深入探讨JAK-STAT信号通路在肿瘤微环境的相关作用机制。

1.  Zou X, Wang K, Deng Y, Guan P, Pu Q, Wang Y, Mou J, Du Y, Lou X, Wang S, Jiang N, Zhou S, Wang H, Du D, Liu X*, Hu H*, Zhang H*. Hypoxia-inducible factor 2α promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism. Immunity. 2024 Nov 21:S1074-7613(24)00496-5. 

2. Wang X, Luo Y, He S, Lu Y, Gong Y, Gao L, Mao S, Liu X, Jiang N, Pu Q, Du D, Shu Y, Hai S, Li S, Chen HN, Zhao Y, Xie D, Qi S, Lei P, Hu H, Xu H, Zhou ZG, Dong B*, Zhang H*, Zhang Y*, Dai L*. Age-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates. Nature Aging. 2024; doi: 10.1038/s43587-024-00572-9.

3.  Lin L, Yu H, Li L, Yang W, Chen X, Gong Y, Lei Q, Li Z, Zhou Z, Dai L, Zhang H*, Hu H*. TRIM55 promotes noncanonical NF-κB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing. Science Signaling. 2023, 16: eabn5410. doi: 10.1126/scisignal. abn5410.

4.  Liu C, Lan Y, Liu B, Zhang H*, Hu H*. T Cell Development: Old Tales Retold by Single-Cell RNA Sequencing. Trends Immunol. 2021 42(2):165-175. doi: 10.1016/j.it.2020.12.004.

5. Gu Z, Chen X, Yang W, Qi Y, Yu H, Wang X, Gong Y, Chen Q, Zhong B, Dai L, Qi S, Zhang Z, Zhang H*, Hu H. The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response. Cell Mol Immunol. 2020, doi: 10.1038/s41423-020-00564-w.

6. Yu H, Lin L, Zhang Z, Zhang H*, Hu H*. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther, 2020, 5(1):209.

7. Gu Z, Chen X, Yang W, Qi Y, Yu H, Wang X, Gong Y, Chen Q, Zhong B, Dai L, Qi S, Zhang Z, Zhang H*, Hu H. The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response. Cell Mol Immunol. 2020, doi: 10.1038/s41423-020-00564-w.

8. Li Q#, Lin L#, Tong Y, Liu Y, Mou J, Wang XD, Wang X, Gong Y, Zhao Y, Liu Y, Zhong B, Dai L, Wei Y, Zhang H*, Hu H*.  TRIM29 negatively controls anti-viral immune response through targeting STING for degradation. Cell Discovery, 2018, 4:13 doi: 10.1038/s41421-018-0010-9.

9. Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, Sun SC, Watowich SS. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 anti-inflammatory activity in hematopoiesis. Proc Natl Acad Sci U S A，2018, 115:E2311-E2319， doi: 10.1073/pnas.1713889115.

10. Caetano MS, Hassane M, Van HT, Bugarin E, Cumpian AM, McDowell CL, Cavazos CG, Zhang H, Deng S, Diao L, Wang J, Evans SE, Behrens C, Wistuba II, Fuqua SAW, Lin H, Stabile LP, Watowich SS, Kadara H, Moghaddam SJ. Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer. Nat Commun, 2018, 9:4589.

11. Caetano MS, Zhang H, Cumpian AM, Gong L, Unver N, Osrin EJ, Daliri S, Chang SH, Ochoa CE, Hanash SM, Behrens C, Wistuba II, Sternberg C, Kadara H, Ferreira CG, Watowich SS, Moghaddam SJ. IL-6 blockade reprograms the lung tumor microenvironment to limit the development and progression of K-ras mutant lung cancer. Cancer Research, 2016；76(11):3189-99. 

12. Zhang H, Hu H, Greeley N, Jin J, Matthews AJ, Ohashi E, Caetano MS, Li HS, Wu X, Mandal PK, McMurray JS, Moghaddam SJ, Sun SC, Watowich SS. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nat Commun, 2014, 5:5798.

13. Yang XO, Zhang H, Kim BS, Niu X, Peng J, Chen Y, Kerketta R, Lee YH, Chang SH, Corry DB, Wang D, Watowich SS, Dong C. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol 2013,14: 732-40.

14.  Zhang H, Nguyen-Jackson H, Panopoulos AD, Li HS, Murray PJ, Watowich SS. STAT3 controls myeloid progenitor growth during emergency granulopoiesis. Blood, 2010, 11:2462- 71.

邮箱：hyzhang@scu.edu.cn