- 陈震华,男,博士。锦州医科大学教授、博士研究生导师。首届"兴辽英才计划"-青年拔尖人才,十二届辽宁青年科技奖获得者,辽宁省“百千万人才工程”百人层次；辽宁省优秀研究生导师，锦州医科大学青年拔尖人才,锦州医科大学药用生物材料学学科带头人,生物医用纳米材料研究方向学术带头人,。主持国家自然科学基金面上项目2项、国家自然科学基金青年基金项目1项、辽宁省自然科学基金2项、辽宁省高等学校创新人才支持计划项目1项、辽宁省高等学校优秀人才支持计划1项；发表SCI文章67篇，第一及通讯作者58篇；获授权发明专利5项。
中文名 |
陈震华 |
主要成就以天然绿茶多酚为原料得到了纳米药物载体材料 |
外文名 |
Zhenhua Chen |
研究了茶多酚对人体结石主要成分草酸钙的 |
国籍 |
中国 |
体外结晶调控机制 |
民族 |
汉 |
研究了透明质酸对人体骨骼无机相成分-羟 |
出生地 |
河南省确山县 |
基磷灰石的结晶调控 |
出生日期 |
1983年2月 |
|
职业 |
教授,硕导 |
|
毕业院校 |
河南师范大学、四川大学 |
代表作品:J. Am. Chem. Soc.,2013,135,4179-4182 |
人物经历
2000.9-2004.7 河南师范大学 本科
2004.9-2007.6 河南师范大学 理学硕士
2007.9-2010.6 四川大学 工学博士
2010.7-2012.6 西北农林科技大学 讲师
2012.7-2018.11 锦州医科大学 副教授
2018.12-至今 锦州医科大学 教授
2015-至今 中国生物材料学会 会员
2019-2023 辽宁省细胞生物学学会组织损伤修复重建与再生医学专业委员会委员
2020.3-至今 《中国修复重建外科杂志》第一、二届中青年编委
2021.9-2022.9 Military Medical Research 科学编辑
获得专利
1.羟基磷灰石纳米复合粒子及其制备方法与应用,ZL200910058587.0,李旭东,陈震华,周慧慧，桑琳，王彩红，顾忠伟，张兴栋
2. 透明质酸－羟基磷灰石纳米复合球及其制备方法,ZL200910059289.3,李旭东,陈震华,王彩红，周慧慧，桑琳，
3. 黄酮-金属络合微球及制备方法与应用,ZL201010207010.4,李旭东,陈震华,王彩红，陈君泽，周慧慧，桑琳，罗冬梅
4. 羟基磷灰石杂化纳米晶组装体及其制备方法与应用,2013批准,ZL201010206973.2,李旭东,王彩红,陈震华,陈君泽，桑琳，罗冬梅
5.羟基磷灰石-多酚复合纳米材料及其制备方法，ZL201310030097.6，李旭东，陈君泽，陈震华，王彩红，彭万佳，周慧慧，马晓敏
获奖记录
辽宁青年科技奖;2019
兴辽英才计划青年拔尖人才;2018
辽宁省自然科学学术成果奖;2018
辽宁省新世纪百千万人才工程,千人层次;2015
辽宁省科技进步三等奖，4/7
获基金资助
国家自然科学基金面上项目,82072076；主持；
国家自然科学基金面上项目,81771987；主持；
国家自然科学基金青年基金，51202199；主持
兴辽英才计划青年拔尖人才支持计划；主持
辽宁省自然科学基金重点项目；主持
辽宁省高等学校创新人才计划；主持
辽宁省高等学校优秀人才计划；主持
辽宁省自然科学基金面上项目；主持
发表论文
代表性论文
1. Chen, Zhenhua; Wang, Caihong; Chen, Junze; Li, Xudong*; Biocompatible, Functional Spheres Based on Oxidative Coupling Assembly of Green Tea Polyphenols; Journal of The American Chemical Society, 2013, 135(11): 4179-4182.
2. Yanan Hu, Shuocheng Huang, Xingjun Zhao, Linna Chang, Xiuli Ren*, Xifan Mei* and Zhenhua Chen*, Photothermal Responsive and ROS generative Gold Nanocages for Cancer Therapy, Chemical Engineering Journal, 2021, 421,129744.
3. Shuocheng Huang, Shibo Xu, Yanan Hu, Xingjun Zhao, Linna Chang, Zhenhua Chen* and Xifan Mei* Preparation of NIR-responsive, ROS-generating and antibacterial black phosphorus quantum dots for promoting the MRSA-infected wound healing in diabetic rats, Acta Biomaterialia, 2022, 137, 199-217.
4. Chen, Zhenhua; Zhou, Huihui; Wang, Xiaoliang; Sang, Lin; Wang, Caihong; Ma, Jianfeng; Li, Xudong*; Controlled mineralization by extracellular matrix: monodisperse, colloidally stable calcium phosphate-hyaluronan hybrid nanospheres, Chemical Communications, 2010,46(8):1278-1280.
5. Chen, Zhenhua; Wang, Caihong; Zhou, Huihui; Sang, Lin; Li, Xudong*; Modulation of calcium oxalate crystallization by commonly consumed green tea; CRYSTENGCOMM 2010,12(3):845-852
论文目录
2022
58. Xiaowei Yin, Shuocheng Huang, Shibo Xu, Linna Chang, Xingjun Zhao, Zhenhua Chen*, Xifan Mei* and Xiuqiu Gao*, Preparation of pro-angiogenic, antibacterial and EGCG-modified ZnO quantum dots for treating bacterial infected wound of diabetic rats, Materials Science & Engineering C, 2022, Article reference MSC_112638
57. Shuocheng Huang, Shibo Xu, Yanan Hu, Xingjun Zhao, Linna Chang, Zhenhua Chen* and Xifan Mei* Preparation of NIR-responsive, ROS-generating and antibacterial black phosphorus quantum dots for promoting the MRSA-infected wound healing in diabetic rats, Acta Biomaterialia, 2022, 137, 199-217.
2021
56. Yanan Hu, Shuocheng Huang, Xingjun Zhao, Linna Chang, Xiuli Ren*, Xifan Mei* and Zhenhua Chen*, Photothermal Responsive and ROS generative Gold Nanocages for Cancer Therapy, Chemical Engineering Journal, 2021, 421,129744.
55. Shibo Xu, Linna Chang, Yanan Hu, Xingjun Zhao, Shuocheng Huang, Zhenhua Chen*, Xiuli Ren*and Xifan Mei*, Tea polyphenol modified, photothermal responsive and ROS generative black phosphorus quantum dots as nanoplatforms for promoting MRSA infected wounds healing in diabetic rats, Journal of Nanobiotechnology, 2021, 19(1), 362.
54. Linna Chang, Shuocheng Huang, Xingjun Zhao, Yanan Hu, Xiuli Ren*, Xifan Mei* and Zhenhua Chen*, Preparation of ROS active and photothermal responsive hydroxyapatite nanoplatforms for anticancer therapy, Materials Science & Engineering C, 2021, 125,112098.
53. Yiyao Zhang, Peng Zhang, Xiuqiu Gao*, Linna Chang, ZhenhuaChen*, XifanMei*, Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis, Materials Science & Engineering C, 2021,110:111671.
52. Dahao Wang, Peng Zhang, Xifan Mei, Zhenhua Chen*; Repair calvarial defect of osteoporotic rats by berberine functionalized porous calcium phosphate scaffold; Regenerative Biomaterials, 2021, 8(3), rbab022.
51. Xiuli Ren, Xinyan Lv, Zhenhua Chen*, Peng Zhang, Xun Hu, and Xifan Mei*，Preparation of Ag Nanoclusters-Modified Non-Sintered Silica Ceramic-Like Nanosheet for Removing Dyes and Bacteria from Water, International Journal of Nanomedicine, 2021, 2021(16), 895-904.
50. Changwei Song†, Shibo Xu†, Linna Chang, Xingjun Zhao, Xifan Mei*, Xiuli Ren* and Zhenhua Chen*, Preparation of EGCG decorated, injectable extracellular vesicles for cartilage repair in rat arthritis, Regenerative Biomaterials, 2021, 8(6), rbab067.
49. Jiaxin Ding, Binbin Gao, Zhenhua Chen* and Xifan Mei*, An NIR-triggered Au nanocage used for photo-thermo therapy of chronic wound in diabetic rats through bacterial membrane destruction and skin cell mitochondrial protection, Frontiers in Pharmacology, 2021, 12, 779944.
48. Zizhi Li*, Linna Chang, Xiuli Ren*, Yanan Hu, and Zhenhua Chen*, Modulation of Rat Kidney Stone Crystallization and the Relative Oxidative Stress Pathway by Green Tea Polyphenol. ACS Omega. 2021, 6(2):1725-1731.
2020
47. Zhanming Zhang, Yiran Wang, Kai Sun, Yuewen Shao, Lijun Zhang, Shu Zhang, Xiao Zhang, Qing Liu, Zhenhua Chen* and Xun Hu*, Steam reforming of acetic acid over Ni-Ba/Al2O3 catalysts: Impacts of barium addition on coking behaviors and formation of reaction intermediates, Journal of Energy Chemistry, 2020, 43, 208-219.
46. Xiaoxiang Ren, Zeng Yi, Zhe Sun, Xiaomin Ma, Guangcan Chen, Zhenhua Chen* and Xudong Li*, Natural polysaccharide-incorporated hydroxyapatite as size-changeable, nuclear-targeted nanocarrier for efficient cancer therapy, Biomaterials Science, 2020, 8(19): 5390-5401.
45. Guanyu Chen, Libang He, Peng Zhang, Jie Zhang, Xifan Mei*, Dahao Wang, Yiyao Zhang, Xiuli Ren* and Zhenhua Chen*, Encapsulation of green tea polyphenol nanospheres in PVA/alginate hydrogel for promoting wound healing of diabetic rats by regulating PI3K/AKT pathway, Materials Science & Engineering C, 2020, 110: 110686.
44. Xiuli Ren, Peng Zhang and Zhenhua Chen*, Dialysis preparation of smart redox and acidity dual responsive tea polyphenol functionalized calcium phosphate nanospheres as anticancer drug carriers, Molecules, 2020, 25(5): 1221.
43. Peng Zhang, Libang He, Jie Zhang, Xifan Mei*, Yiyao Zhang, HeTian* and Zhenhua Chen*, Preparation of novel berberine nano-colloids for improving wound healing of diabetic rats by acting Sirt1/NF-κB pathway, Colloids and Surfaces B: Biointerfaces, 2020, 187: 110647.
42. Junze Chen, Guigao Liu, Yue-zhou Zhu, Min Su, Pengfei Yin, Xue-jun Wu, Qipeng Lu, Chaoliang Tan, Meiting Zhao, Zhengqing Liu, Weimin Yang, Hai Li, Gwang-Hyeon Nam, Liping Zhang, Zhenhua Chen, Xiao Huang, Petar M. Radjenovic, Wei Huang, Zhong-qun Tian, Jian-feng Li*, and Hua Zhang*, Ag@MoS2 Core-Shell Heterostructure as SERS Platform to Reveal the Hydrogen Evolution Active Sites of Single-Layer MoS2, Journal of the American Chemical Society, 2020,142(15):7161-7167.
2019
41. Zhenhua Chen*, Guanyu Chen, Kang Zhou, Peng Zhang, Xiuli Ren* and Xifan Mei*, Toxicity of food sweetener-sodium cyclamate on osteoblasts cells, Biochemical and biophysical research communications, 2019, 508(2): 507-511.
40. Huiping Wang, Libang He, Peng Zhang, Jie Zhang, Zhenhua Chen*, Xiuli Ren* and Xifan Mei*, Folate-modified hydroxyapatite nanorods induce apoptosis in MCF-7 cells through a mitochondrial-dependent pathway, New Journal of Chemistry, 2019, 43(37): 14728-14738.
39. Jie Zhang, Xiuli Ren, Xiaohan Tian, Peng Zhang, Zhenhua Chen*, Xun Hu* and Xifan Mei*, GSH and enzyme responsive nanospheres based on self-assembly of green tea polyphenols and BSA used for target cancer chemotherapy, Colloids and Surfaces B: Biointerfaces, 2019, 173: 654-661.
38. Xiuli Ren, Libang He, Xiaohan Tian, Peng Zhang, Zhenhua Chen* and Xifan Mei*, pH and folic acid dual responsive polysaccharide nanospheres used for nuclear targeted cancer chemotherapy, Colloids and Surfaces B: Biointerfaces, 2019, 178: 445-451.
37. Peng Zhang, Dan Li, Guanyu Chen, Xifan Mei*, Jie Zhang, and Zhenhua Chen*, Preparation of tea polyphenol-modified copper nanoclusters to promote the proliferation of MC3T3-E1 in high glucose microenvironment, New Journal of Chemistry, 2019, 43(10): 4082-4091.
2018
36. Zhenhua Chen*, Xinyan Lv, Mengen Zhao, Peng Zhang, Xiuli Ren* and Xifan Mei*, Encapsulation of green tea polyphenol by pH responsive, antibacterial, alginate microgels used for minimally invasive treatment of bone infection, Colloids and Surfaces B: Biointerfaces, 2018, 170: 648-655.
35. Zhenhua Chen*, Mengen Zhao, Xinyan Lv, Kang Zhou, Xiaoqian Jiang, Xiuli Ren* and Xifan Mei*, Fast ion transport through ultrathin shells of metal sulfide hollow nanocolloids used for high-performance energy storage, Scientific reports, 2018, 8(1): 1-9.
34. Zhenhua Chen*, Mengen Zhao, Jie Zhang, Kang Zhou, Xiuli Ren, and Xifan Mei*, Construction of injectable, pH sensitive, antibacterial, mineralized amino acid yolk-shell microspheres for potential minimally invasive treatment of bone infection, International journal of nanomedicine, 2018, 13: 3493-3506.
33. Jie Zhang, Mengen Zhao, Xiaohan Tian, Xinyan Lv, Zhenhua Chen*, Kang Zhou, Xiuli Ren*, Peng Zhang and Xifan Mei*, Protein-mediated mineralization of edaravone into injectable, pH-sensitive microspheres used for potential minimally invasive treatment of osteomyelitis, New Journal of Chemistry, 2018, 42(7): 5447-5455.
32. Xiaohan Tian, Jie Zhang, Fan Zhang, Mengen Zhao, Zhenhua Chen*, Kang Zhou, Peng Zhang, Xiuli Ren*, Xiaoqian Jiang and Xifan Mei*, Preparation of anticancer micro-medicine based on quinoline and chitosan with pH responsive release performance, Colloids and Surfaces B: Biointerfaces, 2018, 165: 278-285.
31. Xinyan Lv, Mengen Zhao, Zhenhua Chen*, Jie Zhang, Xiaohan Tian, Xiuli Ren* and Xifan Mei*, Prepare porous silica nanospheres for water sustainability: high efficient and recyclable adsorbent for cationic organic dyes, Colloid and Polymer Science, 2018, 296(1): 59-70.
30. Kang Zhou, Xiuli Ren, Mengen Zhao, Xifan Mei*, Peng Zhang, Zhenhua Chen* and Xiangdong Zhu*, Promoting proliferation and differentiation of BMSCs by green tea polyphenols functionalized porous calcium phosphate, Regenerative biomaterials, 2018, 5(1): 35-41.
29. Zhang Fan, Tian Xiaohan, Wang Gang and Chen Zhenhua*, Preparation of pH Responsive Anticancer Micro-Medicine Based on Quinoline and Polysaccharide, Journal of Biomaterials and Tissue Engineering, 2018, 8(7): 941-948.
28. Dan Li, Kang Zhou, Zhenhua Chen* and Xifan Mei*, Aggregation of silver nanoplates in the presence of l-cysteine and the application for separation, IET nanobiotechnology, 2018, 12(5): 609-612.
2017
27. Mengen Zhao, Zhenhua Chen*, Xinyan Lv, Kang Zhou, Jie Zhang, Xiaohan Tian, Xiuli Ren* and Xifan Mei*, Preparation of core-shell structured CaCO3 microspheres as rapid and recyclable adsorbent for anionic dyes, Royal Society open science, 2017, 4(9): 170697.
26. Dan Li, Yanqing Zhao, Zhenhua Chen*, Xifan Mei* and Xiaozhong Qiu, Enhancement of fluorescence brightness and stability of copper nanoclusters using Zn2+ for ratio-metric sensing of S2−, Materials Science and Engineering: C, 2017, 78: 653-657.
25. Xian-hui Gao, Dan Li, Zhen-hua Chen* and Yan Wang*, Synthesis of Egg White Protected Gold Nanoclusters and the Determination of Tracinge Amounts of Hg2+ in Polluted Water, Spectroscopy and Spectral Analysis, 2017, 37(10):3112-3117.
24. Dan Li*, Zhenhua Chen and Xifan Mei*, Fluorescence enhancement for noble metal nanoclusters, Advances in colloid and interface science, 2017, 250: 25-39
2016
23. Zhenhua Chen*, Zhanghui Wan, Tiezhu Yang, Mengen Zhao, Xinyan Lv, Hao Wang, Xiuli Ren* and Xifan Mei*, Preparation of nickel cobalt sulfide hollow nanocolloids with enhanced electrochemical property for supercapacitors application, Scientific reports, 2016, 6(1): 1-8.
22. Dan Li, Zhenhua Chen*, Zhanghui Wan, Tiezhu Yang, Hao Wang and Xifan Mei*, One-pot development of water soluble copper nanoclusters with red emission and aggregation induced fluorescence enhancement, RSC advances, 2016, 6(41): 34090-34095.
21. Tiezhu Yang, Zhanghui Wan, Zhiyuan Liu, Haihong Li, Hao Wang, Nan Lu, Zhenhua Chen*, Xifan Mei* and Xiuli Ren*, In situ mineralization of anticancer drug into calcium carbonate monodisperse nanospheres and their pH-responsive release property, Materials Science and Engineering: C, 2016, 63: 384-392.
20. Dan Li, Zhenhua Chen*, Tiezhu Yang, Hao Wang, Nan Lu and Xifan Mei*, Green synthesis of highly fluorescent AuNCs with red emission and their special sensing behavior for Al3+, RSC advances, 2016, 6(23): 19182-19189.
19. Dan Li, Zhenhua Chen* and Tiezhu Yang, Fluorescence enhancement of DHLA protected gold nanoclusters in the presence of salt, New Journal of Chemistry, 2016, 40(4): 3781-3785.
18. Jia, Ang; Yang, Tiezhu; Wan, Zhanghui; Lv, Xinyan; Zhao, Mengen; Wang, Hao; Chen, Zhenhua*, Ren, Xiuli; Mei, Xifan*, Facile Preparation of Anticancer Drug Encapsulated Chitosan Nanospheres and Their pH Stimulus Responsive Release Property, Journal of Biomaterials and Tissue Engineering, 2016, 6(5): 384-389.
17. Xintian Shao, Jing Zhang, Donghui Li, Jingli Yue* and Zhenhua Chen*, Preparation of Fe2O3-Clorprenaline/Tetraphenylborate Nanospheres and Their Application as Ion Selective Electrode for Determination of Clorprenaline in Pork, Nanoscale research letters, 2016, 11(1): 1-8.
16. Xianhui Gao, Dan Li, Zhenhua Chen*, Xifan Mei* and Yan Wang*, Ultrafast synthesis of silver nanoplates in ethanol at room temperature, New Journal of Chemistry, 2016, 40(9): 7265-7268.
15. Xiaomin Ma, Ting Zhu, Zhenhua Chen, Jianfeng Ma, Yaping Zhang and Xudong Li*, Gelatin intervened synthesis of calcite cocoon-like microparticles assembled with small rhombohedra at low temperature, Advances in Applied Ceramics, 2016, 115(1): 1-5.
2015
14. Yang, Tiezhu; Wang, Hao; Zhang, Fuqaing; Meng, Guodong; Chen, Zhenhua*, Ren, Xiuli*, Glucocorticoid Modulated Crystallization of Apatite Nanocrystals, Journal of Biomaterials and Tissue Engineering, 2015, 5(9): 697-702
2014
13. Jing Zhang, Xintian Shao, Jingli Yue*, Donghui Li* and Zhenhua Chen*, Preparation of ractopamine-tetraphenylborate complexed nanoparticles used as sensors to rapidly determine ractopamine residues in pork, Nanoscale research letters, 2014, 9(1): 1-7.
12. Jingli Yue, Zhenhua Chen*, Yifeng E, Lianshan Chen, Jing Zhang, Yimeng Song and Yuchun Zhai*, Preparation TiO2 core-shell nanospheres and application as efficiency drug detection sensor, Nanoscale Research Letters, 2014, 9(1):465-465.
2013
11. Zhenhua Chen, Caihong Wang, Junze Chen, and Xudong Li*, Biocompatible, functional spheres based on oxidative coupling assembly of green tea polyphenols, Journal of the American Chemical Society, 2013, 135(11): 4179-4182.
10. Huijuan Song, Chang Su, Wenyu Cui, Bingya Zhu, Liwei Liu, Zhenhua Chen and Liang Zhao*, Folic acid-chitosan conjugated nanoparticles for improving tumor-targeted drug delivery, BioMed research international, 2013, 2013,723158.
2012
9. Zhen-Hua Chen*, Xiu-Li Ren, Hui-Hui Zhou and Xu-Dong Li*, The role of hyaluronic acid in biomineralization, Frontiers of Materials Science, 2012, 6(4): 283-296.
8. Junze Chen, ZhenHua Chen*, Caihong Wang and XuDong Li*, Calcium-assisted hydrothermal carbonization of an alginate for the production of carbon microspheres with unique surface nanopores, Materials Letters, 2012, 67(1): 365-368.
2010
7. Zhenhua Chen, Huihui Zhou, Xiaoliang Wang, Lin Sang, Caihong Wang, Jianfeng Ma and Xudong Li*, Controlled mineralization by extracellular matrix: monodisperse, colloidally stable calcium phosphate-hyaluronan hybrid nanospheres, Chemical communications, 2010, 46(8): 1278-1280.
6. Zhenhua Chen, Caihong Wang, Huihui Zhou, and Xudong Li*, Biomimetic crystallization of toplike calcite single crystals with an extensive (00.1) face in the presence of sodium hyaluronate, Crystal growth & design, 2010, 10(11): 4722-4727.
5. Zhenhua Chen, Caihong Wang, Huihui Zhou, Lin Sang and Xudong Li*, Modulation of calcium oxalate crystallization by commonly consumed green tea, CrystEngComm, 2010, 12(3): 845-852.
4. Lin Sang, Xiaoliang Wang, Zhenhua Chen, Jiao Lu, Zhongwei Gu and Xudong Li*, Assembly of collagen fibrillar networks in the presence of alginate, Carbohydrate polymers, 2010, 82(4): 1264-1270.
3. Lin Sang, Jie Huang, Dongmei Luo, Zhenhua Chen and Xudong Li*, Bone-like nanocomposites based on self-assembled protein-based matrices with Ca2+ capturing capability, Journal of Materials Science: Materials in Medicine, 2010, 21(9): 2561-2568.
2009
2. Yang Zhao, Zhenhua Chen, Huiyong Wang, and Jianji Wang*, Crystallization control of CaCO3 by ionic liquids in aqueous solution, Crystal growth & design, 2009, 9(11): 4984-4986.
1. Yang Zhao, Zhenhua Chen, Jianji Wang* and Kelei Zhuo, Solution thermodynamics of some imidazolium-based ionic liquids in water and aliphatic alcohols, Zeitschrift für Physikalische Chemie, 2009, 223(8): 857-868.