With the help of BMTMers and collaborators, the research group has gradually changed from "standing firm" to "seeking progress in stability" to "riding on the momentum" in three years. Looking back on 2021, the BMTM team worked hard, instead of slacking off, and "Everything comes to him who waits ", and achieved satisfactory results.
1. Team members
In 2021, there are a total of 41 people in the BMTM research group, namely PI Qihui Zhou, 3 assistant professors, 1 pharmacist in charge, 1 assistant researcher, 3 doctoral students, 12 graduate students, and 20 undergraduate students. The research direction of the research group is guided by the actual rigid needs of clinical practice, with the help of chemistry, materials science, tissue engineering and regenerative medicine, cell and molecular biology, clinical medicine and other multidisciplinary intersections, with advanced biomedical materials as tools to focus on the interaction between biomaterial interfaces and (stem) cells, controlled drug release systems, tissue repair and regeneration, antibacterial/cancer, hemostasis and other aspects of basic and applied research. It has established an interdisciplinary comprehensive research platform and R&D team integrating material synthesis, modification, testing and biological evaluation and clinical research.
2. Scientific research
In 2021, the research group published a total of 16 SCI papers and 1 book chapter, all papers with an impact factor greater than 5 and more than the second region of the Chinese Academy of Sciences, 6 papers in the first region of the Chinese Academy of Sciences, a total of 4 papers with an impact factor greater than 10, a maximum impact factor of 60.62 (cover papers), and a cumulative impact factor of 187. Added 3 ESI highly cited papers and 1 hot paper. So far, the research group has published a total of 53 SCI papers, with a total of 1392 citations .The research group work has also been widely cited by many top magazines such as Nature Reviews Chemistry, Advanced Materials, Biomaterials, etc., and has been highlighted and recommended by domestic and foreign media. In terms of patents, the research group authorized 1 invention patent this year, applied for 1 international invention PCT patent and 4 Chinese invention patents.
SCI paper：
1. Liangliang Yang#, Sara Pijuan-Galito#, Hoon Suk Rho#, Aliaksei S Vasilevich#, Aysegul Dede Eren#, Lu Ge#, Pamela Habibović, Morgan Alexander, Jan de Boer, Aurélie Carlier, Patrick van Rijn*, Qihui Zhou*. High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology. Chemical Reviews 2021, 121: 4561–4677. (IF: 60.622, Chinese Academy of Sciences category I, ESI highly cited papers, cover papers)
2. Xiangyi Yin#, Yuanping Hao#, Yun Lu, Dongjie Zhang, Yaodong Zhao, Li Mei, Kunyan Sui, Qihui Zhou*, Jilin Hu*. Bio-multifunctional Hydrogel Patches for Repairing Full-thickness Abdominal Wall Defect. Advanced Functional Materials 2021, 2105614. (IF: 18.808, Chinese Academy of Sciences category I)
3. Zheng Wang, Xiaojing Wang, Yingruo Wang, Yanli Zhu, Xinqiang Liu*, Qihui Zhou*. NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance. Journal of Nanobiotechnology 2021, 19:353. (IF: 10.435, Chinese Academy of Sciences category I)
4. Lubin Liu, Zeyu Han, Fei An, Xuening Gong, Chenguang Zhao, Weiping Zheng, Li Mei, Qihui Zhou*. Aptamer-based biosensors for the diagnosis of sepsis. Journal of Nanobiotechnology 2021, 19 (1): 1-22. (IF: 10.435, Chinese Academy of Sciences category I)
5. Weiping Zheng, Yuanping Hao, Danyang Wang, Hailin Huang, Fangze Guo, Zhanyi Sun, Peili Shen, Kunyan Sui, Changqing Yuan*, Qihui Zhou*. Preparation of triamcinolone acetonide-loaded chitosan/fucoidan hydrogels and its potential application as an oral mucosa patch. Carbohydrate Polymers 2021, 272: 118493. (IF: 9.381, Chinese Academy of Sciences category I)
6. Yanjing Ji, Zeyu Han, Han Ding, Xinkai Xu, Danyang Wang, Yanli Zhu, Fei An, Shang Tang, Hui Zhang, Jing Deng*, Qihui Zhou*. Enhanced Eradication of Bacterial/fungi Biofilms by Glucose Oxidase-modified Magnetic Nanoparticles as a Potential Treatment for Persistent Endodontic Infections. ACS Applied Materials& Interfaces 2021, 13: 17289–17299. (IF: 9.229, Chinese Academy of Sciences category I)
7. Weiping Zheng, Qihui Zhou*, Changqing Yuan*. Nanoparticles for oral cancer diagnosis and therapy. Bioinorganic Chemistry and Applications 2021, 9977131. (IF: 7.778, Chinese Academy of Sciences category II)
8. Yun He#, Wenwen Zhao#, Zuoxiang Dong, Yanjing Ji, Min Li, Yuanping Hao, Demeng Zhang, Changqing Yuan, Jing Deng, Peng Zhao*, Qihui Zhou*. A biodegradable antibacterial alginate/carboxymethyl chitosan/Kangfuxin sponges for promoting blood coagulation and full-thickness wound healing. International Journal of Biological Macromolecules 2021, 167: 182-192. (IF: 6.953, Chinese Academy of Sciences category II, ESI highly cited papers)
9. Yanli Zhu, Zheng Wang, Longjian Bai, Jing Deng*, Qihui Zhou*. Biomaterial-based Encapsulated Probiotics for Biomedical Applications: Current Status and Future Perspectives. Materials&Design 2021, 210: The Second District of the Chinese Academy of Sciences110018. (Accepted; IF:7.991, Chinese Academy of Sciences category II)
10. Yanli Zhu, Lubin Liu, Zhanyi Sun, Yanjing Ji, Danyang Wang, Li Mei, Peili Shen, Zhixin Li, Shang Tang , Hui Zhang, Qihui Zhou*, Jing Deng*. Fucoidan as a marine-origin prebiotic modulates the growth and antibacterial ability of Lactobacillus rhamnosus. International Journal of Biological Macromolecules 2021, 180: 599-607. (IF: 6.953, Chinese Academy of Sciences category II)
11. Yuanping Hao, Weiping Zheng, Zhanyi Sun, Demeng Zhang, Kunyan Sui, Peili Shen, Peifeng Li*, Qihui Zhou*. Marine polysaccharide-based composite hydrogels containing fucoidan: preparation, physicochemical characterization, and biocompatible evaluation. International Journal of Biological Macromolecules 2021, 183: 1978-1986. (IF: 6.953, Chinese Academy of Sciences category II)
12. Min Li#, Wenshuai Deng#, Jun Zhang, Weiping Zheng, Tao Yu*, Qihui Zhou*. Aligned electrospun PLLA/graphene microfibers with nanotopographical surface modulate the mitochondrial responses of vascular smooth muscle cells. Advanced Materials Interfaces 2021, 2100229. (IF: 6.147, Chinese Academy of Sciences category II)
13. Zheng Wang#, Li Mei#, Xinqiang Liu*, Qihui Zhou*. Hierarchically hybrid coatings on Ti implants for enhanced antibacterial activity and osteogenesis. Colloids and Surfaces B: Biointerfaces 2021, 204: 111802. (IF:5.268, 中科院大类二区)
14. Yiwen Chen #, Huilin Zhu #, Yuanping Hao, Zhanyi Sun, Peili Shen, Qihui Zhou*. Preparation of Fucoidan-based Electrospun Nanofibers and their Interaction with Endothelial Cells. Frontiers in Bioengineering and Biotechnology 2021, 9:739209. (IF: 5.89, Chinese Academy of Sciences category II)
15. Wenwen Zhao, Chunxia Li, Hao Zhang, Qihui Zhou, Xuehong Chen, Yantao Han*, Xiuping Chen*, Dihydrotanshinone I attenuates plaque vulnerability in ApoE-/- mice: role of RIP3. Antioxidants and Redox Signaling 2021, 34(5):351-363. (IF: 8.401, Chinese Academy of Sciences category II)
16. Yaofang Fan, Yanming Liu, Qihui Zhou, Hao Du, Xueyang Zhao, Fei Ye, Huimin Zhao*. Catalytic hairpin assembly indirectly covalent on Fe3O4@C nanoparticles with high signal-to-background ratio for intracellular miRNAs visualization. Talanta. 2021, 223: 121675. (IF: 6.057, Chinese Academy of Sciences category II)
Book chapters：
1. “Cho-Macrophages and their Role in Inflammation. Chapter 6: Biomaterials modulate macrophage polarization and inflammatory responses.”
Editors: Jae Youl Cho; Authors: Weiping Zheng#, Hailin Huang#, Fangze Guo#, Changqing Yuan*, Qihui Zhou*. Elsevier. 2021.
Patent：
1. "Preparation method, composite sponge and application of marine polysaccharide composite sponge", inventors: Qihui Zhou, Yuanping Hao, Changqing Yuan, Peifeng Li, authorization number: ZL201910930314.4, 2021.
2."Preparation method of urine-derived stem cell capture scaffold, urine-derived stem cell capture scaffold and its application", inventors: Qihui Zhou, Mingzhe Yan, application number: CN202110892921.3, 2021. (International PCT Patent).
3."Aptamer nanocolorbiometric biosensor and its application and product, detection method of E. coli", inventors: Qihui Zhou, Lubin Liu, Zeyu Han, application number: 202110984452.8, 2021.
4. "Carbon Quantum Dots- Magnetic Nanoparticles and Their Preparation Methods and Applications", Inventors: Qihui Zhou, Xinkai Xu, Yuying Jiang, Application No.: 202111306249.1, 2021.
5. "A kind of astaxanthin nanofiber oral mucosal patch and preparation method thereof", inventors: Jing Deng, Hui Zhang, Qihui Zhou, application number: CN202010728843.9, 2021.
Third、Research projects
In 2021, the research group won a total of 6 fund projects, of which 4 were provincial and ministerial projects, with a cumulative funding of more than 400,000 yuan. So far, the research group has applied for 9 national, provincial and ministerial projects, with a total funding of more than 1.6 million yuan.
1. Project Name: Preparation of a new type of marine Traditional Chinese Medicine Polyelectrolyte Composite Membrane and its application in the treatment of oral mucosal precancerous lesions, Project Approval Number: 2021Q069, Implementation Year: 2022.02~2024.01, Project Source: Shandong Provincial Traditional Chinese Medicine Science and Technology Project Youth Project, Funding: 80,000, Project Leader: Qihui Zhou
2. Project Name: Functional Modification of Alginate, Project Approval Number: HZHX-202108, Implementation Year: 2021.03~2021.12, Project Source: State Key Laboratory of Seaweed Active Substances Opening Fund, Fund: 30,000, Project Leader: Qihui Zhou
3.Project Name: Taishan Science and Technology Forum - Research and Application of Marine Biological Materials, Project Approval Number: SS2100005373, Implementation Period: 2021.05~2021.11, Project Source: Shandong Science and Technology Association Class A Project, Funding: 10,000, Project Leader: Qihui Zhou
4. Project Name: Qingdao University Undergraduate Innovation and Entrepreneurship Fund, Project Approval Number: SA2100004605, Implementation Period: 2021.05~2022.11, Project Source: Qingdao University, Funding: 26,000, Project Leader: Qihui Zhou
5. Project Name: New photosensitizer for the preparation and basic research of antibacterial photodynamic therapy for periodontitis, project approval number: ZR2021QH251, implementation year: 2022.01~2024.12, project source: Shandong Provincial Natural Science Foundation Youth Project, funding: 150,000, project leader: Xue Li
6. Project Name: Research on Serum Biomarkers of Ovarian Cancer Based on Sugar Fingerprint Technology, Project Approval Number: ZR2021QH207, Implementation Year: 2022.01~2024.12, Project Source: Shandong Natural Science Foundation Youth Project, Funding: 150,000, Project Leader: Pengjiao Zeng
Fourth. Honors and Awards
(1) National projects and awards
1. National College Students Innovation and Entrepreneurship Project Conclusion Excellent: Lubin Liu & Han Zeyu Team;
2. National College Students Innovation and Entrepreneurship Project： Xinkai Xu team, Banghui Wang team and Zhenhuan Zhang team;
3. The 17th "Challenge Cup" National College Students Extracurricular Academic Science and Technology Works Competition " Taking the lead " Special Competition National Third Prize: Fengyuan Liu, Yuying Jiang, Jinglin Lu.
4. National Scholarship for Master's Degree Students: Xiangyi Yin.
5. Undergraduate National Scholarship: Yuying Jiang.
(2) Provincial awards
1. Provincial Bronze Award of Internet + College Students Innovation and Entrepreneurship Competition: Xinkai Xu Team and Wanli Song Team
2. The second provincial prize of the 2nd Shandong Provincial College Students Medical And Health Innovation and Entrepreneurship Competition: Xinkai Xu 's team, Wanli Song 's team, Zhenhuan Zhang 's team and Yifei Li 's team
(3) Awarded at the school level
1. Third Prize of the 4th Postgraduate Academic Forum Conference Of Qingdao University School of Medicine: Yanjing Ji
2. Qingdao University Internet + College Students Innovation and Entrepreneurship Competition: Xinkai Xu team and Wanli Song team (gold award), Zhenhuan Zhang team (silver award).
3.The 8th Qingdao University College Students Science and Technology Innovation Competition: Xinkai Xu 's team (first prize), Wanli Song 's team (second prize).
4. The Second Prize of the 2nd Qingdao University Basic Medical Innovation Competition: Yuxin Liu.
5. Qingdao University President's Scholarship: Cong Li, Wanli Song.
6. Tsingtao Beer Scholarship: Ruizhe Zhao.
7. Bank of Qingdao Scholarship: Yuxin Liu, Luhan Yuan.
8. First Prize of Qingdao University Scholarship: Cong Li, Mingzhe Yan, Pengyu Gao, Yuxin Liu, Zirui Bian, Yuying Jiang, Wanli Song, Ruizhe Zhao, Luhan Yuan.
9. Second Prize of Qingdao University Scholarship: Danyang Wang, Xiaowen Kong, Junmiao Xue, Pengfei Jia, Fengyuan Liu, Jinglin Lu, Yu Liang.
(4) Instructor Awards & Certificates
1. Winner of China Postdoctoral Innovation and Entrepreneurship Competition: Qihui Zhou
2. The 7th Qingdao University Internet + College Students Innovation and Entrepreneurship Competition and the 8th Qingdao University University Student Science and Technology Innovation Competition Outstanding Instructor: Qihui Zhou
3. International Entrepreneurship Coach (Intermediate) Certificate: Qihui Zhou
4.Qingdao University "Jiezheng" Education Fund Innovation and Entrepreneurship Award: Qihui Zhou
Fifth、Talent development
In 2021, a total of 1 postdoctoral researcher and 5 master's students successfully graduated.
1. Postdoctoral Fellow Yuanping Hao successfully left the station and joined Qingdao Stomatological Hospital (Class A tertiary hospital);
2. Master student Yanjing Ji received an excellent graduation thesis from Qingdao University and was funded by the National Scholarship Council to pursue a doctorate at the University of Groningen Medical Center in the Netherlands;
3. Master student Yanli Zhu obtained the excellent graduation thesis of Qingdao University and joined the Department of Stomatology of Qingdao Women and Children's Hospital (Class A tertiary hospital);
4. Master student Weiping Zheng works in Weihai Stomatological Hospital (Class A tertiary hospital);
5. Master student Zheng Wang joined Yantai Stomatological Hospital;
6. Undergraduate student Cao Wen was successfully admitted to Southern University of Science and Technology to pursue a master's degree.
Sixth、Academic exchanges
In 2021, the research group will hold 1 provincial academic forum, 1 meeting in English, and 3 high-level academic conferences
1. Held "Taishan Science and Technology Forum - Research and Application of Marine Biomaterials"
As the person in charge, Professor Qihui Zhou of the research group successfully applied for the "Taishan Science and Technology Forum - Research and Application of Marine Biological Materials" Class A project and organized the 47th Total 311th Taishan Science and Technology Forum.The forum was hosted by Shandong Science and Technology Association, held by Qingdao University, and co-organized by Qingdao Mingyue Seaweed Group Co., Ltd., with the theme of "Research and Application of Marine Biological Materials".The forum invited Professor Yang Liu of Nankai University, Professor Qiang Wei of Sichuan University, Professor Jinfei Yang of Rehabilitation University, Researcher Yong Liu of Wenzhou Research Institute of Chinese Academy of Sciences, Demeng Zhang, Assistant President of Mingyue Seaweed Group, Professor Liangming Jin and Professor Tong Wu of Qingdao University to attend the forum and made relevant academic reports.The forum was attended by more than 100 teachers and students, and was jointly held online and offline.The successful holding of this forum has strengthened the cooperation and academic exchanges between universities, scientific research institutions and enterprises, promoted the research and clinical transformation and application of marine biological materials, and has far-reaching significance for making full use of marine biological materials to treat diseases.
2. The research group participated in the "Micro and Nano Technology and Medical Health Innovation Conference (2021) and the 5th Micro and Nano Technology Application Innovation Conference of the Chinese Society of Micro and Nanotechnology"
On May 31, 2021, the members of the research group participated in the "Micro and Nano Technology and Medical Health Innovation Conference (2021) and the Fifth Micro and Nano Technology Application Innovation Conference of the China Society of Micro and Nanotechnology" held in Shanghai, and were invited to give an oral report on "Artificial Molecular Motors for Regulating the Fate of Mesenchymal Stem Cells". Mei Li and Danyang Wang made a poster display.The conference was hosted by the China Society for Micro and Nanotechnology and co-hosted by Shanghai Jiao Tong University and the National Engineering Research Center for Nanotechnology and Applications. With the theme of "Promoting the Integration and Development of Micro and Nano Technology and Medical Health", the conference brought together outstanding micro and nano technology scientists from all over the world, displayed the latest academic achievements in the application of micro and nano technology in the biomedical field, and exchanged and discussed the future development direction of the industry.The conference specially invited nearly 60 academicians such as Academician Yuliang Zhao, Academician Xiyun Yan, Academician Benzhong Tang, etc., which lasted for 3 days, 10 sub-venues, more than 450 wonderful reports, and more than 1,000 people participated.As an interdisciplinary micro-nano technology has been more and more widely used in the field of biomedicine, the combination of micro and nano technology and medical health can solve the problems that cannot be solved in biology, medicine, public health, etc., and has a wide range of application prospects and significance.
3. The research group participated in the "China Biomaterials Conference"
Qihui Zhou led the students to participate in the "China Biomaterials Conference" held in Shanghai from October 11 to 14, 2021, and Danyang Wang and Mingzhe Yan made a poster display.Hosted by the Chinese Society of Biomaterials (CSBM), hosted by Shanghai University and East China University of Science and Technology, and co-organized by Shanghai Zhangjiang (Group) Co., Ltd., with the theme of "Biomaterials: Innovative Development, Serving Health", the conference focuses on the frontier direction, research hotspots and latest progress of biomaterials, and pays attention to the transformation and supervision of relevant achievements in the field.The conference specially invited academician Xingdong Zhang, academician Yingjun Wang, academician Changsheng Liu and other nearly 60 academicians, Jie Qing and Yangtze River scholars, which lasted for 3 days and was divided into 20 sub-venues, 20 themes and 101 wonderful reports.As an interdisciplinary biomaterials in the field of biomedicine has been more and more widely used, the combination of biomaterials and medical health can solve problems in the fields of biology, medicine, public health and other fields, with a wide range of application prospects and far-reaching significance.
4. Qihui Zhou was invited to participate in the "Oriental Precision Medicine Summit Forum and the First Gastrointestinal Surgery Youth Forum"
On December 4, 2021, Professor Zhou Qihui was invited to participate in the "Oriental Precision Medicine Summit Forum and the First Smart Gastrointestinal Surgery Youth Forum" held in Qingdao, and gave an oral report on "Application of Biofunctional Hydrogel in Tissue Trauma".The conference was attended by Professor Xuan Dong, President of the Affiliated Hospital of Qingdao University, and Vice President of Qingdao University、Professor Hong Jiang, a specially appointed expert of Taishan Scholars in Shandong Province, delivered a welcome speech.Through expert lectures, academic reports by young scholars, and discussions at the venue, this series of conferences aims to promote the exchange of scholars in the basic research of precision medicine and clinical diagnosis and treatment technology, and promote the landing and transformation of precision medicine scientific research innovations.
5. Professor Zhou Qihui presided over the "3rd China-Japan-Korea Young Physicians Forum" in English
On December 4, 2021, Professor Zhou Qihui presided over the "3rd China-Japan-Korea Young Physicians Forum Conference" in English and commented on the reporters in English.The forum was presided over by Professor Xiaoming Xing, Assistant Director of the Medical Department of Qingdao University, Assistant Dean of Qingdao University Medical Group, and Director of the Department of Scientific Research and Foreign Affairs of the Affiliated Hospital of Qingdao University.Adhering to the spirit of innovation and cooperation, keeping up with the forefront of the times, basing on clinical work practice, focusing on scientific research and academic development, and jointly improving the ability and level of clinical scientific research, this forum has enhanced the friendship between young physicians in China, Japan and South Korea, and laid a solid foundation for the future development of the hospital.
Seventh、Journal appointments
2021.12—hitherto Biomedical Engineering Research（Core journal of Chinese science and technology）Associate Editor
2021.12—hitherto Journal of Precision Medicine（Core journal of Chinese science and technology）Editorial Board
2021.12—hitherto Burns & Trauma (IF: 5.099, Chinese Academy of Sciences category I) Youth Editorial Board
2021.10—hitherto Frontiers in Bioengineering and Biotechnology (IF: 5.89, Chinese Academy of Sciences category II) Guest Associate Editor/Feature Editor
2021.09—hitherto Frontiers in Chemistry (IF: 5.229, Chinese Academy of Sciences category II) Guest Associate Editor/Feature Editor
2020.09—hitherto Military Medical Research (IF: 3.329, Chinese Academy of Sciences category II)，Youth Editorial Board
Eighth、Team building and attention
1. The research group roared in team building
In order to let the students relax in the heavy scientific research, narrow the distance between teachers, students and classmates, and feel the beauty of scientific research life, the BMTM research group launched the team building activity on October 7, 2021.Members gathered together to enjoy leisure time, unleash the pressure of deposition, and take the opportunity to feel relaxed in the midst of laughter and laughter.After the preparation work is completed, everyone enjoys the hot pot dinner while chatting about learning and life, and the warm dining table is a happy and harmonious big family;After drinking and eating, everyone entered the wonderful and rich after-dinner activities:Thrilling blindfolding, testing and condensing leggings forward, hula hoop passing for competitive speed, male and female division of labor pitching, and so on.
This team-building activity alleviated the fatigue of the members of the research group who are usually devoted to scientific research work, and the simple small game not only shortened the distance between each other, but also improved the cohesion of the research group, laying a solid foundation for better scientific research work in the future.
2. Focus of the research group
In 2021, a total of 12 tweets were posted on "Biomaterials and Translational Medicine Research Group Public Account" , and the cumulative number of reads exceeded 4600 times, and the number of followers reached 414; The total number of Research group website（https://www.xmol.com/groups/BMTMers）views exceeded 40,000 times.
Ninth、Year-end summary of the research group
On the morning of January 21, 2022, the "Big Butler" Dou Keke organized and presided over the BMTM year-end summary meeting.The conference included four links: watching the opening video, student work summary and prospect, undergraduate talent show and Qihui Zhou 's year-end summary, at the same time, the research group also prepared BMTM customized experimental clothes and U disks, snack packages and other surprises for everyone. BMTMer sorts out its own gains and insights from the aspects of scientific research, clinical, and life, summarizes its own shortcomings, and also formulates new plans and New Year's goals for itself.After the report，The undergraduate students of the research group brought wonderful performances such as songs, magic tricks, and sketches to everyone.Everyone tasted the custom cake while cheering for the show, pushing the conference atmosphere to a climax. At last, Qihui Zhou reviewed and summarized the achievements and harvests of the 2021 BMTM research group . On the one hand, it affirms the struggle of BMTMers in the past year, on the other hand, it also looks forward to the new chapter that will be opened soon, and believes that BMTM will continue to work hard in 2022, seek steady progress and continue to create good results.
Outlook for 2022
2021 is a year of continuous learning for BMTMers and a year of harvest. Looking forward to 2022, the BMTM research group will continue to devote itself to scientific research work in a down-to-earth manner, adhere to the rigorous and truth-seeking scientific research attitude, maintain the spirit of overcoming difficulties, continue to burst out new vitality and passion, and strive to achieve better results and more results in the new year, serve the development of disciplines, and cultivate talents. Looking forward to 2022
The research group and collaborators have made greater breakthroughs in high-level papers, scientific research projects, awards and honors!
