Recently, Professor Qihui Zhou of the BMTM Research Group was reported by the "Journal of Biomedical Materials IOP" Outstanding Young Scholar Column.
Screenshot of the report:
Lead:
Biomedical materials are an important branch of the materials discipline and occupy a very important position in the regenerative repair of tissues and organs. The acceleration of the aging process of the population and the pursuit of health and longevity by human beings have stimulated the demand for biomedical materials in society.
With the vigorous development and major breakthroughs of regenerative medicine technology, biomaterials have become a hot spot for scientists from all over the world to compete for research and development. In recent years, many outstanding young talents have emerged in the field of biomedical materials research in China, as the core driving force for the development of the field, promoting the vigorous development of biomedical materials research in China. Therefore, we specially launched the "Outstanding Young Scholars of Biomedical Materials" column to introduce the research directions and outstanding achievements of these outstanding young scholars to the public, and welcome attention, forwarding and self-recommendation.
Body:
Qihui Zhou
Distinguished Professor, Qingdao University
Distinguished Professor of Qingdao University,Principal investigator of the Research Group(PI) of "Biomaterials and Translational Medicine". Director of Precision Medicine Center, Deputy Director of Scientific Research of Oral Medicine Center, Master Tutor. Leader of outstanding youth innovation team of colleges and universities in Shandong Province. He was sponsored by the National Scholarship Fund to study at the University Medical Center Groningen in the Netherlands and obtained a doctorate in biomedical engineering.
The research direction of the research group focuses on the intersection of materials science, tissue engineering and regenerative medicine, cell and molecular biology, clinical medicine and other multidisciplinary intersections, focusing on advanced biomaterials interface and (stem) cell interaction, disease diagnosis, drug controlled release system, hemostasis, tissue repair and regeneration, intensive care medicine and other aspects of basic and applied research. It has established an interdisciplinary comprehensive research platform and R&D team integrating material synthesis, modification, testing and biological evaluation and clinical research. In addition, the construction and development of the research group also fully relies on the Stomatology Center of the Affiliated Hospital of Qingdao University, the Key Laboratory of Digital Medicine and Computer-Aided Surgery of Shandong Province, the Center for Critical Care Medicine, and the State Key Laboratory of Seaweed Active Substances.
To date, he has published 33 SCI papers in international journals in biomaterials and biomedical-related fields, including Science Advances, ACS Applied Materials & Interfaces, Nanoscale, Stem Cell Reports, Biomacromolecules, Biofabrication, Advanced Materials Interfaces, Journal of Tissue Engineering and Regenerative Medicine, etc., including 14 SCI papers published as the first or corresponding author. He has applied for 6 international and Chinese invention patents. Published 1 monograph &1 chapter.
At present, Professor Qihui Zhou is presiding over the projects of the National Natural Science Foundation of China, the Natural Science Foundation of Shandong Province, the Youth Innovation Science and Technology Program of Shandong Colleges and Universities, the Key Laboratory of Hyaluronic Acid Open Project, the Talent Startup Fund of Qingdao University and a number of horizontal projects. He is a member of the American Chemical Society, the Dutch Society of Biomaterials and Tissue Engineering, the Netherlands Extracellular Matrix Society, the Chinese Society of Biomaterials, etc., and has served as a special guest reviewer of several SCI journals and a review expert of the National Natural Science Foundation of China.
Main research directions:
1. Basic research on the interaction of biomaterial interfaces with (stem) cells
2. Design, preparation and application of multifunctional hydrogels in hemostasis, tissue repair and regeneration
3. Clinical-oriented biomedical materials and device research and development
4. Preparation of nanomaterials and their applications in antibacterial, antiviral, anticancer and sepsis treatment
Key research innovations:
1. Artificial molecular motors are used to regulate the fate of stem cells
Collaboration with Professor Ben L. Feringa, 2016 Nobel Prize in Chemistry, used artificial molecular motors to provide molecular-level mechanical movements induced by light to successfully regulate the fate of stem cells. The mechanism of action between molecular motors and proteins and cells was further explored, and it was found that the rotational movement of molecular motors can affect the number and secondary conformation of protein adsorption, regulate the signaling of integrin-adhesion plaque-cytoskeletal actin-nucleus, and then regulate the specific protein and gene expression of mesenchymal stem cells, affecting the differentiation and dry maintenance of mesenchymal stem cells. This work provides a research basis for the application of biomimetic intelligent artificial molecular machines in biomedicine.
2. Gradient interface for high-throughput screening of stem cell differentiation
Aiming at the inefficiency of biomaterials in regulating stem cell differentiation, a series of gradient interfaces of high-throughput screening platforms are designed for the matrix based on general polymer materials, which proves the accuracy and efficiency of the directional differentiation of high-throughput screening stem cells, and can confirm the optimal interface parameter range. It accelerates the design and preparation of high-performance biomaterials, providing a new method for accelerating the future clinical application transformation of tissue engineered products. The big data or "material biology genome" obtained based on the above high-throughput screening platform system can help researchers put forward more reasonable experimental hypotheses, and even predict the interaction between materials and cells, which can improve experimental efficiency, optimize scientific research resources and save costs.
3. Biomimetic nanomaterials for tissue repair and regeneration
The bionic functionalized nanofibers were designed and prepared by the components, structure, dimensions and arrangements of the biomimetic natural extracellular matrix, and it was found that it was conducive to cell adhesion, proliferation and functionalization, which in turn was conducive to wound repair, tissue engineering blood vessel and bone construction, and explored the mechanism of action between them and cells.
Research Group Official Accounts: "Biomaterials and Translational Medicine Research Group". This research group warmly welcomes undergraduate, master's and doctoral students and postdoctoral researchers from the fields of biology, medicine, chemistry, materials and other fields, and welcomes hospitals, university research units and enterprise personnel to carry out different forms of cooperation and exchange with us.
Email: qihuizhou@qdu.edu.cn / zhouqihui521@163.com; Phone: 17660670299
