胡晓兰 

暨南大学 环境与气候学院 质谱仪器与大气环境研究所

职称：助理研究员

邮箱：xiaolanhu@jnu.edu.cn

研究方向

1.呼气代谢组分析方法研究及其在临床诊断、治疗监测中的应用；

2.蛋白组学分析方法的研究及其在环境污染物毒理机制方面的应用。

主要教育经历

2018.09-2021.07——澳门科技大学——中药学专业——博士学位

2009.09-2012.07——沈阳药科大学——天然药物化学专业——硕士学位

2005.09-2009.07——天津中医药大学——中药学专业——学士学位

主持项目

国家自然科学基金青年基金、广州市基础与应用基础研究等科研项目

发表论文

2024

[1]  Xing Chen^†, Xiaolan Hu^†, Xieguang Zhang^†, Hui Huang, Heng Meng, Jianming Yang, Chen Tao, Wei Zhang, Xue Li^*, Keda Zhang*. Breath analysis, Harnessing its potential for non–volatile drug caffeine monitoring in human body. Microchemical Journal, 2024, 198, 110130.

[2] Xiaolan Hu, Jianlin Wu*, Quan He, Zhiqi Xiong, Na Li*. Strategy for cysteine-targeting covalent inhibitors screening using in-house database based LC-MS/MS and drug repurposing. Journal of Pharmaceutical Analysis, 2024, 101045.

[3] Haojie Zhang, Yaliang Lai, Hu Yang, Xianchao Zhou, Zijun Yuan1, Li Deng, Xiaolan Hu*, Xue Li, Xiaoping Zhou*, Dan Li, Homochiral metalated  tetraphenylethylene-based organic cages: unusual chiral and luminescent behavior depending on thermodynamic and kinetic aggregation. Aggregate, 2024, e598.

2023及以前

[1] Xiaolan Hu, Shilin Gong, Quan He, Jian-Lin Wu^*, and Na Li^*. Less is more: A new perspective for toxicity of emerging contaminants by structures, protein adducts and proteomics. TrAC Trends in Analytical Chemistry, 2023, 117289. 

[2]   Xiaolan Hu, Jian-Lin Wu^*, Wen Miao, Fei Long, Hudan Pan, Tao Peng, Xiaojun Yao, and Na Li^*. Covalent Protein Modification: An Unignorable Factor for Bisphenol A-induced Hepatotoxicity. Environmental Science & Technology, 2022, 56, 9536−9545. 

[3] Shilin Gong^†, Xiaolan Hu^†, Shengshuang Chen, Baoqing Sun, Jian-Lin Wu^*, Na Li^*. Dual roles of drug or its metabolite-protein conjugate (DMPC): cutting-edge strategy of drug discovery using shotgun proteomics. Medicinal Research Reviews, 2022,42, 1704-1734. 

[4] Xiaolan Hu^†, Xiqing Bian^†, Wan-Yi Gu, Baoqing Sun, Xiang Gao, Jian-Lin Wu*, Na Li*. Stand out from matrix: Ultra-sensitive LC-MS/MS method for determination of histamine in complex biological samples using derivatization and solid phase extraction. Talanta, 2021, 225, 122056. 

[5]  Yue Zhuo, Yida Zhang, Meng Li, Haiying Wu, Shilin Gong, Xiaolan Hu, Yu Fu, Xinzi Shen, Baoqing Sun, Jian-Lin Wu, Na Li^*. Drug Hepatotoxic Evaluation via Biomarker Quantification and Pathway Mapping of Large-Scale Chemical Proteomics. Food and Chemical Toxicology, 2021, 153, 112257.

[6]Shilin Gong, Yue Zhuo, Shengshuang Chen, Xiaolan Hu, Xing-xing Fan, Jian-Lin Wu^*, Na Li^*. Quantification of Osimertinib and Metabolite-Protein Modification Reveals Its High Potency and Long Duration of Effects on Target Organs. Chemical research in toxicology, 2021, 34(11), 2309–2318.

[7] Sajad Fakhri, Merve Tomas, Esra Capanoglu, Yaseen Hussain, Fatemeh Abbaszadeh, Baiyi Lu, Xiaolan Hu, Jian-Lin Wu, Liang Zou, Antonella Smeriglio, Jesus Simal-Gandara, Hui Cao, Jianbo Xiao^*, Haroon Khan^*. Antioxidant and anticancer potentials of edible flowers: where do we stand? Critical reviews in food science and nutrition, 2021,1–57. 

[8] Xiao-Cui Zhuang, Yong-Li Zhang, Gui-Lin Chen, Ye Liu, Xiaolan Hu, Na Li, Jian-Lin Wu, Ming-Quan Guo^*. Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Warburgia ugandensis Employing Multi-Target Affinity Ultrafiltration and LC-MS. Pharmaceuticals (Basel, Switzerland), 2021, 14(4), 313.

[9] Xiqing Bian, Jiao Bai^*, Xiaolan Hu, Xin Wu, Chunmei Xue, Aihong Han, Guangyue Su, Huiming Hua, Yuehu Pei. Penioxalicin, a novel 3-nor-2, 3-seco-labdane type diterpene from the fungus Penicillium oxalicum TW01-1. Tetrahedron letters, 2015, 56(35), 5013-5016.

[10] Xiaolan Hu, Xi-Qing Bian, Xin Wu, Jian-Yong Li, Hui-Ming Hua, Yue-Hu Pei, Ai-Hong Han, Jiao Bai^*. Penioxalamine A, a novel prenylated spiro-oxindole alkaloid from Penicillium oxalicum TW01-1. Tetrahedron Letters, 2014, 55(29), 3864-3867.

[11]  Xiao-Lei Zhou, Jiu-Hong WU^*, Jiao Bai, Xiaolan Hu, En-Zhen LI, Ning SHI, Yue-Hu PEI. A new aristolactam alkaloid from the stems of Dasymaschalon trichophorum. Chinese Journal of Natural Medicines, 2013, 11(1), 81-83.

专利

[1] 裴月湖，白皎，陈刚，胡晓兰。双四氢苯并吡喃酮二聚体类化合物在抗癌药物中的应用，发明专利，专利申请号： 201110332660.6

[2] 李娜，伍建林，胡晓兰。 一种筛选潜在共价药物的方法, 澳门科技大学，发明专利，专利申请号：202310372589.7.