Dose-Response is an open access peer-reviewed online journal publishing will publish high quality, original findings, clinical observation or report, epidemiological analysis, comprehensive or narrative review, letter to the Editor, and editorial specifically for the original work accompanied same issue, on the occurrence of dose-response relationships across a broad range of disciplines. These will include the dose-response investigation in the genomics, epigenetics, biochemistry, molecular biology, physiology and toxicology, pharmacology, medicine, experimental biology, as well as environmental and related sciences, for the responses of these biological variables to environmental chemical, factors, radiation, climate changes (heat, air pollution, geographic variation), life-style change, and even biological stress, and the underlying mechanisms by which nonlinear dose-response occurs. Particular interest focuses on experimental evidence providing mechanistic understanding of nonlinear dose-response relationships.

Target Audience
Researchers who explore fundamental hormetic and/or adaptive mechanisms as well as those interested in risk assessments of air pollutions, chemicals, metals, pharmaceuticals, heat (climate) changes, ionizing and non-ionizing radiation, life-style changes, and physiological and pathological (early and late) remodeling and (temporal and permanent) dysfunction.

Article Types
Original research or short reports, clinical observation or case report, comprehensive or narrative reviews on specific topics, commentaries, letters to the editor and also editorial specifically for the original work published in the same issue.

Topics of Interest

U-shaped Dose Response
J-shaped Dose Response
Non-monotonic Dose Response
Non-linearity
Hormesis/Hormetic Dose Response
Biphasic Dose Response
Pre/Post Conditioning
Adaptive Response
Drug resistance
Mechanistic study on the difference for low and high dose effect
Essential and non-essential metal toxic differences
Interruption of the Dose-Response with two-hits

Editor
Edward J. Calabrese
University of Massachusetts, USA
Editor-in-Chief
Edward J. Calabrese
University of Massachusetts, USA
Editor Emerita
Barbara G. Callahan
University of Massachusetts, USA
Managing Editor
Denise Leonard
University of Massachusetts, USA
Editorial Board
Jean Lud Cadet
NIH/NIDA IRP, USA
Lu Cai
University of Louisville, USA
Chris Cutler
Nova Scotia Agricultural College, Canada
Gaurav Dhawan
University of Massachusetts, USA
George Gray
George Washington University, USA
Jaap Hanekamp
Roosevelt Academy, Netherlands
Mark Mattson
NIA, India
Ken Maynard
Takeda Pharmaceuticals International, Inc., Switzerland
Jay Mitchell
Harvard, USA
Zsolt Radak
Semmelweis University, Hungary
Suresh Rattan
Univerity of Aarhus, Denmark
Michael Ristow
University of Jena, Germany
Bobby Scott
Lovelace Respiratory Research Institute, USA
David Sinclair
Harvard Medical School, USA
Brant Ulsh
M.H. Chew and Associates, USA
Reinhard Wetzker
University of Jena, Germany