The journal publishes reports of original research investigations in clinical, translational, and clinically relevant basic science as well as substantive reviews, clinically focused reviews, and articles on special topics. Anesthesiology seeks to publish a breadth of topics covering an array of issues affecting the specialty, which will be of interest to scientists and clinicians in the specialty, and broadly in science and medicine. Submitted manuscripts should have a robust evidence-base and present novel and important data or concepts that can be implemented in practice, policy, or future scientific inquiry.