In patients with disorders of gut–brain interaction (DGBI), overlapping non-gastrointestinal conditions and symptoms are common, as is overlap among DGBI in different regions of the gastrointestinal tract. This Review describes these overlapping conditions and symptoms, detailing key features, pathophysiology and insights into management.

In this Review, Ludvigsson and colleagues describe the epidemiological associations between coeliac disease and a variety of complications and comorbidities, and discuss the pathophysiology underlying these complications as well as implications for follow-up and treatment.

This Review describes the progression of advanced chronic liver disease (ACLD) from its early stages (compensated ACLD) to more advanced disease (decompensated ACLD). Evidence supporting strategies to manage ACLD and prevent decompensation, as well as the tests used to stratify risk, are discussed.

The European–Latin American Research Consortium towards Eradication of Preventable Gallbladder Cancer (EULAT Eradicate GBC) is identifying geographical, environmental, lifestyle, genetic and molecular risk factors for gallbladder cancer. Collaborative research is essential to improve prevention of this aggressive tumour, especially in high-incidence, low-income and middle-income regions.