The loss of CFTR-dependent anion and fluid secretion in the ducts of the exocrine pancreas contributes to pancreatitis. In this study, the authors evaluated the effects of pro-inflammatory cytokines on CFTR function using porcine pancreas-derived organoids. The combination of IL-1β, IL-6, IFN-γ, and TNF-α significantly enhanced CFTR expression and anion secretion in the ductal epithelial monolayers, whereas individual cytokines had minimal effects. This up-regulation of CFTR during early inflammation may facilitate the removal of pathogenic stimuli from the ductal tree and limit tissue injury.
Thematic Series
The Exosome Collection
Thematic Series
Tumor Plasticity and Microenvironmental Heterogeneity in Metastasis
Thematic Series
Gene regulation tools for treating genetic diseases and cancers based on CRISPR-related technologies
Thematic Series
Molecular mechanisms of cell fate decisions during cellular stress
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Collection on Non-coding RNAs
Thematic Series
Celebrating 25 Years of Cellular & Molecular Biology Letters
Thematic Series
Invited papers
Edited by:
Leszek Kotula, MD, PhD, Upstate Medical University, United States of America
Submission Status: Open until 30 April 2025
As guidance on submissions does change over time, particularly relating to expectations that authors provide original images/blots and considerations for non-coding RNA papers, we ask that authors please ensure they read and comply with the guidance in the author guidelines which they can find here. Please note instructions may vary slightly by article type. Failure to comply with this guidance could result in delays in processing manuscripts.
Cellular & Molecular Biology Letters is an international journal dedicated to the dissemination of fundamental knowledge in all areas of cellular and molecular biology, cancer cell biology, and certain aspects of biochemistry, biophysics and biotechnology.
Aleksander Sikorski, University of Wrocław, Poland
Cellular & Molecular Biology Letters was founded in 1996 and transferred to BioMed Central in 2016. Previously, its publishers were Walter De Gruyter in 2015 (content available from De Gruyter's archive), and Springer from 2006–2014 (content available from BMC web page). Articles published between 1996 and 2005 can be found at the CMBL home page, on the Volume List tab. To request free electronic versions of these articles, please contact cmbl@cmbl.org.pl.
Citation Impact 2023
Journal Impact Factor: 9.2
5-year Journal Impact Factor: 8.1
Source Normalized Impact per Paper (SNIP): 1.476
SCImago Journal Rank (SJR): 2.229
Speed 2024
Submission to first editorial decision (median days): 10
Submission to acceptance (median days): 128
Usage 2024
Downloads: 839,019
Altmetric mentions: 428