Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors

Xin-heng He
Jun-rui Li
H. Eric Xu

Article 06 December 2024

Featured

Humanized dual-targeting antibody–drug conjugates specific to MET and RON receptors as a pharmaceutical strategy for the treatment of cancers exhibiting phenotypic heterogeneity

Minghai Wang
Qi Ma
Hang-ping Yao
ArticleOpen Access21 Jan 2025
Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy

Yu Wei
Ming-ming Sun
Jian-ping Lin
ArticleOpen Access03 Jan 2025
Acyl-CoA thioesterase 8 induces gemcitabine resistance via regulation of lipid metabolism and antiferroptotic activity in pancreatic ductal adenocarcinoma

Bo-rui Li
Ting Wang
Xiao-wu Xu
ArticleOpen Access12 Feb 2025
New advances in novel pharmacotherapeutic candidates for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) between 2022 and 2024

Shu Wei Wong
Yong-yu Yang
Jian Wu
Review Article27 Jan 2025

Current issue

How improvements in US FDA regulatory process and procedures led to the drug approval for first ever treatment of a common liver disease

Brian E. Harvey
Perspective07 Nov 2024
Modulation of autophagy by melatonin and its receptors: implications in brain disorders

Chen-ze Zhu
Gui-zhi Li
Xiang-nan Zhang
Review Article24 Oct 2024
Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets

Meng Sun
Zhen-ru Chen
Jing Feng
Review Article18 Oct 2024
Cardiovascular adverse effects of antiviral therapies for COVID-19: Evidence and plausible mechanisms

Eileen Chen
Lei Xi
Review ArticleOpen Access09 Sept 2024
AI-driven antibody design with generative diffusion models: current insights and future directions

Xin-heng He
Jun-rui Li
H. Eric Xu
Review Article30 Sept 2024
Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1⁺ microglial phenotype via a PPARγ-dependent mechanism

Nai-jun Yuan
Wen-jun Zhu
Jia-xu Chen
Article04 Nov 2024

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p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation

Meng-lu Song
Yun-yun Sun
Hua Yang
Article14 Mar 2025
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice

Ting-ting Li
Xiao-fan Guo
Zhen Wang
Article12 Mar 2025
Epigenetic regulation of iron metabolism and ferroptosis in Parkinson’s disease: Identifying novel epigenetic targets

Xiao-die Gao
Jian-e Ding
Hua-min Xu
Review Article11 Mar 2025
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism

Li-da Du
Cheng Fang
Yin-zhong Ma
Article11 Mar 2025
CYP2A6 suppresses hepatocellular carcinoma via inhibiting SRC/Wnt/β-Catenin pathway

Yi-fan Liu
Li-ya Feng
Xiu-li Guo
Article11 Mar 2025
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor

Ze-chen Wang
Yue Zeng
Wei-feng Li
Article11 Mar 2025
Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease

Wen-sheng Yang
Qing Liu
Zhi-ping Li
Article11 Mar 2025
CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling

Yi-hong Wen
Heng-li Zhao
Zhi-xin Shan
ArticleOpen Access11 Mar 2025
Gracillin suppresses cancer progression through inducing Merlin/LATS protein-protein interaction and activating Hippo signaling pathway

Jin-xuan Su
Hai-xia Zhou
Yu-bo Zhang
Article07 Mar 2025

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State Key Laboratory of Materials-Oriented Chemical Engineering in the field of materials-oriented chemical engineering.

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Talent Recruitment: Faculty & Postdoc Positions at IIINN, Fudan University

Join the International Institute for Intelligent Nanorobots and Nanosystems (IIINN) at Fudan University.

Shanghai, China

International Institute for Intelligent Nanorobots & Nanosystems, Fudan University
Permanent Researcher Positions for Materials Science [R25-03~R25-11]

Overview National Institute for Materials Science (NIMS, Tsukuba, Japan) invites international applications from researchers who can conduct resear...

Tsukuba, Ibaraki (JP)

National Institute for Materials Science (NIMS)
Permanent Researcher Positions for Materials Science (for women) [R25-02]

Basic, fundamental and applied research on materials and substances with a view to their application as materials. In particular, ...

Tsukuba, Ibaraki (JP)

National Institute for Materials Science (NIMS)
Permanent Researcher Positions for Materials Science [R25-01]

Basic, fundamental and applied research on materials and substances with a view to their application as materials. In particular, ...

Tsukuba, Ibaraki (JP)

National Institute for Materials Science (NIMS)

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors

Featured

Humanized dual-targeting antibody–drug conjugates specific to MET and RON receptors as a pharmaceutical strategy for the treatment of cancers exhibiting phenotypic heterogeneity

Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy

Acyl-CoA thioesterase 8 induces gemcitabine resistance via regulation of lipid metabolism and antiferroptotic activity in pancreatic ductal adenocarcinoma

New advances in novel pharmacotherapeutic candidates for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) between 2022 and 2024

Current issue

How improvements in US FDA regulatory process and procedures led to the drug approval for first ever treatment of a common liver disease

Modulation of autophagy by melatonin and its receptors: implications in brain disorders

Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets

Cardiovascular adverse effects of antiviral therapies for COVID-19: Evidence and plausible mechanisms

AI-driven antibody design with generative diffusion models: current insights and future directions

Luteolin ameliorates chronic stress-induced depressive-like behaviors in mice by promoting the Arginase-1⁺ microglial phenotype via a PPARγ-dependent mechanism

Browse articles

p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation

Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice

Epigenetic regulation of iron metabolism and ferroptosis in Parkinson’s disease: Identifying novel epigenetic targets

MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism

CYP2A6 suppresses hepatocellular carcinoma via inhibiting SRC/Wnt/β-Catenin pathway

An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor

Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease

CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling

Gracillin suppresses cancer progression through inducing Merlin/LATS protein-protein interaction and activating Hippo signaling pathway

Trending - Altmetric

Science jobs

Recruitment of Overseas Outstanding Young Scholars

Talent Recruitment: Faculty & Postdoc Positions at IIINN, Fudan University

Permanent Researcher Positions for Materials Science [R25-03~R25-11]

Permanent Researcher Positions for Materials Science (for women) [R25-02]

Permanent Researcher Positions for Materials Science [R25-01]

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CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling

The role of G protein-coupled receptor kinases in the pathology of malignant tumors

Semaglutide ameliorates metabolic disorders in offspring via regulation of oocyte ROS of pre-pregnancy obesity mice

Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats

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