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Editor-in-Chief
Selected Honors and AccoladesAcademician of Chinese Academy of Sciences Outstanding Achievement Award of 2020 Asian Biological Inorganic Chemistry (AsBIC) Luigi Sacconi Medal (Italian Chemical Society) The First Prize of the Ministry of Education of Natural Science in China Changjiang Professorship
Current ResearchGiven the importance of metals in biology and in the development of modern chemotherapeutic agents, the major research interest of Dr. Guo’s lab focuses on the chemical biology of metals and metallodrugs. In the last two decades or so, he has been working on the design and application of fluorescent sensors for biological metals such as zinc, copper and iron, etc. Visible light excitable and ratiometric metal sensors have been constructed based on a number of design strategies. Localization and intracellular distribution of metal species can be tracked using sensors of different emission wavelengths in combination with fluorescent microscopic techniques. He has also been focusing on the understanding of mechanism of action of platinum anticancer drugs and the development of anti-tumor active metal complexes with novel structural features. Multi-nuclear platinum(II) complexes with novel DNA binding ability, platinum(II)/(IV) complexes with tissue and organelle-targeting abilities have been designed. Approaches towards the targeted delivery of clinically-used anticancer platinum drugs have been adopted including the use of native ferritin, superparamagnetic iron nanoparticles, and stimuli-responsive biodegradable nanomaterials. BiographyZijian Guo was born in Hebei, China in 1961. He received his PhD degree from the University of Padova and worked as a postdoctoral research fellow at Birkbeck College, the University of London. He worked also as a research associate at the University of Edinburgh. He joined the School of Chemistry and Chemical Engineering at Nanjing University as a professor of chemistry in 1999, where he served as the director of the State Key Laboratory of Coordination Chemistry from 2000 to 2009 and the dean of the School of Chemistry and Chemical Engineering from 2006 to 2014. He received the national science fund for distinguished young scholars in 1999. He is the Changjiang professor in the same school. He founded Chemistry and Biomedicine Innovation Center (ChemBIC) in Nanjing University in 2019, and is serving as the director of ChemBIC since then. He was elected to the fellow of the Chinese Academy of Sciences in 2017. He served as an associated Editor for Coord. Chem. Rev. He has authored or co-authored more than 400 peer-reviewed articles on basic and applied research topics, with a primary focus on fluorescent probes, chemical biology of metals, and metal-based antitumor complexes.
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