许莲花 - 浙江理工大学 - 海洋活性分子实验室

研究领域

①X射线衍射蛋白质三维结构解析；②海洋天然产物生物合成途径及相关酶的功能研究；③利用海洋功能酶的生物催化及生物转化研究；④功能酶的分子改造及药物生产工业应用研究

近期论文

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Xu L-H.*, Du Y-L. Rational and semi-rational engineering of cytochrome P450s for biotechnological applications. Synthetic and Systems Biotechnology（2018）3(4): 283-290 Zhang C. #, Xu L-H. #, Zhou H.,Tan Z., Xie Q., Xu Y. Biodegradation of n-hexadecane by enteric bacteria isolated from an oil-field wastewater treatment plant. Fresenius Environmental Bulletin（2018）27(7): 4942-4951 Xu L-H., Tan Z., Zhang C.*, Liu L., Liu Y., Zhang X., Wu J., Xie Q. Performance and microbial diversity of a full-scale oilfield wastewater treatment plant. Desalination and Water Treatment 99: 239-247 (2017) Yao Q., Ma L., Liu L., Ikeda H., Fushinobu S., Li S., Xu L-H*. Hydroxylation of compactin (ML-236B) mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis. Journal of Microbiology and Biotechnology, 27(5): 956-964, (2017) Liu L., Yao Q., Ma Z., Ikeda H., Fushinobu S., Xu L-H*. Hydroxylation of flavanones by Cytochrome P450 105D7 from Streptomyces avermitilis. Journal of Molecular Catalysis B: Enzymatic, 132: 91-97 (2016) Xu L-H*, Ikeda H., Liu L., Arakawa T., Wakagi T., Shoun H., Fushinobu S. Structural basis for the 4’-hydroxylation of diclofenac by a microbial cytochrome P450 monooxygenase. Applied Microbiology and Biotechnology, 99 (7): 3081-3091 (2015) Takamatsu S.#, Xu L-H.#, Fushinobu S., Shoun H., Komatsu M., Cane D.E., Ikeda H.* Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: Hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SVA_7469) of Streptomyces avermitilis. Journal of Antibiotics, 64 (1): 65-71 (2011) Xu L-H., Fushinobu S., Takamatsu S., Wakagi T., Ikeda H., and Shoun H.* Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis. Journal of Biological Chemistry, 285 (22): 16844-16853 (2010) Xu L-H., Fushinobu S., Ikeda H., Wakagi T. and Shoun H.* Crystal structures of Cytochrome P450 105P1 from Streptomyces avermitilis: conformational flexibility and histidine-liganded state. Journal of Bacteriology, 191 (4): 1211-1219 (2009)