王凡 - 中国科学院生物物理研究所 -

个人简介

1984 - 1988 吉林大学，物理学，学士 1988 - 1991 吉林大学，生物化学，硕士 1994 - 1997 中国原子能科学研究院，同位素技术，博士 1998 - 2000 美国橡树岭国家实验室、华盛顿大学医学院，博士后 1991 - 2008 中国原子能科学研究院，助理研究员、副研究员、研究员 2001 - 至今北京大学医学部，教授 2013 - 至今中科院生物物理所，客座研究员

研究领域

分子影像是近年来发展十分迅速的一个交叉学科，它是应用影像学方法，对活体状态下的生物过程进行细胞和分子水平的定性和定量研究，涉及生物学、基础医学、临床医学、化学、物理学、药学等多个学科，具有无创、实时、动态、特异等特点，被美国医学会评为未来最具有发展潜力的十个医学科学前沿领域之一。分子探针的研究是分子影像领域的核心，本课题组针对疾病特别是肿瘤在不同发展阶段的特异性标志物设计构建分子探针，在完成临床前动物显像的基础上进行临床转化研究，进行疾病的早期诊断、分期、预后、疗效评价以及个体化治疗。

近期论文

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Ma X, Yao M, Shi J, Li X, Gao Y, Luo Q, Hou R, Liang X* and Wang F*, High Intensity Focused Ultrasound-Responsive and Ultra-stable Cerasomal Perfluorocarbon Nanodroplets for Alleviating Tumor Multidrug Resistance and Epithelial-Mesenchymal Transition, ACS Nano, 2020, DOI: 10.1021/acsnano.0c07287. Gao H#, Wu Y#, Shi J#, Zhang X, Liu T, Hu B, Jia B, Liu Z, Wan Y, Wang F*. Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy. J Immunother Cancer 2020;0:e001156. Gao S#, Jia B#, Feng G#, Dong C#, Du H, Bai L, Zhong Q, Ma Q*, Zeng M*, Wang F*. First-in-human pilot study of an integrin α6-targeted radiotracer for SPECT imaging of breast cancer. Sig Transduct Target Ther. 2020, 5:147. Wu Y#, Li L#, Wang Z, Shi J, Hu Z, Gao S, Miao W, Ma Q, Dong C*, Wang F*. Imaging and monitoring HER2 expression in breast cancer during trastuzumab therapy with a peptide probe (99m)Tc-HYNIC-H10F, Eur. J. Nucl. Med. Mol. Imaging, 2020. 47, 2613-2623. Yao M, Ma X, Zhang X, Shi L, Liu T, Liang X, Zhao H, Li X, Li L, Gao H, Jia B*, Wang F*. Lectin-mediated pH-sensitive Doxorubicin Prodrug for Pre-targeted Chemotherapy of Colorectal Cancer with Enhanced Efficacy and Reduced Side Effects. Theranostics. 2019, 9(3):747-760. Ma, X.; Li, X.; Shi, J.; Yao, M.; Zhang, X.; Hou, R.; Shao, N.; Luo, Q.; Gao, Y.; Du, S.; Liang, X.*; Wang, F*. Host-Guest Polypyrrole Nanocomplex for Three-Stimuli-Responsive Drug Delivery and Imaging-Guided Chemo-Photothermal Synergetic Therapy of Refractory Thyroid Cancer. Advanced healthcare materials 2019, 8, e1900661. Gao H, Luo C, Yang G, Du S, Li X, Zhao H, Shi J*, and Wang F*. Improved in Vivo Targeting Capability and Pharmacokinetics of 99mTc-Labeled isoDGR by Dimerization and Albumin-Binding for Glioma Imaging. Bioconjug Chem. 2019 Jul 17;30(7):2038-2048. Jia B#, Zhang X#, Wang B, Chen M, Lv F, Wang S *, and Wang F*. Dual-Modal Probe Based on Polythiophene Derivative for Pre- and Intraoperative Mapping of Lymph Nodes by SPECT/Optical Imaging. ACS Appl Mater Interfaces 2018, 10, 6646-6651. Liang X*, Fang L, Li X, Zhang X, Wang F*. Activatable near infrared dye conjugated hyaluronic acid based nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy. Biomaterials. 2017, 132:72-84. Li, L.#; Wu, Y.#; Wang, Z.; Jia, B.; Hu, Z.; Dong, C.; Wang, F*. SPECT/CT Imaging of the Novel HER2-Targeted Peptide Probe 99mTc-HYNIC-H6F in Breast Cancer Mouse Models. J Nucl Med. 2017, 58, 821-826. Yu X, Wu Y, Liu H, Gao L, Sun X, Zhang C, Shi J, Zhao H, Jia B, Liu Z, Wang F*. Small-Animal SPECT/CT of the Progression and Recovery of Rat Liver Fibrosis by Using an Integrin alphavbeta3-targeting Radiotracer. Radiology, 2016.5.01, 279(2):502~512. Liu Z*, Liu H, Ma T, Sun X, Shi J, Jia B, Sun Y, Zhan J, Zhang H, Zhu Z, Wang F*. Integrin αvβ6-targeted SPECT imaging for pancreatic cancer detection. J Nucl Med. 2014, 55(6):989-994. Liu Z*, Sun X, Liu H, Ma T, Shi J, Jia B, Zhao H, Wang F*. Early Assessment of Tumor Response to Gefitinib Treatment by Noninvasive Optical Imaging of Tumor Vascular Endothelial Growth Factor Expression in Animal Models. J Nucl Med. 2014, 55(5):818-23. Shi J, Fan D, Dong C, Liu H, Jia B, Zhao H, Jin X, Liu Z, Li F, Wang F*. Anti-tumor Effect of Integrin Targeted 177Lu-3PRGD2 and Combined Therapy with Endostar. Theranostics. 2014, 4(3):256-266. Zhu Z, Weibing Miao W, Li Q, Dai H, Ma Q, Wang F, Yang A, Jia B, Jing X, Sha L, Shi J, Liu Z, Zhao Z, Wang F*, Li F*. 99mTc-3PRGD2 for Integrin Receptor Imaging of Lung Cancer: a Multi-Center Study. J Nucl Med. 2012, 53(5):716-722. Liu Z, Liu Y, Jia B, Zhao H, Jin X, Li F, Chen X, Wang F*. Epidermal Growth Factor Receptor-Targeted Radioimmunotherapy of Human Head and Neck Cancer Xenografts Using 90Y-Labeled Fully Human Antibody Panitumumab. Mol Cancer Ther. 2010, 9(8):2297-2308.