个人简介
1993年毕业留校后一直从事药代动力学研究和教学工作20余年，期间在国家药品审评中心外聘工作近一年。现为国家药品审评专家，江苏省药品审评专家，中国定量药理药理学会委员
研究领域
数学建模与仿真。应用于创新药物的早期临床探索研究，儿童给药方案探索研究，生物类似物评价研究
近期论文
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1) Fan G, Cao Y, Yang J(Correspondence Author). In vitro inhibition and induction of human cytochrome P450 enzymes by SIPI5357, a potential antidepressant. Biopharm Drug Dispos. 2015 Mar 16. doi: 10.1002/bdd.1947
2) Jing Z, Kuang L, Liu N, Yang J(Correspondence Author). LC-MS/MS for the simultaneous determination of polar endogenous ADMA and CML in plasma and urine from diabetics. Bioanalysis. 2015 May;7(10):1261-71. doi: 10.4155/bio.15.58.
3) Xu R, Liu X, Yang J(Correspondence Author). A semi-physiologically based pharmacokinetic pharmacodynamic model for glycyrrhizin-induced pseudoaldosteronism and prediction of the dose limit causing hypokalemia in a virtual elderly population. PLoS One. 2014 Dec 2;9(12): e114049. doi: 10.1371/journal.pone.0114049. eCollection 2014
4) Biao Yu, Pengcheng Ma, Linwen Yuan, Dingding Chen, and Jin Yang∗(Correspondence Author) Evaluation of change in the skin concentration of tazarotene and betamethasone dipropionate based on drug–drug interaction for transdermal drug delivery in miniature pig. Xenobiotica. 2014 Nov 20:1-5.
5) Xu R, Wang Q, Zhang J, Zang M, Liu X, Yang J(Correspondence Author). Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat. Xenobiotica. 2014 Jun;44(6):541-6.
6) Min Zang, Xiaoqiang Liu, Lin Chen, Qingqing Xiao, Linwen Yuan, Jin Yang∗(Correspondence Author) Determination of BmKCT-13, a chlorotoxin-like peptide, in rat plasma by LC–MS/MS: Application to a preclinical pharmacokinetic study Journal of Chromatography B, 947–948 (2014) 125– 131
7) Liqing Kuang, Zhiqiang Jing, Jing Wang, Liyuan Ma, Xiaoqiang Liu, Jin Yang (Correspondence Author) Quantitative determination of ε-N-Carboxymethyl-L-lysine in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis(IF=2.97) Journal of Pharmaceutical and Biomedical Analysis 90 (2014) 1–6
8) Shuming LI, Xiangyang WANG, Wei LI, Yang CHU. Jiahua GUO, Xiaohui MA, Jin YANG (Correspondence Author) Characterization of Metabolites in Rat after Administration of Danshensu by Liquid Chromatography-tandem Mass Spectrometry Lat. Am. J. Pharm. 2013:32 (4): 582-6
9) Yuan Lu • Jinbo Yang • Haiyan Zhang • Jin Yang. (Correspondence Author) Prediction of Warfarin Maintenance Dose in Han Chinese Patients Using a Mechanistic Model Based on Genetic and Non-Genetic Factors. Clinical Pharmacokinetics(IF=5.40). (2013) 52:567–581
10) R. Xu, Q. Xiao, Y. Cao, J.Yang(Correspondence Author) Comparison of the Exposure of Glycyrrhizin and its Metabolites and the Pseudoaldosteronism after Intravenous Administration of Alpha- and Beta-glycyrrhizin in Rat. Drug Res (Stuttg). 2013 Jul 17
11) Xu R, Zhang X, Yang J(Correspondence Author), Liu X, Davey AK, Wang J. Effects of glycyrrhizin on biliary transport and hepatic levels of glutathione in rats. Biopharm Drug Dispos(IF=2.07). 2012 Apr 17. doi: 10.1002/bdd.1789.
12) Min Zhang, Jin Yang(Correspondence Author), Lei Tao, Lingjun Li, Pengcheng Ma, and John Paul Fawcett, Acarbose Bioequivalence: Exploration of New Pharmacodynamic Parameters AAPS J(IF=5.09). 2012 Jun;14(2):345-51.
13) Feng-Juan Zhao, Hong Tang, Qing-Hua Zhang, Jin Yang, (Correspondence Author), Andrew K., Daveyc, Ji-ping Wang. Salting-out homogeneous liquid–liquid extraction approach applied in sample pre-processing for the quantitative determination of entecavir in human plasma by LC–MS Journal of Chromatography B(IF=2.89), 881–882 (2012) 119– 125
14) Guo-fu LI, Kun WANG, Rui CHEN, Hao-ru ZHAO, Jin YANG, Qing-shan ZHENG, Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling. Acta Pharmacologica Sinica (2012) 33: 1359–1371
15) Chen Yanxiao Xu Ruijuan Yang Jin(Correspondence Author) Organic anion and cation transporters are possibly involved in renal excretion of entecavir in rats Life Sciences 89 (2011) (IF=2.56) 1–6
16) Xiong Yu ; Yang yuqing ; Yang jin, Dr.; chai hong yan; Li ying; Yang Jing , Dr. Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanolinduced liver steatosis in mice， Toxicology. 2010 Sep 30;276(1):64-72.
17) Qing-Hua Zhang, Jin Yang(Correspondence Author) Food effect on the pharmacokinetics of entecavir from dispersible tablets following oral administration in healthy Chinese volunteers Arzneimittelforschung 2010;60(10):640–644
18) L. Chen, J. Yang(Correspondence Author), A. K. Davey, Y.-X. Chen, J.-P. Wang, and X.-Q. Liu Efects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism Xenobiotica(IF=1.918), 2009; 39(12): 955–963
19) Jin Yang, Ying He Pharmacokinetic Properties of S-adenosylmethionine after Oral and intravenous administration of its Tosylate disulfate salt: a Multiple-dose, Open-Label, Parallel-Group study in Healthy Chinese volunteers Clinical Therapeutics Volume 31, Number 2, 2009 (IF=3.261)：311-320
20) Jin Yang, Liang Zhou, JipingWang, GuangjiWang, Andrew K Davey The Disposition of Diammonium Glycyrrhizinate and Glycyrrhetinic Acid in the Isolated Perfused Rat Intestine and Liver Planta Medica 2008; 74: 1351–1356
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