孙凌云 - 中国药科大学 - 基础医学与临床药学学院

个人简介

孙凌云，主任医师、博士、教授、博士生导师，南京大学医学院附属鼓楼医院副院长，风湿免疫科行政主任，南京大学风湿免疫研究所所长。现任国家干细胞专家委员会委员、中国医药学会干细胞质量控制和研究委员会副主任委员，中国抗衰老学会交叉委员会副主任委员，江苏风湿病学会主任委员。曾任全国风湿病学会副主任委员。在国际上首先开展异体间充质干细胞治疗红斑狼疮等自身免疫病，已完成968例，在国际大会发言40余次。在Cell Stem Cell、Immunity、Nat Immunol、Nat Med、JEM、Cell Reserch、ARD等国内外发表论文455篇，其中SCI论文135篇，主参编专著16部。Int J Rheum Dis、Pathologie Biologie副主编，Arthritis Res Ther、QJM编委。获江苏省科技进步一等奖、中华医学二等奖等。承担国家省部级科研项目22项。2015年获第七届国家卫生计生突出贡献中青年专家。江苏省医学杰出人才、江苏省中青年首席科学家、南京十大科技之星、南京科技功臣。2002国务院特殊津贴。 1987.9-1990.7 南京医科大学硕士研究生 1990.8-至今南京鼓楼医院风湿科 1994.8-1995.11 意大利费拉拉大学进修 2003.9-2007.7 南京医科大学博士研究生 2004.2-2004.8 英国谢菲尔德大学进修

研究领域

MSC治疗自身免疫病的基础和临床研究自身免疫病发病机制研究

近期论文

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Sun L(#)(*), Wang D, Liang J, Zhang H, Feng X, Wang H, Hua B, Liu B, Ye S, Hu X, Xu W, Zeng X, Hou Y, Gilkeson GS, Silver RM, Lu L, Shi S. Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum. 2010;62:2467-2475. Sun L(#)(*), Akiyama K, Zhang H, Yamaza T, Hou Y, Zhao S, Xu T, Le A, Shi S. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells. 2009;27:1421-1432. Sun L(#)(*), Zhou K, Feng X, Zhang H, Ding X, Jin O, Lu L, Lau C, Hou Y, Fan L. Abnormal surface markers expression on bone marrow CD34+ cells and correlation with disease activity in patients with systemic lupus erythematosus. ClinRheumatol. 2007;26:2073-2079. Chen C(#), Wang D, Moshaverinia A, Liu D, Kou X, Yu W, Yang R, Sun L(*), Shi S(*). Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis. Cell Res. 2017;27:559-577. Zhang Z(#), Feng R(#), Niu L, Huang S, Deng W, Shi B, Yao G, Chen W, Tang X, Gao X, Feng X(*), Sun L(*). Human Umbilical Cord Mesenchymal Stem Cells Inhibit T Follicular Helper Cell Expansion Through the Activation of iNOS in Lupus-Prone B6.MRL-Fas(lpr) Mice. Cell Transplant. 2017;26:1031-1042. Liu C(#), Zhang H(#), Yao G, Hu Y, Qi J, Wang Y, Chen W, Tang X, Li W, Lu L, Gu L(*), Sun L(*). Characteristics of primary Sjogren's syndrome patients with IgG4 positive plasma cells infiltration in the labial salivary glands. ClinRheumatol. 2017;36:83-88. FengX(#)(*), Chen W(#), Xiao L, Gu F, Huang J, Tsao BP, Sun L(*). Artesunate inhibits type I interferon-induced production of macrophage migration inhibitory factor in patients with systemic lupus erythematosus. Lupus. 2017;26:62-72. Chu C(#), Zhou N(#), Zhang H, Dou X, Li M, Liu S, Zhu Y, Chen W, Chan Q, He J(*), Sun L(*), Zhou Z(*). Correlation between intravoxel incoherent motion MR parameters and MR nodular grade of parotid glands in patients with Sjogren's syndrome: A pilot study. Eur J Radiol. 2017;86:241-247. Wang D(#), Niu L(#), Feng X, Yuan X, Zhao S, Zhang H, Liang J, Zhao C, Wang H, Hua B, Sun L(*). Long-term safety of umbilical cord mesenchymal stem cells transplantation for systemic lupus erythematosus: a 6-year follow-up study. ClinExp Med. 2017;17:333-340. Ma X(#), Chen Z(#), Hu W, Guo Z, Wang Y, Kuwana M, Sun L(*). Clinical and serological features of patients with dermatomyositis complicated by spontaneous pneumomediastinum. ClinRheumatol. 2016;35:489-493. Wang D(#), Chen H, Wang S, Zou Y, Li J, Pan J, Wang X, Ren T, Zhang Y, Chen Z, Feng X, Sun L(*). Thalidomide treatment in cutaneous lesions of systemic lupus erythematosus: a multicenter study in China. ClinRheumatol. 2016;35:1521-1527. Chen J(#), Wang Q(#), Feng X, Zhang Z, Geng L, Xu T, Wang D, Sun L(*). Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria. Stem Cells Int. 2016;2016:4062789-42062789. Huang S(#), Wang D(#), Gu F(#), Zhang Z, Deng W, Chen W, Tang X, Yao G, Feng X, Sun L(*). No significant effects of Poly(I:C) on human umbilical cord-derived mesenchymal stem cells in the treatment of B6.MRL-Fas(lpr) mice. Curr Res Transl Med. 2016;64:55-60. FengX(#)(*), Pan W, Liu L, Wu M, Ding F, Hu H, Ding X, Wei H, Zou Y, Qian X, Wang M, Wu J, Tao J, Tan J, Da Z, Zhang M, Li J, Sun L(*), Jiangsu Lupus Collaborative G. Prognosis for Hospitalized Patients with Systemic Lupus Erythematosus in China: 5-Year Update of the Jiangsu Cohort. PLoS One. 2016;11:e0168619. Deng W(#), Feng X, Li X, Wang D, Sun L(*). Hypoxia-inducible factor 1 in autoimmune diseases. Cell Immunol. 2016;303:7-15. Liang J(#), Wang D, Dominique F, Sun L(*). Mesenchymal stem cells for treating autoimmune diseases: The Chinese experience from lab to clinics. Curr Res Transl Med. 2016;64:115-120.