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个人简介

教育经历 1995/09-1998/12 南京农业大学微生物学专业,博士 1985/09-1988/07 南京农业大学植物生理与生物化学专业,硕士 1981/09-1985/07 南京农业大学农学系,学士 工作经历 2009/09-至今 南京师范大学生命科学学院,教授 2007/09-2009/08 美国加州大学医学院基因中心,访问教授 2005/08-2007/08 南京师范大学生命科学学院,教授 2002/04-2005/08 美国加州大学戴维斯分校生物学部,博士后 1988/08-2002/04 南京师范大学生物系任助教、讲师、副教授

研究领域

丝状真菌功能基因调控机理; 丝状真菌曲霉生长和形态发育调控机制; 微生物资源开发利用

近期论文

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Li X.D., Li Y.K., Wang R., Wang Q.Z., Lu L., Toxoflavin produced by Burkholderia gladioli from Lycoris aurea is a new broad-spectrum fungicide. Appl. Environ. Microbiol. 2019, 85:e00106-19. Cai Z.D., Du W.L., Liu L., Pan D.D., Lu L., Molecular Characteristics of the Conserved Aspergillus nidulans Transcription Factor Mac1 and Its Functions in Response to Copper Starvation. mSphere 2019, 4(1): p. e00670-18. Long N.B., Orasch T., Zhang S.Z., Gao L., Xu X.L., Hortschansky P., Ye J., Zhang F.L., Xu K., Gsaller F., Strassburger, M., Binder, U., Heinekamp, T., Brakhage, A. A., Haas, H., Lu, L., The Zn(2)Cys(6)-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus. Plos Genet 2018, 14(10) : p. e1007762-84. Song J.X., Zhang S.Z., Lu L., Fungal cytochrome P450 protein Cyp51: What we can learn from its evolution, regulons and Cyp51-based azole resistance. Fungal Biol Rev 2018, 32(3): p. 131-142. Cai Z.D., Du W.L., Zhang Z., Guan L.Y., Zeng Q.Q., Chai Y.F., Dai C.C., Lu L., The Aspergillus fumigatus transcription factor AceA is involved not only in Cu but also in Zn detoxification through regulating transporters CrpA and ZrcA. Cell Microbiol 2018, 20(10): p. e12864-78. Wei H., Yue S., Zhang S.Z., Lu L., Lipid-Lowering Effect of the Pleurotus eryngii (King Oyster Mushroom) Polysaccharide from Solid-State Fermentation on Both Macrophage-Derived Foam Cells and Zebrafish Models. Polymers 2018, 10(5): p. 492-502. Zhang C., Meng X.H., Gu H.Y., Ma Z.H., Lu L., Predicted Glycerol 3-Phosphate Dehydrogenase Homologs and the Glycerol Kinase GlcA Coordinately Adapt to Various Carbon Sources and Osmotic Stress in Aspergillus fumigatus. G3 2018, 8(7): p. 2291-2299. Takeshita N., Evangelinos M., Zhou L., Serizawa T., Somera-Fajardo R.A., Lu L., Takaya N., Nienhaus G.U., Fischer R., Pulses of Ca(2+) coordinate actin assembly and exocytosis for stepwise cell extension. Proc Natl Acad Sci U S A 2017, 114(22): p. 5701-5706. Wei, X., P. Chen, R. Gao, Y. Li, A. Zhang, F. Liu, and Lu L., Screening and Characterization of a Non-cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance. Antimicrob Agents Chemother, 2017. 61(1): p. 1e02101-16 Song, J., P. Zhai, and L. Lu, Damage resistance protein (Dap) contributes to azole resistance in a sterol-regulatory-element-binding protein SrbA-dependent way. Appl Microbiol Biotechnol, 2017. 101(9): p. 3729-3741. Long, N., X. Xu, Q. Zeng, H. Sang, and Lu L., Erg4A and Erg4B Are Required for Conidiation and Azole Resistance via Regulation of Ergosterol Biosynthesis in Aspergillus fumigatus. Appl Environ Microbiol, 2017. 83(4): p. e02924-16 Jiang, P., W.F. Wei, G.W. Zhong, X.G. Zhou, W.R. Qiao, R. Fisher, and Lu L ., The function of the three phosphoribosyl pyrophosphate synthetase (Prs) genes in hyphal growth and conidiation in Aspergillus nidulans. Microbiology, 2017. 163(2): p. 218-232. Zhang, Y., Q. Zheng, C. Sun, J. Song, L. Gao, S. Zhang, A. Munoz, N.D. Read, and Lu L., Palmitoylation of the Cysteine Residue in the DHHC Motif of a Palmitoyl Transferase Mediates Ca2+ Homeostasis in Aspergillus. PLoS Genet, 2016. 12(4): p. e1005977-6006. Zhang, C., X. Meng, X. Wei, and Lu L., Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus. Fungal Genet Biol, 2016. 86: p. 47-57. Wang, S., X. Liu, H. Qian, S. Zhang, and Lu L., Calcineurin and Calcium Channel CchA Coordinate the Salt Stress Response by Regulating Cytoplasmic Ca2+ Homeostasis in Aspergillus nidulans. Appl Environ Microbiol, 2016. 82(11): p. 3420-30. Song, J., P. Zhai, Y. Zhang, C. Zhang, H. Sang, G. Han, N.P. Keller, and Lu L., The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility. MBio, 2016. 7(1): p. e01919-15. Lu, L., P. Sirish, Z. Zhang, R.L. Woltz, N. Li, V. Timofeyev, A.A. Knowlton, X.D. Zhang, E.N. Yamoah, and N. Chiamvimonvat, Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. J Biol Chem, 2015. 290(8): p. 4663-76.

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