邓成 - 南京师范大学

个人简介

邓成，男，四川乐山人。教授，博士生导师，国家级青年人才项目入选者。动物遗传资源研究所所长，南京师范大学生命科学学院青年委员会主任。 2014.11-至今 :南京师范大学生命科学学院，教授 2011-2014: 斯坦福大学医学院，博士后 2004-2010: 中国科学院遗传与发育生物学研究所，理学博士 2000-2004: 武汉大学国家生物学人才培养基地专业，理学学士

研究领域

以演化生物学和生物信息学分析为基础，以分子细胞生物学实验手段研究人类孤儿G蛋白偶联受体-GPCR的新功能和其多肽激素配体适应性演化及其生理功能适应，开发人类疾病相关的新多肽药物和新药靶。具体包括：多肽家族GPCR受配体关系的起源和演化分子模型 GPCR受体基因和多肽激素配体基因的协同演化和适应性演化研究孤儿GPCR在哺乳动物和人类中的适应性演化和蛋白结构变化及引起的功能适应孤儿GPCR的去孤儿化和功能研究，哺乳动物新多肽激素配体的预测和功能鉴定 GPCR受体配体对在细胞水平（in vitro）和模式老鼠动物水平（in vivo）的功能研究，GPCR靶点药物和新多肽药物的开发

近期论文

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Huihao Tang#, ChuanjunShu#, Haidi Chen#, Xiaojing Zhang, ZhuqingZang, Cheng Deng* (2019).Constitutively active BRS3 is a genuinely orphan GPCR in placental mammals.Plos Biology.DOI: 10.1371/journal.pbio.3000175.*通讯作者(SCI, 5-Yr IF=9.53) Lu Zhou#, Hang Sun#, Ran Cheng, Xiujun Fan, Shanshan Lai*, Cheng Deng*. (2019).ELABELA, as a potential diagnostic biomarker of pre-eclampsia, regulates Abnormally shallow placentation via APJ. American Journal of Physiology-Endocrinology and Metabolism.doi.org/10.1152/ajpendo.00383.2018.*通讯作者 (SCI, 5-Yr IF=4.1) Haidi Chen#, Li Chen#, Yune Wu, HaoShen, Guang Yang, Cheng Deng* (2017).The exonization and functionalization of an Alu-J element in the protein coding region of glycoprotein hormone alpha gene represent a novel mechanism to the evolution of hemochorial placentation in primates. Molecular Biology and Evolution ,Volume 34,Issue 12,1 December 2017,Pages 3216–3231 *通讯作者(SCI, 5-Yr IF=13.3) Cheng Deng*, Haidi Chen, Na Yang, Yi Feng, Aaron J. W. Hsueh*. (2015) Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling. Journal of Biological Chemistry. DOI: 10.1074/jbc.M115.648238 *通讯作者(SCI, 5-Yr IF=4.3) Cheng Deng* & Aaron J. W. Hsueh. (2013) Evolution of a potential hormone antagonist following gene splicing during primate evolution.Plos One. DOI: 10.1371/journal.pone.0064610.*通讯作者(SCI, 5-Yr IF=4.1) Cheng Deng*, Ximiao He, Aaron J. W. Hsueh*. (2013) A single-nucleotide polymorphism of human Neuropeptide S gene originated from Europe shows decreased bioactivity. Plos One.DOI: 10.1371/journal.pone.0083009. *通讯作者(SCI, 5-Yr IF=4.1) Cheng Deng, Pradeep Reddy, Yuan Cheng, Ching-Wei Luo, Chih-Lun Hsiao, and Aaron J. W. Hsueh. (2013) Multi-functional norrin is a ligand for the LGR4 receptor. Journal of Cell Science.DOI: 10.1242/jcs.123471.(SCI, 5-Yr IF=6.1) Cheng Deng, Chi-Hing Cheng, Hua Ye, Ximiao He, Liangbiao Chen. (2010) Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict. Proc. Natl. Acad. Sci. USA.107:21593–8.(SCI, 5-Yr IF=9.7) Yang Na1, Peng Changlian1, Cheng Deng, Huang Qiao, XuGuanghui, GaoFei, Chen Liangbiao. (2013). The over-expression of calmodulin from Antarcticnotothenioidfish increases cold tolerance in tobacco. Gene. doi: 10.1016/j.gene.2013.03.048.1共同第一作者 Chen, Z., Cheng, C.H., Zhang, J., Cao, L., Chen, L., Zhou, L., Jin, Y., Ye, H., Deng, C., Dai, Z.,et al. (2008). Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fishes. Proc. Natl. Acad. Sci. USA. 105:12944-12949. Zhang J, Deng C, Wang J. and Chen Liangbiao. (2009). Identification of a two-domain antifreeze protein gene in Antarctic eelpout Lycodichthysdearborni. Polar Biol. DOI 10.1007/s00300-008-0499-8. Chen L, Cao L, Zhou L, Jing Y, Chen Z, Deng C, Shen Y, (2007). Trehalose as a good candidate for enriching full-length cDNAs in cDNA library construction. J. Biotech. 127: 402-407.