王加生 - 江南大学

个人简介

教育经历 1994-1995，美国约翰霍普金斯大学分子流行病学，博士后 1990-1994，美国波士顿大学医学院，病理与免疫学专业，博士 1978-1981，上海第一医学院预防医学系，营养与食品卫生专业，硕士 1975-1978, 上海第一医学院预防医学系，本科。工作经历 2008年至今，美国乔治亚大学公共卫生学院环境健康科学系，教授，系主任 2006-2008，美国德州理工大学环境毒理系，教授 2006-2008，美国德州理工大学环境和人类健康研究所，人类健康部主任 2006-2008，美国德州理工大学西南癌症研究中心，癌症预防项目主管 2000-2005，美国德州理工大学环境毒理系，副教授 1997-2000，美国约翰霍普金斯大学公共卫生学院环境健康科学系，研究助理教授 1994-1996，美国约翰霍普金斯大学公共卫生学院环境健康科学系，资深副研究员 1992-1993 美国麻省理工学院毒理中心，兼职研究员 1990-1993，美国波士顿大学医学院，病理学系，研究助理 1986-1991，美国麻省理工学院营养与食品科学系，访问学者 1982-1986，南京铁道医学院预防医学系，系主任助理，教研室主任

研究领域

一直致力于食物活性成分对肿瘤与其它慢性疾病的干预作用研究和食物与环境生物毒素的联合毒性作用机理研究。主要学术成果包括：研发了以黄曲霉毒素和黄曲霉毒素-赖氨酸加合物单克隆抗体制备免疫亲和层析柱的方法

近期论文

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Tang, L., Xu, L., Afriyie-Gyawu, E., Liu, W., Wang, P., Tang, Y., Wang, Z., Henry J. Huebner, H. J., Ankrah, N.-A., Ofori-Adjei, D., Williams, J. H., Wang, J.-S., and Phillips, T. D. (2008). Aflatoxin-albumin adducts correlates with decreased serum levels of vitamins A and E in an adult Ghanaian population. Food Additives & Contam, In press Afriyie-Gyawu, E., Wang, Z., Ankrah, N-A., Johnson, N. M., Tang, L., Xu, L., Ofosuhene, M., Kumi, J., Huebner, H. J., Jolly, P. E., Ellis, Taylor, R., Brattin, B., W. O., Ofori-Adjei, D., Williams, J. H., Wang, J-S., and Phillips, T. D. (2008) Clinical intervention trial with NovaSil clay in Ghanaians at high risk for aflatoxicosis: Nutrient utilization and non-nutritional factors. Food Additives & Contam, In press Jiang, Y., Jolly, P. E., Preko, P. O., Wang, J.-S., Ellis, W. O., Williams, J. H. and Phillips, T. D. (2008) Aflatoxin related immune dysfunction in health and in human immunodeficiency virus disease. Clinic. Develop. Immunol. Article ID 790309, doi:10.1155/2008/790309. Tang, L., Tang, M., Xu, L., Luo, H., Huang, T., Yu, J., Zhang, L., Cox, SB., Gao, W.-M and Wang, J.-S. (2008). Modulation of Aflatoxin Biomarkers in Human Blood and Urine by Green Tea Polyphenols Intervention. Carcinogenesis 29(2):411-417. Wang, J.-S., Luo, H., Wang, P. Tang, L., Yu, J., Huang, T., Cox, S. B., Gao, W. (2008). Validation of Green Tea Polyphenol Biomarkers in a Phase II Human Intervention Trial. Food Chem Toxicol. 46:232-240. Shen, C.-L., P. Wang., Guerrier, J., Yeh, J. K. and J.-S. Wang (2008) Protective effect of green tea polyphenols on bone loss in middle-aged female rats. Osteopros Int. 19(7):979-990. Afriyie-Gyawu, E., Ankrah, N.-A., Huebner, H. J., Ofosuhene, M., Kumi, J., Johnson, N. M., Tang, L., Xu, L., Jolly, P.E., Ellis, W. O., Ofori-Adjei, D., Williams, J. H., Wang, J.-S. & Phillips, T. D. (2008). NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis. I. Study design and clinical outcomes. Food Additives & Contam, 25(1):76-87. Phillips, T. D., Afriyie-Gyawu, E., Williams, J., Huebner, H., N-A. Ankrah, N-A., Ofori-Adjei, D., Jolly, P., Johnson, N., Taylor, J., Marroquin-Cardona, A., Xu, L., Tang, L., Wang, J.-S. (2008). Reducing Human Exposure to Aflatoxin through Use of Clay. Food Additives & Contam, 25(2):134-145. Billam, M., Mukhi, S., Tang, L., Gao, W., and Wang, J.-S. (2008) Toxic response indicators of microcystin-LR in F344 rats following a single dose treatment. Toxcon 51(6):1068-1080. Wang, P., Afriyie-Gyawu, E., Tang, Y., Johnson,N. M., Xu, L., Tang, L., Huebner, H. J., Ankrah, N.-A., Ofori-Adjei, D., Ellis, W., Jolly, P. E., Williams, J. H., Wang, J.-S., Phillips, T. D. (2008).NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis: II. Reduction in biomarkers of aflatoxin exposure in blood and urine, Food Additives & Contam, 25 (5):622-634. Cai, Q., Tang, L. and Wang, J.-S. (2007). Validation of fumonisin biomarkers in F344 rats. Toxicol Appl. Pharmacol. 225:28-39. Tang, L., Guan H., Ding, X. and Wang, J.-S. (2007). Modulation of aflatoxin toxicity and biomarkers by lycopene in F-344 rats. Toxicol Appl. Pharmacol. 219:10-17. Sun, G., Wang, S., Hu, X., Su, J., Huang, T., Yu, J., Tang, L., Gao, W. and Wang, J.-S. (2007). Fumonisin B1 contamination of home-grown corn in high-risk areas of esophageal and liver cancers in China. Food Additives & Contam. 24(2):181-185. Dash, B., Afriyie-Gyawu, E, Huebner, H. J., Porter, W., Wang, J.-S, Jolly, P. E.,Phillips, T. D. (2007). Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaians. J Toxicol. Environ. Health Part A 70:58-66. Jolly, P. E., Jiang, Y., Ellis, W. O., Awuah, R. T., Appawu, J., Nnedu, O., Stiles, J. K., Wang, J-S., Adjei, O., Jolly, C. M., Williams, J. H. (2007). Association between aflatoxin exposure and health characteristics, liver function, hepatitis and malaria infections in Ghanaians. J. Nutri & Environ. Med. 16 (3):1-16. Luo, H., Cox, SB., Gao, W.-M., Yu, J., Tang, L. and Wang, J.-S. (2006). Metabolic Profiling in Validation of Plasma Biomarkers for Green Tea Polyphenols. Metabolomics, 2(4):235-241. Wang, Z., Tang, L., Sun, G., Tang, Y., Xie, Y., Wang, S., Hu, X., Gao, W., Cox, S. B. and Wang J.-S. (2006). Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China. BMC Cancer 2006, 6:287 doi:10.1186/1471-2407-6-287 Pan XP, Zhang BH, Tian K, Jones LE, Liu J, Anderson TA, Wang J.-S.,Cobb GP (2006). Liquid chromatography-electrospray ionization-tandem mass spectrometry analysis of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). Rapid Commun. Mass Spectrom 20:2222-2226. Egner, PA, Groopman, JD., Wang, J.-S., Kensler, TW., and Friesen, MD (2006). Quantification of aflatoxin B1-N7-guanine in human urine by HPLC-Isotope-Dilution Tandem Mass Spectrometry. Chem. Res. Toxicol. 18:1191-1195. Wang, S-L., He, X-Y., Shen, J., Wang, J.-S. and Hong, J-Y. (2006) The Missense Genetic Polymorphisms of Human CYP2A13: Functional Significance in Carcinogen Activation and Identification of A Null Allelic Variant . Toxicol. Sci. 94(1):38-45. Luo, H., Tang, L., Billam, M., Tang, M.,Huang, T., Yu, J., Wei, Z., Liang, Y., Wang, K., Zhang, Z., Zhang, L., and Wang, J.-S. (2006). Phase IIa chemoprevention trial of green tea polyphenols in high-risk population of liver cancer: II. Modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. Carcinogenesis. 27:262-268. Billam, M., Tang, L., Cai, Q., Mukhi, S., Guan, H., Wang, P., Wang, Z. and Wang, J.-S. (2006). Seasonal Variations in the Concentration of Microcystin-LR Contamination in Lakes of West Texas. Environ. Toxicol. Chem. 25(2):356-366. McKean, C., Tang, L., Billam, M., Tang, M., Theodorakis, C. W., Kendall, R. J. and Wang, J.-S (2006). Comparative acute and combinative toxicity of aflatoxin B1 and T-2 toxin in animals and immortilized human cell lines. J. Appl Toxicol.26(2):139-147. McKean, C., Tang, L., Tang, M., Billam, M., Wang, Z.,Theodorakis, C. W., Kendall, R. J. and Wang, J.-S (2006). Comparative acute and combinative toxicity of aflatoxin B1 and fumonisin B1 in animals and human cell lines. Food Chem. Toxicol.44(6):868-876. Liu, F., Wang, J.-S., and Theodorakis, C.W. (2006). Genotoxicity and oxidative stress caused by sodium arsenate and sodium perchlorate in zebrafish Danio rerio. Environ Sci. Technol. 40:3429-3436. Dash, B., Afriyie-Gyawu, E, Huebner, H. J., Porter, W., Wang, J.-S, Jolly, P. E.,Phillips, T. D. (2006). Noninvasive identification of inter-individual variation in xenobiotic metabolizing enzymes: implications for cancer epidemiology and biomarker studies. J Toxicol. Environ. Health A 69(13):1203-1216. He, X-Y., Tang, L., Wang, S-L., Cai, Q., Wang, J.-S. and Hong, J-Y. (2006). Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract. Int. J. Cancer, 118(11):2665-2671. Jolly, P., Jiang, Y., Ellis, W., Awuah, R., Nnedu, O., Phillips, T., Wang, J.-S., Tang, L., Afriyie-Gyawu, E., Person, S., Williams, T. and Jolly, C. (2006). Determinants of aflatoxin levels in Ghanaians: sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices. Int. J. Hyg. Environ.-Health209:345-358.