施杰 - 江南大学 - 生物工程学院

个人简介

2006,09-2010,07 兰州大学生命科学学院生物技术专业学士 2010,09-2013,07 兰州大学生命科学学院肿瘤生物学与新药筛选研究所硕士 2013,11-2017,11 荷兰乌特勒支大学药学院博士 2017,12-2018,12 葛兰素史克(西班牙)研发中心 2019,01-至今江南大学生物工程学院副研究员

研究领域

营养物质依赖的蛋白质翻译后O-GlcNAc 糖基化修饰对细胞生理功能的调控及其与肿瘤病理变化的联系; O-GlcNAc糖基转移酶的活性调控机理及其靶向干预抑制剂的发现；肿瘤相关纳米抗体药物和检测探针的开发和应用

近期论文

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[1] Shi, J., R. Ruijtenbeek, and R.J. Pieters. (2018). Demystifying O-GlcNAcylation: hints from peptidesubstrates. Glycobiology, 28(11): p. 814-824 [2] Shi, J., Tomasic, T., Sharif, S., Brouwer, A. J., Anderluh, M., Ruijtenbeek, R., and Pieters, R. J.(2017). Peptide microarray analysis of the cross-talk between O-GlcNAcylation and tyrosinephosphorylation, FEBS Lett. 591, 1872-1883. [3] Shi, J., S. Sharif, R. Ruijtenbeek and R. J. Pieters. (2016). Activity Based High-Throughput Screeningfor Novel O-GlcNAc Transferase Substrates Using a Dynamic Peptide Microarray. PLoS One 11(3):e0151085. [4] Sharif S, Shi J, Ruijtenbeek R, Pieters RJ. (2019). Study of cross talk between phosphatases and OGAon a ZO-3-derived peptide. Amino Acids. (出版中) [5] Zhang, H., Tomašič, T., Shi, J., Weiss, M., Ruijtenbeek, R., Anderluh, M., and Pieters, R.J. (2018).Inhibition of O-GlcNAc transferase (OGT) by peptidic hybrids. MedChemComm 9(5): p. 883-887. [6] Sharif, S., Shi, J., Bourakba, M., Ruijtenbeek, R., and Pieters, R. J. (2017). Measuring O-GlcNAccleavage by OGA and cell lysates on a peptide microarray, Anal. Biochem. 532, 12-18. [7] Shi, J., J. Chen, N. Serradji, X. Xu, H. Zhou, Y. Ma, Z. Sun, P. Jiang, Y. Du, J. Yang, C. Dong and Q.Wang. (2013). PMS1077 sensitizes TNF-alpha induced apoptosis in human prostate cancer cells byblocking NF-kappaB signaling pathway. PLoS One 8(4): e61132. [8] He, J., J. Shi, X. Xu, W. Zhang, Y. Wang, X. Chen, Y. Du, N. Zhu, J. Zhang, Q. Wang and J. Yang,(2012). STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalingpathway. J Biosci 37(2): 243-257. [9] Lei Jia*, Jie Shi, Zhihong Sun, Feifei Li, Yuan Wang, Weina Wu and Qin Wang*, (2012). Synthesis,crystal structure, DNA-binding properties, cytotoxic and antioxidation activities of several ternary copper(II) complexes with a new reduced Schiff base ligand, Inorganica Chimica Acta. 391, 121–129.