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个人简介

谢赛赛,男,出生于1988.12,博士,副教授,硕士生导师,中共党员,汉族,毕业于中国药科大学,工作单位:国家工程中心.

研究领域

基于天然产物的合理药物设计、合成与活性研究

近期论文

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1) Qi He?, Jing Liu?, Jin-Shuai Lan, Jiaoli Ding, Yongbing Sun, Yuanying Fang, Neng Jiang, Zunhua Yang, Liyuan Sun, Yi Jin*, Sai-Sai Xie*. Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation [J]. Bioorganic Chemistry. 2018,81:512-528.(IF=3.92) 2) Neng Jiang?, Qichun Huang?, Jing Liu Ningsheng Liang *, Qing Li, Qinghua Li, Sai-Sai Xie *. Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease [J]. European journal of medicinal chemistry. 2018,146:287-298. (IF=4.82) 3) Jin-Shuai Lan, Yun Liu, Jian-wei Hou, Jing Yang, Xin-Yu Zhang, Yuan Zhao, Sai-Sai Xie *, Yue Ding*, Tong Zhang. Design, synthesis and evaluation of resveratrol-indazole hybrids as novel monoamine oxidases inhibitors with amyloid-β aggregation inhibition. [J]. Bioorganic Chemistry. 2018,76:130-139.(IF=3.92) 4) Jin-Shuai Lan?, Yue Ding?, Yun Liu, Ping Kang, Jian-Wei Hou, Xin-Yu Zhang, Sai-Sai Xie* Tong Zhang*. Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2017, 139: 48-59. (IF=4.82) 5) Jin-Shuai Lan?, Tong Zhang?, Yun Liu, Jing Yang, Sai-Sai Xie*, Jing Liu, Ze-Yang Miao, Yue Ding*. Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors. European journal of medicinal chemistry, 2017, 133: 184-196. (IF=4.82) 6) Sai-Sai Xie?, Jin-Shuai Lan?, Xiaobing Wang, Zhi-Min Wang, Neng Jiang, Fan Li, Jia-Jia Wu, Jin Wang and Ling-Yi Kong*. Design, synthesis and biological evaluation of novel donepezil–coumarin hybrids as multi-target agents for the treatment of Alzheimer’s disease. Bioorganic & medicinal chemistry, 2016, 24: 1528-1539. (IF=2.93) 7) Sai-Sai Xie, Xiaobing Wang, Neng Jiang, Wenying Yu, Kelvin D. G. Wang, Jin-Shuai Lan, Zhong-Rui Li and Ling-Yi Kong*. Multi-Target Tacrine-Coumarin Hybrids: Cholinesterase and Monoamine Oxidase B Inhibition Properties against Alzheimer’s Disease. European journal of medicinal chemistry, 2015, 95: 153-165. (IF=4.82) 8) Sai-Sai Xie?, Jin-Shuai Lan?, Xiao-Bing Wang, Neng Jiang, Ge Dong, Zhong-Rui Li, Kelvin D.G. Wang, Ping-Ping Guo and Ling-Yi Kong*. Multifunctional tacrine–trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties. European journal of medicinal chemistry, 2015, 93: 42-50. (IF=4.82) 9) Sai-Sai Xie, Xiao-Bing Wang, Jiang-Yan Li, Lei Yang and Ling-Yi Kong*. Design, synthesis and evaluation of novel tacrine–coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease. European journal of medicinal chemistry, 2013, 64: 540-553. (IF=4.82) 10) Sai-Sai Xie, Xiao-Bing Wang, Jiang-Yan Li and Ling-Yi Kong*. Design, Synthesis and Biological Evaluation of Novel 7-Mercaptocoumarin Derivatives as α1-Adrenoceptor Antagonists. Chemical and Pharmaceutical Bulletin, 2013, 61(1): 16-24. (IF=1.59)

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