张真庆 - 苏州大学 - 医学部药学院

个人简介

学历背景 1996.09 - 2000.06：中国海洋大学，药学 2000.09 - 2006.06：中国海洋大学，工学博士，研究方向糖科学工作经历 2006.08 - 2009.09：美国Rensselaer Polytechnic Institute, 博士后 2009.10 –2012.08：美国Baxter Healthcare,研究员 2012.08 – 目前：苏州大学药学院，教授

研究领域

1、肝素及肝素类药物的分析，鉴定 2、糖蛋白和蛋白聚糖的糖基化分析 3、活性糖链的生物合成、衍生以及蛋白的多糖修饰研究 4、活性糖链与抗肿瘤和抗神经退行性疾病的构效关系研究 5、糖类药物的研究与开发

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. M. Guerrini, D. Beccati, Z. Shriver, A. Naggi, K. Viswanathan, A. Bisio, I. Capila, J.C. Lansing, S. Guglieri, B. Fraser, A. Al-Hakim, N.S. Gunay, Z. Zhang, L. Robinson, L. Buhse, M. Nasr, J. Woodcock, R. Langer, G. Venkataraman, R.J. Linhardt, B. Casu, G. Torri, R. Sasisekharan*. Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events, Nature Biotechnolology, 2008, 26(6): 669-675. 影响因子31 2. M. Guerrini,1 Z. Zhang,1 Z. Shriver,1 A. Naggi , S. Masuko , R. Langer, B. Casu , R. J. Linhardt , G. Torri, R. Sasisekharan*, Orthogonal analytical approaches to detect potential contaminants in heparin, PNAS, 2009, 106, 16956-61. 1Co- first authors.影响因子9.8 3. Z. Zhang, S.A. McCallum, J. Xie, L. Nieto, F. Corzana, J. Jiménez-Barbero, M. Chen, J. Liu, R.J. Linhardt*. Solution Structures of Chemoenzymatically Synthesized Heparin and Its Precursors, Journal of the American Chemical Society, 2008, 130(39): 12998-3007.影响因子9.0 4. H. Liu, Z. Zhang, R.J. Linhardt*. Lessons learned from the contamination of heparin, Natural Product Reports (NPR), highlight paper, 2009, 26(3):313-321.影响因子7.7 5. Z. Zhang*, N. Khan, C.M. Szabo, Complete Monosaccharide Analysis by High Performance Anion Exchange Chromatography with Pulsed Amperometric Detection. Anal. Chem. 2012, 84, 4104-4110. 影响因子5.8 6. Z. Zhang, J. Xie, H. Liu, J. Liu, R.J. Linhardt*. Quantitification of Heparan Sulfate Disaccharides Using Ion-pairing, Reverse-Phase, Micro-flow, High Performance Liquid Chromatography with Electrospray Ionization Trap Mass Spectrometry. Analytical Chemistry, 2009, 81, 4349-4355. 影响因子5.8 7. Z. Zhang, M. Weïwer, B. Li, M.M. Kemp, T.H. Daman, R.J. Linhardt*. Oversulfated Chondroitin Sulfate: Impact of a Heparin Impurity, Associated with Adverse Clinical Events, on Low-Molecular-Weight Heparin Preparation. Journal of Medicinal Chemistry, 2008, 51(18): 5498-501. 影响因子5.2 8. Z. Zhang, J. Xie, J. Liu, R.J. Linhardt*. Tandem MS can distinguish hyaluronic acid from N-acetylheparosan, Journal of the American Society of Mass Spectrometry, 2008, 19(1): 82-90. 影响因子3.8 9. Z. Zhang, G. Yu, X Zhao, H. Liu, H Guan, A.M. Lawson W. Chai*. Sequence analysis of alginate-derived oligosaccharide by ESI/CID-MS/MS. Journal of theAmerican Society of Mass Spectrometry, 2006, 17, 621–630. “ SCI ” 影响因子3.8 10. Z. Zhang, J. Xie, F. Zhang, R.J. Linhardt*. Thin-layer chromatography for the analysis of glycosaminoglycan oligosaccharides. Analytical Biochemistry, 2007, 371(1): 118-120. “ SCI ” 影响因子3.3 11. Z. Zhang, Y. Park, M.M. Kemp, W. Zhao, D. Shaya, M. Cygler, Y.S. Kim, R.J. Linhardt*.Liquid chromatography–mass spectrometry to study chondroitin lyase action pattern,Analytical Biochemistry, 2009, 385(1): 57-64. 影响因子3.3 12. Z. Zhang, B. Li, J. Suwan, F. Zhang, R.J. Linhardt*. Analysis of pharmaceutical heparins and potential contaminants using 1H-NMR and PAGE, Journal of Pharmaceutical Science, 2009, 98(11):4017-4026. 影响因子3.0 13. Z. Zhang, R.J. Linhardt*. Sequence analysis of native oligosaccharides using negative ESI tandem MS, Current Anal. Chemistry, 2009, 5, 225-237. 影响因子2.1 14. Z. Zhang, G. Yu*, H. Guan, X. Zhao, Y. Du, X. Jiang, Preparation and structure elucidation of alginate oligosaccharides degraded by alginate lyase from Vibrio Sp510. Carbohydrate Research, 2004, 399,1475-1481.影响因子2.0 15. Z. Zhang, Z. Xiao, R.J. Linhardt*. Thin Layer Chromatography for the Separation and Analysis of Acidic Carbohydrates, Journal of Liquid Chromatography & Related Technologies, 2009, 1711-1732. 影响因子1.0 16. Z. Wang, B. Yang, Z. Zhang, M. Ly, M. Takieddin, S. Mousa, J. Liu, J. S. Dordick, R.J. Linhardt* Control of the heparosanN-1 deacetylation leads to animproved bioengineered heparin.Applied Microbiology and Biotechnology,2011,91-99. 影响因子3.3 17. G. Yu, Y. Zhang,Z. Zhang, L. Song, W. Chai*, The Effect and Limitation of Excess Ammonium on the Release of O-Glycansin Reducing Forms from Glycoproteins under Mild Alkaline Conditions for Glycomic and Functional Analysis.Analytical Chemistry,2010, 82, 9534-9542. 影响因子5.8 18. T. N. Laremore, M. Ly, Z. Zhang, K. Solakyildirim, S. McCallum, R. T. Owens, R. J. Linhardt*, LC-MS disaccharide composition analysis for the domain structure elucidation of decorin glycosaminoglycan.Biochemical Journal, 2010, 431:199-205. 影响因子5.2 19. Z. Xiao, W. Zhao, B. Yang, Z. Zhang, H. Guan, R. J. Linhardt*, HeparinaseⅠ susceptible 3,6-di-O-sulfo-2-deoxy-2- sulfamido- a-D-glucopyranose (1,4) 2-O-sulfo- a-L-idopyranosyluronic acid linkage. Glycobiology, 2011, 21: 13-22. “ SCI ” 影响因子3.9 D. Shaya, W. Zhao, M.L. Garron, Z. Xiao, Q. Cui, Z. Zhang, T. Sulea, R.J. Linhardt, M. Cygler, Catalytic mechanism of heparinase II investigated by site-directed mutagenesis and the crystal structure with its substrate. J. Biol. Chem, 2010, 25; 285(26):20051-61. 影响因子6.9 21. Z. Wang, Z. Zhang, SA McCallum, RJ Linhardt*, Nuclear magnetic resonance quantification for monitoring heparosan K5 capsular polysaccharide production. Analytical Biochemistry, 2010, 398, 275-277. 影响因子3.3