张秀莉 - 苏州大学 - 医学部药学院

个人简介

1、学历背景： 1996.9-2000.7 南开大学，本科 2000.9-2007.2 中国科学院大连化学物理研究所，博士（硕博连读） 2、国外学习研究经历： 2003.4-2005.3：德国国家环境健康研究中心，进修 3、工作经历： 2007.03-2009.11 中国科学院大连化学物理研究所，助理研究员 2009.12-2013.06 中国科学院大连化学物理研究所，副研究员 2013.06-2019.04 中国科学院大连化学物理研究所，研究员 2019.05-至今苏州大学医学部药学院中药系，特聘教授

研究领域

1.多维制备色谱技术用于天然产物药效物质基础研究 2.器官芯片技术/3D器官打印技术用于天然产物的毒效/药效评价 3.先进光学成像技术用于天然产物的毒效/药效评价

近期论文

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[1] X. You, X. Zhang, Y. Luo, L. Liu, W. Zhao, B. Lin, Establishment of 3D Organ Chip for Multiplexed Assessment of Type 2 Diabetes Drugs, Progress in Biochemistry and Biophysics, 46 (2019) 620-630. [2] F. Xu, H. Zhou, X. Liu, X. Zhang, Z. Wang, T. Hou, J. Wang, L. Qu, P. Zhang, H. Piao, X. Liang, Label-free cell phenotypic study of FFA4 and FFA1 and discovery of novel agonists of FFA4 from natural products, Rsc Advances, 9 (2019) 15073-15083. [3] J. Deng, X. Zhang, Z. Chen, Y. Luo, Y. Lu, T. Liu, Z. Wu, Y. Jin, W. Zhao, B. Lin, A cell lines derived microfluidic liver model for investigation of hepatotoxicity induced by drug-drug interaction, Biomicrofluidics, 13 (2019). [4] J. Deng, Z. Chen, X. Zhang, Y. Luo, Z. Wu, Y. Lu, T. Liu, W. Zhao, B. Lin, A liver-chip-based alcoholic liver disease model featuring multi-non-parenchymal cells, Biomedical Microdevices, 21 (2019). [5] W. Zhou, J. Wang, Y. Zhao, L. Yu, Y. Fang, H. Jin, H. Zhou, P. Zhang, Y. Liu, X. Zhang, X. Liang, Discovery of β2-adrenoceptor agonists in Curcuma zedoaria Rosc using label-free cell phenotypic assay combined with two-dimensional liquid chromatography, Journal of Chromatography A, 1577 (2018) 59-65. [6] Y. Zhang, Y. Liu, L. Wu, C. Fan, Z. Wang, X. Zhang, A. Alachkar, X. Liang, O. Civelli, Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3, Faseb Journal, 32 (2018) 3184-3192. [7] P. Zhang, J. Wang, Y. Zhao, X. Zhang, L. Qu, C. Wang, J. Feng, A. Wang, W. Zhou, Y. Liu, T. Hou, H. Zhou, Z. Wang, X. Liang, Discovery of novel antagonists on beta2-adrenoceptor from natural products using a label-free cell phenotypic assay, Naunyn-Schmiedeberg's archives of pharmacology, 391 (2018) 1411-1420. [8] L. Wei, T. Hou, C. Lu, J. Wang, X. Zhang, Y. Fang, Y. Zhao, J. Feng, J. Li, L. Qu, H.-l. Piao, X. Liang, SAR Studies of N- 2-(1H-Tetrazol-5-yl)phenyl benzamide Derivatives as Potent G Protein-Coupled Receptor-35 Agonists, Acs Medicinal Chemistry Letters, 9 (2018) 422-427. [9] J. Wang, H. Qi, X. Zhang, W. Si, F. Xu, T. Hou, H. Zhou, A. Wang, G. Li, Y. Liu, Y. Fang, H.-L. Piao, X. Liang, Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting beta-catenin signaling, Biomedicine & pharmacotherapy, 108 (2018) 724-733. [10] Y. Luo, X.L. Zhang, Y.J. Li, J. Deng, X.R. Li, Y.Y. Qu, Y. Lu, T.J. Liu, Z.G. Gao, B.C. Lin, High-glucose 3D INS-1 cell model combined with a microfluidic circular concentration gradient generator for high throughput screening of drugs against type 2 diabetes, Rsc Advances, 8 (2018) 25409-25416. [11] F. Yang, M.X. Zhao, X.L. Zhang, Q. Li, Y.S. Xiao, X. Ke, J. He, L. Ye, J.T. Feng, X.F. Hao, Z.H. Ke, X.M. Liang, Exploratory Purification of Compounds from Aqueous Extracts of Pinus massoniana Lamb. by Two-Dimensional Preparative Liquid Chromatography, Chromatographia, 80 (2017) 39-43. [12] L. Wei, J.X. Wang, X.L. Zhang, P. Wang, Y.P. Zhao, J.Q. Li, T. Hou, L.L. Qu, L.Y. Shi, X.M. Liang, Y. Fang, Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists, Journal of Medicinal Chemistry, 60 (2017) 362-372. [13] C. Fan, L.-H. Wu, G.-F. Zhang, F. Xu, S. Zhang, X. Zhang, L. Sun, Y. Yu, Y. Zhang, R.D. Ye, 4 '-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice, Plos One, 12 (2017). [14] N. Du, Y. Liu, X. Zhang, J. Wang, J. Zhao, J. He, H. Zhou, L. Mei, X. Liang, Discovery of new muscarinic acetylcholine receptor antagonists from Scopolia tangutica, Scientific Reports, 7 (2017). [15] Y. Zhang, Z. Long, Z. Guo, Z. Wang, X. Zhang, R.D. Ye, X. Liang, O. Civelli, Hydroxycinnamic acid amides from Scopolia tangutica inhibit the activity of M1 muscarinic acetylcholine receptor in vitro, Fitoterapia, 108 (2016) 9-12. [16] Y. Zhang, H. Jin, X. Li, J. Zhao, X. Guo, J. Wang, Z. Guo, X. Zhang, Y. Tao, Y. Liu, D. Chen, X. Liang, Separation and characterization of bufadienolides in toad skin using two-dimensional normal-phase liquid chromatography x reversed-phase liquid chromatography coupled with mass spectrometry, Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 1026 (2016) 67-74. [17] L. Wang, Y. Zhang, Z. Wang, N. Gong, T.D. Kweon, B. Vo, C. Wang, X. Zhang, J.Y. Chung, A. Alachkar, X. Liang, D.Z. Luo, O. Civelli, The Antinociceptive Properties of the Corydalis yanhusuo Extract, Plos One, 11 (2016) e0162875. [18] J. Wang, X. Zhang, X. Li, Y. Zhang, T. Hou, L. Wei, L. Qu, L. Shi, Y. Liu, L. Zou, X. Liang, Anti-gastric cancer activity in three-dimensional tumor spheroids of bufadienolides, Scientific Reports, 6 (2016) 24772-24781. [19] J. Wang, X. Zhang, Y. Fang, X. Liang, Label-Free Cell Phenotypic Assays for Assessing Drug Polypharmacology, Current Pharmaceutical Design, 22 (2016) 3190-3200. [20] H. Jin, Y. Liu, Z. Guo, J. Wang, X. Zhang, C. Wang, X. Liang, Recent development in liquid chromatography stationary phases for separation of Traditional Chinese Medicine components, Journal of Pharmaceutical and Biomedical Analysis, 130 (2016) 336-346.