个人简介
学习及工作经历:
2013/06 -至今,安徽大学,生命科学学院,副教授
2013/06 – 2018/12,安徽大学,生命科学学院,讲师
2006/09 - 2012/06,中国科学技术大学,生命科学学院
2002/06 - 2006/06,东南大学,吴健雄学院
研究领域
主要
酶催化与调节的结构基础
基因表达调控重要蛋白质的结构与功能
近期论文
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Yanhong Liu, Jigang Yu., Fudong Li, Hui Peng, Xuecheng Zhang, Yazhong Xiao, and Chao He*, Crystal structure of a raw-starch-degrading bacterial alpha-amylase belonging to subfamily 37 of the glycoside hydrolase family GH13, Scientific reports, 2017, 7: 44067.
Chao He#, Jing Li#, Wei Li, Yi Xue, Zeming Fang, Wei Fang, Xuecheng Zhang, Xiaotang Wang, Yazhong Xiao*, Structures of PspAG97A alpha-glucoside hydrolase reveal a novel mechanism for chloride induced activation, Journal of structural biology, 2016, 196: 426-436.
Chao He*, Xianyu Huang, Yanhong Liu, Fudong Li, Yang Yang, Hongru Tao, Chuanchun Han, Chen Zhao, Yazhong Xiao, Yunyu Shi, Structural insights on mouse L-threonine dehydrogenase: A regulatory role of Arg180 in catalysis, Journal of structural biology, 2015, 192: 510-518.
Chao He#, Fudong Li#, Jiahai Zhang, Jihui Wu*, Yunyu Shi*, The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition, The Journal of biological chemistry, 2013, 288: 4692-4703.
Chao He, Sreerekha S. Francesca Taglini, Fudong Li, Ke Ruan, Jiahai Zhang, Jihui Wu, Yunyu Shi*, Elizabeth H. Bayne*, Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification, Proceedings of the National Academy of Sciences of the United States of America, 2013, 110: E1879-1888.
Changlin Xie, Chao He, Yiyang Jiang, Hailong Yu,Lin Cheng, Gilbert Nshogoza, Moududee Sayed Ala, Changlin Tian, Jihui Wu, Yunyu Shi* andFudong LibStructural insights into the recognition of phosphorylated Hop1 by Mek1, Acta Crystallographica Section D-Structural Biology, 2018, 74: 1027-1038
Yaqing Zhao#, Guang Zhang#, Chao He, Yide Mei, Yunyu Shi*, Fudong Li*, The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA, Cell research, 2018, 28: 130-134
Wei Li#, Han Fan#, Chao He, Xuecheng Zhang, Xiaotang Wang, Jing Yuan, Zemin Fang, Wei Fang*, Yazhong Xiao*, PspAG97A: A Halophilic alpha-Glucoside Hydrolase with Wide Substrate Specificity from Glycoside Hydrolase Family 97. Journal of microbiology and biotechnology, 2016, 26: 1933-1942.