个人简介
谭高翼，男，1981年11月生于湖北宜昌。博士/副研究员/硕士生导师。2014年3月毕业于上海交通大学生命科学技术学院(微生物代谢国家重点实验室)，获微生物学专业博士学位；2015年3月获武汉大学医学部助研任职资格；2016年10月加入华东理工大学任助理研究员、副研究员，目前为生物反应器工程国家重点实验室固定成员。主要从事微生物发酵与次级代谢调控、代谢工程及合成生物学相关的研究。现已发表学术论文20多篇，其中包括在Nature Communications (2019)，Current Opinion in Biotechnology (2017)，Metabolic Engineering (2015, 2017)，ACS Synthetic Biology (2017)，Biotechnology and Bioengineering (2013)等专业领域著名学术期刊发表第一作者/通讯作者论文15篇。申请/授权国家发明专利7项。研究论文曾获Faculty of 1000的推荐。多次参加国际会议并受邀作学术报告。带队/指导华东理工大学首届本科生iGEM(国际遗传工程机器大赛)项目，连续两年比赛获团队金奖(2017, 2018)。目前担任Sci. Rep.，Appl. Microbiol. Biotechnol.，Process Biochem.，Biotechnol. J.，Biochem. Eng. J.等多个SCI期刊论文审稿人。曾先后主持中国博士后科学基金、湖北省自然科学基金面上项目、国家自然科学基金青年基金、国家自然科学基金面上项目，同时还参与国家973项目、国家重点实验室开放课题等多个研究项目。
教育经历
2009. 9 - 2014. 3, 上海交通大学, 生命科学技术学院(微生物代谢国家重点实验室), 理学博士
2004. 9 - 2007. 7, 华南农业大学, 动物科学学院, 农学硕士
2000. 9 - 2004. 7, 武汉轻工大学, 动物科学与营养工程学院, 工学学士
研究经历
2016.11 至今，华东理工大学生物工程学院(生物反应器工程国家重点实验室)，副研究员
2016.10 - 2016. 11, 华东理工大学生物工程学院，助理研究员
2014. 4 - 2016. 9，武汉大学药学院，博士后/助理研究员
2007. 8 - 2009. 8, 中国农业科学院, 北京畜牧兽医研究所(动物营养学国家重点实验室), 研究助理
研究领域
1. 工业微生物的代谢工程改良与遗传育种：利用代谢工程、合成生物学技术提高工业高产菌(e.g. Saccbaropolyspora spinosa, Rhodobacter sphaeroides, Streptomyces avermitilis)的产物合成效率。
2. 海洋放线菌次级代谢产物挖掘及合成与调控机制研究：海洋来源放线菌的沉默基因簇非靶向/靶向激活，例如新颖聚酮类化合物等。
3. 合成生物学新技术开发与应用：基于CRISPR/Cas系统的使能技术开发。例如大片段DNA的高效捕捉，代谢物的高通量检测和筛选等。
近期论文
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16. Mindong Liang#, Zilong Li#, Weishan Wang#, Jiakun Li#, Leshi Liu, Loganathan Karthik, Guoliang Zhu, Kefeng Wang, Yuting Shuai, Jiaming Yu, Lu Zhang, Chuang Li, Qian Zhang, Tong Shi, Liming Zhou, Man Wang, Zhong Wang, Jing Yu, Feng Xie, Huanqin Dai, Xuetin Liu, Jingyu Zhang, Guang Liu, Buchang Zhang, Chenli Liu, Shanshan Li, Xuekui Xia, Yaojun Tong, Yanwen Liu, Gao-Yi Tan*, Li-Xin Zhang*. 2019. A CRISPR/Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. Nature Communications. (Accepted)
15. Jiaqian Cao#, Yongpeng Yao#, Keqiang Fan, Gaoyi Tan, Wensheng Xiang, Xuekui Xia, Shanshan Li*, Weishan Wang*, Lixin Zhang*. 2018. Harnessing a previously unidentified capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro. Science Advances. 4(11): aau4602. [Fulltext]
14. Qiang Gao#, Gao-Yi Tan#, Xuekui Xia, Lixin Zhang*. 2017. Learn from microbial intelligence for avermectins overproduction. Current Opinion in Biotechnology. 48, 251-257. [Fulltext]
13. Gao-Yi Tan, Kunhua Deng, Xinhua Liu, Hui Tao, Yingying Chang, Jia Chen, Kai Chen, Xu Li, Zixin Deng, Tiangang Liu*. 2017. Heterologous biosynthesis of spinosad: an omics-guided large polyketide synthase gene cluster reconstitution in Streptomyces. ACS Synthetic Biology. 6(6): 995-1005. [Fulltext]
12. Gao-Yi Tan, Tiangang Liu*. 2017. Rational synthetic pathway refactoring of natural products biosynthesis in Actinobacteria. Metabolic Engineering. 39: 228-236. [Fulltext]
11. Gao-Yi Tan, Fayin Zhu, Zixin Deng, Tiangang Liu*. 2016. In vitro Reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors. Synthetic and Systems Biotechnology. 1 (1): 25-33. [Fulltext]
10. Ziling Ye, Xiaowei Li, Yongbo Cheng, Zhijie Liu, Gaoyi Tan, Fayin Zhu, Shuai Fu, Zixin Deng, Tiangang Liu*. 2016. Evaluation of 3-hydroxypropionate biosynthesis in vitro by partial introduction of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula. Journal of Industrial Microbiology & Biothechnolgy, 1(1): 25-33. [Fulltext]
9. Qian Liu, Liping Xiao, Yuanjie Zhou, Kunhua Deng, Gaoyi Tan, Yichao Han, Xinhua Liu, Zixin Deng, Tiangang Liu*. 2016. Development of Streptomyces sp. FR-008 as an emerging chassis. Synthetic and Systems Biotechnology, 1(3): 207-214. [Fulltext]
8. Gao-Yi Tan, Zixin Deng, Tiangang Liu*. 2015. Recent advances in the elucidation of enzymatic function in natural product biosynthesis. F1000Research, 4(F1000 Faculty Rev): 1399. [Fulltext]
7. Gao-Yi Tan, Yao Peng, Chenyang Lu, Linquan Bai*, Jian-Jiang Zhong*. 2015. Engineering validamycin production by tandem deletion of g-butyrolactone receptor genes in Streptomyces hygroscopicus 5008. Metabolic Engineering, 28:74-81. (Highlighted in F1000 Prime by Prof. Gregory Stephanopoulos, March 15, 2016) [Fulltext]
6. Gao-Yi Tan, Linquan Bai*, Jian-Jiang Zhong*. 2013. Exogenous 1, 4-butyrolactone stimulates A-factor-like cascade and validamycin biosynthesis in Streptomyces hygroscopicus 5008. Biotechnology and Bioengineering. 110(11):2984-2993. [Fulltext]
5. Gao-Yi Tan, Min-Hong Zhang*, Jin-Hai Feng, Ai-Yun Han, Shan-Shan Zheng, Peng Xie. 2010. Effects of pretreatment by the flavanol ampelopsin on porcine kidney epithelial cell injury induced by hydrogen peroxide. Agricultural Sciences in China (Continued as Journal of Integrative Agriculture), 9(4): 598-604. [Fulltext]
4. Lin Yang#, Gao-Yi Tan#, Yu-Qiang Fu, Jing-Hai Feng, Min-Hong Zhang*. 2010. Effects of acute heat stress and subsequent stress removal on function of hepatic mitochondrial respiration, ROS production and lipid peroxidation in broiler chickens. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology 151: 204-208. [Fulltext]
3. Gao-Yi Tan, Lin Yang, Yu-Qiang Fu, Jin-Hai. Feng, Min-Hong Zhang*. 2010. Effects of different acute high ambient temperatures on function of hepatic mitochondrial respiration, antioxidative enzymes, and oxidative injury in broiler chickens. Poultry Science, 89:115-122. (Highlighted in “Insight into oxidative stress in varicocele-associated male infertility. Nature Reviews Urology. 2012, 9: 678-690”) [Fulltext]
2. Gao-Yi Tan, Shan-Shan Zheng, Min-Hong Zhang*, Jing-Hai Feng, Peng Xie, Jin-Ming Bi. 2008. Study of oxidative damage in growing–finishing pigs with continuous excess dietary chromium picolinate intake. Biological Trace Element Research, 126:129-140. [Fulltext]
1. Gao-Yi Tan, Jin-Ming Bi, Min-Hong Zhang*, Jing-Hai Feng, Peng Xie, Shan-Shan Zheng. 2008. Effects of chromium picolinate on oxidative damage in primary piglet hepatocytes. Biological Trace Element Research, 126: S69-S79. [Fulltext]
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