夏建业 - 华东理工大学 - 生物工程学院

个人简介

2008年获得华东理工大学生物化工专业博士学位，主要研究领域为生物反应器流场特性的实验及数值模拟研究与基于细胞生理特性与反应器流场特性的生物过程放大方法的理论与应用技术研究。2008年7月留校担任教职。先后承担973项目子课题一项，863项目子课题一项，科技部支撑计划项目子课题一项，自然科学基金青年基金一项，教育部中央高校探索基金一项。2016年获得国家留学基金委资助赴瑞典查尔姆斯理工大学Jens Nielsen教授的系统生物学实验室进行为期一年的访问学者。科研之外还注重将科研成果向产业化的应用，先后在国内多家大型生物制药企业进行横向课题合作，成功应用生物反应器的流场研究进行工业规模反应器的改造和优化。在上述研究与工业应用实践过程中，发表SCI研究论文12篇，国内核心期刊研究论文7篇，并获得2008年上海市科技进步一等奖、2011年国家科技进步奖二等奖。2014年中国产学研创新成果奖。并被评为奉贤区青年五四标兵。

研究领域

1、生物反应器内流场的实验及数值模拟研究 2、生物过程反应动力学 3、基于反应动力学与流体动力学整合的生物过程放大理论与方法

近期论文

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1. Jian-Ye Xia, Si-Jing Wang, Si-Liang Zhang, Jian-Jiang Zhong, 2008, Computational investigation of fluid dynamics in a recently developed centrifugal impeller bioreactor, Biochemical Engineering Journal, 38(3): p.406-413. 2. Jian-Ye Xia, Yong-Hong Wang, Si-Liang Zhang, Ning Chen, Peng Yin, Ying-Ping Zhuang, Ju Chu, 2009, Fluid dynamics investigation of variant impeller combinations by simulation and fermentation experiment, Biochemical Engineering Journal, 43(3):p.252-260. 3. Ming-Hui Xie, Guo-Zhong Zhou*, Jian-Ye Xia*, Chen Zou, Pei-Qing Yu, Si-Liang Zhang, 2011, Comparison of power number for paddle-type impellers by tree methods, Journal of Chemical Engineering of Japan, 44(11):p.840-844. 4. Xiang Zou, Jian-Ye Xia, Ju Chu*, Ying-Ping Zhuang, Si-Liang Zhang, 2012, Real-time fluid dynamics investigation and physiological response for erythromycin fermentation scale-up from 50L to 132 m3 fermenter, Bioprocess and Biosystems Engineering, 35(5):p.789-800. 5. Yang Y.M., J.Y. Xia*, J.H. Li, J. Chu*, L. Li, Y.H. Wang, Y.P. Zhuang, S.L. Zhang, 2012, A novel impeller configuration to improve fungal physiology performance and energy conservation for cephalosporin C production, Journal of Biotechnology, 161(3): 250-256. 6. Chao Li, Jian-Ye Xia*, Ju Chu, Yong-Hong Wang*, Ying-Ping Zhuang, Si-Liang Zhang, 2013, CFD analysis of the turbulent flow in baffled shake flasks, Biochemical Engineering Journal, 70:140-150. 7. Ming-Hui Xie, Jian-Ye Xia*, Guo-Zhong Zhou, Pei-Qing Yu, Si-Liang Zhang, 2012, Hydrodynamics characterization of the ellipse gate impeller by experimental and numerical studies, Chemical Engineering & Technology, 36(1):115-122. 8. Ming-Hui Xie, Jian-Ye Xia*, Zhen Zhou, Guo-Zhong Zhou, Ju Chu, Ying-Ping Zhuang, Si-Liang Zhang, Henk Noorman, 2014, Power consumption, local and average volumetric mass transfer coefficient in multiple-impeller stirred bioreactors for xanthan gum solutions, Chemical Engineering Science, 106:144-156. 9. Ming-Hui Xie, Jian-Ye Xia*, Zhen Zhou, Ju Chu, Yingping Zhuang, and Siliang Zhang, 2014, Flow pattern, mixing, gas hold-up and mass transfer coefficient of triple-impeller configurations in stirred tank bioreactors, Industrial & Engineering Chemistry Research, 53(14):5941-5953. 10. Jian-Ye Xia, Guan Wang, Jihan Lin, Yonghong Wang, Ju Chu, Yingping Zhuang, and Siliang Zhang, Advances and practices of bioprocess scale-up, Advances in Biochemical Engineering/ Biotechnology, 2015,152(1):1-15，DOI: 10.1007/10_2014_293 11. Hongzhong Lu, Chao Li, Wenjun Tang, Zejian Wang, Jianye Xia*, Siliang Zhang, Yingping Zhuang, Ju Chu*, Henk Noorman, 2015, Dependence of fungal characteristics on seed morphology and shear stress in bioreactors, Bioprocess and Biosystems Engineering, 38(5):917-928. 12. Wenjun Tang, Ao Pan, Hongzhong Lu, Jianye Xia*, Yingping Zhuang, Siliang Zhang, Ju Chu*, Henk Noorman, 2015, Improvement of glucoamylase production using axial impellers with low power consumption and homogeneous mass transfer, Biochemical Engineering Journal, 99(15):167-176.