方泉 - 兰州大学 - 甘肃省新药临床前研究重点实验室

个人简介

方泉，男，副教授，硕士生导师。2007年6月获兰州大学生物化学与分子生物学专业的博士学位，同年留校，目前在生理学和心理学研究所从事教学和科研工作。主持国家自然科学基金1项，教育部博士点基金新教师项目1项，兰州大学校内基金3项；并作为主要项目组骨干成员参与科技部“十一五”和“十二五”国家科技重大专项、国家自然科学基金委重点项目、国家自然科学基金委重大研究计划培育项目等科研课题多项。已发表了学术论文10余篇，其中以第一作者在Neuropharmacology、Peptides、Neuropeptides、Regulatory Peptides和European Journal of Pharmacology等国际知名期刊上发表了SCI论文10篇，申请国家发明专利1项

研究领域

1. 神经肽生理与药理神经肽是机体内一类重要的神经递质/调质，本课题组利用不同效能和效价的肽类分子作为药理学工具，来探讨内源性神经肽及其受体系统的生理学和药理学功能及其作用机制。　2. 神经肽与疼痛神经肽在痛觉的传导和调节中扮演重要的角色，本课题组全面地探讨了神经肽的痛觉调节机制。在此研究基础上，以内源性神经肽（特别是阿片肽和阿片调节肽）为化学模板构建一系列的全新的肽类分子，筛选获得具有高效、低副作用、镇痛类多肽药物的先导化合物。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Fang Q, Han ZL, Li N, Wang ZL, H N, Wang R. Effects of neuropeptide FF system on CB1 and CB2 receptors mediated antinociception in mice. Neuropharmacology 2011; Doi: 10.1016/j.neuropharm.2011.09.013. (SCI, IF2010 = 4.677) 2. Fang Q, Jiang TN, Li N, Han ZL, Wang R. Central Administration of Neuropeptide FF and Related Peptides Attenuate Systemic Morphine Analgesia in Mice. Protein & Peptide Letters 2011; 18(4): 403-409. (SCI, IF2010 = 1.849) 3. Fang Q, Li N, Jiang TN, Liu Q, Li YL, Wang R. Pressor and tachycardic responses to intrathecal administration of Neuropeptide FF in anesthetized rats. Peptides 2010; 31(4): 683-688. (SCI, IF2010 = 2.654) 4. Fang Q, Liu Q, Li N, Jiang TN, Li YL, Yan X, Wang R. Cardiovascular effects of intravenous administered 26RFa, a novel RF-amide peptide ligand for GPR103, in anaesthetized rats. European Journal of Pharmacology 2009; 621(1-3): 61-66. (SCI, IF2010 = 2.737) 5. Fang Q, Wang YQ, He F, Guo J, Guo J, Chen Q, Wang R. Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist. Regulatory Peptides 2008; 147(1-3): 45-51. (SCI, IF2010 = 2.473) 6. Fang Q, Zhang BZ, Wang R. Progress in the structure-activity relationship studies of neuropeptide FF. Progress in Chemistry 2007; 19: 1977-1985. (SCI, IF2010 = 0.560, Review, in Chinese) 7. Fang Q, He F, Wang YQ, Guo J, Zhang BZ, Chen Q, Wang R. Pharmacological effects of the dansylated neuropeptide FF analogues on body temperature and morphine analgesia. Neuropeptides 2007; 41(5): 339-347. (SCI, IF2010 = 1.917) 8. Fang Q, Guo J, He F, Peng YL, Chang M, Wang R. In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides 2006; 27(9): 2207-2213. (SCI, IF2010 = 2.654) 9. Fang Q, Guo J, Peng YL, Chang M, He F, Chen Q, Wang R. In vitro and in vivo studies of dansylated compounds, the putative agonists and antagonists on neuropeptide FF receptors. Peptides 2006; 27(6): 1297-1304. (SCI, IF2010 = 2.654) 10. Fang Q, Guo J, Chang M, Chen LX, Chen Q, Wang R. Neuropeptide FF receptors exert contractile activity via inhibition of nitric oxide release in the mouse distal colon. Peptides 2005; 26(5): 791-797. (SCI, IF2010 = 2.654) 11. Chen LX , Fang Q, Chen Q, Guo J, Wang ZZ, Chen Y, Wang R. Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3. Peptides 2004; 25(8): 1349-1354. (SCI, IF2010 = 2.654) 12. Wang YQ, Guo J, Wang SB, Fang Q, He F, Wang R. Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice. Peptides 2008; 29(7):1183-90. (SCI, IF2010 = 2.654) 13. Chen LX, Wang ZZ, Wu H, Fang Q, Chen Y, Guo J, Chen Y, Wang R. Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice. Neuroscience Letters 2002; 331(2): 95-98. (SCI, IF2010 = 2.055) 14. Wang YQ, Wang SB, Ma JL, Guo J, Fang Q, Sun T, Zhuang Y, Wang R. Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice. Peptides. 2011; 32(4): 702-706. (SCI, IF2010 = 2.654)