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1. H. Xie, C. Peng, J. Huang, B. E. Li, W. Kim, E. C. Smith, Y. Fujiwara, J. Qi, G. Cheloni, P. P. Das, M. Nguyen, S. Li, J. E. Bradner, S. H. Orkin, Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2. Cancer discovery 6, 1237-1247 (2016) 2. H. Xie, J. Xu, J. H. Hsu, M. Nguyen, Y. Fujiwara, C. Peng, S. H. Orkin, Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell stem cell 14, 68-80 (2014) 3. H. Xie, C. V. Laiosa, T. Graf, Reprogramming of committed lymphoid cells by enforced transcription factor expression. Methods in molecular biology 636, 219-232 4. H. Xie, S. H. Orkin, Immunology: changed destiny. Nature 449, 410-411 (2007) 5. H. Xie, M. Ye, R. Feng, T. Graf, Stepwise reprogramming of B cells into macrophages. Cell 117, 663-676 (2004) 6. M. A. Erb, T. G. Scott, B. E. Li, H. Xie, J. Paulk, H. S. Seo, A. Souza, J. M. Roberts, S. Dastjerdi, D. L. Buckley, N. E. Sanjana, O. 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Kobayashi, Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-beta signalling. Nature communications 7, 12047 (2016) 10. E. Danis, T. Yamauchi, K. Echanique, X. Zhang, J. N. Haladyna, S. S. Riedel, N. Zhu, H. Xie, S. H. Orkin, S. A. Armstrong, K. M. Bernt, T. Neff, Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. Cell reports 14, 1953-1965 (2016) 11. J. Yin, J. W. Leavenworth, Y. Li, Q. Luo, H. Xie, X. Liu, S. Huang, H. Yan, Z. Fu, L. Y. Zhang, L. Zhang, J. Hao, X. Wu, X. Deng, C. W. Roberts, S. H. Orkin, H. Cantor, X. Wang, Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proceedings of the National Academy of Sciences of the United States of America 112, 15988-15993 (2015) 12. J. Xu, Z. Shao, D. Li, H. Xie, W. Kim, J. Huang, J. E. Taylor, L. Pinello, K. Glass, J. D. Jaffe, G. C. Yuan, S. H. Orkin, Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Molecular cell 57, 304-316 (2015) 13. P. P. Das, D. A. Hendrix, E. Apostolou, A. H. Buchner, M. C. Canver, S. Beyaz, D. Ljuboja, R. Kuintzle, W. Kim, R. Karnik, Z. Shao, H. Xie, J. Xu, A. De Los Angeles, Y. Zhang, J. Choe, D. L. Jun, X. Shen, R. I. Gregory, G. Q. Daley, A. Meissner, M. Kellis, K. Hochedlinger, J. Kim, S. H. Orkin, PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell reports 12, 1456-1470 (2015) 14. T. Neff, A. U. Sinha, M. J. Kluk, N. Zhu, M. H. Khattab, L. Stein, H. Xie, S. H. Orkin, S. A. Armstrong, Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proceedings of the National Academy of Sciences of the United States of America 109, 5028-5033 (2012) 15. A. He, Q. Ma, J. Cao, A. von Gise, P. Zhou, H. Xie, B. Zhang, M. Hsing, D. C. 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