于日磊 - 中国海洋大学

个人简介

教育背景 2009年6月至2013年1月昆士兰大学分子生物研究院药物化学b 博士工作经历 2020年9月至今中国海洋大学医药学院教授 2014年10月至2020年8月中国海洋大学医药学院副教授 2013年1月至2014年9月牛津大学生物化学系博士后

研究领域

1.海洋多肽药物设计、合成与构-效关系研究 2.约束肽药物设计、合成与活性研究 3.靶向膜蛋白受体的海洋活性化合物发现与作用机制研究 4.计算机辅助药物设计与分子动力学模拟

近期论文

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Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J,Rilei Yu*, Lu Z*.SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.Mol Cell. 2021 Jun 3;81(11):2303-2316.e8 （IF: 17.97） Li X, Tae HS, Chu Y, Jiang T, Adams DJ*,Rilei Yu*.Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor.PharmacolTher. 2021 Jun;222:107792.(IF:12.3) Jiazhen Liang, Han-Shen Tae, Xiaoxiao Xu, Tao Jiang, David J. Adams and Rilei Yu*. Dimerization of α-conotoxins as a strategy to enhance the inhibition of the human α7 and α9α10 nicotinic acetylcholine receptors. J. Med. Chem. 2020 Feb 26. doi: 10.1021/acs.jmedchem.9b01536. (IF:6.2) Rilei Yu*, Wang J, So LY, Harvey PJ, Shi J, Liang J, Dou Q, Li X, Yan X, Huang YH, Xu Q, Kaas Q, Chow HY, Wong KY, Craik DJ, Zhang X, Jiang T, Wang Y*. Enhanced Activity against Multi-drug Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway. J. Med. Chem. 2020 Jan 31. doi: 10.1021/acs.jmedchem.9b01563. (IF:6.2) Rilei Yu*, Han-Shen Tae, Qingliang Xu, David J. Craik, David J. Adams, Tao Jiang and Quentin Kaas*. An antagonist-bound structure of the human α4β2 nicotinic acetylcholine receptor. Br. J. Pharmacol.,2019,doi: 10.1111/bph.14698(IF:7.2) Rilei Yu*#, Han-Shen Tae#, Nargis Tabassum, Juan Shi, Tao Jiang, and David J. Adams*. Molecular determinants conferring the stoichiometric-dependent activity of α-conotoxins at the human α9α10 nicotinic acetylcholine receptor subtype. J. Med. Chem., 2018. DOI: 10.1021/acs.jmedchem.8b00115(IF:6.2) Rilei Yu.; Kompella, S. N.; Adams, D. J.; Craik, D. J.*; Kaas, Q.* Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor. J. Med. Chem. 2013, 56 (9), 3557–3567.(IF:5.3) Zhang Y, Yin R, Wu G, Yu M, Liu J, Wang X, Liu X, Guan H, Rilei Yu,* Jiang T*.Self-assembling nanoparticles of dually hydrophobic prodrugs constructed from camptothecin analogue for cancer therapy.Eur J Med Chem. 2020 Aug 15;200:112365. doi: 10.1016/j.ejmech.2020.112365. Epub 2020 Apr 30.(IF:5.5) Rilei Yu, Craik DJ, Kaas Q.*Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations.PLoSComput Biol.2011 Mar;7(3):e1002011. doi: 10.1371/journal.pcbi.1002011. Epub 2011 Mar 3 (IF:5.3)