赵峡 - 中国海洋大学

个人简介

赵峡，男，1969年5月生。中国海洋大学医药学院，山东省糖科学与糖工程重点实验室，海洋药物教育部重点实验室，教授、博士生导师；青岛海洋生物医药研究院糖工程药物研发室主任。主要从事海洋糖类创新药物和功能产品的研发和药学专业的相关教学工作。主持和参与国家创新药物重大科技专项，国家“863”计划，国家自然科学基金，国家科技支撑计划，国家海洋公益专项和国际科技合作等国家级课题20项。先后主持或参与抗尿路结石药物古糖酯，抗乙肝病毒药物PGS，抗动脉粥样硬化药物几丁糖酯，抗肿瘤药物海藻多糖BG136和灰树花多糖，抗糖尿病药物HS203，降脂抗栓药物甘糖酯等多个糖类创新药物的研究；并参与降糖、排铅、抗疲劳、耐缺氧等4个国家保健食品的研发工作；参与“海洋糖库”的构建和海洋寡糖标准品的研发等工作。在海洋生物多糖的提取分离、分子修饰和结构鉴定；海洋寡糖的降解制备、分离纯化和微量分析方法建立等方面具有丰富的经验和积累。

研究领域

1、海洋糖类的提取分离、结构分析和分子修饰 2、海洋糖类创新药物的研究和开发 3、糖类化合物的分析方法建立 4、海洋生物多糖载体缓控释和纳米粒制剂

近期论文

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Yanyun Gao, Wei Liu, Wei Wang, Xia Zhao*, Fahe Wang. Polyguluronate sulfate (PGS) attenuates immunological liver injury in vitro and in vivo. International Journal of Biological Macromolecules, 2018, 114: 592-598 Mingyue Bai, Wenwei Han, Xia Zhao*, Qingchi Wang, Yanyun Gao, Shiming Deng. Glycosaminoglycans from a Sea Snake (Lapemis curtus): Extraction, structural characterization and antioxidant activity. Marine Drugs, 2018, 16(5): 170-183. Jianghua Pu, Xia Zhao*, Lin Xiao, Haitao Zhao. Development and validation of a HILIC-ELSD method for simultaneous analysis of non-substituted and acetylated xylo-oligosaccharides. Journal of Pharmaceutical and Biomedical Analysis, 2017, 139:232-237. Mengyi Cong, Zhongyu Wu, Xuelian Xu, Jiaqi Yin, Hongxia Li, Bo Zhuang, Cheng Wanga, Xia Zhao*. Novel oleyl amine-modified polymannuronic acid micelle loading tacrolimus for therapy of allergic conjunctivitis. International Journal of Biological Macromolecules, 2017, 104: 862-873 Jian Wu, Meng Zhang, Yiran Zhang, Yangyang Zeng, Lijuan Zhang, Xia Zhao*. Anticoagulant and FGF/FGFR signal activating activities of the heparinoid propylene glycol alginate sodium sulfate and its oligosaccharides. Carbohydrate Polymers, 2016, 136: 641-648. Lijuan Wu, Wei Wang, Xiaoshuang Zhang, Xia Zhao*. Guangli Yu. Anti-HBV activity and mechanism of marine-derived polyguluronatesulfate (PGS) in vitro. Carbohydrate Polymers, 2016, 143: 139-148 Qing-Chi Wang, Xia Zhao*. Jiang-Hua Pu, Xiao-Hong Luan. Influences of acidic reaction and hydrolytic conditions on monosaccharide composition analysis of acidic, neutral and basic polysaccharides. Carbohydrate Polymers, 2016, 143: 296-300 Jianghua Pu, Xia Zhao*, Qingchi Wang, Yingdi Wang, Hui Zhou. Development and validation of a HPLC method for determination of degree of polymerization of xylo-oligosaccharides. Food Chemistry, 2016, 213 654-659 Yinzhi Lang, Xia Zhao*, Lili Liu, and Guangli Yu*, Applications of Mass Spectrometry to Structural Analysis of Marine Oligosaccharides, Marine Drugs, 2014, 12(7): 4005–4030. Jian Wu, Xia Zhao*, Li Ren, Yiting Xue, Chunxia Li, Guangli Yu, Huashi Guan, Determination of M/G ratio of propylene glycol alginate sodium sulfate by HPLC with pre-column derivatization, Carbohydrate Polymers, 2014, 104: 23–28.