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个人简介

教育经历 2005.11-2007.6 博士学位,美国Texas A&M University与华东师范大学联合培养 2004.6-2005.11 博士生,华东师范大学生命科学学院 2001.9-2004.6 硕士学位,湖南师范大学生命科学学院 工作经历 2015.12-至今 华东师范大学生命医学研究所,研究员,博士生导师 2010.1-2015.12 华东师范大学生命医学研究所,副教授(破格) 2007.7-2009.12 华东师范大学生命医学研究所,讲师 荣誉及奖励 2020年“创青春”全国大学生创业大赛优秀指导教师 2020第六届中国“互联网+”大学生创新创业大赛“优秀指导教师” 2020第六届中国“互联网+”大学生创新创业大赛上海赛区“优秀指导教师” 2020上海市长宁区专业技术拔尖人才(第十轮) 2019年第五届中国“互联网+”大学生创新创业大赛上海赛区“优秀指导教师”。证书编号201910323 2019年华东师范大学创新创业优秀指导教师 2019年华东师范大学校友创新创业大赛行业十强、全球6强 2019第五届中国“互联网+”大学生创新创业大赛全国“优秀指导教师”(铜奖) 2019年第四届全国大学生生命科学创新创业大赛优秀成果指导教师二等奖(创新类)。结直肠癌精准治疗药物的筛选和研究。证书编号:NDC2019CXCY02187 2018年度教育部高等学校科学研究优秀成果奖,自然科学一等奖(第九完成人)。生物靶向诊治肿瘤方法学研究。证书编号2018-55 2018年第四届中国“互联网+”大学生创新创业大赛上海赛区“优秀指导教师”(银奖) 2017年华东师范大学生命与健康论坛暨生命科学学院校友联谊会知识成果转化平台系列活动, “止血和生物粘合剂”项目荣获二等奖 2012年国家科技进步一等奖(第九完成人)。“前列腺癌诊疗体系的创新及其关键技术的应用” 2012年华东师范大学第六届优秀本科生导师奖

研究领域

抗肿瘤新药研发(前列腺癌、乳腺癌、结肠癌、胰腺癌、淋巴瘤、白血病等):筛选了2万多种中药单体、合成小分子,发现了12种新的抗癌先导化合物,3种进入临床前研究。 相关成果发表于Advanced Science、Nature communications、Leukemia和Cancer research等SCI国际知名期刊,申请国内外专利90项,其中授权29项,11项已转让 新型医用材料研发:主要包括医用组织修复材料等。相关成果发表于ACS Nano、J Mater Chem B、Adv. Funct. Mater.等

近期论文

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Chen H, Bian A, Yang LF, Yin X, Wang J, Ti C, Miao Y, Peng S, Xu S, Liu M*, Qiu WW*, Yi Z*. Targeting STAT3 by a small molecule suppresses pancreatic cancer progression. Oncogene. 2021 2021 Feb;40(8):1440-1457. (SCI,IF=7.97,通讯作者). He Y, Kan W, Li Y, Hao Y, Huang A, Gu H, Wang M, Wang Q, Chen J, Sun Z, Liu M*, Chen Y*, Yi Z*. A potent and selective small molecule inhibitor ofmyoferlin attenuates colorectal cancer progression. Clin. Transl. Med. 2021 Feb;11(2):e289. (SCI,IF=7.9,通讯作者). He QR, Tang JJ, Liu Y, Chen ZF, Liu YX, Chen H, Li D, Yi ZF*, Gao JM*. Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer. Br J Pharmacol. 2021 Mar 9 (SCI,IF=6.5,通讯作者). Chen S, Zhu G, Yang Y, Wang F, Xiao YT, Zhang N, Bian X, Zhu Y, Yu Y, Liu F, Dong K, Mariscal J, Liu Y, Soares F, Loo Yau H, Zhang B, Chen W, Wang C, Chen D, Guo Q, Yi Z, Liu M, Fraser M, De Carvalho DD, Boutros PC, Di Vizio D, Jiang Z, van der Kwast T, Berlin A, Wu S, Wang J, He HH, Ren S. Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression. Nat Cell Biol.2021 Jan;23(1):87-98. (SCI, IF=20.042). Lu W, Yu W, He J, Liu W, Yang J, Lin X, Zhang Y, Wang X, Jiang W, Luo J, Zhang Q, Yang H, Peng S, Yi Z, Ren S, Chen J, Siwko S, Nussinov R, Cheng F, Zhang H, Liu M. Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer. EMBO Mol Med.2021 Jan 11;13(1):e12798. (SCI, IF=8.8). Lin Q, He Y, Wang X, Zhang Y, Hu M, Guo W, He Y, Zhang T, Lai L, Sun Z, Yi Z,* Liu M* and Chen Y*. Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Cancer Progression. Advanced. Science. 2020 Mar 12;7(9):1903483. (SCI,IF =15.8, 通讯作者). Peng S, Wang J, Chen H, Hu P, He XL, He Y, Wang M, Tang W, He Q, Wang YY, Xie J, Guo D, Ren S, Liu M, Qiu WW, Yi Z*. Regression of castration-resistant prostate cancer by a novel compound QW07 targeting androgen receptor N-terminal domain. Cell Biol Toxicol. 2020 Jan 30. (SCI, IF=5.1, 通讯作者) Lu T, Gao H, Liao B, Wu J, Zhang W, Huang J, Liu M, Huang J, Chang Z, Jin M, Yi Z*, Jiang D*. Characterization and optimization of production of bacterial cellulose from strain CGMCC 17276 based on whole-genome analysis. Carbohydr Polym. 2020 Mar 15;232:115788. (SCI,IF=6.0,通讯作者) Guo W, Xing Y, Zhang Q, Xie J, Huang D, Gu H, He P, Zhou M, Xu S, Pang X, Liu M*, Yi Z*, Chen Y*. Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of N-phenyl-4-pyrimidinamine Derivatives Bearing Potent Activities against Tumor Growth. J Med Chem. 2020 Jan 2. doi: 10.1021/acs.jmedchem.9b01618. (SCI,IF =6.1,通讯作者). Fan T, Guo W, Shao T, Zhou W, Hu P, Liu M, Chen Y, Yi Z*. Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membrane. Eur J Med Chem. 2020 Mar 15; 190: 112141. (SCI,IF=4.83,通讯作者). Zhang P, Li Y, Tang Y, Shen H, Li J, Yi Z*, Ke Q*, Xu H*. Copper-Based Metal-Organic Framework as A Controllable Nitric Oxide-Releasing Vehicle for Enhanced Diabetic Wound Healing. ACS Applied Materials & Interfaces. 2020 Apr 22;12(16):18319-18331.(SCI,IF =8.0,通讯作者). Wang ZC, Wang J, Chen H, Tang J, Bian AW, Liu T, Yu LF, Yi Z*, Yang F*. Synthesis and anticancer activity of novel 9,13-disubstituted berberine derivatives. Bioorg Med Chem Lett.2020 Jan 15;30(2):126821.(SCI,IF=2.5,通讯作者). Hu P, Guo D, Xie J, Chen H, Hu S, Bian A, Xu S, Yi Z, Peng S*, Liu M*. Determining the Drug-Like Properties of Ailanthone, a Novel Chinese Medicine Monomer with Anti-CRPC Activity. Planta Med. 2020 Mar 13. doi: 10.1055/a-1125-0385. (SCI,IF=2.687) Jiang, Yuqi; Li, You; Li, Jiankai; Han, Yiming; Zhang, Pengju; Yi, Zhengfang*; Ke, Qinfei*; Xu, He*. A Mussel-Inspired Extracellular Matrix-Mimicking Composite Scaffold for Diabetic Wound Healing. ACS Applied Bio Materials, 2020, 3(7): 4052-4061. (SCI,IF=8.456,通讯作者) Ting Shao, Tingting Fan, Wenshu Tang, Yanting Sun, Song Gao, Huang Chen, Zhenliang Sun,*Mingyao Liu,* and Zhengfang Yi*. Ethyl-N-dodecanoyl-L-arginate hydrochloride combats pathogens with low-resistance generation by membrane attack and modifies gut microbiota structure. Microb Biotechnol. 2020 May;13(3):722-737.(SCI,IF =4.86,通讯作者). Shao T, Tang W, Li Y, Gao D, Lv K, He P, Song Y, Gao S, Liu M, Chen Y*, Yi Z*. Research on Function and Mechanisms of a Novel Small Molecule WG449E for Hypertrophic Scar. J Eur Acad Dermatol Venereol. 2020 Mar;34(3):608-618.(SCI,IF =5.1,通讯作者). Wang J, Xing Y, Wang Y, He Y, Wang L, Peng S, Yang L, Xie J, Li X, Qiu W*, Yi Z*, Liu M*. A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer. J Exp Clin Cancer Res. 2019 Oct 22;38(1):422. (SCI,IF =6.2,通讯作者). Huiqing Chen, Yajing Xing, Jia Xie, Jiuqing Xie, Dong Xing, Jie Tang, Fan Yang, Zhengfang Yi* and Wen-Wei Qiu*. Synthesis and biological evaluation of 3-nitro-4-chromanone derivatives as potentialantiproliferative agents for castration-resistant prostate cancer.RSC Adv., 2019, 9, 33794–33799. (SCI,IF =3.3,通讯作者) Han Y, Jiang Y, Li Y, Wang M, Fan T, Liu M, Ke Q, Xu H*, Yi Z*. An aligned porous electrospun fibrous scaffold with embedded asiatic acid for accelerating diabetic wound healing. J Mater Chem B. 2019 Sep 25. (SCI,IF =5.04,通讯作者) Li Y, He Y, Shao T, Pei H, Guo W, Mi D, Krimm I, Zhang Y, Wang P, Wang X, Liu M, Yi Z*, Chen Y*. Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin. J Med Chem. 2019 May 8. (SCI,IF =6.1,通讯作者) Zhi-Cheng Wang, Jing Wang, Huang Chen, Jie Tang, Ai-Wu Bian, Ting Liu, Li-Fang Yu, Zhengfang Yi*, Fan Yang*. Synthesis and anticancer activity of novel 9,13-disubstituted berberine derivatives. Bioorganic & Medicinal Chemistry Letters. 2019. (SCI,IF =4.86,通讯作者). Bai J, Xie J, Xing Y, Wang LT, Xie J, Yang F, Liu T, Liu M, Tang J, Yi Z, Qiu WW*. Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oral anti-late-onset hypogonadism agents. Eur J Med Chem. 2019 May 8; 176: 21-40. (SCI, IF =4.8) Chen H, Xie J, Xing D, Wang J, Tang J, Yi Z, Xia F, Qiu WW, Yang F*. Diastereoselective synthesis of 3,3-disubstituted 3-nitro-4-chromanone derivatives as potential antitumor agents. Org Biomol Chem. 2019 Jan 31;17(5):1062-1066.(SCI, IF =3.49) Yu Q, Han Y, Tian T, Zhou Q, Yi Z, Chang J, Wu C.Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction.Biomaterials. 2019 Feb; 194:25-35 (SCI, IF =10.273). Yang LF, Xing Y, Xiao JX, Xie J, Gao W, Xie J, Wang LT, Wang J, Liu M, Yi Z*, Qiu WW*. Synthesis of Cyanoenone-Modified Diterpenoid Analogs as NoveBmi-1-Mediated Antitumor Agents. ACS Med. Chem. Lett. 2018 Sep 27;9(11):1105-1110 (SCI,IF =3.9,通讯作者). Zhang T, Li J, He Y, Yang F, Hao Y, Jin W, Wu J, Sun Z, Li Y, Chen Y*, Yi Z*, Liu M*. A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nature communications. 2018 Sep 13;9(1):3726. (SCI,IF =11.5,通讯作者). Yu Q, Han Y, Wang X, Qin C, Zhai D, Yi Z*, Chang J, Xiao Y, Wu C*. Copper Silicate Hollow Microspheres-Incorporated Scaffolds for Chemo-Photothermal Therapy of Melanoma and Tissue Healing. ACS Nano. 2018 Mar 12. (SCI,IF =13.942, 通讯作者). Ren X, Han Y, Wang J, Jiang Y, Yi Z*, Xu H*, Ke Q*. An aligned porous electrospun fibrous membrane with controlled drug delivery- an efficient strategy to accelerate diabetic wound healing with improved angiogenesis. Acta Biomater. 2018 Feb 14. (SCI,IF =6.6,通讯作者). Zhang T, Li J, Ma X, Yang Y, Sun W, Jin W, Wang L, He Y, Yang F, Yi Z, Hua Y, Liu M, Chen Y, Cai Z.Inhibition of HDACs-EphA2 Signaling Axis with WW437 Demonstrates Promising Preclinical Antitumor Activity in Breast Cancer. EBioMedicine. 2018 May;31:276-286. Wang X, Lv F, Li T, Han Y, Yi Z*, Liu M, Chang J, Wu C*. Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing. ACS Nano. 2017 Nov 28;11(11):11337-11349. (SCI,IF =13.942, 通讯作者). Lv F, Wang J, Xu P, Han Y, Ma H, Xu H, Chen S, Chang J, Ke Q, Liu M, Yi Z*, Wu C*. A conducive bioceramic/polymer composite biomaterial for diabetic wound healing.Acta Biomater. 2017 Jul 13. pii: S1742-7061(17)30457-9. (SCI,IF =6.6,通讯作者). He XL, Xing Y, Gu XZ, Xiao JX, Wang YY, Yi Z*, Qiu WW*. The synthesis and antitumor activity of lithocholic acid and its derivatives.Steroids. 2017 Jun 23. pii: S0039-128X(17)30102-2. (SCI,IF =2.3,通讯作者). Lv F, Cong X, Tang W, Han Y, Tang Y, Liu Y, Su L, Liu M, Jin M, Yi Z*. Novel hemostatic agents based on gelatin-microbial transglutaminase mix.Sci China Life Sci. 2017 Apr;60(4):397-403. (SCI,IF =2.8,通讯作者). Peng S, Yi Z*, Liu M*. Ailanthone: a new potential drug for castration-resistant prostate cancer. Chin J Cancer. 2017 Mar 3;36(1):25.(SCI,IF =4.4,通讯作者) Ying, X., Huang, A., Xing, Y., Lan, L., Yi, Z., and He, P. (2017). Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway. Sci China Life Sci. 2017 Apr;60(4):417-428. (SCI,IF =2.8,通讯作者) Liu,Y.,He,Y.,Yang,F.,Cong,X.,Wang,J.,Peng,S.,Gao,D.,Wang,W.,Lan,L.,Ying,X.,Liu,M.,Chen,Y.,and Yi,Z*.(2017). A novel synthetic small moleculeYF-452 inhibits tumor growth through an tiangiogenesis by suppressing VEGF receptor2 signaling. Sci China Life Sci. 2017 Feb;60(2):202-214. (SCI,IF =2.8,通讯作者) Jinyan Li, Fang Lv, He Xu, Yali Zhang, Jie Wang, Zhengfang Yi*, Jingbo Yin, Jiang Chang, Chengtie Wu*. A patterned nanocomposite membrane for high-efficiency healing of diabetic wound. J Mater Chem B. 2017. (SCI,IF =4.8,通讯作者) Wang J, Yang T, Chen H, Xu YN, Yu LF, Liu T, Tang J, Yi Z, Yang CG, Xue W, Yang F. The synthesis and antistaphylococcal activity of 9, 13-disubstituted berberine derivatives.Eur J Med Chem. 2017 Jan 9;127:424-433. (SCI,IF =3.5,通讯作者). He Y, Peng S, Wang J, Chen H, Cong X, Chen A, Hu M, Qin M, Wu H, Gao S, Wang L, Wang X*, Yi Z*, Liu M*. Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nature communications. 2016 Dec 13;7:13122. (SCI,IF =11.5,通讯作者). Zhou W, Tang W, Sun Z, Li Y, Dong Y, Pei H, Peng Y, Wang J, Shao T, Jiang Z, Yi Z*, Chen Y. Discovery and Optimization of N-Substituted 2-(4-pyridinyl)thiazole carboxamides against Tumor Growth through Regulating Angiogenesis Signaling Pathways.Sci Rep. 2016 Sep 16;6:33434. (SCI,IF =5.5,通讯作者). Mao SW, Chen H, Yu LF, Lv F, Xing YJ, Liu T, Xie J, Tang J, Yi Z*, Yang F. Novel 3,4-seco bile acid diamides as selective anticancer proliferation and migration agents.Eur J Med Chem. 2016 Oct 21;122:574-83.(SCI,IF =3.5,通讯作者). Wang YY, He Y, Yang LF, Peng SH, He XL, Wang JH, Lv F, Hao Y, Liu MY, Yi Z*, Qiu WW*. Synthesis of novel diterpenoid analogs with in-vivo antitumor activity.Eur J Med Chem. 2016 May 2;120:13-25. (SCI,IF =3.5,通讯作者). Wang X, Lin Q, Lv F, Liu N, Xu Y, Liu M, Chen Y*, Yi Z*. LG-362B targets PML-RARα and blocks ATRA resistance of acute promyelocytic leukemia.Leukemia. 2016 Jul; 30 (7): 1465- 74.(SCI,IF =12.104 通讯作者). Li J, Zhai D, Lv F, Yu Q, Ma H, Yin J, Yi Z*, Liu M, Chang J, Wu C*. Preparation of copper- containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis, antibacterial activity and wound healing.Acta Biomater. 2016 May; 36:254-66. (SCI,IF =6.025. 通讯作者). Cui HW, Peng S, Gu XZ, Chen H, He Y, Gao W, Lv F, Wang JH, Wang Y, Xie J, Liu MY, Yi Z*, Qiu W W*. Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents. Eur J Med Chem. 2016 Mar 23;111:126-37. (SCI,IF =3.5 通讯作者). Yang F, Peng S, Li Y, Su L, Peng Y, Wu J, Chen H, Liu M, Yi Z*, Chen Y*. A hybrid of thiazolidinone with the hydroxamate scaffold for developing novel histone deacetylase inhibitors with antitumor activities.Org Biomol Chem. 2016 Jan 27;14(5):1727-35 (SCI, IF =3.0 通讯作者). Hongshi Ma, Chuan Jiang, Dong Zhai, Yongxiang Luo, Yu Chen, Fang Lv, Zhengfang Yi, Yuan Deng, Jinwu Wang, Jiang Chang*, Chengtie Wu*. A biofunctional biomaterial with photothermal effect for tumor therapy and bone. Adv. Funct. Mater. 2016, 26, 1197–1208 (SCI, IF =11.8). He Xu, Fang Lv, YaliZhang, Zhengfang Yi*, Qinfei Ke *, Chengtie Wu *, Mingyao Liu, Jiang Chang. Hierarchically micro-patterned nanofibrous scaffolds with nanosized bio-glass surface for accelerating wound healing. Nanoscale. 2015 Nov 28;7(44):18446-52. (SCI,IF =7.4 通讯作者). Qin M, Peng S, Liu N, Hu M, He Y, Li G, Chen H, He Y, Chen A, Wang X, Liu M, Chen Y, Yi Z*. LG308, a novel synthetic compound with anti-microtubule activity in prostate cancer cells, exerts effective antitumor activity.J Pharmacol Exp Ther. 2015 Dec;355(3):473-483. (SCI,IF =3.9 通讯作者). Hu M, Peng S, He Y, Qin M, Cong X, Xing Y, Liu M, Yi Z*. Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer. Oncotarget. 2015 Jun 20;6(17):15348- 61. (SCI,IF =6.4 通讯作者). Li J, Zhang T, Yang F, He Y, Dai F, Gao D, Chen Y, Liu M, Yi Z*. Inhibition of breast cancer progression by a novel histone deacetylase inhibitor, LW479, through down-regulating EGFR expression.Br J Pharmacol. 2015 Aug;172(15):3817-30. (SCI,IF =5.2,通讯作者). Cui HW, He Y, Wang J, Gao W, Liu T, Qin M, Wang X, Gao C, Wang Y, Liu MY, Yi Z*, Qiu WW*. Synthesis of heterocycle-modified betulinic acid derivatives as antitumor agents.Eur J Med Chem. 2015 May 5;95:240-8. (SCI,IF =3.3,通讯作者). Li P, Liu Y, Wang H, He Y, Wang X, He Y, Lv F, Chen H, Pang X, Liu M, Shi T*, Yi Z*. PubAngioGen: a database and knowledge for angiogenesis and related diseases.Nucleic Acids Res.2015 Jan 28;43(Database issue): D963-7. (SCI,IF =9.1. 通讯作者). Chen A, Qin X, Lu J, Yi Z, Liu M, Wang X. Development of a validated LC-MS/MS method for the determination of ailanthone in rat plasma with application topharmacokinetic study. J Pharm Biomed Anal. 2015 Jan; 102:514-8. Zhou W, Huang A, Zhang Y, Lin Q, Guo W, You Z, Yi Z, Liu M*, Chen Y*. Design and optimization of hybrid of 2,4-diaminopyrimidine and arylthiazole scaffold as anticancer cell proliferation and migration agents. Eur J Med Chem. 2015 Apr 13;96:269-280. Rodriguez M, Siwko S, Zeng L, Li J, Yi Z, Liu M. Prostate-specific G-protein-coupled receptor collaborates with loss of PTEN to promote prostate cancer progression. Oncogene. 2015 Jun 1. Dai F, Chen Y, Huang L, Wang J, Zhang T, Li J, Tong W, Liu M, Yi Z*. A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. J Cell Mol Med. 2014 Oct 29. (SCI,IF =4.76,通讯作者). Dong Y, Zhang T, Li J, Deng H, Song Y, Zhai D, Peng Y, Lu X, Liu M, Zhao Y*, Yi Z*. Oridonin Inhibits Tumor Growth and Metastasis through Anti-Angiogenesis by Blocking the Notch Signaling. PLoS One. 2014 Dec 8;9(12):e113830. (SCI,IF =4.4,通讯作者). Yang F, Zhang T, Wu H, Yang Y, Liu N, Chen A, Li Q, Li J, Qin L, Jiang B, Wang X, Pang X, Yi Z*, Liu M*, Chen Y*. Design and Optimization of Novel Hydroxamate-Based HDAC Inhibitors of Bis-substituted Aromatic Amides Bearing Potent Activities against Tumor Growth and Metastasis.J Med Chem. 2014 Nov 26;57(22):9357-69. (SCI,IF=5.614,通讯作者). Zhang T, Chen Y, Li J, Yang F, Wu H, Dai F, Hu M, Lu X, Peng Y, Liu M, Zhao Y, Yi Z*. Antitumor Action of a Novel Histone Deacetylase Inhibitor, YF479, in Breast Cancer.Neoplasia.2014 Aug;16(8):665-77.(SCI IF=5.47,通讯作者). Wu J, Yu L, Yang F, Li J, Wang P, Zhou W, Qin L, Li Y, Luo J, Yi Z*, Liu M*, Chen Y*. Optimization of 2-(3-(arylalkyl amino carbonyl) phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives as potent antitumor growth and metastasis agents.Eur J Med Chem. 2014 Jun 10;80C:340-351. (SCI,IF=3.2,通讯作者). Gao C, Dai FJ, Cui HW, Peng SH, He Y, Wang X, Yi ZF*, Qiu WW*. Synthesis of novel heterocyclic ring-fused 18β-glycyrrhetinic acid derivatives with antitumor and antimetastatic activity.Chem Biol Drug Des.2014 Aug;84(2):223-33.(SCI,IF=2.2,通讯作者). Liu S, Lai L, Zuo Q, Dai F, Wu L, Wang Y, Zhou Q, Liu J, Liu J, Li L, Lin Q, Creighton CJ, Costello MG, Huang S, Jia C, Liao L, Luo H, Fu J, Liu M, Yi Z*, Xiao J*, Li X*. PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis.J Mol Cell Cardiol. 2014 Jul;72:28-38. (SCI,IF=5.2,通讯作者). Zheng C, Fang Y, Tong W, Li G, Wu H, Zhou W, Lin Q, Yang F, Yang Z, Wang P,PengY,PangX,Yi Z,LuoJ,LiuM,ChenY.Synthesisand biological evaluation of novel tetrahydro -β-carboline derivatives as anti-tumor growth and metastasis agents through inhibiting the transforming growth factor-β signaling pathway. J Med Chem. 2014 Feb 13;57(3): 600-12. (SCI,IF=5.614). M Rodriguez, W Luo, J Weng, L Zeng, Z Yi, S Siwko and M Liu. PSGR promotes prostatic intraepithelial neoplasia and prostate cancer xenograft growth through NF-κB. Oncogenesis (2014) 3, e114. (SCI IF=3.952). Dai F, Chen Y, Song Y, Huang L, Zhai D, Dong Y, Lai L, Zhang T, Li D, Pang X, Liu M, Yi Z*. A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells. PLOS ONE.2012. 10.1371/journal.pone.0052162 (SCI, IF=4.4,通讯作者). Zhang T, Li J, Dong Y, Zhai D, Lai L, Dai F, Deng H, Chen Y, Liu M, Yi Z*.Cucurbitacin E inhibits breast tumor metastasis by suppressing cell migration and invasion.Breast Cancer Res Treat. 2012 Sep;135(2):445-58.(SCI, IF=4.4,通讯作者). Song Y, Dai F, Zhai D, Dong Y, Zhang J, Lu B, Luo J, Liu M, Yi Z*. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways. Angiogenesis. 2012 Sep;15(3):421-32.(SCI, IF=6.2,通讯作者). Lai L, Liu J, Zhai D, Lin Q, He L, Dong Y, Zhang J, Lu B, Chen Y, Yi Z*, Liu M*.Plumbagin Inhibits Tumor Angiogenesis and Tumor Growth through VEGFR2-mediated Ras Signaling Pathway.Br J Pharmacol. 2012 Feb;165(4b):1084-96.(SCI, IF= 5.2. 通讯作者). Chen J, Wang J, Lin L, He L, Wu Y, Zhang L, Yi Z, Chen Y, Pang X, Liu M. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012 Feb;11(2):277-87. Zhang X, Song Y, Wu Y, Dong Y, Lai L, Zhang J, Lu B, Dai F, He L, Liu M, Yi Z*. Indirubin inhibits tumor growth by anti-tumor angiogenesis through blocking VEGFR2 mediated JAK/STAT3 signaling in endothelial cell. Int J Cancer. 2011 Nov 15;129(10):2502-11.(SCI,IF=5.2,通讯作者). Chen J, Li T, Wu Y, He L, Zhang L, Shi T, Yi Z, Liu M, Pang X.Prognostic significance of vascular endothelial growth factor expression in gastric carcinoma: a meta-analysis. J Cancer Res Clin Oncol. 2011 Sep 15. He L, Wu Y, Lin L, Wang J, Wu Y, Chen Y, Yi Z, Liu M, Pang X.Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway. Cancer Sci. 2011 Jan;102(1):219-25. (SCI, IF=3.7). 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学术兼职

国家自然科学基金函评专家 教育部学位与研究生教育评审专家 捷克共和国国家科学基金外籍评审专家 上海市科技奖励评审专家 Breast Cancer Research and Treatment、American Medical Journal 等SCI期刊审稿人 中国细胞生物学学会会员(会员号S233100450M) 上海市徐汇区科技创新创业协会第一届理事会理事

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