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2003年6月获中国人民解放军军需大学博士学位。2003年9月至2005年9月在第二军医大学医学免疫学国家重点实验室从事博士后研究。2005年10月受聘为华东师范大学生命科学学院副教授。2008年9月至2010年9月在美国国立卫生研究院(NIH)从事博士后研究。2011年晋升为教授。主要从事GPCR对免疫细胞如NK、DC、T细胞的调控、自身免疫病及肿瘤的免疫治疗如CAR-T、CAR-NK的研究。已主持国家自然科学基金等各项课题10余项,在国内外杂志发表研究论文100余篇,其中以第一作者或通讯作者发表论文50余篇。申请国家发明专利30余项,主编或参编教材或专著8部。获省科技进步一等奖(2005,排名第3),中国实验动物学会科学技术奖二等奖(2020,排名第5)。先后入选上海市青年科技启明星(2006)、教育部新世纪优秀人才支持计划(2012)、上海市课思政教学名师(2022)。国家级精品视频公开课《免疫与人类健康》负责人(2016),上海高校市级重点课程《免疫学》负责人(2021),上海高校一流本科课程《趋向型CAR-T细胞治疗骨肉瘤虚拟仿真实验》负责人(2021),上海市课程思政示范课程《免疫学》负责人(2022),上海高校一流本科课程《免疫学》负责人(2023),中国大学MOOC课程《免疫学》负责人(2023)。获华东师范大学第七届青年教师课堂教学大奖赛“特等奖”(2007),华东师范大学本科教学年度贡献奖(2019),2020年全国高校生命科学类微课教学比赛二等奖(2021),华东师范大学创新创业优秀指导教师(2021),全国宝钢优秀教师奖(2022),2021年全国高校生命科学类微课教学比赛三等奖(2022),第三、四届上海市大学生生命科学竞赛“特等奖”指导教师(2021,2022),第五、六届全国大学生生命科学竞赛“一等奖”指导教师(2021,2022)。2018-2022年教育部高等学校生物技术、生物工程类专业教学指导委员会委员,第三届《高校生物学教学研究(电子版)》常务编委,第四届中国生物化学与分子生物学会教育专业分会副主任委员,《生物工程学报》第六届编委会编委,第十二届上海市药学会常务理事, 第十二届上海市药学会生化与生物技术药物专业委员会主任委员,中国药理学会第十三届抗炎免疫药理专业委员会常务委员,中国药理学会抗炎免疫药理专业委员会第一届青年委员会常务委员。担任EMBO J, Front Immunol, OncoImmunology, Int J Mol Sci, Vaccine, 生物工程学报,中国免疫学杂志,微生物学通报等30余本国外或国内杂志审稿人。 教育经历 1990.9-1994.7 解放军军需大学(现吉林大学) 食品卫生检验专业 本科 1994.9-1997.7 解放军军需大学(现吉林大学) 微生物学及免疫学专业 硕士 1999.9-2003.7 解放军军需大学(现吉林大学) 解放军基因工程重点实验室 病毒学专业 博士 工作经历 1997.7-2003.9 解放军军需大学(现吉林大学) 助教、讲师 2003.9-2005.9 第二军医大学 医学免疫学国家重点实验室 博士后 2005.10-2011.12 华东师范大学 生命科学学院 副教授/硕导 2008.9-2010.9 美国国立卫生研究院(NIH)博士后 2011.12-至今 华东师范大学 生命科学学院 教授/博导 2016.11-2016.12 法国里昂高等师范学院(ENS Lyon) 高级访问学者 荣誉及奖励 解放军军需大学优秀博士论文(2003) 吉林省科技进步一等奖(2005,排名第三) 上海市青年科技启明星(2006) 华东师范大学第七届青年教师课堂教学大奖赛“特等奖”(2007) 教育部新世纪优秀人才(2012) 国家级精品视频公开课《免疫与人类健康》负责人(2016) 华东师范大学本科教学年度贡献奖(2019) 华东师范大学第一届课程思政教学设计比赛三等奖(2019) 第一届上海市大学生生命科学竞赛“一等奖”指导教师(2019) 第三届全国大学生生命科学竞赛“三等奖”指导教师(2019) 中国实验动物学会科学技术奖二等奖 (2020,排名第五) 2020年全国高校生命科学类微课教学比赛二等奖(2021) 上海高校市级重点课程《免疫学》负责人(2021) 华东师范大学大夏学堂优质示范课程《免疫学》负责人(2021) 上海高校一流本科课程《趋向型CAR-T细胞治疗骨肉瘤虚拟仿真实验》负责人(2021) 第三届上海市大学生生命科学竞赛“特等奖”指导教师(2021) 第五届全国大学生生命科学竞赛“一等奖”指导教师(2021) 华东师范大学创新创业优秀指导教师(2021) 第四届上海市大学生生命科学竞赛“特等奖”指导教师(2022) 第六届全国大学生生命科学竞赛(科学探究类)“一等奖”指导教师(2022) 华东师范大学优秀指导教师奖(2022) 2021年全国高校生命科学类微课比赛三等奖(2022) 上海市课程思政示范课程《免疫学》负责人 (2022) 上海市课程思政教学名师 (2022) 全国宝钢优秀教师奖(2022) 上海高校一流本科课程《免疫学》负责人(2023) 大学MOOC课程《免疫学》负责人(2023)

研究领域

肿瘤的细胞免疫治疗(如CAR-T、CAR-NK等)研究 GPCR对固有免疫细胞(如DC细胞、NK细胞、T细胞等)的免疫调控作用及其分子机制研究 GPCR在自身免疫性疾病(如EAE、IBD等)发病中的作用及其机制研究

近期论文

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Su Q, Yao J, Farooq MA, Ajmal I, Duan Y, He C, Hu X, Jiang W*. Modulating cholesterol metabolism via ACAT1 knockdown enhances anti-B-cell lymphoma activities of CD19-specific chimeric antigen receptor T cells by improving the cell activation and proliferation. Cells, 2024,13(6):555. Zhou Y, Farooq MA, Ajmal I , He C, Gao Y, Guo D, Duan Y, Jiang W*. Co-expression of IL-4/IL-15-based inverted cytokine receptor in CAR-T cells overcomes IL-4 signaling in immunosuppressive pancreatic tumor microenvironment. Biomed Pharmacother. 2023, 168: 115740. Farooq MA, Ajmal I, Hui X, Chen Y, Ren Y , Jiang W*. β2-adrenergic receptor mediated inhibition of T cell function and its implications for CAR-T cell therapy. Int J Mol Sci. 2023, 24: 12837. Guo D, Jin C, Gao Y, Lin H, Zhang L, Zhou Y, Yao J, Duan Y, Ren Y, Hui X, Ge Y, Yang R, Jiang W*. GPR116 receptor regulates the antitumor function of NK cells via Gαq/HIF1α/NF-κB signaling pathway as a potential immune checkpoint. Cell Biosci. 2023, 13(1): 51. Khan MZI, Nazli A, Al-Furas H, Asad MI, Ajmal I, Khan D, Shah J, Farooq MA, Jiang W*. An overview of viral mutagenesis and the impact on pathogenesis of SARS-CoV-2 variants. Front Immunol. 2022, 13: 1034444. Yu Y, Wu X, Wang M, Liu W, Zhang L, Zhang Y, Hu Z, Zhou X, Jiang W, Zou Q, Cai F, Ye H. Optogenetic-controlled immunotherapeutic designer cells for post-surgical cancer immunotherapy. Nat Commun. 2022, 13(1): 6357. Ajmal I, Farooq MA, Abbas SQ, Shah J, Majid M, Jiang W*. Isoprenaline and Salbutamol inhibit pyroptosis and promote mitochondrial biogenesis in arthritic chondrocytes by downregulating β-arrestin and GRK2. Front Pharmacol. 2022, 13: 996321. Gao Y, Lin H, Guo D, Cheng S, Zhou Y, Zhang L, Yao J, Asad Farooq M, Ajmal I, Duan Y, He C, Tao L, Wu S, Liu M, Jiang W*. Suppression of 4.1R enhances the potency of NKG2D-CAR T cells against pancreatic carcinoma via activating ERK signaling pathway. Oncogenesis. 2021, 10: 62. Li Z, Gao Y, He C, Wei H, Zhang J, Zhang H, Hu L, Jiang W*. Purinergic receptor P2Y6 is a negative regulator of NK cell maturation and function. J Immunol, 2021, 207(6): 1555-1565. Guo D, He L, Gao Y, Jin C, Lin H, Zhang L, Wang L, Zhou Y, Yao J, Duan Y, Yang R, Qiu W, Jiang W*. Obeticholic acid derivatives,T-2054 suppresses osteoarthritis via inhibiting NF-κB signaling pathway. Int J Mol Sci. 2021, 22: 3807. Zhang J, Wencker M, Marliac Q, Berton A, Hasan U, Schneider R, Laubreton D, Cherrier DE, Mathieu AL, Rey A, Jiang W, Caramel J, Genestier L, Mar?ais A, Marvel J, Ghavi-Helm Y, Walzer T. Zeb1 represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1.1+ T cell development. Cell Mol Immunol. 2021, 18(9): 2140-2152. Tao L, Asad Farooq M, Gao Y, Zhang L, Niu C, Ajmal I, Zhou Y, He C, Zhao G, Yao J, Liu M, Jiang W*. CD19-CAR-T cells bearing a KIR/PD-1-based inhibitory CAR eradicate CD19+HLA-C1- malignant B cells while sparing CD19+HLA-C1+ healthy B cells. Cancers. 2020, 12(9):2612. He C, Zhou Y, Li Z, Asad Farooq M, Iqra Ajmal I, Zhang H, Zhang L, Tao L, Yao J, Du B, Liu M, Jiang W*. Co-expression of IL-7 improves NKG2D-based CAR T Cell therapy on prostate cancer by enhancing the expansion and inhibiting the apoptosis and exhaustion. Cancers.2020;12(7): 1969. Li Z, He C, Zhang J, Zhang H, Wei H, Wu S, Jiang W*. P2Y6 Deficiency Enhances DC-mediated Th1/Th17 Differentiation and Aggravates Experimental Autoimmune Encephalomyelitis. J Immunol. 2020, 205(2): 387-397. Yin C, Cheng L, Pan J, Chen L, Xue Q, Qin J, Wang S, Du B, Liu M, Zhang Y, Jiang W, Qian M, Ren H. Regulatory role of Gpr84 in the switch of alveolar macrophages from CD11b lo to CD11b hi status during lung injury process. Mucosal Immunol. 2020,13(6): 892-907. Hu X, Zhong Y, Lambers TT, Jiang W*. Anti?inflammatoryactivity of extensively hydrolyzed casein is mediatedby granzyme B. Inflamm Res. 2019, 68(8): 715-722. Zhang L, Zhu X, Wu S, Chen Y, Tan S, Liu Y, Jiang W*, Huang J*. Fabricationand evaluation of a γ-PGA-based self-assembly transferrin receptor-targetinganticancer drug carrier. Int J Nanomedicine. 2018, 13: 7873-7889. Shi Y, Li Z, Chen R, Zhang J, Hu X, He C, Su Q, Ma H, Ren H, Qian M, Cui S,Jiang W*. Immethridine, histamine H3-receptor (H3R) agonist, alleviated experimental autoimmune encephalomyelitis viainhibiting the function of dendritic cells. Oncotarget. 2017,.8:.75038-75049. Zhang J, Li Z, Hu X, Su Q, He C, Liu J, Ren H, Qian M, Liu J, Cui S,Jiang W*. Knockout of P2Y12 aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells. Brain Behav Immun. 2017, 62: 245-255. Shi J, Zhang X, Wang S, Wang J, Du B, Wang Z, Liu M,Jiang W, Qian M, Ren H. Gpr97 is dispensable for metabolic syndrome but is involved in macrophage inflammation in high-fat diet-induced obesity in mice. Sci Rep. 2016,6:24649. Shi JP, Wang SY, Chen LL, Zhang XY, Zhao YH, Du B,Jiang WZ, Qian M, Ren H. P2Y6 contributes to ovalbumin-induced allergic asthma by enhancing mast cell function in mice. Oncotarget. 2016, 7(38): 60906-60918. Shi JP, Li XN, Zhang XY, Du B,Jiang WZ, Liu MY, Wang JJ, Wang ZG, Ren H, Qian M. Gpr97 is dispensable for inflammation in OVA-induced asthmatic mice. PLoS One. 2015, 10(7): e0131461. Ren H, Teng Y, Tan B, Zhang X, Jiang W, Liu M,Jiang W, Du B, Qian M. Toll-like receptor-triggered calcium mobilization protects mice against bacterial infection through extracellular ATP release. Infect Immun. 2014, 82(12): 5076-5085. Jiang W*, Chen R, Kong X, Long F, Shi Y. Immunization with adenovirus LIGHT-engineered dendritic cells induces potent T cell responses and therapeutic immunity in HBV transgenic mice. Vaccine. 2014, 32(35):4565-4570. Wen J, Hao W, Fan Y, Du J, Du B, Qian M,Jiang W*. Co-delivery of LIGHT expression plasmid enhances humoral and cellular immune responses to HIV-1 Nef in mice. Arch Virol. 2014, 159(7): 1663-1669. Du J, Wu X, Long F, Wen J, Hao W, Chen R, Kong X, Qian M,Jiang W*. Improvement in efficacy of DNA vaccine encoding HIV-1 Vif by LIGHT gene adjuvant. Viral Immunol. 2013, 26(1): 68-74. Jiang W*.Blockade of B7-H1 enhances dendritic cell-mediated T cell response and antiviral immunity in HBV transgenic mice. Vaccine. 2012? 30(4): 758-766. Jiang W? Chai NR? Maric D? Bielekova B. Unexpected Role for Granzyme K in CD56bright NK Cell-Mediated Immunoregulation of Multiple Sclerosis. J Immunol. 2011? 187(2): 781-790. Fan Y?Jiang W*? Wen J? Hao W? Du J? Liu X? Qian M. B7-DC-silenced dentritic cells induce stronger anti-HBV immunity in transgenic mice. Arch Virol. 2009? 154(11): 1813-1821. Zhang Y?Jiang W*? Fan Y? Wen J? Hao W? Qian M. Engineering enhancement of immune response to HBV DNA vaccine in mice through the use of LIGHT gene adjuvant. J Virol Methods, 2008. 53(2): 142-148. Jiang W*? Fan Y? Liu X? Zhang Y? Wen J? Hao W? Qian M. Therapeutic potential of dendritic cell-based immunization against HBV in transgenic mice. Antivir Res. 2008? 77(1): 50-55. Jiang W? Ren L? Jin N.HIV-1 DNA vaccine efficacy is enhanced by coadministration with plasmid encoding IFN-α. J Virol Methods. 2007? 146(1-2): 266-273. Zhang LS? Jin NY? Song YJ? Wang H? Ma HW? Li ZJ?Jiang WZ. Construction and characterization of a recombinant fowlpox virus containing HIV-1 multi epitope-p24 chimeric gene on mice. Sci China Ser C. 2007? 50(2): 212-220. Jiang W? Jin N? Cui S? Li Z? Zhang L? Wang H? Han W. Enhancing immune responses against HIV-1 DNA vaccine by coinoculating IL-6 expression vector. J Virol Methods. 2006? 136(1-2):1-7. Jiang W? Jin N? Cui S? Li Z? Zhang L? Zhang H? Wang H? Han W. Construction and characterization of recombinant fowlpox virus coexpressing HIV-1CN gp120 and IL-2. J Virol Methods. 2005? 130(1-2):95-101. Jiang W? Jin N? Li Z? Zhang L? Wang H? Zhang Y? Han W. Expression and characterization of Gag protein of HIV-1CNinPichia pastoris. J Virol Methods. 2005? 123(1): 35-40. Wang HW? Cole D?Jiang WZ? Jin HT? Fu N? Chen ZL? Jin NY. Engineering and functional evaluation of a single-chain antibody against HIV-1 external glycoprotein gp120. Clin Exp Immunol. 2005? 141(1) 72-80. Jin NY? Zhang HY? Yin GG? Zheng M? Liu T?Jiang WZ? Li ZJ. Immunogenicity of recombinant fowlpox virus co-expressing structural protein precursor P1-2A and proteinase 3C of FMDV. Chinese Sci Bull. 2004? 49(8): 823-827. Zhang YJ? Jin NY?Jiang WZ? Zhu XJ? Shen JC. Cloning and expression of external glycoprotein gene mutant from HIV-2 in methyltrophic yeast?Pichia pastoris and identification of the glycoprotein. Biotechnol Appl Biochem. 2001? 34:1-4.

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