孙建伟 - 香港科技大学

个人简介

Education 2008 Ph.D. in Organic Chemistry, The University of Chicago 2004 M.S. in Organic Chemistry, Nanjing University 2001 B.S. in Chemistry, Nanjing University Experience 2022 Member of the Chiral Chemistry Committee, Chinese Chemical Society 2022 Senior Member, Chinese Chemical Society 2021 Fellow of the Royal Society of Chemistry (FRSC) 2020 UROP Faculty Research Award, HKUST 2019-present Professor, Department of Chemistry The Hong Kong University of Science and Technology 2015-2019 Associate Professor, Department of Chemistry The Hong Kong University of Science and Technology 2010-2015 Assistant Professor, Department of Chemistry The Hong Kong University of Science and Technology 2008-2010 Postdoctoral fellow, Department of Chemistry Massachusetts Institute of Technology Awards 2022 Member of the Chiral Chemistry Committee, Chinese Chemical Society 2022 Senior Member, Chinese Chemical Society 2021 Fellow of the Royal Society of Chemistry 2020 UROP Faculty Research Award, HKUST 2019 Elected Member, The Hong Kong Young Academy of Sciences (YASHK) 2019 ACP Lectureship Award (by Taiwan) 2018 NHU-CJC Innovation Award, Chinese Journal of Chemistry 2017 Asian Core Program Lectureship Award (by Japan) 2015 Asian Core Program Lectureship Award (by Korea) 2014 Thieme Chemistry Journal Award 2013 School of Science Research Award, HKUST 2013 Asian Core Program Lectureship Award (by Singapore) 2012 Early Career Award, Research Grants Council, Hong Kong 2011 Asian Core Program Lectureship Award (by Japan) 2008 Elizabeth R. Norton Prize for Excellence in Research in Chemistry, University of Chicago 2007 Abbott Fellowship in Synthetic Organic Chemistry, Abbott Laboratories 1999 Outstanding Student Award, Nanjing University 1997 People Fellowship, Nanjing University (four times, 1997-2000)

研究领域

Our research program is focused on the development of new methods for organic synthesis, with an emphasis on organocatalysis. We are also interested in applying our new methods in the synthesis of useful molecules, such as biologically active compounds and light-harvesting materials. Current areas of interest of our laboratory include Asymmetric nucleophilic catalysis (e.g., N-heterocyclic carbenes, chiral amines); Brønsted acid catalysis (e.g., chiral phosphoric acids); Lewis acid catalysis; Synthesis of biologically active compounds and light-harvesting materials.

近期论文

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Catalytic Enantioselective Nucleophilic α-Chlorination of Ketones with NaCl Li, Z.; Wang, B.; Zhang, C.; Lo, W. Y.; Yang, L.; Sun, J.*J. Am. Chem. Soc. 2024, 146, 2779-2788. Mild Stereoselective Synthesis of Densely Substituted [3]Dendralenes via Ru-Catalyzed Intermolecular Dimerization of 1,1-Disubstituted Allenes Li, S.; Feng, Q.; Song, L.;* Zhang, X.; Wu, Y.-D.;* Sun, J.*J. Am. Chem. Soc. 2024, 146, 1532-1542. Primary activation of para-quinone methides by chiral phosphoric acid for enantioselective construction of tetraarylmethanes Han, Z.; Zhu, B.; Zang, Y.; Zhang, C.; Dong, X.-Q.; Huang, H.;* Sun, J.*Chem. Sci. 2024, 15, 720-725. Heterodifunctionalization of Electron-Rich Alkynes Catalyzed by in Situ Generated Silylium Ions Su, X.; Wang, Y.; Feng, Q.; Sun, J.*Org. Lett. 2024, 26, 421-426. Organocatalytic Enantioselective Nucleophilic Addition of Indole Imine 5-Methides Li, Y.; Huang, J.; Han, Z.; Huang, H.;* Hong, B.;* Sun, J.*Org. Lett. 2024, 26, 396-400. Asymmetric Synthesis of Remotely Chiral Naphthols and Naphthylamines via Naphthoquinone Methides Liu, S.; Chan, K. L.; Lin, Z.;* Sun, J.* J. Am. Chem. Soc. 2023, 145, 12802-12811. Pd-Catalyzed Ligand-Directed Divergent Cycloaddition of Cyclic 1-Azadienes with Oxo-1,4-dipoles Xie, H.; Chen, L.; Han, Z.; Yang, Z.; Sun, J.;* Huang, H.* Org. Lett. 2023, , ASAP. Chiral Phosphoric Acid Catalyzed Redox Deracemization of Triarylmethanes Liu, C.; Li, Z.; Li, P.;* Sun, J.* Chem. Synth. 2023, 3, 22. Near-Infrared Aggregation-Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease Zhang, T.; Chen, X.; Yuan, C.; Pang, X.; Shangguan, P.; Liu, Y.; Han, L.; Sun, J.; Lam, J. W. Y.; Liu, Y.; Wang, J.;* Shi, B.;* Tang, B. Z.* Angew. Chem., Int. Ed. 2023, 62, e202211550. In Situ Synthesis of AIEgen-based Porous Organic Polymer Films by Interfacial Amino-yne Click Polymerization for Efficient Light-Harvesting Song, B.; Zhang, L.; Sun, J.; Lam, J. W. Y.;* Tang, B. Z.* Angew. Chem., Int. Ed. 2023, 62, e202302543. Dual Behavior Regulation: Tether-Free Deep-Brain Stimulation by Photothermal and Upconversion Hybrid Nanoparticles Sun, F.; Shen, H.; Yang, Q.;* Yuan, Z.; Chen, Y.; Guo, W.; Wang, Y.; Yang, L.; Bai, Z.; Liu, Q.; Jiang, M.; Lam, J. W. Y.; Sun, J.; Ye, R.; Kwok, R. T. K.;* Tang, B. Z.* Adv. Mater. 2023, 35, 2210018. An Alkaline Phosphatase-Responsive Aggregation-Induced Emission Photosensitizer for Selective Imaging and Photodynamic Therapy of Cancer Cells Lam, K. W. K.; Chau, J. H. C.; Yu, E. Y.; Sun, F.; Lam, J. W. Y.; Ding, D.; Kwok, R. T. K.;* Sun, J.; He, X.;* Tang, B. Z.* ACS Nano 2023, 17, 7145-7156. Aggregation-Induced Emission Macromolecular Materials for Antibacterial Applications Zuo, Y.; Kwok, R. T. K; Sun, J.; Lam, J. W. Y.;* Tang, B. Z.* Marcromol. Rapid Commun. 2023, 44, 2300104. Chiral Phosphine Catalyzed Allylic Alkylation of Benzylidene Succinimides with Morita-Baylis-Hillman Carbonates Liu, C.; Sun, J.;* Li, P.* Molecules 2023, 28, 12825. Electricity-Driven Asymmetric Bromocyclization Enabled by Chiral Phosphate Anion Phase-Transfer Catalysis Tan, X.;* Wang, Q.; Sun, J.* Nat. Commun. 2023, accepted. Ir-Catalyzed Regioselective Dihydroboration of Thioalkynes toward Gem-Diboryl Thioethers Wang, Y.;1 Li, Y.;1 Wang, L.; Ding, S.; Song, L.;* Zhang, X.;* Wu, Y.-D.;* Sun, J.* (1: equal contribution) J. Am. Chem. Soc. 2023, 145, ASAP. Enantioselective Synthesis of Tetraarylmethanes through meta-Hydroxyl-directed Benzylic Substitution Tan, X.;1 Deng, Z.;1 Wang, Q.; Chen, S.; Zhu, G.;* Sun, J.* (1: equal contribution)Nat. Synth. 2023, , accepted. Near-Infrared Aggregation-Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease Zhang, T.; Chen, X.; Yuan, C.; Pang, X.; Shangguan, P.; Liu, Y.; Han, L.; Sun, J.; Lam, J. W. Y. L.; Liu, Y.; Wang, J.;* Shi, B.;* Tang, B. Z.* Angew. Chem., Int. Ed. 2023, 62, e202211550. Catalytic Enantioselective Synthesis of 2,3'-Bis(indolyl)methanes Bearing All-Carbon Quaternary Stereocenters via 2?Indole Imine Methides Han, Z.; Wang, W.; Zhuang, H.; Wang, J.; Wang, C.; Wang, J.;* Huang, H.;* Sun, J.* Org. Lett. 2023, 25, ASAP. Metal-free Multicomponent Polymerization of Activated Diyne, Electrophilic Styrene and Isocyanide Towards Highly Substituted and Functional Poly(cyclopentadiene) Liu, X.; Yang, X.; Li, X.; Sun, J.;* He, B.;* Lam, J. W. Y.;* Tang, B. Z.* Sci. Chin. Chem. 2023, , In press. Catalytic Asymmetric Synthesis of α-Tertiary Aminoketones from Sulfoxonium Ylides Bearing Two Aryl Groups Zhou, Y.; Yue, X.; Jiang, F.; Sun, J.; Guo, W.* Chem. Commun. 2023, , Advance Article. Visible-light-induced Organocatalytic Enantioselective N-H Insertion of α-Diazoesters Enabled by Indirect Free Carbene Capture Guo, W.;* Zhou, Y.; Xie, H.; Yue, X.; Jiang, F.; Huang, H.; Han, Z.; Sun, J.* Chem. Sci. 2023, , Advance Article. Design of Smart Aggregates: Toward Rapid Clinical Diagnosis of Hyperlipidemia in Human Blood Sun, F.; Zhao, W.; Shen, H.; Fan, N.; Zhang, J.; Liu, Q.; Xu, C.; Luo, J.; Zhao, M.; Chen, Y.; Lam, K. W. K.; Yang, X.; Kowk, R. T. K.; Lam, J. W. Y.; Sun, J.; Zhang, H.;* Tang, B. Z.* Adv. Mater. 2022, 34, 2207671. Construction of diverse polycyclic N-heterocycles via cascade allylic amination/Diels-Alder reaction Yang, Z.; Xie, H.; Tang, L.; Sun, J.; Han, Z.; Huang, H.* Chem. Commun. 2022, 58, 13258-13261. Nickel-Catalyzed Asymmetric Dicarbofunctionalization of Alkynes to Access Axially Chiral Styrenes Tan, X.; Sun, J.* Chem Catal. 2022, 2, 2813-2815. (Invited Preview article) Rapid Biotransformation of Luminescent Bimetallic Nanoparticles in Hepatic Sinusoids Tan, Y.; Cai, W.; Luo, C.; Tang, J.; Kwok, R. T. K.; Lam, J. W. Y.; Sun, J.; Liu, J.;* Tang, B. Z.* J. Am. Chem. Soc. 2022, 144, 20653-20660. Total Synthesis of Yuzurine-type Alkaloid Daphgraciline Li, L.-X.; Min, L.; Yao, T.-B.; Ji, S.-X.; Qiao C.; Tian, P.-L.; Sun, J.;* Li, C.-C.* J. Am. Chem. Soc. 2022, 144, 18823-18828. Palladium-Catalyzed Intramolecular Enantioselective C(sp3)-H Insertion of Donor/donor Carbenes Li, W.; Zhang, H.; Jiang, H.; Sun, J.; Zhu, S.* Chem. Sci. 2022, 13, 12396-12402. Catalyst-Controlled Divergent Reactions of 2,3-Disubstituted Indoles with Propargylic Alcohols: Synthesis of 3H-Benzo[b]azepines and Axially Chiral Tetrasubstituted Allenes Qian, C.; Huang, T.; Sun, J.;* Li, P.* Org. Lett. 2022, 24, 6472-6476. Organocatalytic Asymmetric Azidation of Sulfoxonium Ylides: Mild Synthesis of Enantioenriched α-Azido Ketones Bearing a Labile Tertiary Stereocenter Guo, W.;* Jiang, F.; Li, S.; Sun, J.* Chem. Sci. 2022, 13, 11648-11655. Construction of Nine-membered N,N,O-Heterocycles via Pd-Catalyzed [6+3] Dipolar Cycloaddition Xie, H.; Yang, Z.; Tang, L.; Han, Z.; Sun, J.;* Huang, H.* Chem. Commun. 2022, 58, 10560-10563. Base-Promoted 5-exo-dig Cyclization of o-Alkynylamides or 2-En-4-ynamides with CO2 toward Fully Substituted Acrylates Sha, Y.; Bai, J.; Li, M.; Gao, W.; Yang, Q.; Sun, J.; Sun, S.* Org. Lett. 2022, 24, 5715-5720. Ru-Catalyzed Hydroboration of Ynones Leads to a Nontraditional Mode of Reactivity Feng, Q.;1 Li, S.;1 Li, Z.; Yan, Q.; Lin, X.; Song, L.;* Zhang, X.;* Wu, Y.-D.;* Sun, J.* (1: equal contribution) J. Am. Chem. Soc. 2022, 144, 14846-14855. Rational Design of NIR-II AIEgens with Ultrahigh Quantum Yields for Photo- and Chemiluminescence Imaging Shen, H.; Sun, F.; Zhu, X.; Zhang, J.; Ou, X.; Zhang, J.; Xu, C.; Sung, H. H. Y.; Williams, I. D.; Chen, S.; Kwok, R. T. K.; Lam, J. W. Y.; Sun, J.; Zhang, F.;* Tang, B. Z.* J. Am. Chem. Soc. 2022, 144, 15391-15402. Ammonia to chiral α-amino acid Yang, L.; Sun, J.* Nat. Catal. 2022, 5, 471-472. Quinone methides and indole imine methides as intermediates in enantioselective catalysis Li, X.; Li, Z.; Sun, J.* Nat. Synth. 2022, 1, 426-438. Ruthenium-Catalyzed Geminal Hydroborative Cyclization of Enynes Tan, Y.-X.; Li, S.; Song, L.;* Zhang, X.; Wu, Y.-D.;* Sun, J.* Angew. Chem., Int. Ed. 2022, 61, e202204319. Secondary through-space interactions facilitated single-molecule white-light emission from clusteroluminogens Zhang, J.; Alam, P.; Zhang, S.; Shen, H.; Hu, L.; Sung, H. H. Y.; Williams, I. D.; Sun, J.; Lam, J. W. Y.;* Zhang, H.;* Tang, B. Z.*Nat. Commun. 2022, 13, 3492. Catalytic Asymmetric Allylic Substitution/Isomerization with Central Chirality Transposition Han, Z.; Zhuang, H.; Tang, L.; Zang, Y.; Guo, W.; Huang, H.;* Sun, J.* Org. Lett. 2022, 24, 4246-4251. Fluorescent Imaging and Sorting of High-Lipid-Content Strains of Green Algae by Using an Aggregation-Induced Emission Luminogen Liu, X.; Yan, N.;* Wong, T. Y.; Lam, H.; Lam, J. W. Y.; Kwok, R. T. K.;* Sun, J.; Tang, B. Z.* ACS Nano 2022, 16, 14973-14981. Enantioselective synthesis of triarylmethanes via organocatalytic transfer hydrogenation of para-quinone methides Han, Z.; Zang, Y.; Liu, C.; Guo, W.; Huang, H.;* Sun, J.* Chem. Commun. 2022, 58, 7128-7131. Reductive Opening of Oxetanes Catalyzed by Frustrated Lewis Pairs: Unexpected Aryl Migration via Neighboring Group Participation Tang, L.; Zang, Y.; Guo, W.; Han, Z.; Huang, H.;* Sun, J.* Org. Lett. 2022, 24, 3259-3264. Photoactive Metal Carbonyl Complexes Bearing N-Heterocyclic Carbene Ligands: Synthesis, Characterization, and Viability as Photoredox Catalysts Tang, M.; Cameron, L.; Poland, E. M.; Yu, L.-J.; Moggach, S. A.; Fuller, R. O.; Huang, H.; Sun, J.; Thickett, S. C.; Massi, M.; Coote, M. L.;* Ho, C. C.;* Bissember, A. C.* Inorg. Chem. 2022, 61, 1888-1898. Organocatalytic discrimination of non-directing aryl and heteroaryl groups: enantioselective synthesis of bioactive indole-containing triarylmethanes Yan, Q.;1 Duan, M.;1 Chen, C.; Deng, Z.; Wu, M.; Yu, P.; He, M.-L.;* Zhu, G.;* Houk, K. N.;* Sun, J.* Chem. Sci. 2022, 13, 5767-5773. (1: equal contribution) Oxygen Quenching-Resistant Nanoaggregates with Aggregation-Induced Delayed Fluorescence for Time-Resolved Mapping of Intracellular Microviscosity Song, F.; Ou, X.; Chou, T. Y.; Liu, J.; Gao, H.;* Zhang, R.; Huang, X.; Zhao, Z.; Sun, J.; Chen, S.;* Lam, J. W. Y.; Tang, B. Z.* ACS Nano 2022, 16, 6176-6184. Asymmetric Synthesis of Pyrrolidines via Oxetane Desymmetrization Zhang, R.;1 Sun, M.;1 Yan, Q.;1 Lin, X.; Li, X.; Fang, X.; Sung, H. H. Y.; Williams, I. D.; Sun, J.* Org. Lett. 2022, 24, 2359-2364.(1: equal contribution) Aggregation-Induced Emission Luminogens for Cell Death Research Zuo, Y.; Shen, H.; Sun, F.; Li, P.; Sun, J.; Kwok, R. T. K.; Lam, J. W. Y.;* Tang, B. Z.* ACS Bio. Med. Chem. Au 2022, 2, 236-257. Chiral phosphoric acid-catalyzed regio- and enantioselective reactions of functionalized propargylic alcohols Qian, C.; Liu, M.; Sun, J.;* Li, P.* Org. Chem. Front. 2022, 9, 1234-1240. Catalytic Enantioselective Synthesis of 2,3-Dihydrobenzo[b]oxepines via Asymmetric Oxetane Opening by Internal Carbon Nucleophiles Zhang, T.; Zhuang, H.; Tang, L.; Han, Z.; Guo, W.; Huang, H.;* Sun, J.* Org. Lett. 2022, 24, 207-212. Asymmetric dearomatization enabled by chiral Bronsted acid activation of ynamides Li, X.; Sun, J.* Sci. Chin. Chem. 2022, 65, 3-4. Visible-Light Photoredox-Catalyzed Dicarbofunctionalization of Styrenes with Oxime Esters and CO2: Multicomponent Reactions toward Cyanocarboxylic Acids and γ-Keto Acids Bai, J.; Li, M.; Zhou, C.; Sha, Y.; Cheng, J.; Sun, J.; Sun, S.* Org. Lett. 2021, 23, 9654-9658. SPHENOL, A New Chiral Framework for Asymmetric Synthesis Zhang, R.;1 Ge, S.;1 Sun, J.* J. Am. Chem. Soc. 2021, 143, 12445-12449. (1: equal contribution) Mild Intermolecular Synthesis of a Cyclopropane-Containing Tricyclic Skeleton: Unusual Reactivity of Isobenzopyryliums Liu, S.; Qian, H.; Zhang, T.; Xie, H.; Han, Z.; Guo, W.; Huang, H.;* Sun, J.*Angew. Chem., Int. Ed. 2021, 60, 21272-21276. Organocatalytic Asymmetric Formal Oxidative Coupling for the Construction of All-Aryl Quaternary Stereocenters Li, Z.; Li, Y.; Li, X.; Wu, M.; He, M.-L.;* Sun, J.* Chem. Sci. 2021, 12, 11793-11798.