Yu, Jin-Quan - The Scripps Research Institute

个人简介

Awards and Honors Award for Creativity in Molecular Design and Synthesis, ACS North Jersey Section, New Jersey, 2024 Chemical Pioneer Award – American Institute of Chemists, 2024 IPMI Henry J. Albert Award, sponsored by BASF Corporation, 2024 Yamada-Koga Prize, Tokyo University, 2024 Tishler Prize, Harvard University, 2024 Morris S. Kharasch Lecturer, University of Chicago, 2023 Hamilton Award, University of Nebraska-Lincoln, 2022 ACS Gabor A. Somorjai Award for Creative Research in Catalysis, 2022 Bristol Myers Squibb Endowed Chair in Chemistry, 2021 Member of the American Academy of Arts and Sciences, 2019 Pedler award, Royal Society Chemistry, 2017 MacArthur Genius Grant, 2016 Elias J. Corey Award, American Chemical Scociety, 2014 Raymond and Beverly Sackler Prize in the Physical Sciences, 2013 Fellow of American Association for the Advancement of Science, 2012 Fellow of the Royal Society of Chemistry, 2012 Mukaiyama Award, Society of Organic Synthesis, Japan, 2012 ACS Cope Scholar Award, 2012 Bristol-Myers Squibb Award, 2012 Novartis Early Career Award in Organic Chemistry, 2011 Hirata Memorial Lectureship Medal, Nagoya, 2010 Distinguished Faculty Award of Chinese-American Chemistry & Chemical Biology Professors Association, 2009 Eli Lilly Grantee Award 2008 Amgen Young Investigator's Award 2008 Sloan Research Fellowship 2008 Journal Award for Synlett & Synthesis 2006 Camille and Henry Dreyfus New Faculty Award 2004 Royal Society University Research Fellowship 2003 Fellowship of St John's College, University of Cambridge (JRF) 1998 Sino-British Scholarship by British Council and Education Ministry of China 1994 President Award for Outstanding Students of Chinese Academy of Sciences 1990 Academic Positions Scripps Research Institute - La Jolla, CA, USA Frank and Bertha Hupp Professor of Chemistry, 2012 Professor of Chemistry, 2010 - 2012 Associate Professor of Chemistry, 2007 - 2010 Brandeis University - Waltham, MA, USA Assistant Professor of Chemistry, 2004 - 2007 University of Cambridge - Cambridge, UK Royal Society Research Fellow, 2003 - 2004 Education Harvard University - Cambridge, MA, USA Postdoctoral Fellow, supervisor: E.J. Corey February 2001 - May 2002 University of Cambridge - Cambridge, UK Junior Research Fellow (JRF) of St. John's College October 1999 - October 2003 University of Cambridge - Cambridge, UK Ph.D. in Chemistry with Jonathan Spencer October 1994 - September 1999 Guangzhou Institute of Chemistry - Guangzhou, China M.Sc. in Chemistry with S.D. Xiao September 1988 - July 1990 Shanghai Institute of Organic Chemistry - Shanghai, China Coursework for M.Sc. degree September 1987 - July 1988 East China Normal University - Shanghai, China B.Sc. in Chemistry Top 5% of national examination for admission to SIOC Supervisors: L.X. Dai and B.Q. Wu September 1982 - July 1987

研究领域

Addressing the four challenges: New concepts for C−H activation and catalyst design 1. Weakly coordinating substrates which recruit and position the Pd catalyst for C–H activation whilst avoiding the scope limitations associated with strongly binding directing groups. 2. Distance and geometry can be rationally tuned and employed as the key element to differentiate multiple remote C–H bonds with highly similar electronic and steric properties, allowing the control of site selectivity through templated macrocyclic transition states. 3. Bifunctional ligands (e.g. mono N-protected amino acids) which actively participate in the C–H cleavage transition state, thus enabling reactivity through ligand acceleration and imbuing C–H activation selectivity through providing a defined chiral environment at the enantiodetermining step. These ligands also have allowed the use of practical oxidants such a peroxides and molecular oxygen for catalytic turnover. The discovery of ligand-supported Pd catalysis marks a significant departure from early studies using simple Pd salts for C–H metalation. Since 2008, several generations of bifunctional ligands have been developed in our laboratory: MPAA, MPAThio, MPAAM, MPAQ, MPAO, Pyridone, Pyridone-Pyridine.

近期论文

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Zi-Yu Zhang, Tao Zhang, Yuxin Ouyang, Jennifer X. Qiao and Jin-Quan Yu."Synthesis of chiral α-amino acids via Pd(II)-catalyzed enantioselective C–H arylation of α-aminoisobutyric acid"Chem. Sci 2024, Advance Article, 10.1039/D4SC05378H. Hua-Chen Shen, Jian-Jun Li, Peng Wang, and Jin-Quan Yu."meta-C–H functionalization of phenylethyl and benzylic alcohol derivatives via Pd/NBE relay catalysis"Chem. Sci. 2024, Advance Article, 10.1039/D4SC03802A. Tao Sheng, Tao Zhang, Zhe Zhuang, and Jin-Quan Yu."Synthesis of chiral carbocycles via enantioselective β,γ-dehydrogenation"Nat. Synth 2024, 10.1038/s44160-024-00628-z. Guangrong Meng, Jie-Lun Yan, Nikita Chekshin, Daniel A. Strassfeld, and Jin-Quan Yu."Ligand-Controlled Nondirected meta- or para-C–H Olefination of Silyl-Protected Phenols" ACS Catal. 2024, 14, 12806. Tao Sheng, Guowei Kang, Tao Zhang, Guangrong Meng, Zhe Zhuang, Nikita Chekshin, and Jin-Quan Yu."One-step Synthesis of Chiral 9,10-Dihydrophenanthrenes via Ligand-enabled Enantioselective Cascade β,γ-Diarylation of Acids" Angew. Chem. Int. Ed. 2024, e202408603. Zhe Zhuang, Tao Sheng, Jennifer X. Qiao, Kap-Sun Yeung, and Jin-Quan Yu."Versatile Copper-Catalyzed γ-C(sp3)–H Lactonization of Aliphatic Acids"J. Am. Chem. Soc. 2024, 146, 17311. Shupeng Zhou, Zi-Jun Zhang, and Jin-Quan Yu."Redox-Neutral Copper-Catalyzed Bimodal Dehydrogenation and Lactonization of C(sp3)−H Bonds"Nature 2024, 629, 363. Tao Zhang, Zi-Yu Zhang, Guowei Kang, Tao Sheng, Jie-Lun Yan, Yuan-Bin Yang, Yuxin Ouyang, and Jin-Quan Yu."Enantioselective Remote Methylene C-H (Hetero)Arylation of Cycloalkane Carboxylic Acids"Science 2024, 384, 793. Hau Sun Sam Chan, Yilin Lu, and Jin-Quan Yu."Palladium-catalyzed methylene C–H lactamization and cycloamination enabled by chlorinated pyridine-pyridone ligands"Nat. Synth. 2024, 10.1038/s44160-024-00517-5. Kevin Wu, Nelson Lam, Daniel A. Strassfeld, Zhoulong Fan, Jennifer X. Qiao, Tao Liu, Dean Stamos, and Jin-Quan Yu."Palladium (II)-Catalyzed C–H Activation with Bifunctional Ligands: From Curiosity to Industrialization"Angew. Chem. Int. Ed. 2024, 63, e202400509. Md. Emdadul Hoque and Jin-Quan Yu."Ligand-Enabled Double γ-C(sp3)−H Functionalization of Aliphatic Acids: One-Step Synthesis of γ-Arylated γ-Lactones".Angew. Chem. Int. Ed. 2023, 62, e202312331. Zhen Li and Jin-Quan Yu."Ligand-Enabled γ-C(sp3)−H Hydroxylation of Free Amines with Aqueous Hydrogen Peroxide".J. Am. Chem. Soc. 2023, 145, 25948. Xin Kuang, Jian-Jun Li, Tao Liu, Chang-Hua Ding, Kevin Wu, Peng Wang, Jin-Quan Yu."Cu-mediated enantioselective C–H alkynylation of ferrocenes with chiral BINOL ligands".Nat. Commmun. 2023, 14, 7698. Tao Sheng, Guowei Kang, Zhe Zhuang, Nikita Chekshin, Zhen Wang, Liang Hu and Jin-Quan Yu."Synthesis of β,γ-Unsaturated Aliphatic Acids via Ligand-Enabled Dehydrogenation".J. Am. Chem. Soc. 2023. Daniel A. Strassfeld, Chia-Yu Chen, Han Seul Park, D. Quang Phan, Jin-Quan Yu."Hydrogen-bond-acceptor ligands enable distal C(sp3)–H arylation of free alcohols".Nature 2023. Luo-Yan Liu, Zhoulong Fan, Md Emdadul Hoque, Shaoqun Qian, Guangrong Meng, Nikita Chekshin, Keita Tanaka, Jennifer X. Qiao, Kap-Sun Yeung, and Jin-Quan Yu."Remote C–H Olefination of Heterocyclic Biaryls Enabled by Reversibly Bound Templates".Angew. Chem. Int. Ed. 2023, e202307581. Pengfei Zhang, Zhiwei Jiang, Zhoulong Fan, Guoshuai Li, Qingxue Ma, Jun Huang, Jinghong Tang, Xiaohua Xu, Jin-Quan Yu, and Zhong Jin."Macrocyclization via Remote meta-Selective C–H Olefination Using a Practical Indolyl Template".Chem. Sci. 2023, 14, 8279. Liang Hu, Guangrong Meng, Xiangyang Chen, Joseph S Yoon, Jing-Ran Shan, Nikita Chekshin, Daniel A. Strassfeld, Tao Sheng, Zhe Zhuang, Rodolphe Jazzar, Guy Bertrand, K. N. Houk, Jin-Quan Yu."Enhancing Substrate-Metal Catalyst Affinity via Hydrogen Bonding: Pd(II)-Catalyzed β-C(sp3)−H Bromination of Free Carboxylic Acids".J. Am. Chem. Soc. 2023, 145, 16297. Martin Tomanik and Jin-Quan Yu."Palladium-Catalyzed Stitching of 1,3-C(sp3)–H bonds with Dihaloarenes: Short Synthesis of (±)-Echinolactone D.".J. Am. Chem. Soc. 2023, 145, 17919. Sanshan Wang, Kaiqi Chen, Fusheng Guo, Wenneng Zhu, Chendi Liu, Haoran Dong, Jin-Quan Yu, and Xiaoguang Lei."C–H Glycosylation of Native Carboxylic Acids: Discovery of Antidiabetic SGLT-2 Inhibitors".ACS Cent. Sci. 2023, ASAP. Jian-Jun Li, Jia-Hui Zhao, Hua-Chen Shen, Kevin Wu, Xin Kuang, Peng Wang, Jin-Quan Yu."Atroposelective remote meta-C–H activation".Chem 2023, 9, 1452. Guowei Kang, Daniel A. Strassfeld, Tao Sheng, Chia-Yu Chen and Jin-Quan Yu."Transannular C–H functionalization of cycloalkane carboxylic acids".Nature 2023, 618, 519. Guowei Kang, Li-Jun Xiao, Kevin D. Hesp, Chan Woo Huh, Yajing Lian, Paul Richardson, Daniel C. Schmitt, Kai Hong, and Jin-Quan Yu."Synthesis of Highly Substituted Aminotetrahydropyrans Enabled by Stereospecific Multivector C–H Functionalization".Org. Lett. 2023, ASAP. Guangrong Meng, Liang Hu, Hau Sun Sam Chan, Jennifer X. Qiao, and Jin-Quan Yu."Synthesis of 1,3-Dienes via Ligand-Enabled Sequential Dehydrogenation of Aliphatic Acids".J. Am. Chem. Soc. 2023, ASAP. Lan Zhou, Hong-Gang Cheng, Lisha Li, Kevin Wu, Jing Hou, Chengkang Jiao, Shuang Deng, Zirui Liu, Jin-Quan Yu, Qianghui Zhou."Synthesis of Planar Chiral Ferrocenes via Enantioselective Remote C–H Activation".Nat. Chem. 2023, ASAP. Ji-Min Yang, Yu-Kun Lin, Tao Sheng, Liang Hu, Xin-Pei Cai, Jin-Quan Yu."Regio-controllable [2+2] benzannulation with two adjacent C(sp3)–H bonds".Science 2023, 380, 639. Zhoulong Fan, Daniel A. Strassfeld, Han Seul Park, Kevin Wu, Prof. Jin-Quan Yu."Formal γ−C−H Functionalization of Cyclobutyl Ketones: Synthesis of cis-1,3-Difunctionalized Cyclobutanes".Angew. Chem. 2023, e202303948. Guangrong Meng, Zhen Wang, Hau Sun Sam Chan, Nikita Chekshin, Zhen Li, Peng Wang, and Jin-Quan Yu "Dual-Ligand Catalyst for the Nondirected C–H Olefination of Heteroarenes"J. Am. Chem. Soc. 2023, ASAP. Liang Hu, Guangrong Meng, and Jin-Quan Yu"Ligand-Enabled Pd(II)-Catalyzed β-Methylene C(sp³)–H Arylation of Free Aliphatic Acids" J. Am. Chem. Soc. 2022, ASAP. Guangrong Meng, Liang Hu, Martin Tomanik and Jin-Quan Yu"β- and γ-C(sp³)−H Heteroarylation of Free Carboxylic Acids: A Modular Synthetic Platform for Diverse Quaternary Carbon Centers" Angew. Chem. Int. Ed. 2022, e202214459. Zhen Li, Han Seul Park, Jennifer X. Qiao, Kap-Sun Yeung, and Jin-Quan Yu"Ligand-Enabled C–H Hydroxylation with Aqueous H2O2 at Room Temperature" J. Am. Chem. Soc. 2022, ASAP. Yi-Hao Li, Yuxin Ouyang, Nikita Chekshin, Jin-Quan Yu"PdII-Catalyzed γ-C(sp3)–H (Hetero)arylation of Ketones Enabled by Transient Directing Groups" ACS Catal. 2022, 12, 10581. Zhoulong Fan, Xiangyang Chen, Keita Tanaka, Han Seul Park, Nelson Y. S. Lam, Jonathan J. Wong, K. N. Houk, Jin-Quan Yu"Molecular Editing of Aza-arene C–H Bonds by Distance, Geometry and Chirality" Nature 2022, ASAP. Tao Sheng, Zhe Zhuang, Zhen Wang, Liang Hu, Alastair N. Herron, Jennifer X. Qiao, Jin-Quan Yu"One-Step Synthesis of β-Alkylidene-γ-lactones via Ligand-Enabled β,γ-Dehydrogenation of Aliphatic Acids" J. Am. Chem. Soc. 2022, 144, 12924. Zhe Zhuang, Shuang Liu, Jin-Tang Cheng, Kap-Sun Yeung, Jennifer X. Qiao, Nicholas A. Meanwell, Jin-Quan Yu"Ligand-Enabled β-C(sp3)–H Lactamization of Tosyl-Protected Aliphatic Amides Using a Practical Oxidant" Angew. Chem. Int. Ed. 2022, 61, e202207354. Martin Tomanik, Shaoqun Qian, and Jin-Quan Yu"Pd(II)-Catalyzed Synthesis of Bicyclo[3.2.1] Lactones via Tandem Intramolecular β-C(sp3)–H Olefination and Lactonization of Free Carboxylic Acids" J. Am. Chem. Soc. 2022, 144, 11955. Alastair N. Herron, Ching-Pei Hsu, and Jin-Quan Yu"δ-C–H Halogenation Reactions Enabled by a Nitrogen-Centered Radical Precursor" Org. Lett. 2022, 24, 3652. Hau Sun Sam Chan, Ji-Min Yang, Jin-Quan Yu"Catalyst-controlled site-selective methylene C–H lactonization of dicarboxylic acids" Science 2022, 376, 1481. Wenju Chang, Yu Chen, Shuo Lu, Hongyun Jiao, Yajun Wang, Tianyu Zheng, Zhuangzhi Shi, Yingbin Han, Yi Lu, Yi Wang, Yi Pan, Jin-Quan Yu, Kendall N. Houk, Fang Liu, Yong Liang"Computationally designed ligands enable tunable borylation of remote C-H bonds in arenes" Chem 2022, 8, 1775. Li-Ping Xu, Zhe Zhuang, Shaoqun Qian, Jin-Quan Yu, and Djamaladdin G. Musaev"Roles of Ligand and Oxidant in Pd(II)-Catalyzed and Ligand-Enabled C(sp3)–H Lactonization in Aliphatic Carboxylic Acid: Mechanistic Studies" ACS Catal. 2022, 12, 4848. Yi-Hao Li, Yuxin Ouyang, Nikita Chekshin and Jin-Quan Yu"PdII-Catalyzed Site-selective β- and γ-C(sp3)−H Arylation of Primary Aldehydes Controlled by Transient Directing Groups" J. Am. Chem. Soc. 2022, 144, 4727. Erika L. Lucas, Nelson Y. S. Lam, Zhe Zhuang, Hau Sun Sam Chan, Daniel A. Strassfeld, Jin-Quan Yu"Palladium-Catalyzed Enantioselective-C(sp3)–H Activation Reactions of Aliphatic Acids: A Retrosynthetic Surrogate for Enolate Alkylation and Conjugate Addition" Acc. Chem. Res. 2022, 55, 537. Jin-Tang Cheng, Li-Jun Xiao, Shao-Qun Qian, Zhe Zhuang, An Liu, Jin-Quan Yu"Palladium(II)-Catalyzed Selective Arylation of Tertiary C‒H Bonds of Cyclobutylmethyl Ketones Using Transient Directing Groups" Angew. Chem. Int. Ed. 2022, 61, e202117233. Nelson Y. S. Lam, Zhoulong Fan, Kevin Wu, Han Seul Park, Su Yong Shim, Daniel A. Strassfeld, and Jin-Quan Yu"Empirical Guidelines for the Development of Remote Directing Templates through Quantitative and Experimental Analyses" J. Am. Chem. Soc. 2022, 144, 2793. Li-Ping Xu, Shaoqun Qian, Zhe Zhuang, Jin-Quan Yu & Djamaladdin G. Musaev"Unconventional mechanism and selectivity of the Pd-catalyzed C–H bond lactonization in aromatic carboxylic acid" Nat. Commun. 2022, 13, 315. Shuang Liu, Zhe Zhuang, Jennifer X. Qiao, Kap-Sun Yeung, Shun Su, Emily C. Cherney, Zheming Ruan, William R. Ewing, Michael A. Poss, and Jin-Quan Yu"Ligand Enabled Pd(II)-Catalyzed γ-C(sp3)–H Lactamization of Native Amides" J. Am. Chem. Soc. 2021, 143, 21657. Tao Zhang, Yu-Xin Luan, Nelson Y. S. Lam, Jiang-Fei Li, Yue Li, Mengchun Ye, Jin-Quan Yu"A directive Ni catalyst overrides conventional site selectivity in pyridine C–H alkenylation" Nat. Chem. 2021, 13, 1207. Nicholas A. Falcone, Aaron T. Bosse, Hojoon Park, Jin-Quan Yu, Huw M. L. Davies, and Erik J. Sorensen"A C−H Functionalization Strategy Enables an Enantioselective Formal Synthesis of (−)-Aflatoxin B2" Org. Lett. 2021, 23, 9393. Philip A. Provencher, John F. Hoskin, Jonathan J. Wong, Xiangyang Chen, Jin-Quan Yu, K. N. Houk, and Erik J. Sorensen"Pd(II)-Catalyzed Synthesis of Benzocyclobutenes by β-Methylene-Selective C(sp³)–H Arylation with a Transient Directing Group" J. Am. Chem. Soc. 2021, 143, 20035. Zhen Wang, Liang Hu, Nikita Chekshin, Zhe Zhuang, Shaoqun Qian, Jennifer X. Qiao, and Jin-Quan Yu."Ligand-controlled divergent dehydrogenative reactions of carboxylic acids via C–H activation" Science 2021, 374, 1281. Yuan Xue, Han Seul Park, Chao Jiang, Jin-Quan Yu."Palladium-Catalyzed C(sp3)H Nitrooxylation of Ketones and Amides Using Practical Oxidants" ACS Catal. 2021, 11, 14188. Wei Hao, Katherine L. Bay, Caleb F. Harris, Daniel S. King, Ilia A. Guzei, Michael M. Aristov, Zhe Zhuang, R. Erik Plata, David E. Hill, K. N. Houk, John F. Berry, Jin-Quan Yu, and Donna G. Blackmond"Probing Catalyst Speciation in Pd-MPAAM-Catalyzed Enantioselective C(sp3)-H Arylation: Catalyst Improvement via Destabilization of Off-Cycle Species" ACS Catal. 2021, 11, 11040. Li-Ping Xu, Brandon E. Haines, Manjaly J. Ajitha, Jin-Quan Yu, and Djamaladdin G. Musaev"Unified Mechanistic Concept of the Copper-Catalyzed and Amide-Oxazoline-Directed C(sp2)–H Bond Functionalization" ACS Catal. 2021, 11, 12620. Tyler G. Saint-Denis, Nelson Y. S. Lam, Nikita Chekshin, Paul F. Richardson, Jason S. Chen, Jeff Elleraas, Kevin D. Hesp, Daniel C. Schmitt, Yajing Lian, Chan Woo Huh, and Jin-Quan Yu"Mechanistic Study of Enantioselective Pd-Catalyzed C(sp3)-H Activation of Thioethers Involving Two Distinct Stereomodels" ACS Catal. 2021, 11, 9738. Zhen Li, Zhen Wang, Nikita Chekshin, Shaoqun Qian, Jennifer X. Qiao, Peter T. Cheng, Kap-Sun Yeung, William R. Ewing, Jin-Quan Yu"A tautomeric ligand enables directed C-H hydroxylation with molecular oxygen" Science 2021, 372, 1452. Zhe Zhuang, Alastair N. Herron, and Jin-Quan Yu"Synthesis of Cyclic Anhydrides via Ligand-Enabled C-H Carbonylation of Simple Aliphatic Acids" Angew. Chem. Int. Ed. 2021, 60, 16382. David E. Hill, Jin-Quan Yu, and Donna G. Blackmond"Insights into the Role of Transient Chiral Mediators and Pyridone Ligands in Asymmetric Pd-Catalyzed C-H Functionalization" J. Org. Chem. 2020, 85, 13674. Zhe Zhuang, Alastair N. Herron, Shuang Liu and Jin-Quan Yu"Rapid Construction of Tetralin, Chromane, and Indane Motifs via Cyclative C-H/C-H Coupling: Four-Step Total Synthesis of (+/-)-Russujaponol F" J. Am. Chem. Soc. 2021, 143, 687. Philip A. Provencher, Katherine L. Bay, John F. Hoskin, K. N. Houk, Jin-Quan Yu and Erik J. Sorensen"Cyclization by C(sp3)-H Arylation with a Transient Directing Group for the Diastereoselective Preparation of Indanes" ACS Catal. 2021, 11, 3115. Jian-Jun Li, Cheng-Gang Wang, Jin-Feng Yu, Peng Wang, and Jin-Quan Yu"Cu-Catalyzed C-H Alkenylation of Benzoic Acid and Acrylic Acid Derivatives with Vinyl Boronates" Org. Lett. 2020, 22, 4692. Nelson Y. S. Lam, Kevin Wu and Jin-Quan Yu"Advancing the logic of chemical synthesis: C-H activation as strategic and tactical disconnections for C-C bond construction" Angew. Chem. Int. Ed. 2020, 60, 15767. Fan Wu, Jing Zhang, Fuhang Song, Sanshan Wang, Hui Guo, Qi Wei, Huanqin Dai, Xiangyin Chen, Xuekui Xia, Xueting Liu, Lixin Zhang, Jin-Quan Yu and Xiaoguang Lei"Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis" ACS Cent. Sci. 2020, 6, 928. Zhoulong Fan, Shuai Zhao, Tao Liu, Peng-Xiang Shen, Zi-Ning Cui, Zhe Zhuang, Qian Shao, Jason S. Chen, Anokha S. Ratnayake, Mark E. Flanagan, Dominik K. Kolmel, David W. Piotrowski, Paul Richardsond and Jin-Quan Yu"Merging C(sp3)-H activation with DNA-encoding" Chem. Sci. 2020, 11, 12282. Hojoon Park and Jin-Quan Yu"Palladium-Catalyzed [3+2] Cycloaddition via Twofold 1,3-C(sp3)-H Activation" J. Am. Chem. Soc. 2020, 142, 16552. Zhe Zhuang and Jin-Quan Yu"Pd(II)-Catalyzed Enantioselective γ-C(sp3)-H Functionalizations of Free Cyclopropylmethylamines" J. Am. Chem. Soc. 2020, 142, 12015. Shaoqun Qian, Zi-Qi Li, Minyan Li, Steven R. Wisniewski, Jennifer X. Qiao, Jeremy M. Richter, William R. Ewing, Martin D. Eastgate, Jason S. Chen, Jin-Quan Yu"Ligand-Enabled Pd(II)-Catalyzed C(sp3)-H Lactonization Using Molecular Oxygen as Oxidant" Org. Lett. 2020, 22, 3960. Luo-Yan Liu, Jennifer X. Qiao, Kap-Sun Yeung, William R. Ewing, Jin-Quan Yu"meta-Selective C-H Arylation of Fluoroarenes and Simple Arenes" Angew. Chem. Int. Ed. 2020, 59, 13831. Han Seul Park, Zhoulong Fan, Ru-Yi Zhu, Jin-Quan Yu"Distal γ-C(sp3)-H Olefination of Ketone Derivatives and Free Carboxylic Acids" Angew. Chem. Int. Ed. 2020, 59, 12853. Guangrong Meng, Nelson Y. S. Lam, Erika L. Lucas, Tyler G. Saint-Denis, Pritha Verma, Nikita Chekshin, Jin-Quan Yu"Achieving Site-Selectivity for C-H Activation Processes Based on Distance and Geometry: A Carpenter's Approach" J. Am. Chem. Soc. 2020, 142, 10571. Yan-Qiao Chen, Sukriti Singh, Yongwei Wu, Zhen Wang, Wei Hao, Pritha Verma, Jennifer X. Qiao, Raghavan B. Sunoj, Jin-Quan Yu"Pd-Catalyzed γ-C(sp3)-H Fluorination of Free Amines" J. Am. Chem. Soc. 2020, 142, 9966. Yan-Qiao Chen, Yongwei Wu, Zhen Wang, Jennifer X. Qiao, Jin-Quan Yu"Transient Directing Group Enabled Pd-catalyzed γ-C(sp3)-H Oxygenation of Alkyl Amines" ACS Catal. 2020, 10, 5657. Qian Shao, Kevin Wu, Zhe Zhuang, Shaoqun Qian, Jin-Quan Yu"From Pd(OAc)2 to Chiral Catalysts: The Discovery and Development of Bifunctional Mono-N-Protected Amino Acid Ligands for Diverse C-H Functionalization Reactions" Acc. Chem. Res. 2020, 53, 833. Zhe Zhuang, Alastair N. Herron, Zhoulong Fan, Jin-Quan Yu"Ligand-Enabled Monoselective β-C(sp3)-H Acyloxylation of Free Carboxylic Acids Using a Practical Oxidant" J. Am. Chem. Soc. 2020, 142, 6769. Li-Jun Xiao, Kai Hong, Fan Luo, Liang Hu, William R. Ewing, Kap-Sun Yeung, Jin-Quan Yu"PdII-Catalyzed Enantioselective C(sp3)-H Arylation of Cyclobutyl Ketones Using a Chiral Transient Directing Group" Angew. Chem. Int. Ed. 2020, 59, 9594. Pritha Verma, Jeremy M. Richter, Nikita Chekshin, Jennifer X. Qiao, and Jin-Quan Yu"Iridium(I)-catalyzed α-C(sp3)-H Alkylation of Saturated Azacycles" J. Am. Chem. Soc. 2020, 142, 5117. Hang Shi, Yi Lu, Jiang Weng, Katherine L. Bay, Xiangyang Chen, Keita Tanaka, Pritha Verma, Kendall N. Houk, Jin-Quan Yu"Differentiation and functionalization of remote C-H bonds in adjacent positions" Nature Chemistry 2020, 12, 399. Zhoulong Fan, Katherine L. Bay, Xiangyang Chen, Zhe Zhuang, Han Seul Park, Kap-Sun Yeung, K. N. Houk and Jin-Quan Yu"Rational Development of Remote C-H Functionalization of Biphenyl: Experimental and Computational Studies" Angew. Chem. Int. Ed. 2020, 59, 4770. Guoqin Xia, Zhe Zhuang, Luo-Yan Liu, Stuart L. Schreiber, Bruno Melillo and Jin-Quan Yu"Ligand-Enabled β-Methylene C(sp3)-H Arylation of Masked Aliphatic Alcohols" Angew. Chem. Int. Ed. 2020, 59, 7783. Alastair N. Herron, Dongxin Liu, Guoqin Xia, Jin-Quan Yu"δ-C-H Mono- and Dihalogenation of Alcohols" J. Am. Chem. Soc. 2020, 142, 2766. Zhe Zhuang, Jin-Quan Yu"Lactonization as a general route to β-C(sp3)-H functionalization" Nature 2020, 577, 656. Jin-Feng Yu, Dr. Jian-Jun Li, Prof. Dr. Peng Wang, Prof. Dr. Jin-Quan Yu"Cu-Mediated Amination of (Hetero)Aryl C-H bonds with NH Azaheterocycles" Angew. Chem. Int. Ed. 2019, 58, 18141. Erik A. Romero, Gang Chen, Milan Gembicky, Rodolphe Jazzar, Jin-Quan Yu, Guy Bertrand"Understanding the Activity and Enantioselectivity of Acetyl Protected Aminoethyl Quinoline Ligands in Palladium-Catalyzed β-C(sp3)-H Bond Arylation Reactions" J. Am. Chem. Soc. 2019, 141, 16726. Keita Tanaka, William R. Ewing, Jin-Quan Yu"Hemilabile Benzyl Ether Enables γ-C(sp3)-H Carbonylation and Olefination of Alcohols" J. Am. Chem. Soc. 2019, 141, 15494. Luo-Yan Liu, Jennifer X. Qiao, Kap-Sun Yeung, William R. Ewing, Jin-Quan Yu"meta C-H Arylation of Electron-Rich Arenes: Reversing the Conventional Site Selectivity" J. Am. Chem. Soc. 2019, 141, 14870. Yan-Shang Kang, Ping Zhang, Min-Yan Li, You-Ke Chen, Hua-Jin Xu, Jing Zhao, Wei-Yin Sun, Jin-Quan Yu and Yi Lu"Ligand-Promoted Rh(III)-Catalyzed Thiolation of Benzamides with a Broad Disulfide Scope" Angew. Chem. Int. Ed. 2019, 58, 9099. Ming Shang, Karla S. Feu, Julien C. Vantourout, Lisa M. Barton, Heather L. Osswald, Nobutaka Kato, Kerstin Gagaring, Case W. McNamara, Gang Chen, Liang Hu, Shengyang Ni, Paula Fernandez-Canelas, Miao Chen, Rohan R. Merchant, Tian Qin, Stuart L. Schreiber, Bruno Melillo, Jin-Quan Yu, and Phil S. Baran"Modular, stereocontrolled C(β)-H/C(α)-C activation of alkyl carboxylic acids"PNAS. 2019, 116, 8721. Michal S Andra, Lukas Schifferer, Corina Pollok, Christian Merten, Lukas J Goossen, Jin-Quan Yu"Enantio-and Diastereoswitchable C-H Arylation of Methylene Groups in Cycloalkanes" Chem. Eur. J. 2019, 25, 8503. Hui Xu, Min Liu, Ling-Jun Li, Ya-Fang Cao, Jin-Quan Yu and Hui-Xiong Dai"Palladium-Catalyzed Remote meta-C-H Bond Deuteration of Arenes Using a Pyridine Template" Org. Lett. 2019, 21, 4887. Hojoon Park, Yang Li, Jin-Quan Yu"Utilizing Carbonyl-Coordination of Native Amides for Pd-catalyzed C(sp3)-H Olefination" Angew. Chem. Int. Ed. 2019, 58, 11424. Guoqin Xia, Jiang Weng, Luoyan Liu, Pritha Verma, Ziqi Li and Jin-Quan Yu"Reversing conventional site-selectivity in C(sp3)-H bond activation" Nature Chemistry 2019, 11, 571. Xiao-Yue Chen,Yichen Wu, Jian Zhou, Peng Wang, and Jin-Quan Yu"Synthesis of β-Arylethenesulfonyl Fluoride via Pd-Catalyzed Nondirected C-H Alkenylation" Org. Lett. 2019, 21, 1426. Minghong Li, Ming Shang, Hui Xu, Xing Wang, Hui-Xiong Dai, and Jin-Quan Yu"Remote Para-C-H Acetoxylation of Electron-Deficient Arenes" Org. Lett. 2019, 21, 540. Jiancong Xu, Jingjing Chen, Feng Gao, Shuguang Xie, Xiaohua Xu, Zhong Jin and Jin-Quan Yu"Sequential Functionalization of meta-C-H and ipso-C-O Bonds of Phenols" J. Am. Chem. Soc. 2019, 141, 1903. Hua-Jin Xu, Yan-Shang Kang, Hang Shi, Ping Zhang, You-Ke Chen, Bing Zhang, Zhi-Qiang Liu, Jing Zhao, Wei-Yin Sun , Jin-Quan Yu , and Yi Lu"Rh(III)-Catalyzed meta-C-H Alkenylation with Alkynes" J. Am. Chem. Soc. 2019, 141, 76. Luo-Yan Liu, Kap-Sun Yeung, Jin-Quan Yu"Ligand-Promoted Non-Directed C-H Cyanation of Arenes" Chem. Eur. J. 2019, 25, 2199. Liang Hu, Peng-Xiang Shen, Qian Shao, Kai Hong, Jennifer X. Qiao and Jin-Quan Yu"Pd(II)-Catalyzed Enantioselective C(sp3)-H Activation/Cross-Coupling Reactions of Free Carboxylic Acids" Angew. Chem. Int. Ed. 2019, 11, 2134. Wei-Jun Kong, Qian Shao, Ming-Hong Li, Zeng-Le Zhou, Hui Xu, Hui-Xiong Dai, and Jin-Quan Yu"Copper-Mediated Diastereoselective C-H Thiolation of Ferrocenes" Organometallics. 2018, 37, 2832. Yan-Qiao Chen, Zhen Wang, Yongwei Wu, Steven R. Wisniewski, Jennifer X. Qiao, William R. Ewing, Martin D. Eastgate and Jin-Quan Yu"Overcoming the Limitations of γ, and δ-C-H Arylation of Amines through Ligand Development" J. Am. Chem. Soc. 2018, 140, 17884. Hojoon Park, Nikita Chekshin, Peng-Xiang Shen and Jin-Quan Yu"Ligand-Enabled, Palladium-Catalyzed β-C(sp3)-H Arylation of Weinreb Amides" ACS Catal. 2018, 8, 9292. Zhe Zhuang, Chang-Bin Yu, Gang Chen, Qing-Feng Wu, Yi Hsiao, Candice L. Joe, Jennifer X. Qiao, Michael A. Poss and Jin-Quan Yu"Ligand-Enabled β-C(sp3)-H Olefination of Free Carboxylic Acids" J. Am. Chem. Soc. 2018, 140, 10363. Marcus E. Farmer, Peng Wang, Hang Shi and Jin-Quan Yu"Palladium-Catalyzed meta-C-H Functionalization of Masked Aromatic Aldehydes" ACS Catal. 2018, 8, 7362. Hang Shi, Alastair N. Herron, Ying Shao, Qian Shao and Jin-Quan Yu"Enantioselective remote meta-C-H arylation and alkylation via a chiral transient mediator" Nature 2018, 558, 581. Hojoon Park, Pritha Verma, Kai Hong and Jin-Quan Yu"Controlling Pd(IV) reductive elimination pathways enables Pd(II)-catalysed enantioselective C(sp3)-H fluorination" Nature Chemistry 2018, 10, 755. Lin-Lin Xu, Xing Wang, Biao Ma, Ming-Xing Yin, Hai-Xia Lin, Hui-Xiong Dai and Jin-Quan Yu"Copper mediated C-H amination with oximes: en route to primary anilines" Chem. Sci. 2018, 9, 5160. Peng-Xiang Shen, Liang Hu, Qian Shao, Kai Hong, and Jin-Quan Yu"Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids" J. Am. Chem. Soc. 2018, 140, 6545. Qian Shao, Qing-Feng Wu, Jian He and Jin-Quan Yu"Enantioselective γ-C(sp3)-H Activation of Alkyl Amines via Pd(II)/Pd(0) Catalysis" J. Am. Chem. Soc. 2018, 140, 5322. Ru-Yi Zhu, Zi-Qi Li, Han Seul Park, Chris H. Senanayake and Jin-Quan Yu"Ligand-Enabled γ-C(sp3)-H Activation of Ketones" J. Am. Chem. Soc. 2018, 140, 3564. Tyler G. Saint-Denis, Ru-Yi Zhu, Gang Chen, Qing-Feng Wu and Jin-Quan Yu"Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts" Science 2018, 359, 759. Qing-Feng Wu, Xiao-Bing Wang, Peng-Xiang Shen and Jin-Quan Yu"Enantioselective C-H Arylation and Vinylation of Cyclobutyl Carboxylic Amides" ACS Catal. 2018, 8, 2577. Guoqiang Yang, Dajian Zhu, Peng Wang, Ri-Yuan Tang and Jin-Quan Yu"Remote C-H Activation of Various N-Heterocycles Using a Single Template" Chem. Eur. J. 2018, 24, 3434. Zhong Jin, Ling Chu, Yan-Qiao Chen and Jin-Quan Yu"Pd-Catalyzed Remote Meta-C-H Functionalization of Phenylacetic Acids Using a Pyridine Template" Org. Lett. 2018, 20, 425. David E. Hill, Qing-lan Pei, En-xuan Zhang, James R. Gage, Jin-Quan Yu and Donna G. Blackmond"A General Protocol for Addressing Speciation of the Active Catalyst Applied to Ligand-Accelerated Enantioselective C(sp3)-H Bond Arylation" ACS Catal. 2018, 8, 1528. Brandon E. Haines, Jin-Quan Yu and Djamaladdin G. Musaev"The mechanism of directed Ni(II)-catalyzed C-H iodination with molecular iodine" Chem. Sci. 2018, 9, 1144. Wei-Jun Kong, Xingrong Chen, Mingming Wang, Hui-Xiong Dai and Jin-Quan Yu"Rapid Syntheses of Heteroaryl-Substituted Imidazo[1,5-a]indole and Pyrrolo[1,2-c]imidazole via Aerobic C2-H Functionalizations" Org. Lett. 2018, 20, 284. Ming-Zhu Lu, Xing-Rong Chen, Hui Xu, Hui-Xiong Dai and Jin-Quan Yu"Ligand-enabled ortho-C-H olefination of phenylacetic amides with unactivated alkenes" Chem. Sci. 2018, 9, 1311. Yoonsu Park, Zachary L. Niemeyer, Jin-Quan Yu and Matthew S. Sigman"Quantifying Structural Effects of Amino Acid Ligands in Pd(II)-Catalyzed Enantioselective C-H Functionalization Reactions" Organometallics 2018, 37, 203.