罗坤甜 - 同济大学

研究领域

致力于DNA损伤与基因组稳定性的研究。工作重点集中在DNA损伤诱导肿瘤相关重要因子的翻译后修饰与肿瘤发生信号调控网络相关性研究。

近期论文

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Luo K （罗坤甜）, Zhang H, Wang L, Yuan J, Lou Z. Sumoylation of MDC1 is important for proper DNA damage response. EMBO J. 2012 May 25;31(13):3008-19. IF=9.025 Yuan J, Luo K（罗坤甜）, Liu T, Lou Z. Regulation of SIRT1 activity by genotoxic stress. Genes Dev. 2012 Apr 15;26(8):791-6. IF=11.659 Luo K（罗坤甜）, Yuan J, Lou Z. Oligomerization of MDC1 protein is important for proper DNA damage response. J Biol Chem. 2011 Aug 12;286(32):28192-9. (第一作者及通讯作者) IF=4.773 Pei H, Zhang L, Luo K（罗坤甜）, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z. MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature. 2011 Feb 3;470(7332):124-8. (并列第二作者) IF=36.280 Yuan J, Luo K（罗坤甜）, Zhang L, Cheville JC, Lou Z. USP10 regulates p53 localization and stability by deubiquitinating p53. Cell. 2010 Feb 5;140(3):384-96. IF=32.403 Luo K（罗坤甜）, Lou Z. Dual roles of topoisomerase II. Cell Cycle. 2009 Mar 1;8(5):679. IF=5.359 Luo K（罗坤甜）, Yuan J, Chen J, Lou Z. Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol. 2009 Feb;11(2):204-10. IF=19.488 Wu L, Luo K（罗坤甜）, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11200-5. (并列第一作者) IF=9.681 Guo Z, Yuan J, Tang W, Chen X, Gu X, Luo K（罗坤甜）, Wang Y, Wan B, Yu L. Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. Mol Biol Rep. 2007 Sep;34(3):137-44. IF=2.929 Guo Z, Tang W, Yuan J, Chen X, Wan B, Gu X, Luo K（罗坤甜）, Wang Y, Yu L. BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260. Biochem Biophys Res Commun. 2006 Sep 8;347(4):867-71. IF=2.484 Yuan J, Tang W, Luo K（罗坤甜）, Chen X, Gu X, Wan B, Yu L. Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53. Mol Biol Rep. 2006 Sep;33(3):151-8. IF=2.929 Luo K（罗坤甜）, Li J, Cui Y, Xu M, Yuan J, Tang W, Wan B, Yu L. Identification and characterization of the human SCAN domain zinc-finger gene ZNF449. Mol Biol Rep. 2006 Mar;33(1):51-7. IF=2.929 Luo K（罗坤甜）, Yuan J, Shan Y, Li J, Xu M, Cui Y, Tang W, Wan B, Zhang N, Wu Y, Yu L. Activation of transcriptional activities of AP1 and SRE by a novel zinc finger protein ZNF445. Gene. 2006 Feb 15;367:89-100. IF=2.341 Yuan J, Shan Y, Chen X, Tang W, Luo K（罗坤甜）, Ni J, Wan B, Yu L. Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B. Mol Biol Rep. 2005 Dec;32(4):205-14. IF=2.929

学术兼职

美国癌症协会（AACR）会员 Mayo Clinic Research Fellow’s Association（梅奥医院研究学者联合会会员） Breast Cancer Research杂志审稿人