当前位置: X-MOL首页全球导师 国内导师 › 陈炳地

个人简介

2005 年于吉林大学获学士学位,2005-2010 在浙江大学硕博连读,师从著名半导体专家阙端麟院士和杨德仁院士;2010 年获博士学位,同年进入同济大学,2014 年晋升为副教授,博士生导师。进入同济大学以来,与海外特聘教授、美籍华人科 学家崔征教授合作,在全世界首创粒细胞抗癌疗法。通过医工交叉,结合纳米技术, 开展癌症的诊断、治疗、康复研究。目前在癌症检测、粒细胞抗癌免疫治疗、营养 抗癌等方向已取得突破性进展。部分科研项目已进入临床转化阶段,并获得福建省 百人计划、福建海峡人才计划等支持。 作为项目负责人承担十余项国家及省部级科研项目,包括国家自然科学基金面 上项目、青年项目、教育部博士点基金、上海市科委生物医药科技支撑项目、上海 市科委西医引导项目、上海市卫计委优青计划、中国博士后科学基金特别资助和面 上资助项目、同济大学青年优秀人才培养行动计划项目等。同时作为主要研究人员 参与国家 973 项目、杰出青年项目、国家 863 项目等多项国家级项目的研究。 作 为第一作者或通信作者在 Advanced Materials(IF=25.809)、ACS Nano(IF=13.903)、 Nano Research (IF=8.515)、Theranostics(IF=8.063)等国际知名学术期刊发表论文 50 余篇,平均影响因子 5.13,总引用次数超过 1900 次,H-index 达到 19。申请国 家发明专利 8 项,已授权 5 项。 主要任职 上海市卫计委优秀青年医学人才 同济大学青年岗位能手 同济大学青年优秀人才培养对象 全国卫生产业企业管理协会转化医学专家委员会委员 全国抗衰老协会肿瘤风险评估与系统康复专委会委员 中国抗癌协会肿瘤标志物委员会 CTC 专家委员会委员 中国微循环学会转化医学专业委员会青年委员 白求恩精神研究会检验医学分会理事 国家/上海市大学生创新计划指导教师

研究领域

肿瘤液体活检:循环肿瘤细胞(CTC)、循环肿瘤 DNA(ctDNA)、 外泌体的检测纳米技术研发 癌症康复治疗:针对癌症常规治疗之后的营养、情绪、免疫 系统等康复治疗研究 肿瘤靶向影像: MRI、CT、超声、荧光成像等多模态医学影 像造影剂的构建及靶向诊断研究

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

M. L. Wu, T. X. Tian, C. Y. Lin, Y. C. Wang, J. Y. Chen, W. J. Le*, M. Y. Sun, J. G. Xu, H. Y. Dai, Y. F. Zhang, C. Y. Xue*, Z. M. Liu, B. D. Chen*, Melanoma Cell Membrane Biomimetic Versatile CuS Nanoprobes for Homologous Targeting Photoacoustic Imaging and Photothermal Chemotherapy, ACS Applied Materials & Interfaces 2020, 1214:16031-16039 (IF=8.758) X. Chen, T. G. Wang, W. J. Le, X. Huang, M. H. Gao, Q. Chen, S. G. Xu, D. Y. Yin, Q. G. Fu*, C.W. Shao*, B. D. Chen*, D. L. Shi, Smart Sorting of Tumor Phenotype with Versatile Fluorescent Ag Nanoclusters by Sensing Specific Reactive Oxygen Species, Theranostics 2020, 10 (8):3430-3450. (IF=8.579) M. L. Wu, W. J. Le, T. X. Mei, Y. C. Wang, B. D. Chen*, Z. M. Liu, C. Y. Xue*, Cell membrane camouflaged nanoparticles: a new biomimetic platform for cancer photothermal therapy. International Journal of Nanomedicine 2019, 14:4431-4448 (IF=5.115) X. Huang, W. J. Le, Q. Chen, J. Y. Chen, Y. Q. Zhu, D. L. Shi, B. D. Chen* , Z. Cui*, Suppression of the innate cancer-killing activity in human granulocytes by stress reaction as a possible mechanism for affecting cancer development. Stress 2019, DOI: 10.1080/10253890. 2019.1645112. (IF=3.102) W. J. Le, B. D. Chen, Z. Cui, Z. M. Liu*, D. L. Shi*, Detection of cancer cells based on glycolytic-regulated surface electrical charges. Biophysics Reports 2019,5, 1:10-18 朱欢欢,李晓峰,朱晋峰,黄鑫,何奇,陈炳地,曹玮,基于氧化石墨烯/金纳米棒的表面增强拉曼散色技术检测循环肿瘤细胞。第二军医大学学报,2019,40(6):643-650. B. B. Zhang, W. Yan, Y. J. Zhu, W.T. Yang, W. J. Le, B. D. Chen*, R. R. Zhu*, L. M. Cheng*, Nanomaterials in Neural‐Stem‐Cell‐Mediated Regenerative Medicine: Imaging and Treatment of Neurological Diseases. Advanced Materials 2018, 30, 1705694 (IF=27.398) X. Huang, C. Q. Fan, H. H. Zhu, W. J. Le, S. B. Cui, X. Chen, W. Li, F. Zhang, Y. Huang, D. L. Shi, Z. Cui, C. W. Shao*, B. D. Chen*, Glypican-1-antibody-conjugated Gd–Au nanoclusters for FI/MRI dual-modal targeted detection of pancreatic cancer. International Journal of Nanomedicine 2018, 13:2585-2599 (IF=5.115) Y. L. Tang, L. F. Dong, S. Mao, H. B. Gu, T. Malkoske, B. D. Chen*, Enhanced Photocatalytic Removal of Tetrabromobisphenol A by Magnetic CoO@graphene Nanocomposites under Visible-Light Irradiation. ACS Applied Energy Materials 2018, 1, 2698-2708 (IF=4.473) W. J. Le, B. D. Chen,, D. Maharaj, Z. Cui*, Natural cancer-killing activity of human granulocytes. Integrative Cancer Science and Therapeutics 2018, 5, 1-7 B. M. Sun, J. Wu, S. B. Cui, H. H. Zhu, W. An, Q. Fu, C. W. Shao, A. H. Yao*, B. D. Chen*, D.L. Shi, In Situ Synthesis of Graphene Oxide/Gold Nanorods Theranostic Hybrids for Efficient Tumor CT Imaging and Photothermal Therapy. Nano Research 2017, 10(1):37-48 (IF=8.183) X. Chen, H. H. Zhu, X. Huang, P. S. Wang, F. L. Zhang, W. Li, G. Chen*, B. D. Chen*, Novel iodinated gold nanoclusters for precise diagnosis of thyroid cancer. Nanoscale, 2017, 9(6): 2219-2231(IF=6.895) B. D. Chen, W. J. Le, Y. L. Wang, Z. Q. Li, D. Wang, L. Lin, S. B. Cui, J. J. Hu, Y. H. Hu, P. Y.Yang, R. C. Ewing, D. L. Shi*, Z. Cui* Targeting Negative Surface Charges of Cancer Cells by Multifunctional Nanoprobes. Theranostics 2016, 6, 11:1887-1898 (IF=8.579) W. J. Le, S. B. Cui, B. M. Sun, Z. Cui, B. D. Chen*, Non-invasive in vivo targeting human pancreatic cancer by magnetic resonance imaging. Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 12(2):529-530 (IF=5.182) F. Liu#, W. J. Le#, T. X. Mei, T. G. Wang, L. G. Chen, Y. Lei, S. B. Cui, B. D. Chen*, Z. Cui, C.W. Shao*, In vitro and in vivo targeting imaging of pancreatic cancer using a Fe3O4 @SiO2 nanoprobe modified with anti-mesothelin antibody. International Journal of Nanomedicine, 2016, 11:2195-2207 (IF=5.115) W. J. Le#, S. B. Cui#, X. Chen, H. H. Zhu, B. D. Chen*, Z. Cui*, Facile Synthesis of Gd-Functionalized Gold Nanoclusters as Potential MRI/CT Contrast Agents. Nanomaterials, 2016, 6(4):65 (IF=4.324) Y. L. Tang, J. L. Tian, M. Tyler, W. J. Le, B. D. Chen*. Facile ultrasonic synthesis of novel zinc sulfide/carbon nanotubes coaxial nanocables for enhanced photodegradation of Methyl Orange. Journal of Materials Science,2017, 52(3):1581-1589 (IF=3.553) C. X. Peng#, B. D. Chen#, Y. Qin, S. H. Yang, S. L. Liu and J. F. Yang, Facile ultrasonic synthesis of CoO quantum dot/Graphene nanosheet composites with high lithium storage capacity, ACS Nano, 2012, 6(2): 1074-1081 (Co-First Author). (IF=14.588) (ESI) B. D. Chen, H. Zhang, C. X. Zhai, N. Du, C. Sun, J. X. Xue, D. R. Yang, H. Huang, B. Zhang, Q.P. Xie and Y. L. Wu, Carbon nanotube-based magnetic-fluorescent nanohybrids as highly efficient contrast agents for multimodal cellular, J. Mater. Chem., 2010, 20(44): 9895-9902 (IF=6.626) B. D. Chen*, H. Zhang, N. Du, B. Zhang, Y. L. Wu, D. L. Shi and D. R. Yang, Magnetic-fluorescent nanohybrids of carbon nanotubes coated with Eu, Gd co-doped LaF3 as a multimodal imaging probe, J. Colloid Interf. Sci., 2012, 367(1): 61-66. (IF=7.489) B. D. Chen, H. Zhang, N. Du, D. S. Li, X. Y. Ma and D. R. Yang, Hybrid nanostructures of Au nanocrystals and ZnO nanorods: layer-by-layer assembly and tunable blue-shift band gap emission, Mater. Res. Bull. 2009, 44(4): 889-892. (IF=4.019) B. D. Chen, C. X. Peng and Z. Cui, Facile ultrasonic synthesis of CoO/graphene nanohybrids as high performance anode materials for lithium ion batteries, T. Nonferr. Metal. SOC. 2012, 22(10): 2517?2522 (IF=2.615) B. D. Chen, Y. Y. Li, B. B. Zhang, B. Zhang, Y. L. Wu and D. L. Shi, Ultraconvenient synthesis of lanthanide based magnetic-fluorescent hydrogels for multimodal cellular imaging, Adv. Mater. Res. 2011, 266, 118-121 (EI) B. D. Chen, T. Zhou, B. Zhang and A. H. Yao, Novel single walled carbon nanotube based magnetic-fluorescent nanohybrids as dual-modal MRI/optical imaging probes, Adv. Mater. Res. 2012, 476-478, 1134-1137 (EI) 陈炳地,单壁碳纳米管与稀土螯合物的磁性-荧光复合体系的制备及其多模成像应用研究,纳米科技,2012,9: 16-21. 周雪,韩俊,吴一凡,陈炳地*,纳米技术在肿瘤靶向诊疗中的研究进展,转化医学电子杂志,2017,4(2):10-16. 韩俊,周雪,吴一凡,陈炳地*,崔征,时东陆,一种用于前列腺癌细胞体外检测生物导航纳米探针的制备,第二军医大学学报,2017,38(6):715-719. F. Zhang, D. Chen, Y. Wang, L. Zhang, W. Dong, J. Dai, C. Jin, X. Dong, Y. Sun, H. Zhao, K. Fan, H. Liu, B. Chen, H. Zou, W. Li. Lysosome-dependent necrosis specifically evoked in cancer cells by gold nanorods. Nanomedicine, 2017, 12(13): 1575–1589 (IF=4.3) X. Han, Z. Deng, Z. Yang, Y. Wang, H. Zhu, B. Chen, Z. Cui, RC. Ewing, D. Shi. Biomarkerless targeting and photothermal cancer cell killing by surface-electrically-charged superparamagnetic Fe3O4 composite nanoparticles. Nanoscale, 2017, 9:1457-1465. (IF=6.895) Z. H. Xue, T. Wang, B. D. Chen, M. Tyler, S. Yu, Y. L. Tang*. Degradation of Tetracycline with BiFeO3 Prepared by a Simple Hydrothermal Method. Materials, 2015, 8: 6360-6378 (IF=3.057) Y. L. Wang, S. Liang, B. D. Chen, F. Guo, S. Yu and Y. Tang, Synergistic removal of Pb(II), Cd(II) and humic acid by Fe3O4@mesoporous silica-graphene oxide composites, PLOS ONE 2013, 8, e65634:1-8 (2013) (IF=2.74) H. Lin*, K. Imakita, M. Fujii*, C. Sun*, B. D. Chen, T. Kanno, H. Sugimoto, New insights into the red luminescent bovine serum albumin conjugated gold nanospecies. Journal of Alloys and Compounds 2017, 691: 860-865 (2017) (IF=4.65) 卢明智,乐文俊,崔少斌,孙兵妹,陈炳地,邵成伟. Mesothelin 抗体修饰的纳米探针对人 胰腺癌细胞 BxPC3 的体外靶向研究。 中华胰腺病杂志,2014,14(6):389-391 N. Du, H. Zhang, B. D. Chen, X. Y. Ma, Z. H. Liu, J. B. Wu and D. R. Yang, Porous indium oxide nanotubes: layer-by-layer assembly on carbon-nanotube templates and application for room-temperature NH3 gas sensors, Adv. Mater. 2007, 19, 1641-1645 (IF=27.398) (ESI) N. Du, H. Zhang, B. D. Chen, J. B. Wu, X. Y. Ma, Z. H. Liu Y. Q. Zhang, D. R. Yang, X. H. Huang and J. P. Tu, Porous Co3O4 nanotubes derived from Co4(CO)12 clusters on carbon nanotube templates: a highly efficient material for Li-battery applications, Adv. Mater. 2007, 19, 4505-4509 (IF=27.398) (ESI) N. Du, H. Zhang, B. D. Chen, X. Y. Ma and D. R. Yang, One-pot, large-scale synthesis of SnO2 nanotubes at room temperature, Chem. Commun. 2008, 3028-3030 (IF=5.996) B. B. Zhang, B. D. Chen, Y. L. Wang, F. F. Guo, Z. Q. Li and D. L. Shi, Preparation of highly fluorescent magnetic nanoparticles for analytes-enrichment and subsequent biodetection, J. Colloid Interf. Sci. 2011, 426-432 (IF=7.489) Y. L. Wang, F. Wang, B. D. Chen, H. Xu and D. L. Shi, Facile one-pot synthesis of yolk–shell superparamagnetic nanocomposites via ternary phase separations, Chem. Commun. 2011, 47, 10350-10352 (IF=5.996) N. Du, H. Zhang, B. D. Chen, X. Ma and D. R. Yang, Ligand-free self-assembly of ceria nanocrystals into nanorods by oriented attachment at low temperature, J. Phys. Chem. C 2007, 111, 12677-12680 (IF=4.189) H. Zhang, N. Du, P. Wu, B. D. Chen and D. R. Yang, Functionalization of carbon nanotubes with magnetic nanoparticles general nonaqueous synthesis and magnetic properties, Nanotechnology 2008, 19, 315604-315609 (IF=3.551) N. Du, H. Zhang, B. D. Chen, J. Wu, D. Li and D. R. Yang, Low temperature chemical reaction synthesis of single-crystalline Eu(OH)3 nanorods and their thermal conversion to Eu2O3 nanorods, Nanotechnology 2007, 18, 065605-065608 (IF=3.551) C. X. Zhai, H. Zhang, N. Du, B. D. Chen, H. Huang, Y. Wu and D. R. Yang, One-pot synthesis of biocompatible CdSe/CdS quantum dots and their applications as fluorescent biological labels, Nanoscale Res. Lett. 2010, 6, 31-35 (IF=3.581) N. Du, H. Zhang, B. D. Chen, J. Wu and D. R. Yang, Low-temperature chemical reaction routefor ZnO based sulfide coxial nanocables: general synthesis and gas sensor application, Nanotechnology 2007, 18, 115619-115625 (IF=3.551) T. F. Cui, H. Zhang, N. Du, B. D. Chen, D. Li and Deren Yang, Morphology and phase selective synthesis of EuF3 nanostructures by polyelectrolyte assisted chemical reaction and their optical properties, Mater. Chem. Phys.2009, 115, 562-566 (IF=3.408) H. Zhang, N. Du, B. D. Chen, T. F. Cui and D. R. Yang, Sub-2 nm SnO2 nanocrystals: a reduction/oxidation chemical reaction synthesis and optical properties, Mater. Res. Bull. 2008, 43, 3164-3170 (IF=4.019) N. Du, H. Zhang, B. D. Chen, X. Ma, X. Huang, J. Tu And D. R. Yang, Synthesis of polycrystalline SnO2 nanotubes on carbon nanotube template for anode material of lithium-ion battery, Mater. Res. Bull. 2009, 44, 211-215 (IF=4.019) N. Du, H. Zhang, J. Chen, J. Y. Sun, B. D. Chen and D. R. Yang, Metal oxide and sulfide hollow spheres: layer-by-layer synthesis and their application in lithium-ion battery, J. Phys. Chem. B 2008, 112, 14836-14842 (IF=2.857) H. Zhang, N. Du, B. D. Chen, D. Li and D. R. Yang, Carbon Nanotube-ZnO Nanosphere Heterostructures: Low-Temperature Chemical Reaction Synthesis, Photoluminescence, and Their Application for Room Temperature NH3 Gas Sensor, Sci. Adv. Mater. 2009, 1, 13-17 (IF=1.117) B. B. Zhang, H. Jin, Y. Li, B. D. Chen, S. Liu and D. L. Shi, Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity, J. Mater. Chem. 2012, 22, 14494-14501 (IF=6.626) F. Wang, Y. Tang, B. Zhang, B. D. Chen and Y. L. Wang, Preparation of novel magnetic hollow mesoporous silica microspheres and their efficient adsorption, J. Colloid Interf. Sci. 2012, 386, 129-134 (IF=7.489)

推荐链接
down
wechat
bug