蒋维 - 四川大学 - 生物治疗国家重点实验室

个人简介

2004年北京大学获病理生理学医学博士学位后，于2004年～2005年，在美国斯坦福大学医学院从事博士后研究，涉及生物信息学和激素领域。2005年～2007年，在加拿大皇后大学生理学系从事博士后研究，涉及心血管系统疾病的炎症药理学领域。目前从事心血管药理学及心血管疾病生物治疗方面的研究

研究领域

(1)以转基因 / 基因敲除动物模型为基础，研究各种心血管系统疾病如高血压、心脏肥大、心肌梗塞和动脉粥样硬化等的发病机制，并探讨可能的药物治疗和生物治疗；(2)研究钙信号、氧自由基等与心血管疾病之间的关系及可能的治疗干预；(3) 研究新的活性肽或激素并探讨它们可能的生理学和药理学效应。利用生物信息学手段和孤儿 G 蛋白偶联受体研究策略，寻找、分离它们可能的受体，并研究受体后信号传递途径，以期开发潜在的肽类或蛋白质药物，并利用它们的受体筛选可能的化学药物；(4)研究花生四烯酸代谢通路（环氧合酶和脂氧合酶通路）中的关键酶及有关代谢产物（如前列腺环素、血栓素、白三烯和半胱氨酸化白三烯等）的信号通路与心血管系统疾病的关系及可能的药物干预。

近期论文

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• Yan Ge, Wei Jiang (Co-first author), Lu Gan, Li-jun Wang, Chang-yan Sun, Pei-yan Ni, Ying Liu, Si-si Wu, Lun-da Gu, Wei Zheng, Frances E. Lund, Hong-Bo Xin. Mouse embryonic fibroblasts from CD38 knockout mice are resistant to oxidative stresses through inhibition of reactive oxygen species production and Ca(2+) overload. Biochem Biophys Res Commun. 2010 Aug 20;399(2):167-172. • Heng-Yu Zhang, Wei Jiang (Co-first and corresponding author), Jian-Ying Liu, Yan Li, Chun-Lin Chen, Hong-Bo Xin, De-Jia Huang. Intermedin is upregulated and has protective roles in a mouse ischemia/reperfusion model . Hypertens Res. 2009 Oct;32(10):861-8. • Wei Zhang, Wei Ke, Si-Si Wu, Lu Gan, Rui Zhou, Chang-Yan Sun, Qing-Shan Long, Wei Jiang , Hong-Bo Xin. An adenovirus-delivered peptide aptamer C1-1 targeting the core protein of hepatitis B virus inhibits viral DNA replication and production in vitro and in vivo. Peptides. 2009 Oct;30(10):1816-21. • Wei Jiang , Sean R. Hall, Moos Micheal, Yang Richard Chao, Kofo O. Ogunyankin, Luis G. Melo, Colin D. Funk. Endothelial Cysteinyl Leukotriene 2 Receptor (CysLT2R) Expression Mediates Myocardial Ischemia-Reperfusion Injury . The American Journal of Pathology, 2008 Mar; 172(3):592-602. • Chun-Shui Pan, Wei Jiang , Sheng-Ying Wu, Jing Zhao, Yong-Zheng Pang, Chao-Shu Tang, Yong-Fen Qi. Potentiated response to adrenomedullin in myocardia and aortas in spontaneously hypertensive rat . Basic Res Cardiol. 2006 May; 101(3):193-203. • Wei Jiang , Da-Yong Cai, Chun-Shui Pan, Yong-Fen Qi, Hong-Feng Jiang, Chao-Shu Tang. Changes in Production and Metabolism of Brain Natriuretic Peptide in Rats with myocardial ischemia . Eur J Pharmacol. 2005 Jan 10; 507(1-3):153-62. • Wei Jiang , Jing-Hui Yang, Chun-Shui Pan, Yong-Fen Qi, Yong-Zheng Pang, Chao-Shu Tang. Effects of Adrenomedullin on Cell P roliferation in Rat A dventitia Induced by Aldosterone. J Hypertens. 2004 Oct; 22(10):1953-61. • Wei Jiang , Hong-Feng Jiang, Da-Yong Cai, Chun-Shui Pan, Yong-Fen Qi, Yong-Zheng Pang, Chao-Shu Tang. Relationship between contents of Adrenomedullin and distributions of neutral endopeptidase in blood and tissues of rats in septic shock . Regul Pept. 2004 May 15; 118(3):199-208. • Wei Jiang , Jing-Hui Yang, Shu-heng Wang, Chun-Shui Pan, Yong-Fen Qi, Jing Zhao, Chao-Shu Tang. Effects of Adrenomedullin on Cell Proliferation in Cultured M yocardial Fibroblasts Induced by Aldosterone . Biochim Biophys Acta. -Molecular Basis of Disease. 2004 Nov 5; 1690(3):265-75. Wei Jiang , Hong-Feng Jiang, Da-Yong Cai, Chun-Shui Pan, Yong-Fen Qi, Yong-Zheng Pang, Chao-Shu Tang. Relationship between the contents of Adrenomedullin and Distributions of Neutral endopeptidase in Blood and Tissues in Spontaneously Hypertensive Rats. Hypertens Res. 2004 Feb; 27(2): 109-17.