朱晓峰 - 四川大学 - 生命科学学院

个人简介

学历 1995-1999年本科四川大学生命科学学院生物基地班 1999-2002年硕士四川大学生命科学学院生化与分子生物学专业 2002-2006年博士英国斯特莱斯克莱德大学 University of Strathclyde格拉斯哥大学University of Glasgow两所大学联合授予生命科学专业博士学位工作简历 2006-2012英国圣安德鲁斯大学 University of St Andrews生物医学科学综合研究中心（BSRC） 2012.10 四川大学

研究领域

结构生物学研究主要通过X-射线晶体衍射、核磁共振或电镜的方法直观反映生物大分子的静、动态结构及其相互作用，直接阐明基本生命现象，因而成为现代生命科学研究的重要主流前沿方向。本课题组主要以生物糖组分、生物卤化物等特殊天然产物的生物合成过程为研究对象，运用X-射线单晶衍射分析对糖基转移酶、卤化酶进行了高分辨率的三维结构解析，并结合其他酶学研究方法，直观反映酶的催化过程，透彻揭示了这些酶的化学反应机理，为酶功能的改造和运用，新型药物的设计开发提供了理论基础。

近期论文

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Yang J., Wang Y., Wang T., Jiang J., Botting C., Liu H., Chen Q., Yang J., Naismith J., Zhu X.*, Chen L.*, Pironetin reacts covalently with Cysteine-316 of α-tubulin to destabilize microtubule. Nat Commun, 2016 (accepted and online) (共同通讯联系人) Zhao Y., Yan B., Yang T., Jiang J., Wei H., Zhu X.*, Purification and crystallographic analysis of a FAD-dependent halogenase from Streptomyces sp. JCM9888. Acta Crystallogr F Struct Biol Commun, 71:972-976, 2015 (通讯联系人) Zhu G., Ren S., Xi L., Du L.*, Zhu X.*, Temperature induced structural transitions from native to unfolded aggregated states of tobacco etch virus protease. Journal of Molecular Structure, 1082: 80-90, 2015 (共同通讯联系人) Wang Z., Xiang Q., Zhu X., Dong H., He C., Wang H., Zhang Y., Wang W.,* Dong C.,* Structural and functional studies of conserved nucleotide-binding protein LptB in lipopolysaccharide transport. Biochemical and Biophysical Research Communications, 452(3): 443-449, 2014 Koehnke J, Bent AF, Zollman D, Smith K, Houssen WE, Zhu X., Mann G, Lebl T, Scharff R, Shirran S, Botting CH, Jaspars M, Schwarz-Linek U, Naismith JH., The cyanobactin heterocyclase enzyme: a processive adenylase that operates with a defined order of reaction, Angew Chem Int Ed Engl, 52(52):13991-13996, 2013 Lapthorn AJ*, Zhu X., Ellis EM, The diversity of microbial aldo/keto reductases from Escherichia coli K12, Chem Biol Interact, 25; 202(1-3):168-77, 2013 Zhu X., Yan X., Carter L., Liu H., Graham S., Coote P. and Naismith J.H*, A model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus, Acta Crystallogr Sect F Struct Biol Cryst Commun, 68 (6): 610-615, 2012 Zhu X., van Pée K.-H. and Naismith J.H*, The ternary complex of PrnB (the second enzyme in pyrrolnitrin biosynthesis pathway), tryptophan and cyanide yields new mechanistic insights into the indolamine dioxygenase superfamily, J Biol Chem, 285: 21126-21133, 2010 Zhu X., Laurentis W.D., Leang K., Hermann J., Ihlefeld K., van Pée K.-H. and Naismith J.H.*, Structural insights in the regioselectivity in the enzymatic chlorination of tryptophan, J Mol Biol, 391: 74-85, 2009 Flecks S., Patallo E.P., Zhu X., Ernyei A.J.,Seifert G., Schneider A. Dong C. Naismith J.H. and van Pée K.-H.*, New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan, Angew Chem Int Ed, 47:9533 -9536, 2008 Deng H., Huang F., Naismith J.H., O'Hagan D., Spencer J.B. and Zhu X., Biological Fluorination in Streptomyces cattleya: The Fluorinase, in Fluorine and Health: Molecular Imaging, Biomedical Materials and Pharmaceuticals, Chapter 18, 761-777, 2008 Zhu X., Robinson D.A., McEwan A.R., O’Hagan D. and Naismith J.H.*, Mechanism of EnzymaticFluorination in Streptomyces cattleya, J Am Chem Soc, 129: 14597-14604, 2007 Zhu X., Lapthorn A.* and Ellis E., The crystal structure of mouse succinic semialdehyde reductase AKR7A5: The structural basis for substrate specificity, Biochemistry, 45: 1562-1570, 2006