代云路 - 澳门大学 - 健康科学学院

个人简介

Education Ph.D. Inorganic Chemistry, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), China (2014) B.Sc. Chemical Engineering and Technology, Harbin Engineering University, China (2009) Academic and Professional Experience 08/2018-present Assistant Professor, Faculty of Health Sciences, University of Macau 09/2016-07/2018 Postdoc Fellow, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), USA 10/2014-09/2016 Research Fellow, The University of Melbourne, Australia 06/2014-10/2014 Lecturer, Harbin Engineering University, China

研究领域

Our group research interest mainly focuses on the nanomaterials for targeted delivery of anticancer therapeutics and multimodal biological imaging (X-ray computed tomography, optical imaging, magnetic resonance imaging and photoacoustic imaging, etc). We aim to develop inorganic nanomaterials and nanoscale coordination materials for gene and drug delivery, immunotherapy and biological imaging. In particular, we are working on designing and preparing multi-functional nanomaterials for enhanced anticancer therapy by exploiting the tumor microenvironment. We are also developing promising nanodrugs for clinical translation.

近期论文

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Lisi Xie†, Guohao Wang†, Wei Sang, Jie Li, Zhan Zhang, Wenxi Li, Jie Yan, Qi Zhao, Yunlu Dai*(corresponding author), Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy. Biomaterials, 2021, 269, 120638. (IF 10.317) Yuxin Guo†, Qing Sun,† Fu-Gen Wu*, Yunlu Dai*(corresponding author), Xiaoyuan Chen*, Polyphenol-Containing Nanomaterials: Synthesis, Properties, and Biomedical Applications. Adv. Mater., 2021, DOI: 10.1002/adma.202007356. (IF 27.398) Zhan Zhang†, Wei Sang†, Lisi Xie†, Wenxi Li, Bei Li, Jie Li, Hao Tian, Zhen Yuan, Qi Zhao, and Yunlu Dai*(corresponding author), Polyphenol-based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment. Angew. Chem. Int. Ed., 2020, DOI: 10.1002/anie.202013406 (IF 12.257) Wei Sang†, Lisi Xie†, Guohao Wang, Jie Li, Zhan Zhang, Bei Li, Sen Guo, Chu-Xia Deng, Yunlu Dai*(corresponding author), Oxygen Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy. Adv. Sci., 2020, DOI: 10.1002/advs.202003338 (IF 15.840) Liwen Zhang, Lisi Xie, Sihao Xu, Rhiannon P. Kuchel, Yunlu Dai*(corresponding author), Kenward Jung*, and Cyrille Boyer*, Dual Role of Doxorubicin for Photopolymerization and Therapy. Biomacromolecules 2020, 21, 3887. (IF 6.092) Jingjing Wang†, Wei Sang†, Zhen Yang, Zheyu Shen, Zhantong Wang, Orit Jacobson, Yundai Chen, Yong Wang, Mingyan Shao, Gang Niu, Yunlu Dai*(corresponding author), and Xiaoyuan Chen* Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy. J. Mater. Chem. B, 2019, DOI: 10.1039/C9TB01597C. (IF 5.047) Zhan Zhang†, Wei Sang†, Lisi Xie, Yunlu Dai*(corresponding author), Metal-organic frameworks for multimodal bioimaging and synergistic cancer chemotherapy. Coordin. Chem. Rev. 2019, 399, 213022. (IF 13.476) Wei Sang†, Zhan Zhang†, Yunlu Dai*(corresponding author), Xiaoyuan Chen* Recent Advances in Nanomaterials-based Synergistic Combination Cancer Immunotherapy. Chem. Soc. Rev., 2019, Advanced Article, DOI: 10.1039/C8CS00896E. (IF 40.182) Zhimei He, Xiaolin Huang, Chen Wang, Xiangli Li, Yijing Liu, Zijian Zhou, Sheng Wang, Fuwu Zhang, Zhantong Wang, Orit Jacobson, Jun-Jie Zhu,* Guocan Yu,* Yunlu Dai*(corresponding author), Xiaoyuan Chen* A Catalase-Like Metal-Organic Framework Nanohybrid for O2-Evolving Synergistic Chemoradiotherapy, Angew. Chem. Int. Ed. 2019, DOI: 10.1002/anie.201902612. (IF 12.102) Lingling Shan, Guizhen Gao, Weiwei Wang, Wei Tang, Zhantong Wang, Zhen Yang, Wenpei Fan, Guizhi Zhu, Kefeng Zhai, Orit Jacobson, Yunlu Dai*(corresponding author), Xiaoyuan Chen,* Self-assembled Green Tea Polyphenol-based Coordination Nanomaterials to Improve Chemotherapy Efficacy by Inhibition of Carbonyl Reductase 1. Biomaterials, 2019, 210, 62. (IF 8.806) Yuan Liu, Christina S. Gong, Lisen Lin, Zijian Zhou, Yijing Liu, Zhen Yang, Zheyu Shen, Guocan Yu, Zhantong Wang, Sheng Wang, Ying Ma, Wenpei Fan, Liangcan He, Gang Niu, Yunlu Dai*(corresponding author), Xiaoyuan Chen* Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy. Theranostics 2019, 9, 2791. (IF 8.712) Zhimei He†, Yunlu Dai†(co-first author), Xiangli Li, Dan Guo, Yijing Liu, Xiaolin Huang, Jingjing Jiang, Sheng Wang, Guizhi Zhu, Fuwu Zhang, Lisen Lin, Jun-Jie Zhu,* Guocan Yu,* Xiaoyuan Chen* Hybrid Nanomedicine Fabricated from Photosensitizer-Terminated Metal-Organic Framework Nanoparticles for Photodynamic Therapy and Hypoxia-Activated Cascade Chemotherapy. Small, 2019, 15, 1804131. (IF 9.598) Zhen Yang, Yunlu Dai*(corresponding author), Lingling Shan, Zheyu Shen, Zhantong Wang, Bryant C Yung, Orit Jacobson, Yijing Liu, Wei Tang, Sheng Wang, Lisen Lin, Gang Niu, Pintong Huang*, Xiaoyuan Chen* Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics, Nanoscale Horiz., 2019, 4, 426. (IF 9.391) Yunlu Dai, Zhen Yang, Siyuan Cheng, Zhongliang Wang,* Ruili Zhang, Guizhi Zhu, Zhantong Wang, Bryant C. Yung, Rui Tian, Orit Jacobson, Can Xu, Qianqian Ni, Jibin Song, Xiaolian Sun, Gang Niu, Xiaoyuan Chen,*. Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles. Adv. Mater., 2018, 30, 1704877. (IF 21.950) Yunlu Dai, Siyuan Cheng, Zhongliang Wang,* Ruili Zhang, Zhen Yang, Jingjing Wang, Bryant C. Yung, Zhantong Wang, Orit Jacobson, Can Xu, Qianqian Ni, Guocan Yu, Zijian Zhou, and Xiaoyuan Chen,* Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase Encapsulated Therapeutic Metal Phenolic Nanoparticles. ACS Nano, 2018, 12, 455. (IF 13.709) Zhen Yang,† Yunlu Dai†(co-first author), Chao Yin, Quli Fan,* Wansu Zhang, Guocan Yu, Wei Tang, Wenpei Fan, Jie Li, Xiang Li, Yufu Tang, Xiangchun Li, Jibin Song,* Wei Huang, Xiaoyuan Chen* Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo Adv. Mater., 2018, 30, 1707509. (IF 21.950) Yunlu Dai, Can Xu, Xiaolian Sun* and Xiaoyuan Chen*. Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment. Chem. Soc. Rev., 2017, 46, 3830-3852. (IF 40.182) Huiting Bi†, Yunlu Dai†(co-first author), Piaoping Yang*, Jiating Xu, Dan Yang, Shili Gai, Fei He, Bin Liu, Chongna Zhong, and Jun Lin*. Glutathione Mediated Size-Tunable UCNPs-Pt(IV)-ZnFe2O4 Nanocomposite for Multiple Bioimaging Guided Synergetic Therapy. Small, 2018, 14, 1703809. (IF 9.598) Zhantong Wang†, Yunlu Dai†(co-first author), Zhe Wang*, Orit Jacobson, Fuwu Zhang, Bryant C. Yung, Pengfei Zhang, Haiyan Gao, Gang Niu, Gang Liu,*, Xiaoyuan Chen,* Metal Ion Assisted Interface Re-engineering of Ferritin Protein Nanocage for Enhanced Biofunctions and Cancer Therapy. Nanoscale, 2018, 10, 1135. (IF 7.233)