张冬梅 - 南京大学 - 生命科学学院

个人简介

副教授，硕士生导师。南京大学本科、硕士和博士。主讲 “生物化学 ”，主编“十二五” 普通高等教育本科国家级规划教材、江苏省“十三五”规划重点教材，主持“生物化学实验”MOOC。科研方向代谢综合征肾损伤病理机制及中药活性成分的保护作用。主持国家自然科学基金、江苏省 “六大人才高峰 ”高层次人才培养计划、江苏省自然科学基金、中央高校基本业务费自由探索项目等科研项目，同时作为学术骨干参加国家重点基础研究发展计划 973计划、国家自然科学基金、江苏省自然科学基金在内多个研究项目。发表 SCI研究论文 31篇，其中一作或通讯作者文章 14篇。

研究领域

代谢综合征肾损伤的病理机制研究及中药活性成分的保护作用代谢重编程诱发足细胞损伤的作用机制

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Gu, Ting-Ting#; Chen, Tian-Yu; Yang, Yan-Zi; Zhao, Xiao-Juan; Sun, Yang; Li, Tu-Shuai; Zhang, Dong-Mei*; Kong, Ling-Dong*. Pterostilbene alleviates fructose-induced renal fibrosis by suppressing TGF-beta1/TGF-beta type I receptor/Smads signaling in proximal tubular epithelial cells. European journal of pharmacology. 2018. 842: 70-78. 2. Minzan Zuo, Weirui Qian, Zuqiang Xu, Wei Shao, Xiao-Yu Hu,* Dongmei Zhang,* Juli Jiang,* Xiaoqiang Sun, and Leyong Wang. I Multi-Responsive Supramolecular Theranostic Nanoplatform Based on Pillar[5]arene and Diphenylboronic Acid Derivatives for Integrated Glucose Sensing and Insulin Delivery. Small. 2018 1801942（DOI: 10.1002/smll.201801942） 3. Yanjing Zheng#, Yumei Li, Hongyan Long, Xiaojuan Zhao, Keke Jia1, Juan Li, Leyong Wang, Ruiyong Wang, Xiancai Lu and Dongmei Zhang*. bifA Regulates Biofilm Development of Pseudomonas putida MnB1 as a Primary Response to H2O2 and Mn2+. Frontiers in Microbiology. 2018 9, 1490（DOI:10.3389/fmicb.2018.01490) 4. Lin, Xin#; Jia, Keke#; Wang, Yichen; Shao, Wei ; Yao, Chenhao ; Peng, Luming; Zhang, Dongmei*; Hu, Xiao-Yu*; Wang, Leyong. Dual-Responsive Bola-Type Supra-Amphiphile Constructed from Water-Soluble Pillar[5]arene and Naphthalimide-Containing Amphiphile for Intracellular Drug Delivery. ACS Applied Materials & Interfaces. 9: 4843-4850. 2017.1.18 5. Gao Lei #, Wang Tingting, Jia Keke, Wu Xuan, Yao Chenhao, Shao Wei, Zhang Dongmei, Hu XiaoYu *, and Wang Leyong *. Glucose-Responsive Supramolecular Vesicles Based on Water- Soluble Pillar[5]arene and Pyridylboronic Acid Derivatives for Controlled Insulin Delivery. Chemistry - A European Journal. 2017.5.11, 23, 6605–6614. 6. Zhang Dong-Mei#, Jiao Rui-Qing, Ling-Dong Kong*. High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions. Nutrients. 2017.4, 9(4), 335; doi:10.3390/nu9040335. 7. Gu Ting-Ting#, Song Lin#, Chen Tian-Yu, Wang Xing, Zhao Xiao-Juan, Ding Xiao-Qin, Yang Yan-Zi, Pan Ying, Zhang Dong-Mei*, Kong Ling-Dong*. Fructose down-regulates miR-330 to induce renal inflammatory response and insulin signaling impairment: Attenuation by morin. Molecular Nutrition & Food Research. 2017.8;61(8). doi: 10.1002/mnfr.201600760. 8. Kang Lin-Lin#, Zhang Dong-Mei#, Ma Chun-Hua, Zhang Jian-Hua, Jia Ke-Ke, Liu Jia-Hui, Wang Rong, Kong Ling-Dong*. Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation. Scientific Reports. 2016.6.8; 6:27460. 9. Ma Chun-Hua#, Kang Lin-Lin, Ren Hong-Mei，Zhang Dong-Mei，Kong Ling-Dong*. Simiao pill ameliorates renal glomerular injury via increasing Sirt1 expression and suppressing NF-kappaB/NLRP3 inflammasome activation in high fructose-fed rats. Journal of Ethnopharmacology. 2015.8.22;172:108-117. 10. Yang Ying#，Zhang Dong-Mei，Liu Jia-Hui，Hu Lin-Shui，Xue Qiao-Chu，Ding Xiao-Qin，Kong Ling-Dong*. Wuling San protects kidneydysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasomeactivation in high fructose-induced hyperuricemic mice. Journal of Ethnopharmacology. 2015.7.1; 169:49-59. 11. Liu Lei#, Zhang Dong-Mei#, Wang Ming-Xin, Fan Chen-Yu, Zhou Fan, Wang Shui-Juan, Kong Ling-Dong*. The adverse effects of long-term l-carnitine supplementation on liver and kidney function in rats. Human & experimental toxicology. 2015.11; 34(11):1148-1161. 12. Wang Ming-Xing#, Liu Yang-Liu, Yang Ying, Zhang Dong-Mei, Kong Ling-Dong*. Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice. European journal of pharmacology. 2015.1.15;15(747):59-70. 13. Hu Xiao-Yu#, Jia Ke-Ke, Cao Yu, Li Yan, Qin Shan, Zhou Fan, Lin Chen, Zhang Dong-Mei, Wang Leyong*. Dual photo- and pH-responsive supramolecular nanocarriers based on water-soluble pillar[6]arene and different azobenzene derivatives for intracellular anticancer drug delivery. Chemistry-A European Journal. 2015.1.12;21(3):1208-1220. 14. Wang Xing#, Zhang Dong-Mei#, Gu Ting-Ting, Ding Xiao-Qin, Fan Chen-Yu, Zhu Qin, Shi Yun-Wei, Hong Ye, Kong Ling-Dong*. Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine phosphate signaling pathway. Biochemical Pharmacology. 2013.12.15.86(12):1791-1804. 15. Guan Fu-Qin#, Wang Hai-Ting, Shan Yu, Zhang Dong-Mei, Zhao You-Yi, Chen Yu, Wang Qi-Zhi, Wang Ming, Feng Xu*. Bigelovii A induces apoptosis of HL ‑60 human acute promyelocytic leukaemia cells. Molecular Medicine Reports. 2013.5;7(5):1585-1590. 16. Zhang Dong-Mei#, Li Yu-Cheng#, Xu De, Ding Xiao-Qin, Kong Ling-Dong*. Protection of curcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signalling in rats. Food Chemistry. 2012.10.15;134(4):2184-2193. 17. Yang Jing-Hua#, Zhao Jing, Xiao Han, Zhang Dong-Mei, Li Gen-Xi*. Study of Hemoglobin and Human Serum Albumin Glycation with Electrochemical Techniques. Electroanalysis. 2011.2 .23(2):463-468. 18. Pan Ying#, Wang Fu-Meng, Qiang Li-Qin, Zhang Dong-Mei, Kong Ling-Dong*. Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats. Psychoneuroendocrinology. 2010.2; 35(2): 272-283. 19. Sun Xue-Song#, Ge Rui-Guang, Zhang Dong-Mei, Sun Hong-Zhe, He Qing-Yu*. Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcus pyogenes. Journal of Biological Inogranic Chemistry. 2010.11;15: 1265-1273.