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1．Lin Hong-Yan, Li Zi-Kang, Bai Li-Fei, Baloch Karim Shahla, Wang Fang, Qiu Han-Yue, Wang Xue, Jin-Liang Qi, Rong-Wu Yang, Wang Xiao-Ming * and Yang Yong-Hua. Synthesis of phenyl thiazole acyl shikonin ester derivatives as anti-cancer agents through microtubule stabilization. Biochemical Pharmacology. 2015, 96(2), 93-106. 2．Qiu Han-Yue, Wang Peng-Fei, Li Zhen, Ma Jun-Ting, Wang Xiao-Ming, * Yang Yong-Hua, Zhu Hai-Liang. Synthesis of dihydropyrazole sulphonamide derivatives that act as anti-cancer agents through COX-2 inhibition. Pharmacological Research. 2016, 104: 86-96. 3．Qiu Han-Yue, Zhu Xiang, Luo Yue-Lin, Lin Hong-Yan, Tang Cheng-Yi, Qi Jin-Liang, Pang Yan-Jun, Yang Rong-Wu, Lu Gui-Hua, Wang Xiao-Ming,* Yang Yong-Hua. Shikonin Derivatives Targeting STAT3 SH2 Domain Induce Antitumor Effects. Scientific Reports 2017, 7, 2863. 4．Hu Yang, Li Cui-Yun, Wang Xiao-Ming, Yang Yong-Hua, Zhu Hai-Liang. 1, 3, 4-Thiadiazole: synthesis, reactions and applications in medicinal, agricultural, materials chemistry. Chemical Reviews. 2014, 114(10): 5572-5610. 5．Sun Wen-Xue, Ji Ya-Jing, Wan Yun, Han Hong-Wei, Lin Hong-Yan, Lu Gui-Hua, Qi Jin-Liang*, Wang Xiao-Ming*, Yang Yong-Hua*. Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents. Bioorganic & Medicinal Chemistry Letters 2017, 27 4066–4074. 6．Zhang Ya-Han, Han Hong-Wei, Qiu Han-Yue, Lin Hong-Yan, Yu Lu-Gang, Zhu Wan-Zhan, Qi Jin-Liang, Yang Rong-Wu, Pang Yan-Jun, Wang Xiao-Ming, * Lu Gui-Hua, and Yang Yong-Hua. Antiviral activity of a synthesized Shikonin ester against influenza A (H1N1)virus and its insights into its mechanism. Biomedicine & Pharmacotherapy 2017,93:636-645. 7．Zhang Ya-Han, Han Hong-Wei, Qiu Han-Yue, Lin Hong-Yan, Yu Lu-Gang, Zhu Wan-Zhan, Qi Jin-Liang, Yang Rong-Wu, Pang Yan-Jun, Wang Xiao-Ming, * Lu Gui-Hua, and Yang Yong-Hua. Antiviral activity of shikonin ester derivative PMM-034 against enterovirus 71 in vitro. Brazilian Journal of Medical and Biological Research 2017,50(10): e6586. 8．Qiu Han-Yue, Wang Fang, Wang Xue, Sun Wen-Xue, Qi Jin-Liang, Pang Yan-Jun, Yang Rong-Wu, Lu Gui-Hua, Wang Xiao-Ming,* Yang Yong-Hua. Design, synthesis, and biological evaluation of chalcone-containing shikonin derivatives as inhibitors of tubulin polymerization.ChemMedChem 2017,12(5):399-406. 9．Wang Zi-Zhen, Sun Wen-Xue, Wang Xue, Zhang Ya-Han, Qiu Han-Yue, Qi Jin-Liang, Pang Yan-Jun, Lu Gui-Hua, Wang Xiao-Ming,* Yu Fu-Gen, Yang Yong-Hua. Design, Synthesis, Biological evaluation and 3D-QSAR Analysis of podophyllotoxin-dioxazole combination as tubulin targeting anticancer agents. Chemical Biology & Drug Design 2017，90:236-243. 10．Qiu Han-Yue, Wang Peng-Fei, Wang Zi-Zhen, Luo Yue-Lin, Hu Dong-Qing, Qi Jin-Liang, Lu Gui-Hua, Pang Yan-Jun, Yang Rong-Wu, Zhu Hai-Liang, Wang Xiao-Ming*, Yang Yong-Hua*. Shikonin derivatives as inhibitors of tyrosyl-tRNA synthetase: Design, synthesis and biological evaluation. RSC Advances, 2016, 6, 83003-83010. 11．Han Hong-Wei, Qiu Han-Yue, Hu Cui, Sun Wen-Xue, Yang Rong-Wu, Qi Jin-Liang, Wang Xiao-Ming,* Lu Gui-Hua and Yang Yong-Hua. Design, synthesis and anti-cancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs. Bioorganic & Medicinal Chemistry Letters 2016,26(14),3237-3242. 12．Baloch Karim Shahla, Ma Lin, Wang Xue-Liang, Shi Jing, Zhu Yu, Wu Feng-Yao, Pang Yan-Jun, Lu Gui-Hua, Qi Jin-Liang, Wang Xiao-Ming,* Gu Hong-We and Yang Yong-Hua. Design, Synthesis and Mechanism of Novel Shikonin Derivatives as Potent Anticancer Agents. RSC Advances, 2015, 5(40), 31759-31767. 13．Lin Hong-Yan, Li Zi-Kang, Han Hong-Wei, Qiu Han-Yue, Gu Hong-Wei, Yang Yong-Hua, Wang Xiao-Ming.* Synthesis of novel aryl dithian valeryl podophyllotoxin ester derivatives as potential anti-tubulin agents RSC Advances, 2015, 5(59),47511-47521. 14．Lin Hong-Yan, Bai Li-Fei, Wang Fang, Wu Xun, Han Lu-Jing, Baloch Karim Shahla, Yang Yong-Hua, Wang Xiao-Ming.* Semi-synthesis and anti-lung cancer activity evaluation of aryl thiazol acyl podophyllotoxin ester derivatives. RSC Advances 2015, 5(35), 27775 - 27784. 15．Baloch Karim Shahla, Ma Lin, Xu Guo-Hua, Bai Li-Fei, Zhao Hua, Tang Cheng-Yi, Pang Yan-Jun, Yang Rong-Wu, Wang Xiao-Ming,* Lu Gui-Hua, Yang Yong-Hua. A Potent Anticancer Agent of Shikonin Derivative Targeting Tubulin, Chirality 2015, 27：274-280. 16．Lin Hong-Yan, Han Hong-Wei, Bai Li-Fei, Qiu Han-Yue, Yin De-Zheng, Qi Jin-Liang, Wang Xiao-Ming,* Gu Hong-Wei and Yang Yong-Hua. Design, Synthesis and Biological Evaluation of Shikonin Thio-glycoside Derivatives: New Anti-Tubulin Agents. RSC Advances 2014,4(91)，49796-49805. 17．Qiu Han-Yue, Wang Zhong-Chang, Wang Peng-Fei, Yan Xiao-Qiang, Wang Xiao-Ming*, Yang Yong-Hua, Zhu Hai-Liang. Design, Synthesis, Evaluation and 3D-QSAR Analysis of Benzosulfonamide Benzenesulfonates as Potent and Selective Inhibitors of MMP-2. RSC Advances 2014, 4(74), 39214−39225. 18．Baloch Karim Shahla, Ling Li-Jun, Qiu Han-Yue, Ma Lin, Lin Hong-Yan, Huang Shou-Cheng, Qi Jin-Liang, Wang Xiao-Ming,* Lu Gui-Hua, Yang Yong-Hua. Synthesis and biological evaluation of novel shikonin ester derivatives as potential anti-cancer agents. RSC Advances 2014, 4(67), 35588−35596. 19．Guo Jing, Chen Xiao-Feng, Liu Jing, Lin Hong-Yan, Han Hong-Wei, Liu Hong-Chang, Huang Shou-Cheng, Baloch Karim Shahla, Andrew Kulek, Qi Jin-Liang,Wang Xiao-Ming, * Ling Li-Jun,* and Yang Yong-Hua. Novel Shikonin Derivatives Targeting Tubulin as Anti-cancer Agents. Chemical Biology & Drug Design 2014, 84(5), 603−615.
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