研究领域
主要从事代谢性疾病、精神性疾病病理机制及中药干预、相关中药新药临床前研究等工作。
近期论文
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Qing-Yu Zhang, Ying Pan, Rong Wang, Lin-Lin Kang, Qiao-Chu Xue, Xiao-Ning Wang , Ling-Dong Kong*. Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats. Journal of Nutritional Biochemistry 2014; 25(4): 420-428.
Ying Pan, Yi Hong, Qing-Yu Zhang, Ling-Dong Kong*. Impaired hypothalamic insulin signaling in CUMS rats: Restored by icariin and fluoxetine through inhibiting CRF system. Psychoneuroendocrinology 2013; 38(1):122-134.
Wang W, Wang C, Ding XQ, Pan Y, Gu TT, Wang MX, Liu YL, Wang FM, Wang SJ, Kong LD*. Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats. British Journal of Pharmacology 2013; 169(6): 1352-1371.
Wang X, Zhang DM, Gu TT, Ding XQ, Fan CY, Zhu Q, Shi YW, Hong Y, Kong LD*. Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. Biochemical Pharmacology 2013 15; 86(12):1791-1804.
Yun-Wei Shi, Cai-Ping Wang, Lei Liu, Xing Wang, Ye Hong, Zhen Li, Ling-Dong Kong*. Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice. Molecular Nutrition & Food Research. 2012; 56(9): 1433-1444.
Dong-Mei Zhang, Yu-Cheng Li, De Xu, Xiao-Qin Ding, Ling-Dong Kong*. Protection of curcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signaling in rats. Food Chemistry 2012; 134(4): 2184–2193.
Chuang Wang, Ying Pan, Qing-Yu Zhang, Fu-Meng Wang, Ling-Dong Kong*. Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation PLoS One. 2012;7(6):e38285.
Yu-Jie Lou, Jian-Mei Li, Yan Lu, Xing Wang, Rui-Qing Jiao, Shui-Juan Wang, Ling-Dong Kong*. Aristolochic acid-induced destruction of organic ion transporters and fatty acid metabolic disorder in the kidney of rats. Toxicology Letters 2011; 201(1):72-79.
Xing Wang, Cai-Ping Wang, Qing-Hua Hu, Yao-Zhong Lv, Ling-Dong Kong*. The dual actions of Sanmiao wan as a hypouricemic agent: down-regulation of hepatic XOD and renal mURAT1 in hyperuricemic mice. Journal of Ethnopharmacology 2010; 128(1): 107-125.
Jian-Mei Li, Yu-Cheng Li, Ling-Dong Kong*, Qing-Hua Hu. Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology 2010; 51(5):1555-1566.
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