宫丽崑 - 中国科学院大学 -

个人简介

教育背景 2002-09--2005-07 中国科学院研究生院博士学历学位 1997-09--2000-06 中国医科大学硕士学历学位 1991-09--1996-07 中国医科大学学士学历学位工作简历 2011-09~现在, 中国科学院上海药物研究所, 研究员，课题组长，安评中心副主任 2006-11~2008-12,日本东京大学药学院, 日本学术振兴会（JSPS）外国人特别研究员 2005-10~2011-09,中国科学院上海药物研究所, 副研究员 2002-09~2005-07,中国科学院研究生院, 博士学历学位 2000-07~2011-07,中国科学院上海药物研究所, 安评中心专题负责人、部门负责人、中心机构负责人助理 1997-09~2000-06,中国医科大学, 硕士学历学位 1996-07~1997-09,沈阳理工大学医院, 医生 1991-09~1996-07,中国医科大学, 学士学历学位

近期论文

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Species-Specific Involvement of Integrin aIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys, Species-Specific Involvement of Integrin aIIbβ3 in a Monoclonal Antibody CH12 Triggers Off-Target Thrombocytopenia in Cynomolgus Monkeys, Molecular Therapy, 2018, 第 11 作者 Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms., Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms., Sci Rep, 2015, 第 11 作者 Hepatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in mice., Acta Pharmacol Sin., 2014, 第 3 作者 ROS generated by CYP450, especially CYP2E1, mediate mitochondrial dysfunction induced by tetrandrine in rat hepatocytes, ROS generated by CYP450, especially CYP2E1, mediate mitochondrial dysfunction induced by tetrandrine in rat hepatocytes, Acta Pharmacol Sin., 2013, 第 11 作者 A 26-week repeated-dose toxicity study of allisartan isoproxil in Sprague-Dawley rats., Drug Chem Toxicol., 2013, 第 11 作者 Computational Models for Predicting Interactions with Membrane Transporters., Current Medicinal Chemistry., 2013, 第 11 作者 Identification of BC005512 as a DNA Damage Responsive Murine Endogenous Retrovirus of GLN Family Involved in Cell Growth Regulation., PLoS One., 2012, 第 3 作者 Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I., Mol Pharm. , 2011, 第 1 作者 Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. , Toxicological Sciences, 2011, 第 1 作者 Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity., Toxicology letters., 2011, 第 11 作者 Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes, Drug Metab Dispos., 2011, 第 11 作者 Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II., Toxicological Sciences. , 2010, 第 11 作者 β-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP 1A dependent mechanism., Acta Pharmacologica Sinica, 2009, 第 11 作者 The construction of Williams design and randomization in cross-over clinical trials using SAS. , Journal of Statistical Software, Code Snippets, 2009, 第 3 作者