胡泽平 - 清华大学

个人简介

分别于山东大学齐鲁医学院、中国食品药品检定研究院和新加坡国立大学获学士、硕士和Ph.D.学位。后于美国西北太平洋国家实验室Richard D. Smith组从事生物质谱和代谢组学的博士后研究。2012年受聘于美国德克萨斯大学西南医学中心任研究助理教授、儿童研究所代谢组学平台技术主任。2016年12月起任清华大学药学院准聘系列PI、特别研究员。长期致力于基于组学技术研发的转化医学和药物研发研究，回国5年多来以通讯（含共同）作者在Journal of Clinical Investigation (2022), Nature Cardiovascular Research (2022), Nature Cancer (2022), Nature Metabolism (2021a; 2021b), Cell Metabolism (2018), Science Translational Medicine (2018), Nature Communications (2021a; 2021b), Cell Discovery (2022), Analytical Chemistry (2021), Particle and Fibre Toxicology (2022), FASEB Journal (2019), Pharmacology & Therapeutics (2021), Clinical Pharmacology & Therapeutics (2019) 等期刊发表论文15篇。此外，一系列重要的合作研究发表于Nature (5篇), Nature Genetics, Nature Cell Biology等期刊，共计发表论文60余篇，被引用6200余次。现（曾）主持国家基金委重大研究计划重点项目、“未来生物技术”原创探索项目、面上项目、科技部国家科技重大专项、重点研发专项等6项国家级科研项目。获邀担任Cell Research, Signal Transduction and Targeted Therapy, Nature Communications, Science Advances, Cell Reports, Trends in Analytical Chemistry等20余个期刊的审稿人，以及国家基金委和科技部的项目评审专家。荣誉和奖项 Bayer Investigator Award（2017）第十四届全国医药卫生青年科技论坛二等奖（2019）中国抗癌协会肿瘤代谢专委会年度优秀委员（2019）清华大学药学院优秀教学奖（2019） Bayer Investigator Award（2020）清华大学优秀博士论文导师（2022）

研究领域

药物新靶标的鉴定（发现与确证）是原创药物研发的关键，也是严重制约当前新药研发的关键瓶颈，亟需实现突破性发展。近年来越来越多的研究证明，除糖尿病、心血管疾病等典型代谢性疾病以外，绝大多数重大疾病，如癌症、病毒性传染病、免疫性疾病、神经退行性疾病等都与代谢异常密切相关。因此，针对疾病代谢异常的功能与分子机制进行深入研究，可以回答重要的基础代谢生物学问题，精准、高效地发现具有治疗靶标潜力的关键通路或分子，为转化医学和药物研发提供重要的潜在药物靶标。代谢组学、代谢流分析和多组学整合分析技术可以对代谢异常进行无偏差的全景式分析，并对其异常通路及分子机制进行深入研究，已经发展成为代谢研究的关键技术手段。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Nie M#, Chen N#, Pang H#, Jiang T#, Jiang W, Tian P, Yao L, Chen Y, DeBerardinis RJ, Li W, Yu Q, Zhou C, Hu ZP*. Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse. Journal of Clinical Investigation. 2022;e160152 Yuan M, Tu B, Li H, Pang H, Zhang N, Bai J, Shu Z, Christopher C, Huo S, Zhai J, Yao K, Wang L, Ying H, Zhu WG, Fu D, Hu ZP*, Zhao Y*. Cancer associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth. Nature Cancer. 2022;3(8):945-960.被Nature Cancer 的News & Views评论 (Tumor Microenvironment: NUFIP1+ stroma keeps PDAC fed, https://www.nature.com/articles/s43018-022-00421-x) Wang W#, Wang J#,*, Yao K#, Wang S#, Nie M, Xu J, Wu G, Lu M, Pei H, Luo X, Li D, Yang T, Li P, Song L*, Hu ZP*. Metabolic characterization of hypertrophic cardiomyopathy in human hearts. Nature Cardiovascular Research. 2022;1(1):445–461 Jiang Y*,#, Deng Y#, Pang H#, Ma T, Ye Q, Chen Q, Chen H, Hu ZP*, Qin CF*, Xu Z*. Treatment of SARS-CoV-2 induced pneumonia with NAD+ and NMN in two mouse models. Cell Discovery. 2022;8:38 Cheng W#, Pang H#, Campen MJ, Zhang J, Li Y, Gao J, Ren D, Ji X, Rothman N, Lan Q, Zheng Y, Leng S*, Hu ZP*, Tang J*. Circulatory metabolites trigger ex vivo arterial endothelial cell dysfunction in population chronically. Particle and Fibre Toxicology. 2022;19(1):20. Nie M#, Yao K#, Zhu X#, Chen N, Xiao N, Wang Y, Peng B, Yao LA, Li P, Zhang P*, Hu ZP*. Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma with therapeutic implications. Nature Communications. 2021;12(1):6479. 被Nature Reviews Cancer 选为Research Highlights (Metabolic Transitions, https://www.nature.com/articles/s41568-021-00438-x) Zhao J#, Yao K#, Yu H#, Zhang L#, Xu Y#, Chen L, Sun Z, Zhu Y, Zhang C, Qian Y, Ji S, Pang H, Zhang M, Chen J, Correia C, Weiskittel T, Lin DW, Zhao Y, Chandrasekaran S, Fu X, Zhang D, Fan HY, Xie W, Li H, Hu ZP*, Zhang J*. Metabolic remodeling during early murine embryo development. Nature Metabolism. 2021;3(10):1372-1384.被选为封面文章(https://www.nature.com/natmetab/volumes/3/issues/10)；被Science选为Editor’s Pick (Translational Metabolism, https://www.science.org/doi/10.1126/science.acx9416) Pang H#, Jiang Y#, Li J#, Wang Y#, Nie M#, Xiao N, Wang S, Song Z, Ji F, Chang Y, Zheng Y, Yao K, Yao L, Li S, Song L*, Lan X*, Xu Z*, Hu ZP*. Aberrant NAD+ metabolism underlies ZIKA virus-induced microcephaly. Nature Metabolism. 2021;3(8):1109-1124. 被Clarivate Analytics的BioWorld Science采访报道(https://www.bioworld.com/articles/510514-aberrant-nad-metabolism-underlies-zika-microcephaly) Xiao N#, Nie M#, Pang H#, Wang B#, Hu J#, Meng X, Li K, Ran X, Long Q, Deng H, Chen N, Li S, Tang N*, Huang A*, Hu ZP*. Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications. Nature Communications. 2021;12(1):1618. Meng X#, Pang H#, Sun F, Jin X, Wang B, Yao K, Yao L, Wang L, Hu ZP*. Simultaneous 3-nitrophenylhydrazine derivatization strategy of carbonyl, carboxyl and phosphoryl submetabolome for LC-MS/MS-based targeted metabolomics with improved sensitivity and coverage. Analytical Chemistry. 2021;93(29):10075-10083. Shi Z, Xu S, Xing S, Yao K, Zhang L, Xue L, Zhou P, Wang M, Yan G, Yang P, Liu J, Hu ZP*, Lan F*. Mettl17, a regulator of mitochondrial ribosomal RNA modifications, is required for the translation of mitochondrial coding genes. The FASEB Journal. 2019;33(11):13040-13050. Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu ZP*, DeBerardinis RJ*. Inosine monophosphate dehydrogenase dependence in a subset of small cell lung cancers. Cell Metabolism. 2018;28(3):369-382.e5. Li XK, Lu QB, Chen WW, Xu W, Liu R, Zhang SF, Du J, Li H, Yao K, Zhai D, Zhang PH, Xing B, Cui N, Yang ZD, Yuan C, Zhang XA, Xu Z, Cao WC*, Hu ZP*, Liu W*. Arginine deficiency is involved in thrombocytopenia and immunosuppression in Severe Fever with Thrombocytopenia Syndrome. Science Translational Medicine. 2018;10(459). pii: eaat4162. 被选为封面文章(https://www.science.org/toc/stm/10/459) Liang L, Sun F, Wang H, Hu ZP*. Metabolomics, metabolic flux analysis and cancer pharmacology. Pharmacology & Therapeutics. 2021;224:107827. (Invited Review) Pang H, Jia W*,Hu ZP*. Emerging applications of metabolomics in clinical pharmacology. Clinical Pharmacology and Therapeutics. 2019;106(3):544-556. (Invited Review) 唐嘉键, 胡泽平*. 代谢组学在精准用药研究中的应用进展. 沈阳药科大学学报. 2021;309(10):1113-1118 李文杰, 胡泽平*. 代谢流分析在肿瘤代谢研究中的应用进展. 中国医学前沿杂志（电子版）2019;11(2):18-22. 姚利昂, 胡泽平*. 肿瘤代谢重编程与药物耐药性. 中国医学前沿杂志（电子版）2019;11(2):23-27. Agathocleous M, Meacham C, Burgess RJ, Piskounova E, Bruner E, Cowin B, Crane GM, Murphy MM, Hu ZP, DeBerardinis RJ, Morrison SJ. Ascorbate regulates haematopoietic stem cell function and suppresses leukaemogenesis. Nature. 2017;549(7673):476-81. Kim J, Hu ZP, Cai L, Choi E, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Unsal-Kacmaz K, Pe?a CG, Castrillon DH, Chen BPC, Wistuba I, Minna JD, DeBerardinis RJ. CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature. 2017;546(7656):168-72. Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, Shah A, Zhang H, Faber JE, Kinter MT, Szweda LI, Xing C, Hu ZP, Deberardinis RJ, Schiattarella G, Hill JA, Oz O, Lu Z, Zhang CC, Kimura W, Sadek HA. Hypoxia induces heart regeneration in adult mice. Nature. 2017;541(7636):222-7. Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu ZP, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. Nature Cell Biology. 2017;19(6):626-38. Piskounova E, Agathocleous M, Murphy MM, Hu ZP, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ. Oxidative stress inhibits distant metastasis by human melanoma cells. Nature. 2015;527(7577):186-91. DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu ZP, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. 2015;47(12):1475-81. Srivastava N, Kollipara RK, Singh DK, Sudderth J, Hu ZP, Nguyen H, Wang S, Humphries CG, Carstens R, Huffman KE, DeBerardinis RJ, Kittler R. Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels. Cell Metabolism. 2014;20(4):650-61. Curtis MM, Hu ZP, Klimko C, Narayanan S, Deberardinis R, Sperandio V. The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape. Cell Host & Microbe. 2014;16(6):759-69. Hu ZP, Browne ER, Liu T, Angel TE, Ho PC, Chan EC. Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model. Journal of Proteome Research. 2012;11(12):5903-13.