赵锡海 - 清华大学

个人简介

05/2019 - now Tenured Associate Professor, Center for Biomedical Imaging Research (CBIR), Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 100084, China 09/2015 - now Vice Chair, Department of Radiology, Beijing Tsinghua Changgung Hospital, Beijing 102218, China 09/2013 - now Adjunct Professor, Beijing Institute for Brain Disorders, Beijing 100054, China 12/2015 - 05/2019 Tenure-Track Associate Professor, Center for Biomedical Imaging Research (CBIR), Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 100084, China 09/2010 - 12/2015 Tenure-Track Assistant Professor, Center for Biomedical Imaging Research (CBIR), Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 100084, China 09/2007 - 05/2010 Senior Research Fellow, Vascular Imaging Lab, Department of Radiology, University of Washington, Seattle 98109, USA. 09/2004 - 08/2007 Attending Physician in Radiology, Department of Radiology, Yangzhou People’s First Hospital, Yangzhou 225001, China 08/1999 - 08/2004 Resident in Radiology, Department of Radiology, Yangzhou People’s First Hospital, Yangzhou 225001, China

研究领域

Our research is focusing on the technical development and clinical application of cardiovascular imaging, particularly characterizing atherosclerosis, cardiomyopathy, and ischemic cerebral disease. The research interests include: Development of novel CT and MR cardiovascular imaging techniques; Investigation of cardiovascular disease risk in symptomatic and asymptomatic populations using noninvasive imaging; Determination of risk factors for the vulnerability of atherosclerotic plaques.

近期论文

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Cui B, Yang D, Zheng W, Wu Y, Yang Q, Wang Z, Zhao X. Plaque enhancement in multi-cerebrovascular beds associates with acute cerebral infarction. ActaRadiol. 2021 Jan;62(1):102-112. Wang Y, Li B, Jiang Y, Zhang R, Meng X, Zhao X, Wang Y, Zhao X, Liu G. YKL-40 Is Associated With Ultrasound-Determined Carotid Atherosclerotic Plaque Instability. Front Neurol. 2021 Feb 17;12:622869. Huo R, Xu H, Yang D, Qiao H, Li J, Han H, Liu Y, Wang T, Yuan H, Zhao X.Associations Between Carotid Plaque Characteristics and Improvement of Cerebral Blood Perfusion in Patients With Moderate to Severe Carotid Stenosis Undergoing Carotid Endarterectomy. J Magn Reson Imaging. 2021 Feb;53(2):613-625. Watase H, Shen M, Sui B, Gao P, Zhang D, Sun J, Balu N, Hippe DS, Jarvik GP, Zhao X, Li R, Chen S, Yuan C, Hatsukami TS. Differences in atheroma between Caucasian and Asian subjects with anterior stroke: A vessel wall MRI study. Stroke Vasc Neurol. 2021 Mar;6(1):25-32. Zheng J, Sun B, Lin R, Teng Y, Zhao X, Xue Y. Association between the vertebrobasilar artery geometry and basilar artery plaques determined by high-resolution magnetic resonance imaging. BMC Neurosci. 2021 Mar 25;22(1):20. Shi Z, Li J, Zhao M, Zhang M, Wang T, Chen L, Liu Q, Wang H, Lu J, Zhao X. Baseline Cerebral Ischemic Core Quantified by Different Automatic Software and Its Predictive Value for Clinical Outcome. Front Neurosci. 2021 Apr 12;15:608799. Li D, Qiao H, Han Y, Han H, Yang D, Cao J, Xu H, Wang T, Wang Y, Shen J, Zhao X. Histological validation of simultaneous non-contrast angiography and intraplaque hemorrhage imaging (SNAP) for characterizing carotid intraplaque hemorrhage. Eur Radiol. 2021 May;31(5):3106-3115. Xin R, Yang D, Xu H, Han H, Li J, Miao Y, Du Z, Ding Q, Deng S, Ning Z, Shen R, Li R, Li C, Yuan C, Zhao X. Comparing Symptomatic and Asymptomatic Carotid Artery Atherosclerosis in Patients With Bilateral Carotid Vulnerable Plaques Using Magnetic Resonance Imaging. Angiology. 2021 May 21:33197211012531. Meng Q, Xie X, Li L, Jiang C, Zhao K, Bai Z, Zheng Z, Yang Y, Yu Y, Zhang H, Zhao X. Assessment of neovascularization of carotid artery atherosclerotic plaques using superb microvascular imaging: a comparison with contrast-enhanced ultrasound imaging and histology. Quant Imaging Med Surg. 2021 May;11(5):1958-1969. Zhou Z, Chen S, Balu N, Chu B, Zhao X, Sun J, Mossa-Basha M, Hatsukami T, B?rnert P, Yuan C. Neural network enhanced 3D turbo spin echo for MR intracranial vessel wall imaging. Magn Reson Imaging. 2021 May;78:7-17. Ning Z, Chen S, Sun H, Shen R, Qiao H, Han H, Yang D, Zhao X. Evaluating renal arterial wall by non-enhanced 2D and 3D free-breathing black-blood techniques: Initial experience. Magn Reson Imaging. 2021 Jun;79:5-12. Deng S, Zheng J, Wu Y, Yang D, Chen H, Sun B, Xue Y, Zhao X. Geometrical characteristics associated with atherosclerotic disease in the basilar artery: a magnetic resonance vessel wall imaging study. Quant Imaging Med Surg. 2021 Jun;11(6):2711-2720. Wang Y, Zhang L, Ning J, Zhang X, Li X, Zhang L, Chen G, Zhao X, Wang X, Yang S, Yuan C, Dong J, Chen H. Preoperative Remnant Liver Function Evaluation Using a Routine Clinical Dynamic Gd-EOB-DTPA-Enhanced MRI Protocol in Patients with Hepatocellular Carcinoma. Ann Surg Oncol. 2021 Jul;28(7):3672-3682. Liu Y, Han Y, Guan M, Cai Y, Wang W, Chen H, Zhao X. Added value of femoral artery atherosclerosis for determining severity of white matter lesion by carotid atherosclerosis: a magnetic resonance imaging study. Acta Radiol. 2021 Aug;62(8):1112-1121. Lu MM, Peng P, Hatsukami TS, Yuan F, Cui YY, Zhang LC, Qiao HY, Yuan C, Cai JM, Zhao XH. A comparison of carotid atherosclerosis in symptomatic patients between 2002-2005 and 2012-2015 cohorts using multi-contrast magnetic resonance vessel wall imaging. J Geriatr Cardiol. 2021 Aug 28;18(8):623-630. Zhang L, Zhu L, Lu M, Zhao X, Li F, Cai J, Yuan C. CARE-II investigators. Comparison of Carotid Plaque Characteristics Between Men and Women Using Magnetic Resonance Vessel Wall Imaging: A Chinese Atherosclerosis Risk Evaluation Study. J Magn Reson Imaging. 2021 Aug;54(2):646-654. Li Y, Wang Y, Qi H, Hu Z, Chen Z, Yang R, Qiao H, Sun J, Wang T, Zhao X, Guo H, Chen H. Deep learning-enhanced T1 mapping with spatial-temporal and physical constraint. Magn Reson Med. 2021 Sep;86(3):1647-1661. Chen L, Zhao H, Jiang H, Balu N, Geleri DB, Chu B, Watase H, Zhao X, Li R, Xu J, Hatsukami TS, Xu D, Hwang JN, Yuan C. Domain adaptive and fully automated carotid artery atherosclerotic lesion detection using an artificial intelligence approach (LATTE) on 3D MRI. Magn Reson Med. 2021 Sep;86(3):1662-1673. Wang E, Wu C, Yang D, Zhao X, Zhao J, Chang H, Yang Q. Association between fluid-attenuated inversion recovery vascular hyperintensity and outcome varies with different lesion patterns in patients with intravenous thrombolysis. Stroke Vasc Neurol. 2021 Sep;6(3):449-457. Song X, Wei Q, Zhao X, Hou D, Zhao H, Wang L, Zhang X, Zheng Z, Wu J. Association between Short-Term Blood Pressure Variability and Intracranial Atherosclerotic Plaque Vulnerability: A High-Resolution Magnetic Resonance Imaging Study. J Atheroscler Thromb. 2021 Oct 28. Chi Z, Yi Y, Wang Y, Wu M, Wang L, Zhao X, Meng Y, Zheng Z, Zhao Q, Zhou J. Adaptive Cylindrical Wireless Metasurfaces in Clinical Magnetic Resonance Imaging. Adv Mater. 2021 Oct;33(40):e2102469. Ning Z, Zhang N, Qiao H, Han H, Shen R, Yang D, Chen S, Zhao X. Free-breathing three-dimensional isotropic-resolution MR sequence for simultaneous vessel wall imaging of bilateral renal arteries and abdominal aorta: Feasibility and reproducibility. Med Phys. 2021 Dec 30. Lu M, Zhang H, Liu D, Liu X, Zhang L, Peng P, Yuan F, Liu S, Sheng F, Liu Y, He Y, Zhao X, Zhang Q, Fu H, Han C, Cai J. Association of intracranial vessel wall enhancement and cerebral hemorrhage in moyamoya disease: a high-resolution magnetic resonance imaging study. J Neurol. 2021 Dec;268(12):4768-4777. Jiang C, Zhang J, Zhu J, Wang X, Wen Z, Zhao X, Yuan C. CARE-II Investigators. Association between coexisting intracranial artery and extracranial carotid artery atherosclerotic diseases and ipsilateral cerebral infarction: a Chinese Atherosclerosis Risk Evaluation (CARE-II) study. Stroke Vasc Neurol. 2021 Dec;6(4):595-602. Baylam Geleri D, Watase H, Chu B, Chen L, Zhao H, Zhao X, Hatsukami TS, Yuan C. CARE-II Study Collaborators. Detection of Advanced Lesions of Atherosclerosis in Carotid Arteries Using 3-Dimensional Motion-Sensitized Driven-Equilibrium Prepared Rapid Gradient Echo (3D-MERGE) Magnetic Resonance Imaging as a Screening Tool. Stroke. 2022 Jan;53(1):194-200. Wang Y, Zhang L, Ning J, Zhang X, Li X, Zhang L, Chen G, Zhao X, Wang X, Yang S, Yuan C, Dong J, Chen H. Preoperative Remnant Liver Function Evaluation Using a Routine Clinical Dynamic Gd-EOB-DTPA-Enhanced MRI Protocol in Patients with Hepatocellular Carcinoma. Ann Surg Oncol. 2020 Nov 23. Epub ahead of print. Liu S, Wu X, He S, Song X, Shang F, Zhao X. Identification of White Matter Lesions in Patients With Acute Ischemic Lesions Using U-net. Front Neurol. 2020 Sep 30;11:1008. Li D, Qiao H, Han Y, Han H, Yang D, Cao J, Xu H, Wang T, Wang Y, Shen J, Zhao X. Histological validation of simultaneous non-contrast angiography and intraplaque hemorrhage imaging (SNAP) for characterizing carotid intraplaque hemorrhage. Eur Radiol. 2020 Oct 14. Epub ahead of print. Huo R, Xu H, Yang D, Qiao H, Li J, Han H, Liu Y, Wang T, Yuan H, Zhao X. Associations Between Carotid Plaque Characteristics and Improvement of Cerebral Blood Perfusion in Patients With Moderate to Severe Carotid Stenosis Undergoing Carotid Endarterectomy. J Magn Reson Imaging. 2021 Feb;53(2):613-625. Shi H, Shao S, Wang G, Zhao X, Li R, Yao B, Sun Q, Watase H, Hippe DS, Yuan C; CARE-II Investigators. Bilaterally Asymmetric Associations Between Extracranial Carotid Artery Atherosclerosis and Ipsilateral Middle Cerebral Artery Stenosis in Symptomatic Patients: A CARE-II Study. Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2965-2974. Liu Y, Han Y, Guan M, Cai Y, Wang W, Chen H, Zhao X. Added value of femoral artery atherosclerosis for determining severity of white matter lesion by carotid atherosclerosis: a magnetic resonance imaging study. Acta Radiol. 2020 Aug 18:284185120950106. Epub ahead of print. Watase H, Shen M, Sui B, Gao P, Zhang D, Sun J, Balu N, Hippe DS, Jarvik GP, Zhao X, Li R, Chen S, Yuan C, Hatsukami TS. Differences in atheroma between Caucasian and Asian subjects with anterior stroke: A vessel wall MRI study. Stroke Vasc Neurol. 2020 Aug 13:svn-2020-000370. Epub ahead of print. Li H, Xu H, Li Y, Jiang Y, Hu Y, Liu T, Tian X, Zhao X, Zhu Y, Wang S, Zhang C, Ge J, Wang X, Wen H, Bai C, Sun Y, Song L, Zhang Y, Hui R, Cai J, Chen J. Alterations of gut microbiota contribute to the progression of unruptured intracranial aneurysms. Nat Commun. 2020 Jun 25;11(1):3218. Shi X, Liu S, Lin X, Zhao X, Fang L, Ding J, Dang Y, Xing H, Han C, Dong C, Hsu B, Fang W, Li F, Huo L, Knuuti J. Characterization of myocardial oxidative metabolism and myocardial external efficiency in high-risk alcohol cardiotoxicity and alcoholic cardiomyopathy via dynamic 11C-Acetate positron emission tomography. J Nucl Cardiol. 2020 Jun 18. Epub ahead of print. Qiao H, Cai Y, Huang M, Liu Y, Zhang Q, Huang L, Chen H, Yuan C, Zhao X. Quantitative assessment of carotid artery atherosclerosis by three-dimensional magnetic resonance and two-dimensional ultrasound imaging: a comparison study. Quant Imaging Med Surg. 2020 May;10(5):1021-1032. Qiao H, Li D, Cao J, Qi H, Han Y, Han H, Xu H, Wang T, Chen S, Chen H, Wang Y, Zhao X. Quantitative evaluation of carotid atherosclerotic vulnerable plaques using in vivo T1 mapping cardiovascular magnetic resonaonce: validation by histology. J Cardiovasc Magn Reson. 2020 May 21;22(1):38. Yang D, Liu Y, Han Y, Li D, Wang W, Li R, Yuan C, Zhao X. Signal of Carotid Intraplaque Hemorrhage on MR T1-Weighted Imaging: Association with Acute Cerebral Infarct. AJNR Am J Neuroradiol. 2020 May;41(5):836-843. Yang D, Ji Y, Wang D, Watase H, Hippe DS, Zhao X, Yuan C. Comparison of carotid atherosclerotic plaques between subjects in Northern and Southern China: a Chinese atherosclerosis risk evaluation study. Stroke Vasc Neurol. 2020 Jun;5(2):138-145. Xu HM, Huo R, Xin RJ, Yang DD, Liu Y, Lang N, Zhao XH, Wang T, Yuan HS. Association of atherosclerotic plaque features with collateral circulation status in elderly patients with chronic carotid stenosis. J Geriatr Cardiol. 2020 Apr;17(4):202-209. Cui B, Yang D, Zheng W, Wu Y, Yang Q, Wang Z, Zhao X. Plaque enhancement in multi-cerebrovascular beds associates with acute cerebral infarction. Acta Radiol. 2021 Jan;62(1):102-112. Song X, Zhao X, Liebeskind DS, Wang L, Xu W, Xu Y, Hou D, Zheng Z, Wu J. Incremental value of plaque enhancement in predicting stroke recurrence in symptomatic intracranial atherosclerosis. Neuroradiology. 2020 Sep;62(9):1123-1131. Liu S, Lin X, Shi X, Fang L, Huo L, Shang F, Knuuti J, Han C, Wu X, Guo R, Ding H, Zhang R, Duan H, Ding J, Xing H, Zhao X. Myocardial tissue and metabolism characterization in men with alcohol consumption by cardiovascular magnetic resonance and 11C-acetate PET/CT. J Cardiovasc Magn Reson. 2020 Apr 16;22(1):23. Jiang P, Chen Z, Hippe DS, Watase H, Sun B, Lin R, Yang Z, Xue Y, Zhao X, Yuan C. Association Between Carotid Bifurcation Geometry and Atherosclerotic Plaque Vulnerability: A Chinese Atherosclerosis Risk Evaluation Study. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1383-1391. Song X, Zhao X, Liebeskind DS, Xu W, Zhang J, Wei C, Xu Y, Wang L, Zheng Z, Wu J. Associations between systemic blood pressure parameters and intraplaque hemorrhage in symptomatic intracranial atherosclerosis: a high-resolution MRI-based study. Hypertens Res. 2020 Jul;43(7):688-695. Wei H, Zhang M, Li Y, Zhao X, Canton G, Sun J, Xu D, Zhou Z, Chen S, Ferguson MS, Hatsukami TS, Li R, Yuan C. Evaluation of 3D multi-contrast carotid vessel wall MRI: a comparative study. Quant Imaging Med Surg. 2020 Jan;10(1):269-282. Li J, Li D, Yang D, Hang H, Wu Y, Yao R, Chen X, Xu Y, Dai W, Zhou D, Zhao X. Irregularity of Carotid Plaque Surface Predicts Subsequent Vascular Event: A MRI Study. J Magn Reson Imaging. 2020 Jul;52(1):185-194. Li J, Li D, Yang D, Huo R, Chen X, Xu Y, Dai W, Zhou D, Zhao X. Co-existing cerebrovascular atherosclerosis predicts subsequent vascular event: a multi-contrast cardiovascular magnetic resonance imaging study. J Cardiovasc Magn Reson. 2020 Jan 13;22(1):4. Zhou D, Li J, Liu D, Ji LY, Wang NQ, Deng J, Wang JC, Ye M, Zhao XH. Irregular surface of carotid atherosclerotic plaque is associated with ischemic stroke: a magnetic resonance imaging study. J Geriatr Cardiol. 2019 Dec;16(12):872-879. Murata K, Murata N, Chu B, Watase H, Hippe DS, Balu N, Sun J, Zhao X, Hatsukami TS, Yuan C; CARE-II Study Collaborators. Characterization of Carotid Atherosclerotic Plaques Using 3-Dimensional MERGE Magnetic Resonance Imaging and Correlation With Stroke Risk Factors. Stroke. 2020 Feb;51(2):475-480. Cao Y, Zhao X, Watase H, Hippe DS, Wu Y, Zhang H, Yue L, Canto GM, Song Y, Shi H, Wang G, Li R, Bao H, Yuan C; investigators of CARE-II study. Comparison of Carotid Atherosclerosis between Patients at High Altitude and Sea Level: A Chinese Atherosclerosis Risk Evaluation Study. J Stroke Cerebrovasc Dis. 2020 Feb;29(2):104448. Lu M, Yuan F, Zhang L, Peng P, Qiao H, Cai J, Zhao X. Segment-specific progression of carotid artery atherosclerosis: a magnetic resonance vessel wall imaging study. Neuroradiology. 2020 Feb;62(2):211-220.