刘晓玲 - 清华大学

个人简介

刘晓玲博士于2000年获得北京大学细胞分子与遗传专业博士学位，之后在荷兰癌症研究所做博士后研究工作，2008年任职于清华大学，现为清华大学医学院医学实验教学中心主任。刘晓玲博士作为清华大学医学院医学实验教学中心的首任主任，从头规划并建设医学实验教学中心，创建了由形态学实验平台（医学标本馆、组织胚胎与发育实验室、病理学实验室）、机能学实验平台（医学生理实验室、病生理实验室、医学遗传学实验室）、病原与免疫实验平台（微生物学实验室、人体寄生虫实验室、免疫学实验室）所组成的全面完整的基础医学实验教学体系。

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*Marieke van de Ven, *Liu X, Eline van der burg, Sjoerd Klaren beek, Xanthippi Alexi, Wilbert Zwart, Fred Dijcks, Peter Bouwman and Jos Jonkers. BRCA1-assiciated mammary tumorigenesis is dependent on oestrogen rather that progesterone signalling. Journal of Pathology. 2018 Sep; 246(1):41-53.*equal contribution *Liu X, Holstege H, van der Gulden H, Treur-Mulder M, Zevenhoven J, Velds A, Kerkhoven RM, van Vliet MH, Wessels LF, Peterse JL, Berns A, Jonkers J. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6. This article has been highlighted by Nature Reviews Cancer, 2007, Sept. Vol.7: nrc 2213 Wijnhoven SW, Speksnijder EN, Liu X, Zwart E, vanOostrom CT, Beems RB, Hoogervorst EM, Schaap MM, Attardi LD, Jacks T, van Steeg H, Jonkers J, de Vries A. Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage. Cancer Res. 2007 May 15;67(10):4648-56. Silver DP, Dimitrov SD, Feunteun J, Gelman R, Drapkin R, Lu SD, Shestakova E, Velmurugan S, Denunzio N, Dragomir S, Mar J, Liu X, Rottenberg S, Jonkers J, Ganesan S, Livingston DM. Further evidence for BRCA1 communication with the inactive X chromosome. Cell. 2007 Mar 9;128(5):991-1002. Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, Peterse JL, Cardiff RD, Berns A, Jonkers J. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell. 2006 Nov;10(5):437-49.