个人简介
清华大学医学院长聘教授，博士，博士生导师。1978-1989就读于西北农业大学并获博士学位，1995-1998在美国圣路易斯大学、华盛顿大学和阿拉巴马大学等医学院从事访问学者和博士后研究。1990-1995受聘西北农业大学副教授，1998-2005受聘清华大学副教授，2005年至今受聘清华大学教授。从事信号转导和肿瘤发生机理的研究，发表Cancer Cell, Molecular Cell, Nature Communications, Cell Research, Oncogene, JCB, CMI和Theranostics等SCI期刊论文120篇，被引用4900多篇次。获北京市科技进步三等奖，青海省科技进步一等奖。目前担任《FEBS Letter》编委。
近期论文
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Liu Yang, et.al. & Zhijie Chang*. CREPT is required for murine stem cell maintenance during intestinal regeneration. Nat Commun. 12(1):270, 2021.
Wanli Zhai, et.al. & Zhijie Chang*. CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner. Br J Cancer. doi: 10.1038/s41416-021-01269-1. Feb 3, 2021.
Mengdi Li, et.al. & Zhijie Chang*. Current understanding of CREPT and p15RS, carboxy-terminal domain (CTD)- interacting proteins, in human cancers. Oncogene. 40(4):705-716, 2021.
Sihan Liu, et.al, Zhijie Chang* & Shigao Yang*. A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering. Cell Mol Immunol. doi: 10.1038/s41423-020-00548-w. Sep 22, 2020.
Yajun Cao, et.al. & Zhijie Chang*. A safety consideration of mesenchymal stem cell therapy on COVID-19. Stem Cell Res. 49:102066, 2020.
Danhui Ma, et.al. & Zhijie Chang*. A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer. Theranostics. 10(8): 3708–3721, 2020.
Chunxiao Liu, et.al. & Zhijie Chang*. Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells. Theranostics. 14;9(5):1369-1384, 2019.
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