张伟 - 清华大学 - 生命科学学院

个人简介

2000-2004年山东大学生命科学学院学士 2004-2010年中国科学院神经科学研究所博士 2010-2016年加州大学旧金山分校/霍华德休斯医学院博士后 2017年至今清华大学生命科学学院助理教授、副教授 2017年至今清华大学生命联合中心/清华-IDG/麦戈文脑科学研究院研究员

研究领域

大脑与体内器官的双向交流由复杂的神经和激素系统控制，对维持人体的生理和心理稳态起着至关重要的作用。体内感受不仅广泛参与本能行为的调控，还会影响高级认知行为，例如记忆、情绪和自我意识。我们实验室采用“受体的生物物理学--神经元的细胞生物学—神经环路的功能学—动物行为学”这一自下而上的模式，探讨体内感受的分子与神经环路机制。

近期论文

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Selected Publications Chenxi Liu*, Wei Zhang*. Molecular basis of somatosensation in insects. Current Opinion in Neurobiology, 2022 Yinjun Jia*, Shuaishuai Li, Xuan Guo, Bo Lei, Junqiang Hu, Xiao-Hong Xu, Wei Zhang*, Selfee, self-supervised features extraction of animal behaviors. Elife, 2022 Liwei Zhang*#, Xuan Guo#, Wei Zhang*. Nutrients and pheromones promote insulin release to inhibit courtship drive. Science Advances. 2022 Tingting Yang, Zixuan Yuan, Chenxi Liu, Ting Liu, Wei Zhang*. A neural circuit integrates pharyngeal sensation to control feeding. Cell Reports. 2021. Rui Luo, Yuxiang Zhang, Yinjun Jia, Yan Zhang, Zongyang Li, Jieqing Zhao, Ting Liu, Wei Zhang*. Molecular basis and homeostatic regulation of Zinc taste. Protein & Cell. 2021. Philip Hehlert, Wei Zhang, Martin C G?pfert, Drosophila Mechanosensory Transduction, Trends in Neurosciences, Volume 44, Issue 4, 323 - 335 Pingping Wang, Yinjun Jia, Ting Liu, Yuh-Nung Jan*, Wei Zhang*. Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor. Neuron. 2020. Chenxi Liu, Bei Zhang, Liwei Zhang, Tingting Yang, Zhewei Zhang, Zihua Gao, Wei Zhang. A neural circuit encoding mating states tunes defensive behavior in Drosophila. Nature Communications. 2020. Liwei Zhang#*, Jie Yu#, Xuan Guo, Jianhua Wei, Ting Liu, Wei Zhang*. Parallel mechanosensory pathways direct oviposition decision of Drosophila. Current Biology. 2020. Yawen Li #, Yufei Hu#, Jiawei Wang, Xin Liu*, Wei Zhang*; Linfeng Sun*. Structural Insights into a Plant Mechanosensitive Ion Channel MSL1. Cell Reports. 2020. Yufei Hu, Zhilin Wang, Ting Liu, Wei Zhang*. Piezo-like Gene Regulates Locomotion in Drosophila Larvae. Cell Reports. 2019. Publications before joining Tsinghua Zhang, W.*, Cheng, L.E.*, Kittelmann, M.*, Li, J., Petkovic, M., Cheng, T., Jin, P., Guo, Z., G?pfert, M., Jan, L.Y., Jan, Y.N. (2015). Ankyrin Repeats Act as a Tether for Conveying Force to Gate the NOMPC Mechanotransduction Channel. Cell. 10 September 2015, 162, Issue 6, p1391–1403. *: Co-first authors. Zhang, W*., Yan, Z.*, Li, B., Jan, Y.L., Jan, Y.N. (2014). Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae. eLife. 2014; 10.7554/eLife.03293. *: Co-first authors. Zhang, W., Yan, Z., Jan, Y.L., Jan, Y.N. (2013). Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae. P.N.A.S. vol. 110, no. 33. Yan, Z.*, Zhang, W.*, He, Y., Gorczyca, D., Xiang, Y., Cheng, L., Meltzer, S., Jan, Y.L., Jan, Y.N. (2013). Drosophila NompC is a mechanotransduction channel subunit for gentle-touch sensation. Nature. 2013 Jan 10; 493(7431): 221-5. *: Co-first authors.