罗三中 - 清华大学

个人简介

EDUCATION 1995.9-1999.7: B.Sc.Zhengzhou University 1999.9-2002.7: M.Sc.Department of Chemistry, Nankai University 2002.9-2004.3: Ph.D.Institute of Chemistry, Chinese Academy of Sciences 2004.3-2005.4: Visiting scholar The Ohio-State University, USA ( P. G. Wang) 2009.1-2009.9: Visiting scholar Stanford University, USA (with B. M. Trost) ACADEMIC CAREER 2005.7: Assistant Professor, ICCAS 2007.10-2011.5: Associate Professor and Principal Investigator, ICCAS 2011-2017: Professor, ICCAS 2017-present: Professor, Tsinghua University ACADEMIC AWARDS 2018: Innovation Leading Scholar, National Ten-thousands Program 2017: POC Youth Award of Chinese Chemical Society 2016: Chiral Youth Award of Chinese Chemical Society (CCS) 2014: National May 4th Youth Medal (“Wu Si” Medal) 2014: Innovation Award for Teaching, ICCAS 2013: Excellence in Research and Management, CAS Beijing Division 2012: National Program for Support of Top-notch Young Professionals 2012: Thieme Journal Award 2011: elected President of Youth Innovation Promotion Association, CAS (2013, re-elected) 2011: Asia Core Program Lectureship 2010: National Science Fund for Distinguished Young Scholar 2009: Lu Jiaxi Young Scientist Award of the Chinese Academy of Science 2008: Young Chemist Award of the Chinese Chemical Society 2007: Rising Star of Science and Technology Research in Beijing

研究领域

Bio-inspired catalysis. One of our primary research goal is to invent and develop novel enantioselective catalysts that enable transformations with fundamental synthetic interests and broad utility. Inspired by Nature, we’re particularly interested in the development of viable small molecular catalysts that operate through novel activation modes using enzymatic principles and strategies. We emphasize the physical organic investigations of these catalytic processes with a long term goal toward rational design and evolution of new catalysts. Therefore, combined experimental and theoretical approaches including DFT calculations and machine learning will be harnessed for this purpose. Physical organic chemistry and Machine learning. Most synthetic reactions are developed via empirical approaches, relying on chemists’ intuition, experience, domain knowledge and occasionally serendipity. Precise and on-time prediction of chemical reactivity, a central yet enduring theme in synthetic chemistry, remains a great challenge. In the Luo group, we investigate the mechanism and underlying principles of molecular catalysis following physical organic chemistry strategies and approaches. These efforts would provide guidance to expand the catalytic applicability and to aid in methodology-development with depth not possible otherwise. We also develop machine learning tools for molecular catalysis and synthesis on the basis of physical organic chemistry. The data-driven approach, which is also rooted in the history of physical organic chemistry, represents a paradigm shift in the development and evolution of molecular catalysis. Our major research topics include: Standard molecular datasets (DeepSynthesis) (3D)-molecular descriptors (SPOC) Close loop AI Catalysis Molecular catalysis for function and energy. We try to expand the domain of organocatalysis to those uncharted territories, namely fringes of molecular catalysis, or molecular fringe catalysis following the concept of Kevin Kelly. We are interested in exploring chiral chemistry at both molecular and supramolecular level from the view-points of molecular catalysis. We’d like to focus new mode and function of molecular catalysis beyond bond formations. Key topics include: Absolute asymmetric catalysis and synthesis Stereocontrolled polymerization Interphase molecular catalysis

近期论文

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Catalytic Asymmetric Visible-Light de Mayo Reaction by ZrCl4-Chiral Phosphoric Acid Complex Wenzhao Zhang, Long Zhang, Sanzhong Luo*J. Am. Chem. Soc. 2023, DOI 10.1021/jacs.3c05334. Asymmetric α-allylic allenylation of β-ketocarbonyls and aldehydes by synergistic Pd/chiral primary amine catalysis Chang You, Mingying Shi, Xueling Mi*, Sanzhong Luo*Nat. Commun. 2023, 14, 2911. Visible Light-Promoted Enantioselective Aerobic Hydroxylation of β-Ketocarbonyls by Chiral Primary Amine Catalysis Mao Cai, Kaini Xu, Haoyuan Jia, Long Zhang, Xueling Mi*, Sanzhong Luo*ACS Catal. 2023, 13, 7538–7543. Catalytic Deracemization Reactions Mouxin Huang, Tianrun Pan, Xieyang Jiang, Sanzhong Luo*J. Am. Chem. Soc. 2023, 145, 10917–10929. Biomimetic asymmetric catalysis Xiao Xiao, Kaini Xu, Zhong-Hua Gao, Zhou-Hao Zhu, Changqing Ye, Baoguo Zhao, Sanzhong Luo, Song Ye, Yong-Gui Zhou, Senmiao Xu, Shou-Fei Zhu, Hongli Bao, Wei Sun, Xiaoming Wang, Kuiling Ding Sci. China Chem. 2023, 66, DOI 10.1007/s11426-023-1578-y. Prediction of Nucleophilicity and Electrophilicity Based on a Machine Learning Approach Yidi Liu, Qi Yang, Junjie Cheng, Long Zhang,* Sanzhong Luo,* and Jin-Pei Cheng ChemPhysChem 2023, e202300162. Enantioselective alkoxylation with electrogenerated chiral carbocation intermediates Qifeng Lin, Yingdong Duan, Yao Li, Ruijun Jian, Long Zhang, Yu Xia, Sanzhong Luo* ChemRxiv 2023, DOI 10.26434/chemrxiv-2023-xtv4f. Visible Light Promoted Direct Deuteration of Alkenes via Co(III)–H Mediated H/D Exchange Zongbin Jia, Sanzhong Luo* CCS Chem. 2023, 5, 1069-1076. Bio-inspired Small Molecular Catalysis Mao Cai, Runze Zhang, Chunming Yang, Sanzhong Luo* Chin. J. Chem. 2023, 41, 548-559. Electrophotochemical Metal-Catalyzed Enantioselective Decarboxylative Cyanation Kai Yang, Yukang Wang, Sanzhong Luo, Niankai Fu* Chem. Eur. J. 2023, 29, e202203962. Organosulfide catalysis for chiral iodinated molecules Yingdong Duan, Sanzhong Luo* Chem. Cata. 2022, 2, 2828-2830. Visible-Light Promoted De Mayo Reaction by Zirconium Catalysis Wenzhao Zhang, Sanzhong Luo* Chem. Commun. 2022, 58, 12979-12982. Catalytic Asymmetric Dearomatization (CADA) through Activation of Ynamide by Chiral Brønsted Acids Wenzhao Zhang, Sanzhong Luo* Chin. J. Org. Chem. 2022, 42, 1562-1564. Chiral Primary Amine Catalyzed α-Arylation of Simple Ketones via Asymmetric Retro-Claisen Cleavage Yanfang Han, Mingying Shi, Xueling Mi, Sanzhong Luo* Chem. Eur. J. 2022, e202202584. Electrophotochemical Metal-Catalyzed Decarboxylative Coupling of Aliphatic Carboxylic Acids Kai Yang, Jiaqing Lu, Liubo Li, Sanzhong Luo, Niankai Fu* Chem. Eur. J. 2022, e202202370. Catalytic Asymmetric α-Alkylsulfenylation with a Disulfide Reagent Mingying Shi, Qi Zhang, Jiali Gao, Xueling Mi*, and Sanzhong Luo* Angew. Chem. Int. Ed. 2022, 134, e202209044. Asymmetric C–H Dehydrogenative Allylic Alkylation by Ternary Photoredox-Cobalt-Chiral Primary Amine Catalysis under Visible Light Zongbin Jia, Long Zhang, and Sanzhong Luo* J. Am. Chem. Soc. 2022, 144, 10705–10710. An Ensemble Structure and Physicochemical (SPOC) Descriptor for Machine-Learning Prediction of Chemical Reaction and Molecular Properties Qi Yang, Yidi Liu, Junjie Cheng, Dr. Yao Li, Siyuan Liu, Yingdong Duan, Prof. Long Zhang*, Prof. Dr. Sanzhong Luo* ChemPhysChem 2022, 23, e202200255. Highly Stereoselective Construction of β,β-Diaryl-α-Branched Ketones by the Chiral Primary Amine-Catalyzed Asymmetric Retro-Claisen Reaction Yanfang Han, Long Zhang, and Sanzhong Luo* Org. Lett. 2022, 24, 1752–1756. Asymmetric Coupling of β-Ketocarbonyls and Alkynes by Chiral Primary Amine/Rh Synergistic Catalysis Jie Zhang, Yaning Wang, Chang You, Mingying Shi, Xueling Mi*, and Sanzhong Luo Org. Lett. 2022, 24, 1186-1189. Bond Energies of Enamines Yao Li, Long Zhang, Sanzhong Luo* ACS Omega 2022, 7, 6354-6374. Deracemization through photochemical E/Z isomerization of enamines Mouxin Huang, Long Zhang, Tianrun Pan, Sanzhong Luo* Science 2022, 375, 869-874. Bio-inspired lanthanum-ortho-quinone catalysis for aerobic alcohol oxidation: semi-quinone anionic radical as redox ligand Ruipu Zhang, Runze Zhang, Ruijun Jian, Long Zhang, Ming-Tian Zhang, Yu Xia, Sanzhong Luo* Nature Commun. 2022, 13, 428-438. Catalytic asymmetric oxidative sulfenylation of β-ketocarbonyls using a chiral primary amine Qi Zhang, Mingying Shi, Xueling Mi and Sanzhong Luo* Org. Chem. Front. 2022, 9, 1276-1281. uantitative Thermodynamic and Kinetic Parameters of Radical Mouxin Huang, Zongbin Jia, Sanzhong Luo*, Jin-Pei Cheng* Chin. J. Org. Chem. 2021, 41, 3892-3902. Catalytic Asymmetric Addition and Telomerization of Butadiene with Enamine Intermediates Yaning Wang, Jie Zhang, Chang You, Xueling Mi* and Sanzhong Luo* CCS Chem. 2021, 3, 2622–2630. Photoredox-Mediated Asymmetric Cross-Dehydrogenative Coupling of Enones and Tertiary Amines by Chiral Primary Amine Catalysis Zongbin Jia, Qi Yang, Sanzhong Luo* Synthesis 2021, 53, 2809-2818. Amine/Ketone Cooperative Catalysis with H2O2 Mao Cai, and Sanzhong Luo* Trend. Chem. 2021, 3, 892-893. Catalytic Asymmetric Disulfuration by a Chiral Bulky Three‐Component Lewis Acid‐Base Qi Zhang, Yao Li, Long Zhang, Sanzhong Luo* Angew. Chem. Int. Ed. 2021, 60, 10971-10976. Chiral Primary Amine/Ketone Cooperative Catalysis for Asymmetric α-Hydroxylation with Hydrogen Peroxide Mao Cai, Kaini Xu, Yuze Li, Zongxiu Nie, Long Zhang* and Sanzhong Luo* J. Am. Chem. Soc. 2021, 143, 1078-1087. Bio-Inspired ortho-Quinone Catalysis Ruipu Zhang, Runze Zhang, Sanzhong Luo* Progress in Chemistry 2020, 32, 1753-1765. Application of Machine Learning in Organic Chemistry Yidi Liu, Qi Yang, Yao Li, Long Zhang*, Sanzhong Luo* Chin. J. Org. Chem. 2020, 40, 3812-3827. Chiral Primary Amine-Catalyzed Divergent Coupling of α-Substituted Acrylaldehydes with α-Diazoesters Zaikun Xue, Yao Li, and Sanzhong Luo* ACS Catal. 2020, 10, 10989-10998. Tailoring Radical by Asymmetric Electrochemical Catalysis Qifeng Lin, Sanzhong Luo* Org. Chem. Front. 2020, 7, 2997-3000. Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions Transformation Yuntao Zhou, Irene Piergentili, Jennifer Hong, Michelle P. van der Helm, Mariano Macchione, Yao Li, Rienk Eelkema*, and Sanzhong Luo* Org. Lett. 2020, 22, 6035-6040. Chirality Tailor: Stereodivergent Pd/Cu Dual Metal Catalysis for the Dynamic Kinetic Asymmetric Transformation Yaning Wang, Sanzhong Luo* Chin. J. Org. Chem. 2020, 40, 2161-2163. Collective enantioselective total synthesis of (+)-sinensilactam A, (+)-lingzhilactone B and (−)-lingzhiol: divergent reactivity of styrene Da-Wei Zhang, Hui-Lan Fan Wenzhao Zhang, Cheng-Ji Li, Sanzhong Luo* and Hong-Bo Qin* Chem. Commun. 2020, 56, 10066-10069. Catalytic Asymmetric Electrochemical α‐Arylation of Cyclic β‐Ketocarbonyls with Anodic Benzyne Intermediates Longji Li, Yao Li, Niankai Fu, Long Zhang, Sanzhong Luo* Angew. Chem. Int. Ed. 2020, 59, 14347-14351. (Selected as VIP) Holistic Prediction of pKa in Diverse Solvents Based on Machine Learning Approach Qi Yang, Yao Li, Jin-Dong Yang, Yidi Liu, Long Zhang*, Sanzhong Luo*, Jin-Pei Cheng Angew. Chem. Int. Ed. 2020, 59, 19282-19291. Photo-mediated [1, 3]-Carbonyl shift of β-Ketocarbonyls Wenzhao Zhang, Yao Li, Sanzhong Luo* J. Photochem. Photobiol., A. 2020, 396, 112553. N‐Chlorosaccharin Sanzhong Luo*，Lu Song e-EROS. 2020. π-Coordinating Chiral Primary Amine/Palladium Synergistic Catalysis for Asymmetric Allylic Alkylation Yaning Wang, Junli Chai, Chang You, Jie Zhang, Xueling Mi, Long Zhang*, Sanzhong Luo* J. Am. Chem. Soc. 2020, 142, 3184-3195.