刘忠英 - 吉林大学

个人简介

刘忠英，女，1964年出生。1985于吉林大学化学系获学士学位，1990于白求恩医科大学获硕士学位，2005于吉林大学化学院获博士研究学位。1985至今在吉林大学工作，2006,10-2007,10国家公派赴加拿大农业部食品研究所留学，访问学者。2016,11-2017,1国家留学基金委公派赴美国威斯康辛大学留学，高级研究学者。现任吉林大学药学院教授，博士生导师。多年来一直从事药物分析和生化分析科研和教学工作，主要开展现代药物分析方法研究，并利用这些先进技术进行中药化学成分分析、体内药物分析以及代谢通路分析，从药物吸收转运机制、代谢组学以及药效学等方面，深入开展中药药效物质基础和作用机制的研究。

研究领域

1.现代药物分析方法学研究； 2.中药药效物质基础研究；

近期论文

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Men Lihui , Pi Zifeng, Zhou Yuan, Liu Yuanyuan, Wei Mengying,Song Fengrui , Liu Zhongying*. Metabolomics insights into diabetes nephropathyand protective effects of Radix Scutellariae on ratsusing ultra-high performance liquidchromatography coupled with quadrupole time-of-flight mass spectrometry. RSC Adv.2017, 7:16494-16504 . Men Lihui, Pi Zifeng , Zhou Yuan, Wei Mengying , LiuYuanyuan, Song Fengrui, Liu Zhongying*. Urine metabolomics of high-fat diet induced obesity using UHPLC-Q-TOF-MS. Journal of Pharmaceutical and Biomedical Analysis. 2017,132:258-266. Jiang Wenyue, Gao Lu, Li Pengdong, Kan Hong, Qu Jiale, Men Lihui,Zhiqiang Liu, Liu Zhongying*, Metabonomics study of the therapeutic mechanism of fenugreekgalactomannanon diabetic hyperglycemia in rats, by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Chromatography B. 2017,8-16, 1044-1045. Chen Weijia, Wu Yi, Zhao Xin, Liu Shu*, Song Fengrui , Liu Zhongying*, Liu Zhiqiang. Screening the anti-gout traditional herbs from TCM using an in vitro method. Chinese Chemical Letters,2016,27: 1701-1707. Ding Ru, Jian Yong, Kan Hong, Liu Zhongying*, Liu Shu , Liu Zhiqiang , Zhou Jun. Studies on the intestinal absorption of the alkaloids in the Gancaofuzi decoction in a Caco-2 cell culture system using UPLC-MS/MS, Chinese Chemical Letters. 2016, 27 : 915-919 . Lin He ，Pi Zifeng，Men Lihui，Chen Weijia，Liu Zhiqiang，Liu Zhongying* . Uinary metabonomic study of Panax ginseng in deficiency of vital energy rat using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Ethnopharmacology, 2016,184:10-17. Ma Yinghui，Wei Mengying, Liu Yuanyuan，Song Fengrui，Liu Zhongying*，Zifeng Pi. Study on Intestinal Transportof Veratrum alkaloids Compatibled with Panax Ginseng across the Caco-2 Cell MonolayerModel by UPLC-ESI-MS Method，Chinese Chemical Letters，2016，27：215-220. Ma Yinghui，Liu Yuanyuan，Wei Mengying ，Liu Zhiqiang，Liu Zhongying*, Pi Zifeng. Study on Intestinal Transport of Ginsenoside Compatibled with Veratrum nigrum acrossthe Caco-2 Cell Monolayer Model by UPLC-ESI-MS Method. Chemical Research in Chinese Universities，2015，31：914-918. Chen Weijia, Wu Yi, Xu Chen , Liu Shu, Wang Wenzhe, Song Fengrui, Liu Zhongying*, LiuZhiqiang. Study on Therapeutic Effects of Ermiao Pill and Ermiao Pill Categorized Formula in Hyperuricemic Rats Using Spectroscopic Methods. Spectroscopy and Spectral Ananysis. 2015,35:956-960. Jiang Wenyue, Kan Hong, Li Pengdong, Liu Zhongying*. Screening and structural characterization of potential α-glucosidase inhibitors from Radix Astragali flavonoids extract by ultrafiltration LC-DAD-ESI-MSn. Analytical Methods. 2015,7: 123-128. Kan Hong, Jiang Wenyue，Ding Ru,Pi Zifeng，Liu Zhiqiang , Liu Zhongying *. Studies of the intestinal absorption of the alkaloids in the Wu-tou decoction combined with different incompatible medicinal herbs in a Caco-2 cell culture system using UPLC–MS/MS，Chinese Chemical Letters，2014，26（5）：590-594. Kan Hong, Yue Yuan, Guo Lina, Li Xiaoping, Liu Zhongying*, Liu Zhiqiang. Microwave-Assisted Hydrolyzation of the Flavonoids in Epimedium Koreamum Nakai. Journal of Liquid Chromatography & Related Technologies 2014,7:2091-2101. Ma Jingwei, Kan Hong, Ma Yinghui, Men Lihui, Pi Zifeng, Liu Zhiqiang, Liu Zhongying*. Qualitative and Quantitative Analysis of Drug Interactions: Fritillary Mediating the Transport of Alkaloids in Caco-2 Cells by P-Glycoprotein. Chemical Research In Chinses Universities.2014, 30:731-737. Bai Yu, Jiang Wenyue, Lin He, Liu Zhiqiang, Liu Zhongying*. Identification of gamma-irradiated Chinese herbs by thermoluminescence analysis. Journal of Radioanalytical and Nuclear Chemistry. 2014, 301(1):125-131. Li Haiyan, Pan Lang, Ke Yueshuang, Batnasan Enkhzaya, Jin Xiangqun, Liu Zhongying*, Ba Xueqing*. Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in|TNF-alpha-stimulated murine lung epithelial cells via depressing PARP-1|activity. Acta Pharmacologica Sinica. 2014,35:496-503. Du Bin，Shen Guopeng, Wang Dandan, Pang Li, Chen, Zheng, Liu Zhongying*. Development and characterization of glimepiride nanocrystal formulation and evaluation of its pharmacokinetic in rats. Drug Delivery .2013, 20(1) : 25-33. Sui Zhigang, Li Na, Liu Zhiqiang, Yan Jun , Liu Zhongying*. Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple-stage tandem mass spectrometry. Xenobiotica.2013,43628-535. Li Na, Tsao Rong, Sui Zhigang, Ma Jingwei, Liu Zhongying*. Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model. Planta Med. 2012, 78:692-7